Mydriasis (DBCOND0001108)

Identifiers

Synonyms

Pupillary dilatation / Dilation of the pupil / Dilatation of the pupil / Pupillary dilation / Pupil Dilation / Dilatation of pupils / Dilation of the pupils / Dilated pupils / Dilated pupil / Pupils dilated / Dilatation pupillary / Dilated pupil (qualifier value) / Instillation of dilating eye drops to eye (procedure)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Atropine	A muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs.	Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M5target Muscarinic acetylcholine receptor M3target Glycine receptor subunit alpha-1target Neuronal acetylcholine receptor subunit alpha-4target Neuronal acetylcholine receptor subunit beta-2target Bile salt export pumptransporter Alpha-1-acid glycoprotein 1carrier
Cyclopentolate	An anticholinergic used to cause mydriasis and cycloplegia for diagnostic testing.	Muscarinic acetylcholine receptor M1target Cholinesteraseenzyme Muscarinic acetylcholine receptor M5target
Epinephrine	A hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma.	Alpha-1A adrenergic receptortarget Beta-1 adrenergic receptortarget Beta-2 adrenergic receptortarget Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Alpha-1B adrenergic receptortarget Alpha-1D adrenergic receptortarget Alpha-2A adrenergic receptortarget Alpha-2B adrenergic receptortarget Tumor necrosis factortarget Catechol O-methyltransferaseenzyme Monoamine oxidaseenzyme
Ibopamine	A sympathomimetic, indicated in the induction of mydriasis and treatment of pos-surgical ocular hypotonia.	No drug targets
Ketorolac	An NSAID used to treat moderate to severe pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders, and headaches.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target UDP-glucuronosyltransferase 2B7enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme
Phentolamine	An alpha-adrenergic blocker used to treat hypertensive episodes, diagnose pheochromocytoma, treat norepinephrine administration site reactions, and reverse soft tissue anesthesia and mydriasis.	Alpha-1 adrenergic receptorstarget Alpha-2 adrenergic receptorstarget ATP-sensitive inward rectifier potassium channel 11target D(2) dopamine receptortarget
Phenylephrine	An alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics.	Alpha-1A adrenergic receptortarget Alpha-1B adrenergic receptortarget Amine oxidase [flavin-containing] Aenzyme Alpha-1D adrenergic receptortarget Cytochrome P450 1A2enzyme Sulfotransferase 1A3enzyme Amine oxidase [flavin-containing] Benzyme D(2) dopamine receptortarget
Tropicamide	A muscarinic receptor antagonist used to induce mydriasis and cycloplegia for diagnostic procedures.	Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M3target
Yohimbine	An alpha-2-adrenergic blocker and sympatholytic found in supplements used to.	Alpha-2A adrenergic receptortarget Alpha-2B adrenergic receptortarget Alpha-2C adrenergic receptortarget 5-hydroxytryptamine receptor 1Atarget 5-hydroxytryptamine receptor 1Btarget 5-hydroxytryptamine receptor 1Dtarget D(2) dopamine receptortarget D(3) dopamine receptortarget 5-hydroxytryptamine receptor 2Atarget 5-hydroxytryptamine receptor 2Ctarget Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme ATP-sensitive potassium channeltarget 5-hydroxytryptamine receptor 2Btarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05880433	The Effects of Mydriatic Eye Drops in Retinopathy of Prematurity Examinations	No drug interventions	Not Available	Not Available	completed
NCT04620213	Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis	Phentolamine	treatment	3	completed
NCT00690222	Intracameral Mydriasis Versus Topical Mydriasis in Cataract Surgery	No drug interventions	treatment	Not Available	terminated
NCT02946125	Study of the Safety, Efficacy and PK of EYN-1601 in Dilation of the Pupil	Phenylephrine	treatment	2	completed
NCT04907474	Evaluation of Pupil Dilation Speed With the MAP Dispenser	Phenylephrine Tropicamide	diagnostic	4	completed
NCT05134974	Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis (MIRA-3)	Phentolamine	treatment	3	completed
NCT03751631	Safety and Efficacy of Phenylephrine 2.5%-Tropicamide 1% Microdose Ophthalmic Solution for Pupil Dilation	Phenylephrine Tropicamide	diagnostic	3	completed
NCT04396301	Effect of Intracameral Injection of Mydriatic Plus Anaesthetic Combination on Corneal Endothelial Count in Phaco	Lidocaine Phenylephrine Tropicamide	other	3	completed
NCT03751098	Safety and Efficacy of Phenylephrine 2.5%-Tropicamide 1% Microdose Ophthalmic Solution for Pupil Dilation	Phenylephrine Tropicamide	diagnostic	3	completed
NCT05223478	Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis in Pediatric Subjects	Phentolamine	treatment	3	completed
NCT06217796	Safety and Efficacy of Fixed Combination Phenylephrine-Tropicamide for Pupil Dilation	Phenylephrine Tropicamide	diagnostic	4	completed
NCT05829122	Sutureless Intrascleral Intraocular Lens Fixation and Modified Iris Cerclage Pupilloplasty	No drug interventions	treatment	Not Available	recruiting
NCT03638726	Subconjunctival Atropine and Intracameral Epinephrine for Pupil Dilation in Phacoemulsification	Atropine Cyclopentolate Epinephrine Phenylephrine	other	4	unknown_status
NCT04024891	Safety and Efficacy of Ophthalmic Phentolamine Mesylate to Reverse Pharmacologically Induced Mydriasis	Phentolamine	treatment	2	completed
NCT01946828	Evaluation of the FIM - a Non Invasive Device for Temporarily and Quick Pupil Dilation (Mydriasis)	No drug interventions	Not Available	Not Available	unknown_status