Drug hypersensitivity reaction (DBCOND0022247)

Identifiers

Synonyms

Drug Hypersensitivity / Hypersensitivity Reaction / Drug hypersensitivity reactions / Hypersensitivity reactions / Sensitivity reactions / Unspecified adverse effect of drug or medicament / Allergic reaction to drug / Allergic reaction caused by drug (disorder) / Allergy to drug (finding) / Drug allergy / Other and unspecified allergy / Allergy, unspecified / Allergy / Hypersensitivity NOS / Hypersensitivity reaction (disorder) / Allergy NOS / Hypersensitivity reaction (NOS) / Reaction hypersensitivity (NOS) / Hypersensitivity / Hypersensitivity symptom

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Cortisone acetate	A steroid hormone used for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses and endocrine disorders associated with inadequate production of steroid hormones.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Annexin A1target Corticosteroid-binding globulincarrier Albumincarrier Solute carrier organic anion transporter family member 1A2transporter ATP-dependent translocase ABCB1transporter Organic anion transporter 3transporter Steroid hormone receptor ERR1target Steroid hormone receptor ERR2target Estrogen-related receptor gammatarget
Dexamethasone	A glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders.	Glucocorticoid receptortarget Annexin A1target Nitric oxide synthase, inducibletarget Nuclear receptor subfamily 0 group B member 1target Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Bile salt export pumptransporter ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Solute carrier organic anion transporter family member 1A2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Steroid 17-alpha-hydroxylase/17,20 lyaseenzyme Cytochrome P450 1A1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A43enzyme Cytochrome P450 4A11enzyme Nuclear receptor subfamily 1 group I member 2target Cytochrome P450 11B1, mitochondrialenzyme Albumincarrier 11-beta-hydroxysteroid dehydrogenase type 2enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme Organic anion transporter 3transporter
Hydrocortisone	A glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders.	Annexin A1target Glucocorticoid receptortarget Sex hormone-binding globulincarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 11B2, mitochondrialenzyme Cytochrome P450 2C8enzyme Corticosteroid-binding globulincarrier Organic anion transporter 3transporter Aldo-keto reductase family 1 member D1enzyme 3-oxo-5-alpha-steroid 4-dehydrogenase 2enzyme 11-beta-hydroxysteroid dehydrogenase type 2enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme
Hydrocortisone phosphate	A corticosteroid used to treat congenital adrenal hyperplasia, for emergency asthma treatment, hypersensitivity, and inflammation.	Annexin A1target Glucocorticoid receptortarget Sex hormone-binding globulincarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 2C8enzyme Corticosteroid-binding globulincarrier 11-beta-hydroxysteroid dehydrogenase type 2target 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target Organic anion transporter 3transporter
Methylprednisolone	A corticosteroid used to treat inflammation or immune reactions across a variety of organ systems, endocrine conditions, and neoplastic diseases.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 3A Subfamilyenzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Annexin A1target 20-ketosteroid reductase (20-hydroxysteroid dehydrogenase)enzyme 11beta-hydroxysteroid dehydrogenaseenzyme Albumincarrier
Pheniramine	An antihistamine used to treat allergic rhinitis and pruritus.	Histamine H1 receptortarget Nuclear receptor subfamily 1 group I member 3target Histamine H4 receptortarget
Prednisolone	A glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.	Corticosteroid-binding globulincarrier Cytochrome P450 3A4enzyme Glucocorticoid receptortarget Solute carrier organic anion transporter family member 1A2transporter ATP-dependent translocase ABCB1transporter Albumincarrier
