NCT04579926
PINPOINT: Gaming Technology for SCD Pain No drug interventions supportive_care Not Available completed NCT06396403
The Role of Red Cell Characteristics, Angiogenesis, Viscosity and Oxygenation in the Pathophysiology of Sickle Cell Related Retinopathy No drug interventions Not Available Not Available recruiting NCT05904093
Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease basic_science 1 not_yet_recruiting NCT02433158
Safety of Rivipansel (GMI-1070) in the Treatment of One or More Vaso-Occlusive Crises in Hospitalized Subjects With Sickle Cell Disease treatment 3 terminated NCT01601340
Effects of HQK-1001 in Patients With Sickle Cell Disease No drug interventions treatment 2 terminated NCT04201210
A Trial to Assess Haploidentical T-depleted Stem Cell Transplantation in Patients With SCD No drug interventions treatment 2 recruiting NCT01356485
Safety Study of MP4CO in Adult Sickle Cell Patients No drug interventions Not Available 1 completed NCT04134299
To Assess Safety, Tolerability and Physiological Effects on Structure and Function of AXA4010 in Subjects With Sickle Cell Disease No drug interventions basic_science Not Available completed NCT01925001
Phase 2 Study of MP4CO to Treat Vaso-occlusive Sickle Crisis No drug interventions treatment 2 withdrawn NCT01322269
A Study of HQK-1001 in Patients With Sickle Cell Disease No drug interventions treatment 2 completed NCT06019208
GenoMed4ALL: Improving SCD Classification and Prognosis by AI No drug interventions Not Available Not Available active_not_recruiting NCT02972138
Vitamin D and Bisphosphonates in the Treatment of Sickle Cell Disease No drug interventions Not Available Not Available completed NCT04156893
RH Genotype Matched RBC Transfusions No drug interventions treatment 1 / 2 recruiting NCT02274415
Immunogenicity Study of an Anti-pneumococcal Vaccination Strategy in Patients With Sickle Cells Disease No drug interventions basic_science 2 completed NCT03474965
Study of Dose Confirmation and Safety of Crizanlizumab in Pediatric Sickle Cell Disease Patients treatment 2 recruiting NCT03264989
Pharmacokinetics and Pharmacodynamics Study of SEG101 (Crizanlizumab) in Sickle Cell Disease (SCD) Patients With Vaso- Occlusive Crisis (VOC) No drug interventions treatment 2 completed NCT05565092
Safety, Efficacy, Pharmacokinetic, and Pharmacodynamic Study of ALXN1820 in Adult Participants With Sickle Cell Disease No drug interventions treatment 2 terminated NCT04053764
Study Exploring the Effect of Crizanlizumab on Kidney Function in Patients With Chronic Kidney Disease Caused by Sickle Cell Disease No drug interventions treatment 2 completed NCT03478917
Early Diagnosis of Sickle Acute Chest Syndrome Using a Combination of Plasma Bimarkers and Chest Imaging No drug interventions Not Available Not Available completed NCT04662931
An Indian Multi-centric Phase IV Study to Assess the Safety of Crizanlizumab in Sickle Cell Disease Patients No drug interventions treatment 4 completed NCT03814746
Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease Patients No drug interventions treatment 3 active_not_recruiting NCT04413539
Evaluation of Impact of Disease on Quality of Life, Education and Socio-professional Integration of Adults and Parents of Children Living With Sickle- Cell Disease in France No drug interventions Not Available Not Available completed NCT06213402
RADeep Multicenter European Epidemiological Platform for Patients Diagnosed With Rare Anemia Disorders (RADs) No drug interventions Not Available Not Available recruiting NCT05953584
A Phase 2 Open-label Study to Evaluate the Activity of Etavopivat on Transcranial Doppler Velocities in Pediatric Patients With Sickle Cell Disease Who Are at Increased Risk for Primary Stroke No drug interventions treatment 2 recruiting NCT04935879
A Study to Assess the Safety and Efficacy of Inclacumab in Participants With Sickle Cell Disease Experiencing Vaso-occlusive Crises No drug interventions treatment 3 completed NCT04983264
A Study to Evaluate GBT021601-012 Single Dose and Multiple Dose in Participants With Sickle Cell Disease (SCD) No drug interventions treatment 1 completed NCT06318143
mAnaging siCkle CELl disEase Through incReased AdopTion of hydroxyurEa in Nigeria No drug interventions treatment Not Available not_yet_recruiting NCT05143021
Sickle Cell Disease Obstetric Multi-Disciplinary Care Programme No drug interventions Not Available Not Available recruiting NCT04157179
Cerebral Oxygen Metabolism in Children No drug interventions basic_science Not Available recruiting NCT03709303
Motivations, Expectations, and Decision-making of Sickle Cell Patients in Clinical Research No drug interventions Not Available Not Available completed NCT04031521
Near Infrared Spectroscopy in Sickle Cell Pediatric Patients No drug interventions Not Available Not Available withdrawn NCT05084521
Interest of Famotidine in Children With Sickle Cell Disease No drug interventions treatment 2 / 3 recruiting NCT05228821
Voxelotor Brain Oxygenation and Neurocognitive Study No drug interventions treatment 4 withdrawn NCT05457790
Feasibility and Preliminary Efficacy of Acceptance and Commitment Therapy (ACT) for Sleep Disturbances in Adults With Sickle Cell Disease (SCD) No drug interventions supportive_care Not Available recruiting NCT03353584
Effect of Virtual Reality Technology for Pain Management of Vaso-Occlusive Crisis in Patients With Sickle Cell Disease No drug interventions supportive_care Not Available recruiting NCT02720679
Investigation of the Genetics of Hematologic Diseases No drug interventions Not Available Not Available recruiting NCT02776202
HLA-Identical Sibling Donor Bone Marrow Transplantation for Individuals With Severe Sickle Cell Disease Using a Reduced Intensity Conditioning Regimen No drug interventions treatment 2 unknown_status NCT02960503
Macrolide Therapy to Improve Forced Expiratory Volume in 1 Second in Adults With Sickle Cell Disease No drug interventions other 1 / 2 withdrawn NCT02675790
Moderate Dose Hydroxyurea for Secondary Stroke Prevention in Children With Sickle Cell Disease in Sub-Saharan Africa No drug interventions prevention 3 completed NCT02448121
Autologous Bone Marrow Stem Cell Transplantation for Osteonecrosis in Sickle Cell Disease No drug interventions treatment 1 / 2 unknown_status NCT02384590
Cognitive Behavioral Therapy and Real-time Self-management Intervention for SCD Via Mobile Applications No drug interventions treatment Not Available completed NCT02061202
Inhaled Mometasone to Reduce Painful Episodes in Patients With Sickle Cell Disease No drug interventions treatment 2 completed NCT01833702
Use of a Mobile-based App for SCD Patients No drug interventions Not Available Not Available completed NCT01673243
Parent Willingness to Participate in Tobacco Trials in the Pediatric Clinical Setting No drug interventions Not Available Not Available completed NCT01566890
Microvascular Blood Flow in Sickle Cell Anemia No drug interventions diagnostic Not Available completed NCT01077921
Study of Propranolol as Anti-Adhesive Therapy in Sickle Cell Disease (SCD) No drug interventions treatment 2 completed NCT00773890
TRF-1101 Assessment in Sickle Cell Disease No drug interventions treatment 1 / 2 terminated NCT00434902
Evaluation of the Prevalence of Pulmonary Hypertension in Adult Patients With Sickle Cell Disease No drug interventions Not Available Not Available unknown_status NCT00066079
Home Based Massage and Relaxation for Sickle Cell Pain No drug interventions treatment 2 completed NCT06546670
A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease No drug interventions treatment 1 / 2 recruiting NCT06529042
SCRIPT: Sickle Cell Risk in Pregnancy Tool No drug interventions Not Available Not Available enrolling_by_invitation NCT06526117
Stroke Prevention in Nigeria 2 Trial prevention 4 recruiting NCT06506461
Gene Editing For Sickle Cell Disease treatment 1 not_yet_recruiting NCT06511453
Acupressure in Patients With Sickle Cell Disease No drug interventions treatment Not Available recruiting NCT06464458
Optimizing the Management of Sickle Cell Patients on Hydroxyurea: The Value of Therapeutic Pharmacological Monitoring No drug interventions treatment Not Available recruiting NCT06442761
SCD Stem Cell Mobilization and Apheresis Using Motixafortide other 1 not_yet_recruiting NCT06417411
LEARNER- Low dosE AspiRiN prEterm tRial (Angola) prevention 1 / 2 recruiting NCT06397118
