Locally Advanced Non-Small Cell Lung Cancer

Also known as: Locally Advanced Non Small Cell Lung Cancer (NSCLC) / Locally Advanced Non Small Cell Lung Cancer (NSCLC)* / Locally Advanced NSCLC / Locally advanced Non small cell lung cancer / Locally Advanced Lung Non-Small Cell Carcinoma / Lung Cancer Non-Small Cell Stage III / Nonsmall Cell Lung Cancer Stage III / Non Small Cell Lung Cancer Stage III / Non-Small Cell Lung Cancer (Stage III) / Stage III Non-small-Cell Lung Cancer / Non Small Cell Lung Cancer (Stage III) / Stage III Non-Small Cell Lung Cancer / Non-small Cell Lung Cancer, Stage III / NSCLC, Stage III / Stage III NSCLC / Non-small Cell Lung Cancer Stage III / Stage 3 Non-small cell lung cancer

DrugDrug NameDrug Description
DB15568AdagrasibA KRAS inhibitor indicated for the treatment of locally advanced or metastatic KRAS G12C-mutated non-small cell lung cancer in patients who have received at least one prior systemic therapy.
DB16695AmivantamabAn EGF and MET receptor targeted antibody indicated in the treatment of non-small cell lung cancer with an EGFR 20 exon insertion mutation.
DB14707CemiplimabA programmed death receptor-1 blocking antibody used to treat cutaneous squamous cell carcinoma, basal cell carcinoma, and non-small cell lung cancer.
DB09375ChymotrypsinA digestive enzyme supplement used as supportive therapy to manage the side effects associated with conventional chemotherapy, radiotherapy, and hormone therapy.
DB16390MobocertinibAn oral kinase inhibitor targeted against EGFR and used in the treatment of NSCLC with EGFR exon 20 insertion mutations.
DB09035NivolumabA PD-1 blocking antibody used to treat melanoma, non small-cell lung cancer, renal cell cancer, head and neck cancer, and Hodgkin lymphoma.
DB01229PaclitaxelA taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer.
DB15569SotorasibAn experimental KRAS inhibitor being investigated for the treatment of KRAS G12C mutant non small cell lung cancer, colorectal cancer, and appendix cancer.
DB00361VinorelbineA vinca alkaloid used in the treatment of metastatic non-small cell lung carcinoma (NSLC) and in conjunction with other drugs in locally advanced NSCLC.
DrugDrug NameTargetType
DB15568AdagrasibGTPase KRastarget
DB15568AdagrasibCytochrome P450 3A4enzyme
DB15568AdagrasibCytochrome P450 2C8enzyme
DB15568AdagrasibCytochrome P450 1A2enzyme
DB15568AdagrasibCytochrome P450 2B6enzyme
DB15568AdagrasibCytochrome P450 2C9enzyme
DB15568AdagrasibCytochrome P450 2D6enzyme
DB15568AdagrasibP-glycoprotein 1transporter
DB16695AmivantamabEpidermal growth factor receptortarget
DB16695AmivantamabHepatocyte growth factor receptortarget
DB16695AmivantamabLow affinity immunoglobulin gamma Fc region receptor III-Atarget
DB14707CemiplimabProgrammed cell death protein 1target
DB16390MobocertinibEpidermal growth factor receptortarget
DB16390MobocertinibCytochrome P450 3A4enzyme
DB16390MobocertinibCytochrome P450 3A5enzyme
DB16390MobocertinibCytochrome P450 3A7enzyme
DB16390MobocertinibP-glycoprotein 1transporter
DB16390MobocertinibATP-binding cassette sub-family G member 2transporter
DB09035NivolumabProgrammed cell death protein 1target
DB09035NivolumabProgrammed cell death 1 ligand 1target
DB01229PaclitaxelApoptosis regulator Bcl-2target
DB01229PaclitaxelTubulin beta-1 chaintarget
DB01229PaclitaxelCytochrome P450 2C8enzyme
