Anesthetic premedication therapy (DBCOND0024223)

Identifiers

Synonyms

Preanesthetic medication therapy / Anesthetic premedication / Anaesthetic premedication / Preanesthetic Medication / Premedication for anesthetic procedure (procedure)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Fentanyl	An opioid analgesic used in anesthesia, for breakthrough cancer pain, or round the clock pain management.	Mu-type opioid receptortarget Delta-type opioid receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Kappa-type opioid receptortarget ATP-dependent translocase ABCB1target Albumincarrier alpha1-acid glycoproteincarrier
Lorazepam	A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures.	UDP-glucuronosyltransferase 2B15enzyme GABA(A) Receptortarget GABA(A) Receptor Benzodiazepine Binding Sitetarget Translocator proteintarget
Meperidine	An opioid agonist with analgesic and sedative properties used to manage severe pain.	Kappa-type opioid receptortarget Cytochrome P450 2D6enzyme Cytochrome P450 2B6enzyme Glutamate receptor ionotropic, NMDA 1target Glutamate receptor ionotropic, NMDA 2Btarget Glutamate receptor ionotropic, NMDA 2Atarget Glutamate receptor ionotropic, NMDA 2Ctarget Glutamate receptor ionotropic, NMDA 2Dtarget Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme Albumincarrier Alpha-1-acid glycoprotein 1carrier Muscarinic acetylcholine receptortarget Mu-type opioid receptortarget Sodium-dependent dopamine transportertarget Sodium-dependent noradrenaline transportertarget Sodium-dependent serotonin transportertarget Liver carboxylesterase 1target Cytochrome P450 1A2enzyme ATP-dependent translocase ABCB1transporter
Pentazocine	An analgesic used to treat moderate to severe pain.	Mu-type opioid receptortarget Kappa-type opioid receptortarget Sigma non-opioid intracellular receptor 1target ATP-dependent translocase ABCB1transporter
Pentobarbital	A barbiturate drug used to induce sleep, cause sedation, and control certain types of seizures.	Gamma-aminobutyric acid receptor subunit alpha-1target Cytochrome P450 3A4enzyme Gamma-aminobutyric acid receptor subunit alpha-4target Gamma-aminobutyric acid receptor subunit alpha-6target Gamma-aminobutyric acid receptor subunit alpha-2target Gamma-aminobutyric acid receptor subunit alpha-3target Gamma-aminobutyric acid receptor subunit alpha-5target Neuronal acetylcholine receptor subunit alpha-4target Neuronal acetylcholine receptor subunit alpha-7target Glutamate receptor 2target Glutamate receptor ionotropic, kainate 2target Cytochrome P450 2C19enzyme Cytochrome P450 2A6enzyme GABA(A) Receptortarget NMDA receptortarget Nuclear receptor subfamily 1 group I member 2target
Scopolamine	A belladonna alkaloid with anticholinergic effects indicated for the treatment of nausea and vomiting associated with motion sickness and postoperative nausea and vomiting (PONV).	Muscarinic acetylcholine receptor M1target Sucrase-isomaltase, intestinaltarget Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M3target Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M5target Neuronal acetylcholine receptor subunit alpha-4target Neuronal acetylcholine receptor subunit beta-2target Cytochrome P450 3A4enzyme
Secobarbital	A barbiturate used for the short-term treatment of insomnia.	Gamma-aminobutyric acid receptor subunit alpha-1target Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Gamma-aminobutyric acid receptor subunit alpha-2target Gamma-aminobutyric acid receptor subunit alpha-3target Gamma-aminobutyric acid receptor subunit alpha-4target Gamma-aminobutyric acid receptor subunit alpha-5target Gamma-aminobutyric acid receptor subunit alpha-6target Neuronal acetylcholine receptor subunit alpha-4target Neuronal acetylcholine receptor subunit alpha-7target Glutamate receptor 2target Glutamate receptor ionotropic, kainate 2target Cytochrome P450 1A2enzyme NMDA receptortarget Cytochrome P450 2C19enzyme

Clinical Trials

Not Available