Prevention of Malnutrition in Children With Sickle Cell Disease No drug interventions prevention Not Available not_yet_recruiting NCT06385886
Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease No drug interventions Not Available Not Available recruiting NCT06171217
Realizing Effectiveness Across Continents With Hydroxyurea treatment 2 recruiting NCT06110754
Development and Adaptation of I-STRONG for SCD No drug interventions supportive_care Not Available recruiting NCT06023199
Assessing Physical Function in Sickle Cell Patients Taking Voxelotor treatment 2 recruiting NCT06016634
Alendronate for Osteonecrosis in Adults With Sickle Cell Disease treatment 2 recruiting NCT05998824
COVID-19 Vaccination Hesitancy in Adults With Sickle Cell Disease No drug interventions treatment Not Available recruiting NCT05780775
Lipid Balance in Adult Sickle Cell Patients No drug interventions basic_science Not Available recruiting NCT05775224
ASH Research Collaborative Data Hub No drug interventions Not Available Not Available enrolling_by_invitation NCT05718687
A GBT021601 ADME Microtracer Study in Healthy Volunteers No drug interventions other 1 completed NCT05506358
Evaluation of Low-cost Techniques for Detecting Sickle Cell Disease and β-thalassemia in Nepal and Canada No drug interventions diagnostic Not Available completed NCT05494541
Characteristics of Patients With Sickle Cell Disease No drug interventions Not Available Not Available completed NCT05469828
Crizanlizumab Improves Tissue Oxygen Supply Demand Matching in Patients With Sickle Cell Anemia treatment 1 / 2 not_yet_recruiting NCT05384756
TMLI and Alemtuzumab for Treatment of Sickle Cell Disease treatment 1 recruiting NCT05383911
Empowering Adolescents and Young Adults With Sickle Cell Disease as Partners in Treatment Decision Making (EMPOWER-AYA) No drug interventions supportive_care Not Available not_yet_recruiting NCT05348915
A Study to Evaluate the Long-term Safety of Inclacumab Administered to Participants With Sickle Cell Disease treatment 3 active_not_recruiting NCT05289700
Hyperbaric-oxygen Therapy (HBOT) Versus Placebo for Treating Vaso-Occlusive Crisis (VOC) in Sickle Cell Disease (SCD) No drug interventions treatment 3 recruiting NCT05285917
Promoting Utilization and Safety of Hydroxyurea Using Precision in Africa treatment 3 recruiting NCT05283148
Sickle Cell Disease (SCD) Bone Pain Study No drug interventions diagnostic Not Available completed NCT05075824
A Study Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Crovalimab as Adjunct Treatment in Prevention of Vaso-Occlusive Episodes (VOE) in Sickle Cell Disease (SCD) treatment 2 recruiting NCT05407805
A Study to Learn About Sickle Cell Disease In Adult Patients No drug interventions Not Available Not Available completed NCT04930445
Oxbryta® Product Registry An Observational Study Designed to Evaluate the Effect of Oxbryta in Individuals With SCD Not Available Not Available recruiting NCT04930328
Retrospective Real World Oxbryta® Data Collection and Analysis Study Not Available Not Available completed NCT04917783
Health Literacy - Neurocognitive Screening in Pediatric SCD No drug interventions health_services_research Not Available completed NCT04906707
Home-Based Intervention for Chronic Pain in Adults With Sickle Cell Disease No drug interventions treatment Not Available completed NCT04877054
Pilot Evaluation of a Motivational Interviewing Intervention Targeting Adherence Behaviors in Youth With Sickle Cell Disease No drug interventions treatment Not Available completed NCT04864041
Evaluation of Left Ventricular Function by Speckle Tracking Echocardiography in Patient Hospitalised in Intensive Care Unit for Vaso-occlusive Crisis No drug interventions Not Available Not Available unknown_status NCT04817345
Peripheral Blood Stem Cell Collection From Patients With Sickle Cell Disease (SCD) Using Plerixafor supportive_care 2 withdrawn NCT04800809
The Afolabi Stroke Registry for Children and Young Adults With SCD in Northern Nigeria No drug interventions Not Available Not Available completed NCT04793854
Sickle Cell Disease, Neurocognitive Disorders, Social Participation No drug interventions Not Available Not Available completed NCT04756375
Evaluation of Virtual Reality to Save Morphinic in the Treatment of Vaso-occlusive Seizures of Sickle Cell Patients Consulting in the Emergency Room No drug interventions supportive_care Not Available completed NCT04983654
Functional and Mechanistic Characterization of Limb Ulcers in Patients With Sickle Cell Disease No drug interventions basic_science Not Available completed NCT04707235
ESCORT-HU Extension: European Sickle Cell Disease Cohort - Hydroxyurea - Extension Study Not Available Not Available active_not_recruiting NCT04667325
Evaluation of Therapeutic Adherence to Inciting Spirometry in Sickle Cell Patients No drug interventions Not Available Not Available completed NCT04676113
Obesity in Pediatric Sickle Cell Disease: A New Phenomenon No drug interventions Not Available Not Available completed NCT04675645
Adherence to HU and HRQOL in Patients With Sickle Cell Disease: An Intervention Study Using HU-Go App No drug interventions supportive_care Not Available completed NCT06264700
Applying Directly Observed Therapy to Hydroxyurea to Realize Effectiveness No drug interventions treatment Not Available not_yet_recruiting NCT05736419
A Study of Immune Suppression Treatment for People With Sickle Cell Disease or β-Thalassemia Who Are Going to Receive an Allogeneic Hematopoietic Cell Transplantation (HCT) treatment 2 recruiting NCT04602728
Building Adaptive Coping and Knowledge to Improve Daily Life No drug interventions supportive_care Not Available completed NCT04586985
Safety, Tolerability and Pharmacokinetics of FTX-6058 treatment 1 completed NCT04476277
Red Cell Half Life Determination in Patients With and Without Sickle Cell Disease basic_science 0 completed NCT04362293
Reduced Intensity Transplantation for Severe Sickle Cell Disease treatment 2 suspended NCT06313398
Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling other 0 recruiting NCT05730205
Effects of the Contraceptive Implant in Women With Sickle Cell Disease treatment 4 recruiting NCT04400487
Actigraphy Improvement With Voxelotor (ActIVe) Study treatment 4 completed NCT04264871
Is the Preoperative Preparation of Sickle Cell Patients Optimal: Assessment of Practices and Post-operative Complications No drug interventions Not Available Not Available unknown_status NCT04190888
Sickle Cell Uric Acid (SCUA) - Cohort Repository No drug interventions Not Available Not Available completed NCT04170348
Daily Vitamin D for Sickle-cell Respiratory Complications prevention 2 active_not_recruiting NCT04156399
Acupuncture for Adults With Sickle Cell Disease (SCD): A Feasibility Study No drug interventions basic_science Not Available terminated NCT03989986
iPeer2Peer Program for Youth With Sickle Cell Disease No drug interventions treatment Not Available active_not_recruiting NCT03975699
Implications of a Paediatrician-psychologist Tandem for Sickle Cell Disease Care and Impact on Cognitive Functioning No drug interventions Not Available Not Available completed NCT03948516
Sickle Cell Disease, Hemechip No drug interventions Not Available Not Available completed NCT03938324
Peer i-Coaching for Activated Self-Management Optimization in Adolescents and Young Adults With Chronic Conditions No drug interventions supportive_care Not Available completed NCT03944447
Outcomes Mandate National Integration With Cannabis as Medicine treatment 2 recruiting NCT03943615
Expanded Access to Voxelotor for Patients With Sickle Cell Disease Who Have No Alternative Treatment Options Not Available Not Available no_longer_available NCT03908385
Hemoglobin Desaturation in Sickle Cell Disease No drug interventions Not Available Not Available completed NCT03903133
Endothelial Monocyte-activating Polypeptide-II in Egyptian Sickle Patients supportive_care 4 completed NCT03825341
Hydroxyurea Therapy: Optimizing Access in Pediatric Populations Everywhere treatment 2 terminated NCT03763656
Pharmacokinetics of Oral Hydroxyurea Solution treatment 2 completed NCT04688411
An mHealth Strategy to Improve Medication Adherence in Adolescents With Sickle Cell Disease No drug interventions supportive_care Not Available recruiting NCT03682211