Prednisone	A corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Cytochrome P450 2C19enzyme Albumincarrier Cytochrome P450 3A5enzyme Corticosteroid-binding globulincarrier Cytochrome P450 3A Subfamilyenzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02839551	Optimal Doses for Drug Provocation Tests to Beta-lactams	No drug interventions	diagnostic	Not Available	completed
NCT06065137	Standardised Drug Provocation Testing in Perioperative Hypersensitivity	No drug interventions	diagnostic	Not Available	recruiting
NCT03076749	Predictive Models for Betalactam Allergy	No drug interventions	Not Available	Not Available	completed
NCT04330118	Origin and Function of Eosinophilic Polynuclear During DRESS Syndrome	No drug interventions	Not Available	Not Available	unknown_status
NCT00505648	Treatment of Hypersensitivity Syndrome (DRESS) With Tegeline® (Human Immunoglobulin)	No drug interventions	treatment	3	terminated
NCT02031120	Management of Drug Hypersensitivity in Children	No drug interventions	Not Available	Not Available	unknown_status
NCT03158831	Drug Challenges Without Prior Skin Testing	No drug interventions	diagnostic	1	completed
NCT06428162	An Evaluation of Healthcare Providers' Adherence to Pharmacovigilance Practices in an African Community	No drug interventions	Not Available	Not Available	completed
NCT06523192	Validation of the English Version of the Drug Hypersensitivity Quality of Life Questionnaire	No drug interventions	Not Available	Not Available	completed
NCT02844712	Negative Predictive Value of Drug Provocation Tests to Beta-lactams	No drug interventions	health_services_research	Not Available	terminated
NCT06406114	Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing	Ampicillin Benzylpenicillin Benzylpenicilloyl polylysine Cefazolin Cefepime Cefotaxime Ceftazidime Ceftriaxone Cefuroxime Histamine	diagnostic	2	not_yet_recruiting
NCT04421638	Cephalosporin Hypersensitivity	No drug interventions	Not Available	Not Available	completed
NCT04827602	Drug Allergy Labels After Drug Allergy Investigation	No drug interventions	Not Available	Not Available	completed
NCT02839811	Medical Device for Drug Allergy Diagnosis	No drug interventions	diagnostic	Not Available	completed
NCT03771118	Drug Provocation Test (DPT) to Paracetamol	No drug interventions	Not Available	Not Available	completed
NCT00198419	Hypersensitivity Reaction to Vitrase (Ovine Hyaluronidase)	Hyaluronidase (ovine)	screening	1	completed
NCT00198458	Hypersensitivity Reaction to Vitrase (Ovine Hyaluronidase)	Hyaluronidase (ovine)	Not Available	1	completed
NCT02983630	Allergy Testing of Patients Labeled as Penicillin Allergic	No drug interventions	Not Available	Not Available	completed
NCT03743220	Drug Provocation Test (DPT) to Non Steroidal Anti-inflammatory Drugs (NSAID)	No drug interventions	Not Available	Not Available	completed
NCT05269082	A Study to Assess the Hypersensitivity to TAK-880 Compared to Gammagard S/D in Blood of Children, Teenagers and Adults	No drug interventions	Not Available	Not Available	completed
NCT01276314	Evaluation of TNF-α Blockade Effect in Patients With Severe Cutaneous Adverse Drug Reactions	Etanercept Prednisolone	treatment	Not Available	completed
NCT04654923	GERAP's Epidemiological Survey on Perioperative Hypersensitivity Reactions	No drug interventions	Not Available	Not Available	recruiting
NCT02185651	A Pilot Study of Zavesca® in Patients With Pompe Disease and Infusion Associated Reaction	Miglustat	treatment	1	terminated
NCT04035707	Serum Tryptase Concentration During General Anaesthesia With Rocuronium	Rocuronium	treatment	Not Available	completed
NCT02349763	Dexamethasone Regimens for Prophylaxis of Paclitaxel-associated Hypersensitivity Reaction	Dexamethasone	prevention	3	completed
NCT04610242	Prediction of Rituximab Hypersensitivity and Desensitization Treatment	No drug interventions	diagnostic	Not Available	unknown_status
NCT03598426	Conventional Prophylactic Oral Dexamethasone vs Short-course IV Dexamethasone in Paclitaxel Hypersensitivity	Dexamethasone	prevention	3	recruiting
NCT04359368	Characteristics of Patients With Hypersensitivity Reactions to Intravenous Iron Infusions	No drug interventions	Not Available	Not Available	completed