Relapsed Acute Myelogenous Leukemia (AML)

Also known as: Acute Myeloid Leukemia, in Relapse / Acute, relapsed Myeloid Leukemia / Relapsed AML / Relapsed Acute Myeloid Leukemia (AML) / Relapsed Acute Myeloid Leukemia / Relapsed Acute Myelogenous Leukemia / Acute, relapsed Myelogenous Leukemia / Acute Myeloid Leukemia (AML) Relapse / Acute Myelogenous Leukemia in Relapse / Myeloid Leukemia in Relapse (Disorder)

DrugDrug NameDrug Description
DB13874EnasidenibAn isocitrate dehydrogenase-2 inhibitor used to treat relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 mutation.
DB00056Gemtuzumab ozogamicinA monoclonal anti-CD33 antibody used to treat CD33-positive acute myeloid leukemia.
DB12141GilteritinibAn AXL receptor tyrosine kinase inhibitor used to treat relapsed or refractory acute myeloid leukemia.
DB14568IvosidenibAn isocitrate dehydrogenase-1 inhibitor used to treat acute myeloid leukemia and cholangiocarcinoma in adults with a susceptible IDH1 mutation.
DB16267OlutasidenibAn isocitrate dehydrogenase-1 (IDH1) inhibitor indicated for the treatment of patients with relapsed or refractory acute myeloid leukemia with a susceptible IDH1 mutation as detected by an FDA-approved test.
DrugDrug NameTargetType
DB13874EnasidenibCytochrome P450 1A2enzyme
DB13874EnasidenibCytochrome P450 2B6enzyme
DB13874EnasidenibIsocitrate dehydrogenase [NADP], mitochondrialtarget
DB13874EnasidenibCytochrome P450 2C8enzyme
DB13874EnasidenibCytochrome P450 2C9enzyme
DB13874EnasidenibCytochrome P450 2C19enzyme
DB13874EnasidenibCytochrome P450 2D6enzyme
DB13874EnasidenibCytochrome P450 3A4enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 1-1enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 1-3enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 1-4enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 1-9enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 2B7enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 2B15enzyme
DB13874EnasidenibP-glycoprotein 1transporter
DB13874EnasidenibATP-binding cassette sub-family G member 2transporter
DB13874EnasidenibSolute carrier family 22 member 6transporter
DB13874EnasidenibSolute carrier organic anion transporter family member 1B1transporter
DB13874EnasidenibSolute carrier family 22 member 2transporter
DB13874EnasidenibSolute carrier organic anion transporter family member 1B3transporter
DB13874EnasidenibSolute carrier family 22 member 8transporter
DB13874EnasidenibSerum albumincarrier
DB00056Gemtuzumab ozogamicinMyeloid cell surface antigen CD33target
DB00056Gemtuzumab ozogamicinLow affinity immunoglobulin gamma Fc region receptor III-Btarget
DB00056Gemtuzumab ozogamicinLow affinity immunoglobulin gamma Fc region receptor III-Atarget
DB00056Gemtuzumab ozogamicinHigh affinity immunoglobulin gamma Fc receptor Itarget
DB12141GilteritinibSerum albumincarrier
DB12141GilteritinibCytochrome P450 3A4enzyme
DB12141GilteritinibReceptor-type tyrosine-protein kinase FLT3target
DB12141GilteritinibSerotonin Receptorstarget
DB12141GilteritinibP-glycoprotein 1transporter
DB12141GilteritinibMultidrug and toxin extrusion protein 1transporter
DB12141GilteritinibATP-binding cassette sub-family G member 2transporter
DB12141GilteritinibSolute carrier family 22 member 1transporter
DB12141GilteritinibTyrosine-protein kinase receptor UFOtarget
DB12141GilteritinibALK tyrosine kinase receptortarget
DB14568IvosidenibIsocitrate dehydrogenase [NADP] cytoplasmictarget
DB14568IvosidenibCytochrome P450 3A4enzyme
DB14568IvosidenibCytochrome P450 2B6enzyme
DB14568IvosidenibCytochrome P450 2C9enzyme
DB14568IvosidenibCytochrome P450 2C8enzyme