Intranasal Fentanyl Versus Intravenous Morphine in the Treatment of Severe Painful Sickle Cell Crises in Children treatment 4 completed NCT03664830
Safety of Blood Stem Cell Mobilization With Plerixafor in Patients With Sickle Cell Disease treatment 1 recruiting NCT03653247
A Study to Assess the Safety, Tolerability, and Efficacy of BIVV003 for Autologous Hematopoietic Stem Cell Transplantation in Patients With Severe Sickle Cell Disease treatment 1 / 2 active_not_recruiting NCT03644953
Hydroxyurea and Transfusion treatment 2 completed NCT03615924
Effect of Ticagrelor vs. Placebo in the Reduction of Vaso-occlusive Crises in Pediatric Patients With Sickle Cell Disease treatment 3 terminated NCT03599609
Central Nervous System Vascular Changes in Adult Sickle Cell Disease and the Effect of Treatment With Simvastatin prevention 1 / 2 unknown_status NCT03528434
Zinc for Infection Prevention in Sickle Cell Anemia (ZIPS) No drug interventions prevention Not Available completed NCT03214354
Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling Donor treatment 2 recruiting NCT04628585
Long-term Follow-up of Subjects With Sickle Cell Disease Treated With Ex Vivo Gene Therapy No drug interventions Not Available Not Available enrolling_by_invitation NCT04629430
Effects of Prebiotics on Gut Microbiome in Patients Undergoing HSCT No drug interventions treatment Not Available completed NCT04839354
Sickle Cell Disease Treatment With Arginine Therapy (STArT) Trial treatment 3 active_not_recruiting NCT05255445
Red Blood Cell - IMProving trAnsfusions for Chronically Transfused Recipients No drug interventions Not Available Not Available completed NCT05445128
Study of MGTA-145 and Plerixafor in Patients With Sickle Cell Disease treatment 2 terminated NCT05228834
Voxelotor Neurocognitive Function Study treatment 3 terminated NCT05519852
Pilates Physical Activity in Sickle Cell Disease No drug interventions treatment Not Available unknown_status NCT05228756
SCD Fit Homebase Program No drug interventions other Not Available withdrawn NCT05748717
Arterial Function Parameters and Transcranial Doppler Velocity in Paediatric Patients With Sickle Cell Disease No drug interventions Not Available Not Available recruiting NCT06287099
Clinical Study of BRL-101 in the Treatment of Sickle Cell Disease No drug interventions treatment Not Available not_yet_recruiting NCT04301336
Different Treatment Modalities in the Management of the Painful Crisis in Pediatric Sickle- Cell Anemia treatment 2 / 3 completed NCT05519111
Cannabinoids for the Reduction of Inflammation and Sickle Cell Related Pain supportive_care 2 recruiting NCT04406818
Metabolic and Hemodynamic Reserve in Pediatric SCA basic_science Not Available recruiting NCT04416178
Sickle Cell Disease and the Genomic and Gene Therapy Needs of Stakeholders No drug interventions Not Available Not Available completed NCT03128515
Optimizing Hydroxyurea Therapy in Children With SCA In Malaria Endemic Areas treatment 3 completed NCT03431935
Predictors and Outcomes in Patients With Sickle Cell Disease No drug interventions Not Available Not Available active_not_recruiting NCT03417947
Vitamin D Supplementation in Children With Sickle Cell Disease No drug interventions other 3 completed NCT03405688
Transfusion in Sickle Cell Disease: Screening of Sickle Cell Disease Trait in Blood Donors No drug interventions diagnostic Not Available completed NCT03421756
Stem Cell Transplant in Patients With Severe Sickle Cell Disease treatment 0 terminated NCT03383913
HRV-B for Symptom Management in Sickle Cell Patients No drug interventions treatment Not Available completed NCT03263559
Haploidentical Bone Marrow Transplantation in Sickle Cell Patients (BMTCTN1507) treatment 2 active_not_recruiting NCT03344900
Re-Aiming at Hydroxyurea Adherence for Sickle Cell With mHealth No drug interventions Not Available Not Available completed NCT03333486
Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer treatment 2 active_not_recruiting NCT03327428
Sickle-cell Disease Registry of the GPOH No drug interventions Not Available Not Available recruiting NCT06301893
Uganda Sickle Surveillance Study (US-3) No drug interventions Not Available Not Available recruiting NCT03298399
Mesenchymal Stromal Cells for Haplo Hematopoietic Cell Transplantation for Sickle Cell Disease No drug interventions treatment 1 withdrawn NCT03293641
Zinc Supplementation in Children With Sickle Cell Disease in Western Kenya prevention Not Available completed NCT03285178
A Study of the Effect of IW-1701 (Olinciguat), a Stimulator of Soluble Guanylate Cyclase (sGC), on Patients With Sickle Cell Disease (SCD) treatment 2 completed NCT03253211
Disseminating NIH Evidence Based Sickle Cell Recommendations in North Carolina No drug interventions Not Available Not Available completed NCT03114137
Heart Arteries and Sickle Cell Disease / Coeur Artères DREpanocytose No drug interventions Not Available Not Available unknown_status NCT03105271
Acute Kidney Injury in Patients With Sickle Cell Disease No drug interventions Not Available Not Available completed NCT05714098
Gerofit Exercise Intervention for Older Adults With Sickle Cell Disease (SICKLE-FIT Study) No drug interventions treatment Not Available recruiting NCT05434000
Primary Prevention of Stroke in Children With Sickle Cell Anaemia in Nigeria in the Community screening Not Available recruiting NCT02770534
Evaluating Thromboelastography (TEG) and ETP in Sickle Adults No drug interventions Not Available Not Available completed NCT02785848
Identifying Barriers and Strategies to Support Self-efficacy for Medication Adherence With Text Messaging No drug interventions Not Available Not Available active_not_recruiting NCT02824406
Cerebrovascular Reserve Measurements in Sickle Cell Disease Not Available Not Available unknown_status NCT02851615
Improving Self-Management in Adolescents With Sickle Cell Disease No drug interventions treatment Not Available completed NCT02867800
Abatacept for GVHD Prophylaxis After Hematopoietic Stem Cell Transplantation for Pediatric Sickle Cell Disease treatment 1 completed NCT02887118
Dense Red Blood Cells in Sickle Cell Children No drug interventions Not Available Not Available terminated NCT02922296
Glucose Metabolism in Sickle Cell Disease No drug interventions Not Available Not Available recruiting NCT03006718
SCD-PROMIS: A Software Platform to Enhance Self-efficacy and Patient-provider Engagement for Patients With Sickle Cell Pain No drug interventions other Not Available completed NCT03041909
An Extension Study to Further Evaluate the Safety, Tolerability of GBT440 in Patients With Sickle Cell Disease Who Participated in the Study GBT440-001 other 2 completed NCT02987725
Laboratory-based Hypnosis Intervention on Pain Responsivity in Adolescents With Sickle Cell Disease No drug interventions supportive_care Not Available completed NCT06158945
The Role of Endothelin 1 as a Marker of Renal Impairment in Sickle Cell Disease No drug interventions Not Available Not Available recruiting NCT02698761
A Comprehensive Care Plan for Pediatric Patients With Vaso-Occlusive Crises No drug interventions supportive_care Not Available terminated NCT02578017
ElectroNic Hydroxyurea AdhereNCE: A Strategy to Improve Hydroxyurea Adherence in Patients With Sickle Cell Disease No drug interventions other Not Available completed NCT02449616
Evaluation of Repeat Administration of Purified Poloxamer 188 treatment 3 completed NCT02443545
Long-term Safety and Efficacy of Ferriprox® in Iron Overloaded Patients With Sickle Cell Disease or Other Anemias treatment 4 terminated NCT02536170
Arginine Therapy for Sickle Cell Disease Pain treatment 2 completed NCT02560935
Primary Prevention of Stroke in Children With SCD in Sub-Saharan Africa II prevention 3 completed NCT02386657
Single-center Prospective Evaluation of Sickle Cell Patient Care in the CHU Brugmann Emergency Department No drug interventions Not Available Not Available completed NCT02394899
Improving Parental Psychosocial Functioning and Early Developmental Outcomes in Children With Sickle Cell Disease No drug interventions prevention Not Available completed NCT02411396
Comparison of Patient Centered Outcomes for People With Sickle Cell Disease in the Acute Care Setting No drug interventions Not Available Not Available completed NCT02410811
Novel Cardiac Magnetic Resonance Imaging to Define a Unique Restrictive Cardiomyopathy in Sickle Cell Disease No drug interventions Not Available Not Available completed NCT02482298