DB01229PaclitaxelCytochrome P450 3A4enzyme
DB01229PaclitaxelCytochrome P450 3A5enzyme
DB01229PaclitaxelCytochrome P450 3A7enzyme
DB01229PaclitaxelBile salt export pumptransporter
DB01229PaclitaxelP-glycoprotein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 7transporter
DB01229PaclitaxelCytochrome P450 19A1enzyme
DB01229PaclitaxelCytochrome P450 1B1enzyme
DB01229PaclitaxelSolute carrier organic anion transporter family member 1B3transporter
DB01229PaclitaxelNuclear receptor subfamily 1 group I member 2target
DB01229PaclitaxelMicrotubule-associated protein 4target
DB01229PaclitaxelMicrotubule-associated protein 2target
DB01229PaclitaxelMicrotubule-associated protein tautarget
DB01229PaclitaxelCanalicular multispecific organic anion transporter 1transporter
DB15569SotorasibGTPase KRastarget
DB15569SotorasibCytochrome P450 3A Subfamilyenzyme
DB15569SotorasibCytochrome P450 2C8enzyme
DB15569SotorasibCytochrome P450 2C9enzyme
DB15569SotorasibCytochrome P450 2B6enzyme
DB15569SotorasibATP-binding cassette sub-family G member 2transporter
DB15569SotorasibP-glycoprotein 1transporter
DB00361VinorelbineTubulin beta chaintarget
DB00361VinorelbineCytochrome P450 3A4enzyme
DB00361VinorelbineCytochrome P450 2D6enzyme
DrugDrug NamePhaseStatusCount
DB11595Atezolizumab1Not Yet Recruiting1
DB01117Atovaquone1Completed1
DB00112Bevacizumab1Recruiting1
DB12267Brigatinib1Recruiting1
DB00958Carboplatin1Recruiting1
DB11890Cilengitide1Completed1
DB00515Cisplatin1Completed1
DB00531Cyclophosphamide1Recruiting1
DB11714Durvalumab1Recruiting2
DB06186Ipilimumab1Active Not Recruiting1
DB17309Minnelide1Recruiting1
DB12824Monalizumab1Recruiting1
DB09035Nivolumab1Active Not Recruiting1
DB15088Oleclumab1Recruiting1
DB09330Osimertinib1Recruiting1
DB01229Paclitaxel1Recruiting1
DB01113Papaverine1Recruiting1
DB09037Pembrolizumab1Active Not Recruiting1
DB09037Pembrolizumab1Recruiting1
DB00642Pemetrexed1Recruiting1
DB00020Sargramostim1Recruiting1
DB12025Triptolide1Recruiting1
DB00361Vinorelbine1Completed1
DB02546Vorinostat1Completed1
DB00958Carboplatin1 / 2Terminated1
DB01229Paclitaxel1 / 2Terminated1
DB11885Anlotinib2Withdrawn1
DB00394Beclomethasone dipropionate2Unknown Status1
DB02379Beta-D-Glucose2Terminated1
DB00112Bevacizumab2Completed1
DB14776Camrelizumab2Recruiting1
DB00958Carboplatin2Completed1
DB00958Carboplatin2Not Yet Recruiting1
DB14547Chloride ion2Terminated1
DB00515Cisplatin2Completed1
DB00515Cisplatin2Terminated1
DB01248Docetaxel2Completed1
DB11714Durvalumab2Terminated1
DB00530Erlotinib2Completed1
DB00773Etoposide2Terminated1
DB06186Ipilimumab2Active Not Recruiting1
DB00727Nitroglycerin2Unknown Status1
DB09035Nivolumab2Active Not Recruiting1
DB01229Paclitaxel2Completed1
DB01229Paclitaxel2Not Yet Recruiting1
DB09037Pembrolizumab2Not Yet Recruiting1
DB00642Pemetrexed2Not Yet Recruiting1
DB00642Pemetrexed2Terminated1
DB12257Platinum2Enrolling by Invitation1
DB12257Platinum2Not Yet Recruiting1
DB12257Platinum2Terminated1
DB14765Rivoceranib2Recruiting1
DB06273Tocilizumab2Active Not Recruiting1
DB15043Toripalimab2Enrolling by Invitation1
DB02379Beta-D-Glucose3Recruiting1
DB00958Carboplatin3Recruiting1
DB14547Chloride ion3Recruiting1
DB00515Cisplatin3Recruiting1
DB11714Durvalumab3Recruiting1
DB00773Etoposide3Recruiting1
DB01229Paclitaxel3Recruiting1
DB00642Pemetrexed3Recruiting1
DB12257Platinum3Recruiting1