Acute Otitis Externa (DBCOND0041609)

Identifiers

Synonyms

Acute otitis externa / Unspecified acute noninfective otitis externa / Acute otitis externa (disorder) / Acute swimmers' ear / Acute bacterial inflammation of external ear (disorder) / Acute swimmer's ear (disorder) / Acute bacterial otitis externa (disorder) / Unspecified otitis externa, unspecified ear / Unspecified otitis externa / Otitis Externa / Disorders of external ear (& [otitis externa] or [pinna]) / Otitis externa (disorder) / Inflammation external ear &/or otitis externa NOS / Otitis externa NOS / Otitis externa NOS (disorder) / External ear inflammation

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Acetic acid	An antimicrobial agent used to treat susceptible infections of the external auditory canal.	Solute carrier organic anion transporter family member 2B1transporter Monocarboxylate transporter 1transporter
Ciprofloxacin	A second generation fluoroquinolone used to treat various susceptible bacterial infections.	DNA gyrase subunit Atarget DNA topoisomerase 4 subunit Atarget DNA topoisomerase 2-alphatarget Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Potassium voltage-gated channel subfamily H member 2target DNA gyrase subunit Atarget DNA topoisomerase 4 subunit Atarget DNA topoisomerase 4 subunit Btarget DNA gyrase subunit Atarget Multidrug resistance protein MdtKtarget Gyrase Atarget DNA gyrase subunit Atarget Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Albumincarrier Thymidylate synthasetarget DNA gyrase subunit Btarget
Dexamethasone	A glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders.	Glucocorticoid receptortarget Annexin A1target Nitric oxide synthase, inducibletarget Nuclear receptor subfamily 0 group B member 1target Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Bile salt export pumptransporter ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Solute carrier organic anion transporter family member 1A2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Steroid 17-alpha-hydroxylase/17,20 lyaseenzyme Cytochrome P450 1A1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A43enzyme Cytochrome P450 4A11enzyme Nuclear receptor subfamily 1 group I member 2target Cytochrome P450 11B1, mitochondrialenzyme Albumincarrier 11-beta-hydroxysteroid dehydrogenase type 2enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme Organic anion transporter 3transporter
Finafloxacin	Finafloxacin is indicated for the treatment of acute otitis externa (AOE) with or without an otowick, caused by susceptible strains of Pseudomonas aeruginosa and Staphylococcus aureus in patients age 1...	DNA gyrase subunit Atarget DNA topoisomerase 4 subunit Atarget DNA topoisomerase 2-alphatarget DNA gyrase subunit Atarget DNA gyrase subunit Btarget
Hydrocortisone	A glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders.	Annexin A1target Glucocorticoid receptortarget Sex hormone-binding globulincarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 11B2, mitochondrialenzyme Cytochrome P450 2C8enzyme Corticosteroid-binding globulincarrier Organic anion transporter 3transporter Aldo-keto reductase family 1 member D1enzyme 3-oxo-5-alpha-steroid 4-dehydrogenase 2enzyme 11-beta-hydroxysteroid dehydrogenase type 2enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00750633	A Phase III Study of an Otic Formulation in Acute Otitis Externa	No drug interventions	treatment	3	completed
NCT02216071	Comparative Efficacy and Safety of Ciprofloxacin 0.3% and Dexamethasone 0.1% in Acute Otitis Externa	No drug interventions	treatment	3	completed
NCT01584271	Study of Ear Comfort Ear Drops to Treat AOE Cases Compared to DexOtic & Otidin(R)	No drug interventions	treatment	2	unknown_status
NCT02801370	Phase 3 Study of OTO-201 in Acute Otitis Externa	No drug interventions	treatment	3	completed
NCT01447017	A Study of DPK-060 to Investigate Clinical Safety and Efficacy in Patients With Acute External Otitis	No drug interventions	treatment	2	completed
NCT04636957	A Phase III Study of Ciprofloxacin Plus Fluocinolone in Acute Otitis Externa (AOE)	Ciprofloxacin Fluocinolone acetonide	treatment	3	unknown_status
NCT02918773	Pediatric Emergency Department Smartphone Otoscope Study (PED-Oto)	No drug interventions	health_services_research	Not Available	completed
NCT03196973	Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Acute Otitis Externa	No drug interventions	treatment	3	completed
NCT00945802	FST-201 In The Treatment of Acute Otitis Externa	No drug interventions	treatment	3	terminated
NCT00961675	FST-201 in the Treatment of Acute Otitis Externa	No drug interventions	treatment	3	completed
NCT01535599	Safety and Efficacy Evaluation of Topical AL-60371 Otic Suspension, 0.3% in the Treatment of Acute Otitis Externa	No drug interventions	treatment	3	completed
NCT01535560	Safety and Efficacy Evaluation of Topical AL-60371 Otic Suspension, 0.3% in the Treatment of Acute Otitis Externa	No drug interventions	treatment	3	completed