A Study to Assess the Effect of Ticagrelor in Reducing the Number of Days With Pain in Patients With Sickle Cell Disease prevention 2 completed NCT02306993
Sickle Cell Hemoglobinopathies and Bone Health No drug interventions Not Available Not Available active_not_recruiting NCT02326597
Decision Aid for Therapeutic Options In Sickle Cell Disease No drug interventions health_services_research Not Available completed NCT02501447
Feasibility of a Stress Reduction Intervention Study in Sickle Cell Disease No drug interventions treatment Not Available completed NCT02504619
Allogeneic SCT of CordIn™, in Patients With Hemoglobinopathies No drug interventions treatment 1 / 2 terminated NCT02373241
Preventing Sickle Cell Kidney Disease treatment 2 terminated NCT02197845
Enhancing Use of Hydroxyurea In Sickle Cell Disease Using Patient Navigators No drug interventions health_services_research Not Available completed NCT02179359
Hematopoietic Stem Cell Transplant for High Risk Hemoglobinopathies No drug interventions treatment Not Available recruiting NCT02065596
Hematopoietic Stem Cell Transplant for Sickle Cell Disease treatment 1 completed NCT02098993
Feasibility Study of Unfractionated Heparin in Acute Chest Syndrome treatment 2 terminated NCT02041299
Efficacy and Safety of Ferriprox® in Patients With Sickle Cell Disease or Other Anemias treatment 4 terminated NCT02013375
SCD-Haplo: Phase II Study of HLA-Haploidentical SCT for Aggressive SCD treatment 2 terminated NCT02042222
Novel Dose Escalation to Predict Treatment With Hydroxyurea treatment 0 completed NCT01976416
Novel Use Of Hydroxyurea in an African Region With Malaria treatment 3 completed NCT01913548
Multi-Center Study of Iron Overload: Survey Study (MCSIO) No drug interventions Not Available Not Available completed NCT01849016
N-Acetylcysteine in Patients With Sickle Cell Disease prevention 3 completed NCT01848925
Study of SANGUINATE™ Versus Hydroxyurea in Sickle Cell Disease (SCD) Patients treatment 1 completed NCT01757418
Intravenous Gammaglobulin for Sickle Cell Pain Crises treatment 1 / 2 recruiting NCT01736657
Evaluation of Spectra Optia Red Blood Cell Exchange in Sickle Cell Patients No drug interventions treatment Not Available completed NCT01685515
Study of Decitabine and Tetrahydrouridine (THU) in Patients With Sickle Cell Disease treatment 1 completed NCT01732718
Effect of Atorvastatin on Endothelial Dysfunction and Albuminuria in Sickle Cell Disease treatment 2 completed NCT01591187
The Feasibility of Text Messaging to Assess Secondhand Smoke Exposure Among Youngsters With Cancer or Sickle Cell Disease No drug interventions Not Available Not Available completed NCT01565954
Sleep Respiratory Disorders Evaluation in Sickle Cell Disease Children No drug interventions Not Available Not Available completed NCT01522196
A Study of Varespladib Infusion in Subjects With Sickle Cell Disease. prevention 2 terminated NCT01518218
Effectiveness of Laying-on-of-hands for Sickle Cell Disease No drug interventions supportive_care 2 completed NCT01476696
A Study of Prasugrel in Pediatric Participants With Sickle Cell Disease treatment 2 completed NCT01393847
Nitric Oxide and Sickle Cell Pain No drug interventions Not Available Not Available terminated NCT01389024
Hydroxyurea to Prevent Brain Injury in Sickle Cell Disease prevention 2 completed NCT01380197
Choosing Opioid Management for Pain and Analyzing Acute Chest Syndrome (ACS) Rates Equally treatment 3 completed NCT01316549
Study of Fludarabine Drug Exposure in Pediatric Bone Marrow Transplantation Not Available Not Available completed NCT01331148
High Dose Vitamin D for Sickle Cell Disease prevention 2 completed NCT01319851
Alefacept and Allogeneic Hematopoietic Stem Cell Transplantation treatment Not Available terminated NCT01220115
A 3-year, Prospective, Non-interventional, Multicenter Registry in Sickle Cell Disease (SCD) Patients No drug interventions Not Available Not Available completed NCT01242878
MACS Study - Microparticles and Coagulation in Sickle Cell Disease No drug interventions Not Available Not Available unknown_status NCT01197417
Intravenous Magnesium for Sickle Cell Vasoocclusive Crisis treatment 2 / 3 completed NCT01195818
Albuminuria Reduction With Renin Angiotensin System Inhibitors in SCA Patients No drug interventions prevention Not Available completed NCT01136941
Trial of Zileuton CR in Children and Adults With Sickle Cell Disease treatment 1 completed NCT01142219
L-Arginine and Sickle Cell Disease treatment 3 completed NCT01119833
Study of GMI-1070 for the Treatment of Sickle Cell Pain Crisis treatment 2 completed NCT00834899
A Safety Study of Eptifibatide in Patients With Sickle Cell Disease treatment 1 / 2 terminated NCT00761085
Methadone in Pediatric and Adult Sickle Cell Patients treatment Not Available completed NCT00711698
Comparison of Patient Controlled Analgesia (PCA) Versus Bolus Narcotic Therapy for the Treatment of Vaso-Occlusive Crisis (VOC) No drug interventions treatment 2 withdrawn NCT00663507
Kidney Transplantation in Patients With Sickle Cell Disease No drug interventions Not Available Not Available terminated NCT00595530
Low-Dose Ketamine Infusion for Children With Sickle Cell Disease-Related Pain treatment 2 terminated NCT00590148
Assessing Function in Pediatric Patients With Sickle Cell Disease No drug interventions Not Available Not Available completed NCT00542230
Blood Sampling for Research Related to Sickle Cell Disease No drug interventions Not Available Not Available recruiting NCT00512577
Transfusion Alternatives Pre-operatively in Sickle Cell Disease (TAPS) No drug interventions treatment 3 terminated NCT00445978
A Phase 2 Study of the Effects of 6R-BH4 in Subjects With Sickle Cell Disease treatment 2 completed NCT00451919
The Link Between Anemia and Deficits in Memory and Attention in Individuals With Sickle Cell Disease No drug interventions Not Available Not Available completed NCT00427661
A Pilot Study of HSCT for Patients With High-risk Hemoglobinopathy Using a Nonmyeloablative Preparative Regimen No drug interventions treatment Not Available completed NCT00386048
Pain Management Protocol for Pediatric Sickle Cell Disease No drug interventions Not Available Not Available completed NCT00305175
Long Term Effects of Hydroxyurea Therapy in Children With Sickle Cell Disease No drug interventions Not Available Not Available completed NCT00270478
Hydroxyurea and Erythropoietin to Treat Sickle Cell Anemia treatment 1 completed NCT00152113
Haploidentical Stem Cell Transplant for Patients With Sickle Cell Disease and Prior Stroke or Abnormal Transcranial Ultrasound No drug interventions treatment 1 completed NCT00153985
Allogeneic Stem Cell Transplantation Following Chemotherapy in Patients With Hemoglobinopathies treatment 2 completed NCT00012545
Collection and Storage of Umbilical Cord Stem Cells for Treatment of Sickle Cell Disease No drug interventions Not Available Not Available recruiting NCT05732922
ORCHARD- Optimising Home Assessment of Rural Patients No drug interventions supportive_care Not Available not_yet_recruiting NCT06155500
Long-term Follow-up (LTFU) of Patients Treated With Genome-edited Autologous Hematopoietic Stem and Progenitor Cells (HSPC) No drug interventions Not Available Not Available recruiting NCT06578507
Pharmacokinetics, Efficacy and Safety of Twice Daily Dosing Regimen of Hydroxycarbamide Dispersible Tablets in Children With Sickle Cell Disease No drug interventions treatment 2 not_yet_recruiting NCT06579703
Ketorolac for Acute Vaso-Occlusive Crisis in Pediatric Sickle Cell Disease No drug interventions treatment 4 not_yet_recruiting NCT06563440
Development and Evaluation of an Information Management System and Communication System for Population-wide Point-of-care Infant Sickle Cell Disease Screening No drug interventions health_services_research Not Available not_yet_recruiting NCT06561061
Zinc for Infection Prevention in Sickle Cell Anemia-2 (ZIPS-2) No drug interventions prevention 2 / 3 not_yet_recruiting NCT06539169
FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases No drug interventions Not Available Not Available recruiting NCT06497153
Lung Ultrasound in Pediatric Acute Chest Syndrome No drug interventions Not Available Not Available recruiting NCT06399107
