Pseudobulbar Affect (PBA) (DBCOND0038672)

Identifiers

Synonyms

Pseudobulbar affect / Pseudobulbar affect (finding) / Affect lability / Labile affect (finding) / Labile affect

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Dextromethorphan	An NMDA receptor antagonist used to treat cases of dry cough.	Sigma non-opioid intracellular receptor 1target Neuronal acetylcholine receptor subunit alpha-2target Sodium-dependent serotonin transportertarget Glutamate receptor ionotropic, NMDA 3Atarget Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A7enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Membrane-associated progesterone receptor component 1target Neuronal acetylcholine receptor subunit alpha-3target Neuronal acetylcholine receptor subunit alpha-4target Neuronal acetylcholine receptor subunit beta-4target Neuronal acetylcholine receptor subunit beta-2target Neuronal acetylcholine receptor subunit alpha-7target Mu-type opioid receptortarget Delta-type opioid receptortarget Kappa-type opioid receptortarget NADPH oxidasetarget Sodium-dependent noradrenaline transportertarget UDP-glucuronosyltransferase 2B4enzyme UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 2B15enzyme UDP-glucuronosyltransferase 2B17enzyme Aromatasetarget
Quinidine	A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias.	Sodium channel protein type 5 subunit alphatarget Alpha-1-acid glycoprotein 1carrier Potassium voltage-gated channel subfamily H member 2target Potassium channel subfamily K member 1target Potassium channel subfamily K member 6target Cytochrome P450 1A2enzyme Cytochrome P450 2E1enzyme Cytochrome P450 1A1enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Organic cation/carnitine transporter 2transporter ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Organic anion transporter 3transporter ATP-binding cassette sub-family C member 2transporter Solute carrier family 22 member 4transporter Solute carrier organic anion transporter family member 1B1transporter Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme Alpha-1A adrenergic receptortarget Alpha-1B adrenergic receptortarget Alpha-1D adrenergic receptortarget Bile salt export pumptransporter Cytochrome P450 2C8enzyme Albumincarrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01799941	Safety, Tolerability and Effectiveness of Nuedexta in the Treatment of Pseudobulbar Affect (PBA)	Dextromethorphan Quinidine	treatment	4	completed
NCT00573443	Safety and Efficacy of AVP-923 in PBA Patients With ALS or MS	Dextromethorphan Quinidine	treatment	3	completed
NCT01832350	Nuedexta in the Treatment of Pseudobulbar Affect in Patients With Alzheimer's Disease	Dextromethorphan Quinidine	supportive_care	4	terminated
NCT06457126	Piloting the Attention Training Technique for Post-Stroke Emotionalism	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT06396260	Structural and Functional Networks in ALS: An Insight Into Pseudobulbar Affect	No drug interventions	other	Not Available	not_yet_recruiting