DB14568IvosidenibSolute carrier family 22 member 8transporter
DB14568IvosidenibP-glycoprotein 1transporter
DB16267OlutasidenibIsocitrate dehydrogenase [NADP] cytoplasmictarget
DB16267OlutasidenibCytochrome P450 3A4enzyme
DB16267OlutasidenibCytochrome P450 2C8enzyme
DB16267OlutasidenibCytochrome P450 2C9enzyme
DB16267OlutasidenibCytochrome P450 1A2enzyme
DB16267OlutasidenibCytochrome P450 2C19enzyme
DB16267OlutasidenibP-glycoprotein 1transporter
DB16267OlutasidenibATP-binding cassette sub-family G member 2transporter
DB16267OlutasidenibSolute carrier organic anion transporter family member 1B1transporter
DB16267OlutasidenibSolute carrier organic anion transporter family member 1B3transporter
DB16267OlutasidenibSolute carrier family 22 member 8transporter
DB16267OlutasidenibSolute carrier family 22 member 2transporter
DB16267OlutasidenibMultidrug and toxin extrusion protein 1transporter
DB16267OlutasidenibMultidrug and toxin extrusion protein 2transporter
DB16267OlutasidenibCytochrome P450 2B6enzyme
DrugDrug NamePhaseStatusCount
DB01390Sodium bicarbonate0Completed1
DB17143APTO-2531Terminated1
DB00928Azacitidine1Not Yet Recruiting1
DB00928Azacitidine1Recruiting1
DB17267BI-8368581Completed1
DB17234Bomedemstat1Recruiting1
DB08875Cabozantinib1Completed1
DB00242Cladribine1Recruiting1
DB09110Coenzyme M1Recruiting1
DB00531Cyclophosphamide1Active Not Recruiting2
DB00531Cyclophosphamide1Recruiting2
DB00987Cytarabine1Not Yet Recruiting1
DB00987Cytarabine1Recruiting5
DB00987Cytarabine1Terminated1
DB01254Dasatinib1Withdrawn1
DB00694Daunorubicin1Recruiting1
DB01262Decitabine1Recruiting2
DB17383FN-15011Terminated1
DB11680Ficlatuzumab1Terminated1
DB00099Filgrastim1Recruiting3
DB01073Fludarabine1Active Not Recruiting2
DB01073Fludarabine1Recruiting4
DB12141Gilteritinib1Recruiting1
DB00741Hydrocortisone1Not Yet Recruiting1
DB00741Hydrocortisone1Recruiting1
DB15126IMG-72891Recruiting1
DB01033Mercaptopurine1Recruiting1
DB00563Methotrexate1Not Yet Recruiting1
DB00563Methotrexate1Recruiting1
DB01204Mitoxantrone1Recruiting1
DB16848ORY-10011Recruiting1
DB05213Quizartinib1Completed1
DB18515Revumenib1Not Yet Recruiting1
DB11942Selinexor1Active Not Recruiting1
DB11942Selinexor1Recruiting1
DB04572Thiotepa1Recruiting1
DB11581Venetoclax1Not Yet Recruiting1
DB11581Venetoclax1Recruiting6
DB02546Vorinostat1Recruiting1
DB17171Ziftomenib1Recruiting1
DB17115AB-89391 / 2Recruiting1
DB00928Azacitidine1 / 2Recruiting1
DB01262Decitabine1 / 2Active Not Recruiting1
DB01262Decitabine1 / 2Completed1
DB15008GO-203-2C1 / 2Active Not Recruiting1
DB12141Gilteritinib1 / 2Active Not Recruiting1
DB14770Lanraplenib1 / 2Active Not Recruiting1
DB09037Pembrolizumab1 / 2Completed1
DB00928Azacitidine2Not Yet Recruiting1
DB00928Azacitidine2Recruiting1
DB00631Clofarabine2Terminated1
DB00531Cyclophosphamide2Terminated1
DB00531Cyclophosphamide2Withdrawn1
DB00987Cytarabine2Not Yet Recruiting1
DB00987Cytarabine2Terminated1
DB00987Cytarabine2Withdrawn1
DB01262Decitabine2Not Yet Recruiting1
DB12109Devimistat2Not Yet Recruiting1
DB00773Etoposide2Terminated1
DB00099Filgrastim2Terminated1
DB00099Filgrastim2Withdrawn1
DB15223Flotetuzumab2Recruiting1
DB01073Fludarabine2Withdrawn2
DB11896Gedatolisib2Terminated1
DB14865Human interleukin-22Withdrawn2
DB00331Metformin2Not Yet Recruiting1
DB15721Natural Killer Cell2Withdrawn1
DB09037Pembrolizumab2Active Not Recruiting1
DB11581Venetoclax2Not Yet Recruiting1
DB11581Venetoclax2Recruiting1
DB11832Crenolanib3Not Yet Recruiting1
DB00987Cytarabine3Not Yet Recruiting1
DB00099Filgrastim3Not Yet Recruiting1
DB01073Fludarabine3Not Yet Recruiting1
DB01177Idarubicin3Not Yet Recruiting1
DB01204Mitoxantrone3Not Yet Recruiting1