Investigation Into the Use of BAH243 Lentiviral Vector for Gene Therapy in Treating Sickle Cell Disease No drug interventions treatment 1 / 2 recruiting NCT06367192
School Readiness Intervention for Preschool Children With Sickle Cell Disease No drug interventions treatment Not Available recruiting NCT06184126
Virtual Reality Devices as an Adjunct to Usual Care for Patients With Sickle Cell Disease Experiencing Vaso-Occlusive Crises No drug interventions treatment Not Available not_yet_recruiting NCT06147414
Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders No drug interventions Not Available Not Available not_yet_recruiting NCT06145282
Non-myeloablative Haploidentical HCT Study for Patients With Sickle Cell Disease, Including Compromised Organ Function treatment 1 / 2 recruiting NCT06074198
Sickle Cell Children's Exercise Study (SuCCESs) No drug interventions treatment Not Available recruiting NCT06072287
The Living With a Long-Term Condition Study No drug interventions Not Available Not Available recruiting NCT05951205
Evaluation of Efficacy and Safety of a Single Dose of Exa-cel in Participants With Severe Sickle Cell Disease, βS/βC Genotype No drug interventions treatment 3 not_yet_recruiting NCT05725902
Study of the Effect of Etavopivat on Cerebral Hemodynamic Response in Children With Sickle Cell Disease No drug interventions treatment 2 recruiting NCT05640271
Tocilizumab for Acute Chest Syndrome No drug interventions treatment 2 recruiting NCT05632354
GBT021601-022: A Study of GBT021601 in Participants With Sickle Cell Disease (SCD) No drug interventions treatment 2 / 3 recruiting NCT05635266
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives No drug interventions Not Available Not Available recruiting NCT05646888
Inflammation, Platelets and Sickle Cell Disease No drug interventions Not Available Not Available recruiting NCT05470998
L-Arginine in Children Having Sickle Cell Disease With Increased Tricuspid Regurgitant Jet Velocity No drug interventions treatment 3 recruiting NCT05470270
Acceptability of a New Paediatric Formulation of Hydroxycarbamide in Children With Sickle Cell Disease. No drug interventions treatment 2 completed NCT05392101
Low Dose Iron Chelation as TReatment of Oxidative Damage in Sickle Cell Disease No drug interventions basic_science 2 completed NCT05376046
Study of Erythrocyte Parameters and Hypercoagulability in Sickle Cell Disease (SCD-TGA) No drug interventions Not Available Not Available recruiting NCT05392894
RElated Haplo-DonoR Haematopoietic stEm Cell Transplantation for Adults With Severe Sickle Cell Disease No drug interventions treatment 3 recruiting NCT05371184
Glutamine Role in Preventing Vaso-occlusive Crisis Among SCD Patients No drug interventions prevention 4 completed NCT05315908
COVID-19 Testing in Underserved and Vulnerable Populations No drug interventions other Not Available terminated NCT05353647
A Gene Transfer Study Inducing Fetal Hemoglobin in Sickle Cell Disease (GRASP, BMT CTN 2001) No drug interventions treatment 2 recruiting NCT05292781
CHOICES3: Sickle Cell Disease Parenting CHOICES No drug interventions prevention Not Available recruiting NCT05261711
AB1 in Adult Patients With Sickle Cell Disease (SCD) No drug interventions treatment 1 / 2 suspended NCT05169580
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of FTX-6058 No drug interventions treatment 1 recruiting NCT05153044
Severe Acute Respiratory Syndrome CoV 2 COVID-19 Survey and Vaccination Coverage in the Sickle Cell Population in Ile-De-France No drug interventions other Not Available unknown_status NCT05099874
Feasibility and Efficacy of Attentional-Control Training in Sickle Cell Disease No drug interventions treatment Not Available recruiting NCT05098028
Pharmacokinetics and Pharmacodynamics of Rifaximin Novel Formulations in Patients With Sickle Cell Disease No drug interventions treatment 2 completed NCT05081349
Hydoxycarbamide and L-Carnitine Therapy in Sickle Cell Anemia No drug interventions treatment 4 completed NCT05053932
Long-term Comparative Cerebrovascular Outcome After Transplantation vs Standard Care in Sickle Cell Anemia No drug interventions Not Available Not Available recruiting NCT05045820
Integrative Medicine in Pain Management in Sickle Cell Disease No drug interventions treatment Not Available recruiting NCT04911049
Prevalence and Pathophysiology of Systemic Arterial Pressure Abnormalities in Childhood Sickle Cell Disease No drug interventions Not Available Not Available unknown_status NCT04925492
PET Imaging of Vaso-Occlusive Crisis (VOC) in SCD No drug interventions screening 1 recruiting NCT04917120
Observational Prospective Study Measuring the Impact of the Use of a Hypnotic Script Associated With Virtual Reality on the Pain of the Child's Sickle Cell During a Vaso-occlusive Crisis No drug interventions supportive_care Not Available unknown_status NCT04906447
Hybrid Effectiveness-Implementation Trial of Guided Relaxation and Acupuncture for Chronic Sickle Cell Disease Pain No drug interventions treatment 2 recruiting NCT04927247
A Study of a Single Dose of Inclacumab to Reduce Re-admission in Participants With Sickle Cell Disease and Recurrent Vaso-occlusive Crises No drug interventions treatment 3 terminated NCT04892160
Distracting Through Procedural Pain and Distress No drug interventions supportive_care Not Available completed NCT04817670
Study to Assess Efficacy and Safety of VIT-2763 (Vamifeport) in Subjects With Sickle Cell Disease No drug interventions treatment 2 completed NCT04808778
Stroke Prevention in Young Adults With Sickle Cell Anemia No drug interventions Not Available Not Available active_not_recruiting NCT04774536
Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease No drug interventions treatment 1 / 2 not_yet_recruiting NCT04772391
Fitness Trial in Adults With Sickle Cell Disease (SCD Fit): A Feasibility Study No drug interventions other Not Available completed NCT04724421
Expanded Access Protocol for Adults and Pediatric Patients With Sickle Cell Disease Who Have No Alternative Treatment Options No drug interventions Not Available Not Available available NCT04754711
Interest of Nutritional Care of Children With Sickle Cell Disease on Bone Mineral Density and Body Composition No drug interventions treatment Not Available active_not_recruiting NCT04678037
Home-based Assessment of PRO Measures in SCD Using A Smartphone App Platform: A Feasibility Study No drug interventions supportive_care Not Available completed NCT06439082
A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE) treatment 3 not_yet_recruiting NCT05139992
COVID-19 Vaccine Response in Sickle Cell Disease No drug interventions Not Available Not Available completed NCT04606160
Utilizing A Single Session Problem-Solving Intervention With Caregivers of Pediatric Patients Receiving Chronic Transfusion to Treat Sickle Cell Disease No drug interventions other Not Available completed NCT06274203
High Dose Vitamin D Supplementation in Children With Sickle Cell Disease No drug interventions treatment Not Available completed NCT04584528
Implementing an Individualized Pain Plan (IPP) for ED Treatment of VOE's in Sickle Cell Disease No drug interventions treatment Not Available completed NCT04574050
SELF-BREATHE RCT for Chronic Breathlessness No drug interventions treatment Not Available completed NCT04587661
Designing an Implementation Strategy for Delivering Routine Mental Health Screening and Treatment No drug interventions treatment Not Available terminated NCT04541875
Medication Adherence and Non-adherence in Adults With Rare Disease No drug interventions Not Available Not Available withdrawn NCT04505969
A Study Aimed to Assess the Needs of Subjects With Sickle Cell Disease and Healthcare Professionals Managing Sickle Cell Disease Patients in Selected Nigerian Centres No drug interventions Not Available Not Available completed NCT04484272
A Stress and Pain Self-management m-Health App for Adult Outpatients With Sickle Cell Disease No drug interventions treatment Not Available recruiting NCT04443907
Study of Safety and Efficacy of Genome-edited Hematopoietic Stem and Progenitor Cells in Sickle Cell Disease (SCD) No drug interventions treatment 1 active_not_recruiting NCT04335721
A Voxelotor for Sickle Cell Anemia Patients at Highest Risk for Progression of Chronic Kidney Disease No drug interventions treatment 1 / 2 recruiting NCT04293185
