Chronic Graft Versus Host Disease

Also known as: GVHD, Chronic / CGVHD / Chronic GVHD / Chronic Graft-Versus Host Disease / Chronic Graft-Versus-Host-Disease / Chronic Graft vs. Host Disease / Chronic Graft-vs.-Host Disease / Chronic Graft vs Host Disease / Chronic Graft-Versus-Host Disease / Chronic GVH disease

DrugDrug NameDrug Description
DB16703BelumosudilAn oral inhibitor of rho-associated coiled-coil-containing protein kinases (ROCK) used in the treatment of chronic graft-versus-host disease (GVHD).
DB09053IbrutinibAn antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia.
DB08877RuxolitinibA kinase inhibitor used to treat various types of myelofibrosis, polycythemia vera in patients who have not responded to or cannot tolerate hydroxyurea, and to treat graft-versus-host disease in cases that are refractory to steroid treatment.
DB01041ThalidomideA medication used to treat cancers, particularly newly diagnosed multiple myeloma, and erythema nodosum leprosum.
DrugDrug NameTargetType
DB16703BelumosudilRho-associated protein kinase 2target
DB16703BelumosudilSerum albumincarrier
DB16703BelumosudilAlpha-1-acid glycoprotein 1carrier
DB16703BelumosudilRho-associated protein kinase 1target
DB16703BelumosudilCytochrome P450 3A4enzyme
DB16703BelumosudilCytochrome P450 2C8enzyme
DB16703BelumosudilCytochrome P450 2D6enzyme
DB16703BelumosudilUDP-glucuronosyltransferase 1-9enzyme
DB16703BelumosudilCytochrome P450 1A2enzyme
DB16703BelumosudilCytochrome P450 2C19enzyme
DB16703BelumosudilUDP-glucuronosyltransferase 1-1enzyme
DB16703BelumosudilP-glycoprotein 1transporter
DB16703BelumosudilATP-binding cassette sub-family G member 2transporter
DB16703BelumosudilSolute carrier organic anion transporter family member 1B1transporter
DB09053IbrutinibTyrosine-protein kinase BTKtarget
DB09053IbrutinibCytochrome P450 3A4enzyme
DB09053IbrutinibCytochrome P450 3A5enzyme
DB09053IbrutinibSerum albumincarrier
DB09053Ibrutinibalpha1-acid glycoproteincarrier
DB09053IbrutinibCytochrome P450 2D6enzyme
DB08877RuxolitinibTyrosine-protein kinase JAK1target
DB08877RuxolitinibTyrosine-protein kinase JAK2target
DB08877RuxolitinibCytochrome P450 3A4enzyme
DB08877RuxolitinibCytochrome P450 2C9enzyme
DB08877RuxolitinibSerum albumincarrier
DB08877RuxolitinibTyrosine-protein kinase JAK3target
DB08877RuxolitinibNon-receptor tyrosine-protein kinase TYK2target
DB01041ThalidomideCytochrome P450 2C19enzyme
DB01041ThalidomideCytochrome P450 2C9enzyme
DB01041ThalidomideProstaglandin G/H synthase 1enzyme
DB01041ThalidomideProstaglandin G/H synthase 2enzyme
DB01041ThalidomideCytochrome P450 3A5enzyme
DB01041ThalidomideDNAtarget
DB01041ThalidomideProtein cereblontarget
DB01041Thalidomidealpha1-acid glycoproteintarget
DB01041ThalidomideCytochrome P450 3A4enzyme
DB01041ThalidomideCytochrome P450 1A1enzyme
DB01041ThalidomideCytochrome P450 2B6enzyme
DrugDrug NamePhaseStatusCount
DB16756Ivarmacitinib0Recruiting1
DB00553Methoxsalen0Completed1
DB00635Prednisone0Recruiting1
DB01281Abatacept1Active Not Recruiting1
DB00041Aldesleukin1Completed1
DB00087Alemtuzumab1Completed1
DB15726Human Umbilical Cord Mesenchymal Stem Cells1Completed1
DB14865Human interleukin-21Active Not Recruiting1
DB01097Leflunomide1Recruiting1
DB04868Nilotinib1Completed1
DB08877Ruxolitinib1Recruiting1
DB16388Axatilimab1 / 2Active Not Recruiting1
DB11817Baricitinib1 / 2Active Not Recruiting1
DB11978Glasdegib1 / 2Active Not Recruiting1
DB09053Ibrutinib1 / 2Active Not Recruiting1
DB09053Ibrutinib1 / 2Terminated1
DB06650Ofatumumab1 / 2Active Not Recruiting1
DB00073Rituximab1 / 2Terminated1
DB11703Acalabrutinib2Recruiting1
DB00041Aldesleukin2Active Not Recruiting2
DB00092Alefacept2Terminated1
DB11885Anlotinib2Terminated1
DB00098Antithymocyte immunoglobulin (rabbit)2Recruiting2
DB01169Arsenic trioxide2Completed1
DB16388Axatilimab2Recruiting1
DB16703Belumosudil2Enrolling by Invitation1
DB16703Belumosudil2Recruiting2
DB00188Bortezomib2Completed1
DB00188Bortezomib2Unknown Status1
DB16741Bortezomib D-mannitol2Completed1
DB16741Bortezomib D-mannitol2Unknown Status1
DB08889Carfilzomib2Completed1
DB00531Cyclophosphamide2Recruiting1
DB00091Cyclosporine2Active Not Recruiting1
DB00091Cyclosporine2Recruiting1
DB01234Dexamethasone2Recruiting1
DB12121Entospletinib2Terminated1
DB14865Human interleukin-22Active Not Recruiting1
DB15127Hydrogen2Recruiting1
DB09053Ibrutinib2Recruiting2
DB00619Imatinib2Terminated1
DB12154Itacitinib2Recruiting2
DB09570Ixazomib2Completed1
DB01097Leflunomide2Recruiting1
DB00553Methoxsalen2Terminated1
DB00959Methylprednisolone2Withdrawn1
DB00471Montelukast2Completed1
DB00688Mycophenolate mofetil2Terminated1
DB06603Panobinostat2Withdrawn1
DB12016Ponesimod2Terminated1
DB00635Prednisone2Completed1
DB00073Rituximab2Completed1
DB00877Sirolimus2Recruiting1
DB00877Sirolimus2Terminated1
DB08828Vismodegib2Terminated1
DB00091Cyclosporine2 / 3Completed1
DB00091Cyclosporine2 / 3Unknown Status1
DB12154Itacitinib2 / 3Active Not Recruiting1
DB00959Methylprednisolone2 / 3Active Not Recruiting1
DB14644Methylprednisolone hemisuccinate2 / 3Active Not Recruiting1
DB00635Prednisone2 / 3Active Not Recruiting1
DB00635Prednisone2 / 3Completed1
DB00877Sirolimus2 / 3Completed1
DB00864Tacrolimus2 / 3Completed1
DB15726Human Umbilical Cord Mesenchymal Stem Cells3Unknown Status1
DB09053Ibrutinib3Completed1
DB09053Ibrutinib3Enrolling by Invitation1
DB00635Prednisone3Completed1
DB01073Fludarabine4Not Yet Recruiting1