smooth muscle relaxation prior to radiological procedures therapy (DBCOND0089477)

Identifiers

Synonyms

Smoth muscle relaxation prior to radiological procedures / Muscle relaxant therapy therapy / Muscle Relaxants / Smooth muscle relaxation prior to radiological procedures / Muscle Relaxant / Skeletal muscle relaxation for surgery / Induction of Muscle relaxation / Muscle relaxant therapy / Muscle hypotonia / Decreased muscle tone (finding) / Hypotonia / Decreased muscle tone / Muscle tone decreased / Poor muscle tone (finding)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Butylscopolamine	An antispasmodic and anticholinergic agent used for the symptomatic treatment of abdominal cramping and pain.	Muscarinic acetylcholine receptor M3target Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M5target
Cisatracurium	A skeletal muscle relaxant used to facilitate tracheal intubation, muscle relaxation in surgery, or mechanical ventilation.	Neuronal Acetylcholine (nACh) Receptor Subunitstarget Acetylcholine receptor subunit alphatarget Muscarinic acetylcholine receptor M2target Neuronal acetylcholine receptor subunit alpha-2target
Ibuprofen	An NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Cytochrome P450 2C9enzyme Albumincarrier ATP-binding cassette sub-family C member 4transporter Multidrug resistance-associated protein 1transporter Solute carrier organic anion transporter family member 1A2transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Solute carrier organic anion transporter family member 2B1transporter ATP-dependent translocase ABCB1transporter UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B4enzyme UDP-glucuronosyltransferase 2B7enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C19enzyme Apoptosis regulator Bcl-2target Thrombomodulintarget Fatty acid-binding protein, intestinaltarget Peroxisome proliferator-activated receptor gammatarget Cystic fibrosis transmembrane conductance regulatortarget Peroxisome proliferator-activated receptor alphatarget Platelet glycoprotein Ib alpha chaintarget Protein S100-A7target Alpha-methylacyl-CoA racemaseenzyme Cytochrome P450 3A4enzyme C-X-C chemokine receptor type 1target C-X-C chemokine receptor type 2target Interleukin-8target
Metamizole	An antipyretic and analgesic drug used to relieve severe and persistent fever and pain.	Prostaglandin G/H synthase 1target Cytochrome P450 2B6enzyme Cytochrome P450 3A4enzyme
Mivacurium	A short-acting non-depolarizing neuromuscular blocking agent used to induce anesthesia during intubation and promote skeletal muscle relaxation during surgery or mechanical ventilation.	Neuronal acetylcholine receptor subunit alpha-2target Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M3target Cholinesterasetarget Cholinesteraseenzyme
Pancuronium	A neuromuscular blocker used as an adjunct to general anesthesia to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.	Neuronal acetylcholine receptor subunit alpha-2target Cholinesteraseenzyme Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M3target Solute carrier family 22 member 1transporter Solute carrier family 22 member 2transporter
Pipethanate	An antimuscarinic agent indicated to treat spastic pain of the gastrointestinal system.	No drug targets
Prazepam	A benzodiazepine used to manage more severe forms of anxiety disorders.	Cytochrome P450 3A4enzyme GABA(A) Receptortarget GABA(A) Receptor Benzodiazepine Binding Sitetarget Translocator proteintarget
Tizanidine	An alpha-2 adrenergic agonist used for the short-term treatment of muscle spasticity.	Alpha-2 adrenergic receptorstarget Cytochrome P450 1A2enzyme Nischarintarget Alpha-1 adrenergic receptorstarget
Vecuronium	A nondepolarizing neuromuscular blocking agent used to relax muscles or as an adjunct in general anesthesia during surgical procedures.	ATP-dependent translocase ABCB1transporter Neuronal acetylcholine receptor subunit alpha-2target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02425449	Fade Upon TOF Stimulation Induced by Succinylcholine	Succinylcholine	other	4	completed
NCT02467595	The Effect of no Muscle Relaxant Versus Reduced-dose Rocuronium on Anesthesia in Adenotonsillectomy	Fentanyl Propofol Rocuronium Sevoflurane	supportive_care	4	unknown_status
NCT02157545	The Dose-Response Relationship of Rocuronium in Patients Taking Pyridostigmine	No drug interventions	Not Available	Not Available	withdrawn
NCT02696837	Pediatric Inguinal Hernia Repair: Are Muscle Relaxants Necessary? Endotracheal Intubation vs Laryngeal Mask Airway	Rocuronium	Not Available	Not Available	completed
NCT02575716	Comparison of Intubating Condition of the Mcgrath Videolaryngoscope With and Without Muscle Relaxant	No drug interventions	treatment	1	completed
NCT03058263	Effect of Neostigmine on the Recovery of Rocuronium: A Comparison Between Partial and TOF Ratio-Based Dose	Neostigmine	supportive_care	1 / 2	completed
NCT04344262	Small Doses Muscle Relaxant in General Anesthesia	Atracurium besylate	treatment	Not Available	recruiting