A Study Evaluating Gene Therapy With BB305 Lentiviral Vector in Sickle Cell Disease No drug interventions treatment 3 recruiting NCT04293172
Study to Evaluate the Effect of Ticagrelor Versus Placebo in Reducing Vaso-Occlusive Crises Rate in Pediatric Patients With Sickle Cell Disease. No drug interventions treatment 3 withdrawn NCT04285827
Safety of Single Doses of CSL889 in Adult Patients With Sickle Cell Disease treatment 1 completed NCT04289311
SMYLS: A Self-management Program for Youth Living With Sickle Cell Disease No drug interventions supportive_care Not Available completed NCT04398628
ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders No drug interventions Not Available Not Available recruiting NCT04614610
Lidocaine Intravenous in the Emergency Department For Sickle Cell Crisis No drug interventions treatment 2 not_yet_recruiting NCT04247594
Dose Escalation Study to Evaluate the Safety, Tolerability, PK and PD of Voxelotor in Patients With SCD treatment 2 terminated NCT04218084
Study to Evaluate the Effect of GBT440 on TCD in Pediatrics With Sickle Cell Disease No drug interventions treatment 3 active_not_recruiting NCT04208529
A Long-term Follow-up Study in Participants Who Received CTX001 other 3 enrolling_by_invitation NCT04205123
Biological, Genetic and Environmental Involved in the Complications of Sickle Cell Disease No drug interventions Not Available Not Available recruiting NCT04188509
Open-Label Extension of Voxelotor No drug interventions treatment 3 recruiting NCT04181944
Qualitative Survey of Potential Exercise Activity in Adults With Sickle Cell Anemia (SCA) No drug interventions other Not Available completed NCT04166526
A Pilot Study on Neuroimaging in SCD: Part of The Boston Consortium to Cure Sickle Cell Disease No drug interventions Not Available Not Available recruiting NCT04150757
Intranasal Ketamine For Pain Control In Patients With Sickle Cell Disease And Vaso-occlusive Episode (VOE) In The PED treatment 3 unknown_status NCT04156906
RHD Genotype Matched Red Cells for Anti-D No drug interventions treatment 0 recruiting NCT04122378
Acupuncture for Pain in Sickle Cell Disease No drug interventions other Not Available active_not_recruiting NCT04109820
Effect of MitoQ on Platelet Function and Reactive Oxygen Species Generation in Patients With Sickle Cell Anemia No drug interventions other Not Available recruiting NCT04046705
Comparison of Allogeneic Matched Related Haematopoietic Stem Cell Transplantation After a Reduced Intensity Conditioning Regimen With Standard of Care in Adolescents and Adults With Severe Sickle Cell Disease No drug interventions treatment 3 not_yet_recruiting NCT04076683
Algorithm for Apherisis Monitoring and Prescription Assistance in Sickle Cell Patients (ALGODREP) No drug interventions supportive_care Not Available completed NCT04075877
FOCUS for Pediatric Sickle Cell Disease and Cancer No drug interventions treatment Not Available unknown_status NCT04018937
Early Human Leukocyte Antigen (HLA) Matched Sibling Hematopoietic Stem Cell Transplantation No drug interventions treatment 2 recruiting NCT03997903
Imatinib for Pain in Sickle Cell Anemia No drug interventions basic_science 1 / 2 recruiting NCT04000165
A Dose-Finding Study of AG-348 in Sickle Cell Disease basic_science 0 completed NCT03985501
DREPAMASSE Study - Evaluation of a Newborn Screening for Sickle Cell Disease by Tandem Mass Spectrometry No drug interventions Not Available Not Available completed NCT03977532
Study of a Red Blood Cell Deformability Parameter in Patients With Sickle Cell Disease No drug interventions other Not Available completed NCT03978156
Dronabinol for Pain and Inflammation in Adults Living With Sickle Cell Disease No drug interventions treatment 1 terminated NCT03964792
Safety and Efficacy of Gene Therapy of the Sickle Cell Disease by Transplantation of an Autologous CD34+ Enriched Cell Fraction That Contains CD34+ Cells Transduced ex Vivo With the GLOBE1 Lentiviral Vector Expressing the βAS3 Globin Gene in Patients With Sickle Cell Disease (DREPAGLOBE) No drug interventions treatment 1 / 2 active_not_recruiting NCT03975894
TAPS2 Transfusion Antenatally in Pregnant Women With SCD No drug interventions treatment 2 unknown_status NCT03958643
Best Noninvasive Predictor of Renal Function in Assessing Adult Sickle Nephropathy No drug interventions Not Available Not Available completed NCT03933397
Comparing Individualized vs. Weight Based Protocols to Treat Vaso-Occlusive Episodes in Sickle Cell Disease No drug interventions treatment 3 terminated NCT03919266
Combined Use of a Respiratory Broad Panel Multiplex PCR and Procalcitonin to Reduce Antibiotics Exposure in Hospitalized Sickle-cell Adults With Acute Chest Syndrome. No drug interventions treatment Not Available completed NCT03899246
Sickle Cell Pain: Intervention With Capsaicin Exposure No drug interventions treatment 1 completed NCT03886753
Pharmacokinetic (PK) and Pharmacodynamics (PD) Study of Ilera Specific Products No drug interventions Not Available Not Available terminated NCT03903289
The Implementation of the Automated Erythrocytapheresis in Egyptian Sickle Cell Disease Center No drug interventions treatment Not Available recruiting NCT03876821
Collect of Cord Blood From Subjects at Risk for Sickle Cell Disease, for the Purpose of Laboratory Research No drug interventions Not Available Not Available completed NCT03815695
A SAD/MAD to Assess the Safety, PK/PD of FT-4202 in Healthy Volunteers and Sickle Cell Disease Patients No drug interventions treatment 1 completed NCT03806452
SIKAMIC (SIklos on Kidney Function and AlbuMInuria Clinical Trial) No drug interventions treatment 2 completed NCT03786549
Pediatric -Adult Care Transition Program of Patients With Sickle Cell Disease No drug interventions health_services_research Not Available recruiting NCT03753854
Sleep Apnea in Sickle Cell Disease No drug interventions basic_science Not Available terminated NCT03758950
Inhaled Mometasone to Promote Reduction in Vasoocclusive Events 2 No drug interventions treatment 2 completed NCT03745287
A Safety and Efficacy Study Evaluating CTX001 in Subjects With Severe Sickle Cell Disease No drug interventions treatment 2 / 3 active_not_recruiting NCT03716726
Sickle Cell Anemia WE CARE No drug interventions screening Not Available completed NCT03719729
Rifaximin to Modify the Disease Course in Sickle Cell Disease treatment 2 unknown_status NCT03111589
Monocytic Expression of Heme Oxidase-1 (HO-1) in Sickle Cell Patients and Correlation With the Humoral Immune Response to Vaccine and With Allo-immunization. No drug interventions basic_science Not Available completed NCT03648710
Community Health Workers and mHealth for Sickle Cell Disease Care No drug interventions supportive_care Not Available active_not_recruiting NCT03655223
Early Check: Expanded Screening in Newborns No drug interventions Not Available Not Available enrolling_by_invitation NCT03629678
Using Patient-Centered Guidelines in a Technology Platform to Improve Health Care in Adults With Sickle Cell Disease No drug interventions prevention Not Available completed NCT03609840
Study of Thiotepa and TEPA Drug Exposure in Pediatric Hematopoietic Stem Cell Transplant Patients No drug interventions Not Available Not Available completed NCT03609827
Study of Melphalan Drug Exposure in Pediatric Hematopoietic Stem Cell Transplant Patients Not Available Not Available completed NCT03577691
Efficacy of a Decision Aid for Hydroxyurea in Sickle Cell Disease No drug interventions supportive_care Not Available terminated NCT03572036
Phosphodiesterase Type-5 Inhibitor Therapy in Sickle Cell People With Pulmonary Hypertension No drug interventions Not Available Not Available completed NCT03573882
Study to Assess the Effect of Long-term Treatment With Voxelotor in Participants Who Have Completed Treatment in Study GBT440-031 treatment 3 active_not_recruiting NCT03513328
Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation No drug interventions treatment 1 / 2 completed NCT03492099
Assessing the Safety of Buprenorphine in People With Sickle Cell Disease No drug interventions treatment 2 completed NCT03488264
Stigma, Self-management, & Quality of Life in SCD No drug interventions Not Available Not Available completed NCT03201874
iCanCope With Sickle Cell Pain No drug interventions treatment Not Available completed NCT04624659
A Study of Etavopivat in Adults and Adolescents With Sickle Cell Disease (HIBISCUS) No drug interventions treatment 2 / 3 recruiting NCT04839159
Study of Biological Markers in Children With Sickle Cell Disease No drug interventions diagnostic Not Available unknown_status NCT05618301
Motixafortide and Natalizumab to Mobilize CD34+ Hematopoietic Stem Cells for Gene Therapies in Sickle Cell Disease (SCD) No drug interventions treatment 1 recruiting NCT05583721
Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET No drug interventions diagnostic 2 recruiting NCT05253781
Low Dose Aspirin for Preventing Intrauterine Growth Restriction and Preeclampsia in Sickle Cell Pregnancy (PIPSICKLE) No drug interventions prevention 3 active_not_recruiting NCT05249452
Adding Azathioprine/Hydroxyurea Preconditioning to Alemtuzumab/TBI to Reduce Risk of Graft Failure in MSD HSCT in Adult SCD Patients No drug interventions Not Available Not Available recruiting NCT05197205
Nasopharyngeal Bacterial Carriage and Antibiotic Resistance in Children With Sickle Cell Disease in Ile-De-France No drug interventions screening Not Available unknown_status NCT05200338
Preservation and Transfer of HBV Immunity After Allogeneic HSCT for SCD No drug interventions other Not Available recruiting NCT05199766
Hemolysis Related Complications in SCD. A Phase II Study With Voxelotor treatment 2 recruiting NCT05211037
Screening for Renal Complications in Children and Young Adults With Major Sickle Cell Disease No drug interventions diagnostic Not Available recruiting NCT05214105
The Predictive Capacity of Machine Learning Models for Progressive Kidney Disease in Individuals With Sickle Cell Anemia No drug interventions Not Available Not Available recruiting NCT05564845
Brain Structure and Neurocognitive Development in Sickle Cell Disease; a Longitudinal Cohort Study (BRICK Study) No drug interventions Not Available Not Available recruiting NCT05334576
Study of Crizanlizumab for Prevention of Silent Cerebral Infarcts in SCA No drug interventions prevention Not Available recruiting NCT05329649
Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Severe Sickle Cell Disease (SCD) No drug interventions treatment 3 recruiting NCT05605366
Minocycline In Neurocognitive Outcomes - Sickle Cell Disease treatment 1 not_yet_recruiting NCT05662098
Alternative Dosing And Prevention of Transfusions (ADAPT) No drug interventions treatment 0 recruiting NCT05861453
Pharmacokinetics, Pharmacodynamics and Safety of Epeleuton in Patients With Sickle Cell Disease No drug interventions treatment 2 recruiting NCT05758766
Study on Use of Omega-3 Fatty Acids to Improve Outcomes in Individuals With Sickle Cell Disease No drug interventions treatment Not Available recruiting NCT05905770
Do Alemtuzumab Levels Predict T Cell Chimerism After MSD SCT for SCD? No drug interventions Not Available Not Available recruiting NCT05837871
Genetic and Haematological Modifiers of SCD Severity in Kaduna State, Northern Nigeria No drug interventions Not Available Not Available not_yet_recruiting NCT05894161
Efficacy of Designed Exercise Program on Pain and Quality of Sleeping in Patient With Sickle Cell Disease Anemia. No drug interventions treatment Not Available completed NCT04417673
Living With Sickle Cell Disease in the COVID-19 Pandemic No drug interventions Not Available Not Available completed NCT03167450
Examining the Knowledge, Attitudes, and Beliefs of Sickle Cell Disease Patients, Parents of Patients With Sickle Cell Disease, and Providers Towards the Integration of CRISPR in Clinical Care No drug interventions Not Available Not Available completed NCT03150433
Sleep and Pain in Sickle Cell Disease No drug interventions treatment Not Available completed NCT03462511
Hydroxyurea Adherence for Personal Best in Sickle Cell Disease (HABIT): Efficacy Trial No drug interventions health_services_research Not Available completed NCT03458897
Quantitative MRI for Patients With Sickle Cell Disease Undergoing Hematopoietic Cell Transplant No drug interventions diagnostic Not Available completed NCT03405402
Transfusion in Sickle Cell Disease: Risk Factors for Alloimmunization No drug interventions screening Not Available completed NCT03240731
HLA Haploidentical Bone Marrow Transplant in Patients With Severe Sickle Cell Disease No drug interventions other 2 active_not_recruiting NCT06300723
Clinical Study of BRL-101 in Severe SCD No drug interventions treatment Not Available enrolling_by_invitation NCT03401112
A Study of IMR-687 in Adult Participants With Sickle Cell Anemia (Homozygous HbSS or Sickle-β0 Thalassemia) No drug interventions treatment 2 completed NCT03387033
Role of Virtual Reality (VR) in Patients With Sickle Cell Disease (SCD) No drug interventions other Not Available terminated NCT03368261
Epidemiology and Pathophysiological Mechanisms of HTAP in SS and SC Children in Martinique and Guadeloupe. No drug interventions other Not Available completed NCT03376893
Epidemiology of Silent and Overt Strokes in Sickle Cell Disease No drug interventions Not Available Not Available recruiting NCT05031780
A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With Sickle Cell Disease (RISE UP) treatment 2 / 3 recruiting NCT04299594
Prevalence of Osteoporosis in Sickle Cell Disease No drug interventions Not Available Not Available completed NCT03250585
sPLA2 in EBC During Acute Chest Syndrome No drug interventions Not Available Not Available completed NCT03291613
Gaming Technology to Engage Adolescent Sickle Cell Patients in Pain Management No drug interventions supportive_care Not Available completed NCT03296345
Adjuvant Low-dose Ketamine in Pediatric Sickle Cell Vaso-occlusive Crisis No drug interventions treatment 2 completed NCT03277547
Kidney Function in Sickle Cell Anemia No drug interventions Not Available Not Available active_not_recruiting NCT03282656
Gene Transfer for Sickle Cell Disease No drug interventions treatment 1 active_not_recruiting NCT03243812
Muscle Function and Its Biological and Physiological Determinants in Sickle Cell Disease No drug interventions basic_science Not Available completed NCT03235011
Evaluation of Knowledge Among Adolescents With Sickle Cell Disease. No drug interventions Not Available Not Available completed NCT05431088
A Phase 2/3 Study in Adult and Pediatric Participants With SCD No drug interventions treatment 2 / 3 recruiting NCT02729350
The Feasibility of the PAINReportIt Guided Relaxation Intervention-INPATIENT No drug interventions treatment Not Available active_not_recruiting NCT02757885
Transplantation for Patients With Sickle Cell Disease From Mismatched Family Donors of Bone Marrow No drug interventions treatment 2 completed NCT02824471
Sickle Cell Disease Biofluid Chip Technology (SCD BioChip) No drug interventions Not Available Not Available recruiting NCT02863068
Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers No drug interventions treatment 2 completed NCT02850406
Study to Evaluate the Effect of GBT440 in Pediatrics With Sickle Cell Disease No drug interventions treatment 2 active_not_recruiting NCT02909283
Sickle Cell Anemia and Cerebral Microcirculation : Multimodal Exploration No drug interventions Not Available Not Available completed NCT02946905
Neurovascular Determinants of Cognitive Function in Adults With Sickle Cell Disease No drug interventions Not Available Not Available completed NCT02947100
Omega-3 Fatty Acids in Sickle Cell Disease No drug interventions treatment 1 / 2 terminated NCT02981329
Fetal Hemoglobin Induction Treatment Metformin treatment 0 completed NCT03007849
A Pilot Study of Fecal Microbiome and Neutrophil Cellular Adhesion Molecules in Patients With Sickle Cell Disease (SCD) No drug interventions Not Available Not Available unknown_status NCT03037021
Improving Sickle Cell Disease (SCD) Care Using Web-based Guidelines No drug interventions Not Available Not Available completed NCT03077542
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease No drug interventions treatment 1 / 2 active_not_recruiting NCT03049475
Pathophysiology of Acute Pain in Patients With Sickle Cell Disease No drug interventions Not Available Not Available completed NCT03029468
Computerized Cognitive Behavioral Therapy Assisted Life Management for Pain in Sickle Cell Disease No drug interventions treatment Not Available completed NCT03012555
Vitamin D3 in Patients With Sickle Cell Disease No drug interventions Not Available Not Available completed NCT03013426
A Phase Ib Study of NVX-508 in Sickle Cell Disease No drug interventions treatment 1 withdrawn NCT02766465
Bone Marrow Transplantation vs Standard of Care in Patients With Severe Sickle Cell Disease (BMT CTN 1503) treatment 2 completed NCT02973360
Dose-Finding Study of SC411 in Children With Sickle Cell Disease treatment 2 unknown_status NCT02709681
Hydroxyurea in the Treatment of Sickle Cell Disease No drug interventions Not Available Not Available completed NCT02580565
Prevalence of Problematic Use of Equimolar Mixture of Oxygen and Nitrous Oxide and Analgesics in the Sickle-cell Disease No drug interventions Not Available Not Available completed NCT02594462
Contraception in Women With Sickle Cell Disease treatment 4 completed NCT02525107
Prevention of Vaso-occlusive Painful Crisis by Using Omega-3 Fatty Acid Supplements No drug interventions treatment 3 unknown_status NCT02620488
A Brief Laboratory-Based Hypnosis Session for Pain in Sickle Cell Disease No drug interventions supportive_care Not Available completed NCT02615847
Clinical Trial to Study the Safety and Tolerability of Memantin Mepha® in Sickle Cell Disease Patients No drug interventions treatment 2 completed NCT02651272
Macitentan in Pulmonary Hypertension of Sickle Cell Disease No drug interventions other 2 terminated NCT02516579
European Sickle Cell Disease Cohort - Hydroxyurea No drug interventions Not Available Not Available completed NCT02511769
Web-MAP Intervention for Youth With Sickle Cell Disease No drug interventions treatment Not Available completed NCT02565082
Evaluation of the Hemostatic Potential in Sickle Cell Disease Patients No drug interventions diagnostic Not Available completed NCT02567682
Drug Interaction Study of GBT440 With Caffeine, S-warfarin, Omeprazole, and Midazolam in Healthy Subjects treatment 1 completed NCT02675959
Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell Disease No drug interventions treatment 2 recruiting NCT02573714
Sub-dissociative Intranasal Ketamine for Pediatric Sickle Cell Pain Crises No drug interventions treatment Not Available unknown_status NCT02678143
Nonmyeloablative Conditioning for Mismatched Hematopoietic Stem Cell Transplantation for Severe Sickle Cell Disease No drug interventions treatment 1 terminated NCT02447627
Study of Methodologies to Measure Blood Flow and Oxygenation in Adults With Sickle Cell Disease No drug interventions Not Available Not Available completed NCT02539771
Sleep Study in Adult Patients With Major Sickle Cell Disease With Paroxysmal Nocturnal Events No drug interventions prevention Not Available completed NCT02596087
Improving Quality by Maintaining Accurate Problems in the EHR No drug interventions other Not Available completed NCT02380079
Dose-Escalation Study of SCD-101 in Sickle Cell Disease No drug interventions treatment 1 active_not_recruiting NCT02314689
A Dose Escalation Study of Intravenous L-citrulline in Steady-state Sickle Cell Disease No drug interventions treatment 1 completed NCT02630394
A Pilot Study of Azithromycin Prophylaxis for Acute Chest Syndrome in Sickle Cell Disease prevention 1 withdrawn NCT02633397
A Multi-Center Study of Riociguat in Patients With Sickle Cell Diseases No drug interventions treatment 2 completed NCT02394431
Added Value of Speckle Tracking in the Evaluation of Patients With Sickle Cell Disease No drug interventions Not Available Not Available completed NCT02475993
SMART Mobile Application Technology Utilization in the Treatment of Sickle Cell Disease Post Day Hospital Discharge No drug interventions supportive_care Not Available completed NCT02247843
Stem Cell Gene Therapy for Sickle Cell Disease No drug interventions treatment 1 / 2 active_not_recruiting NCT02285088
A Study of the Safety, Blood Levels and Biological Effects of GBT440 in Healthy Subjects and Subjects With Sickle Cell Disease No drug interventions treatment 1 completed NCT02270060
Music Therapy in Sickle Cell Pain Mixed Methods Study No drug interventions treatment Not Available completed NCT02273310
Families Taking Control (FTC): Family-based Problem-solving Intervention for Children With Sickle Cell Disease No drug interventions prevention Not Available completed NCT02225132
Assessment of Algorithm-Based Hydroxyurea Dosing on Fetal Hemoglobin Response, Acute Complications, and Organ Function in People With Sickle Cell Disease No drug interventions treatment 1 / 2 completed NCT02212691
Functional Neuroimaging of Pain Using EEG and fMRI No drug interventions Not Available Not Available completed NCT02222246
Comparing Acute Pain Management Protocols for Patients With Sickle Cell Disease No drug interventions supportive_care 4 completed NCT02187445
Inhaled Corticosteroid Use to Prevent Acute Chest Syndrome Recurrence in Children Between 1 and 4 With Sickle Cell Disease: a Feasibility Trial No drug interventions prevention 1 completed NCT02151526
A Study Evaluating the Safety and Efficacy of LentiGlobin BB305 Drug Product in β-Thalassemia Major (Also Referred to as Transfusion-dependent β-Thalassemia [TDT]) and Sickle Cell Disease treatment 1 / 2 completed NCT02193191
Escalation of Plerixafor for Mobilization of CD34+ Hematopoietic Progenitor Cells and Evaluation of Globin Gene Transfer in Patients With Sickle Cell Disease treatment 1 active_not_recruiting NCT02179177
Apixaban in Patients With Sickle Cell Disease No drug interventions prevention 3 terminated NCT02140554
A Study Evaluating the Safety and Efficacy of bb1111 in Severe Sickle Cell Disease No drug interventions treatment 1 / 2 completed NCT02149537
Risk Clinical Stratification of Sickle Cell Disease in Nigeria, Assessment of Efficacy/Safety of Hydroxyurea Treatment No drug interventions treatment 4 completed NCT02133560
Use of Mobile Technology for Intensive Training in Medication Management No drug interventions health_services_research Not Available completed NCT02114515
PATient Navigator to rEduce Readmissions No drug interventions health_services_research Not Available completed NCT02105766
Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure treatment 2 recruiting NCT02029742
Hydroxyurea Adherence for Personal Best in Sickle Cell Treatment: HABIT No drug interventions treatment Not Available completed NCT01989078
Losartan for Sickle Cell Kidney Disease No drug interventions treatment 0 completed NCT02012777
Propanolol and Red Cell Adhesion Non-asthmatic Children Sickle Cell Disease No drug interventions treatment 1 terminated NCT01987908
Evaluation of Different Dose Regimens of Aes-103 Given for 28 Days to Subjects With Stable Sickle Cell Disease No drug interventions treatment 2 terminated NCT02007746
Liver Fibrosis in Sickle Cell Disease No drug interventions Not Available Not Available completed NCT01945073
Improving Disease Knowledge in Adolescents With Sickle Cell Disease No drug interventions Not Available Not Available completed NCT01966367
CD34+ (Non-Malignant) Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation No drug interventions treatment 1 / 2 active_not_recruiting NCT01954927
Pain Management in Children and Young Adults With Sickle Cell Disease treatment 2 completed NCT01932554
Abciximab (ReoPro) as a Therapeutic Intervention for Sickle Cell Vaso-Occlusive Pain Crisis No drug interventions treatment 2 withdrawn NCT01950429
Evaluation of Sickle Cell Liver Disease No drug interventions Not Available Not Available completed NCT01911871
Multicenter Observational Study on Myocardial Iron Overload in 3 Multitransfused Populations No drug interventions Not Available Not Available completed NCT01895361
Study to Assess Safety and Impact of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Pain Crises No drug interventions treatment 2 completed NCT01895998
Quantifying the Presence of Lung Disease and Pulmonary Hypertension in Children With Sickle Cell Disease No drug interventions diagnostic 1 completed NCT01877837
Stem Cell Transplantation for Sickle Cell Anemia No drug interventions treatment 3 completed NCT01879592
Molecular Phenotyping of Asthma in Sickle Cell Disease No drug interventions Not Available Not Available completed NCT01891812
Nitrous Oxide Analgesia Vaso-occlusive Crisis No drug interventions treatment 2 terminated NCT01888614
Exhaled Carbon Monoxide as a Marker of Hemolysis in Sickle Cell Disease- an Exploratory Study No drug interventions Not Available Not Available withdrawn NCT01783691
Safety, Pharmacokinetic, and Pharmacodynamic Study of NKTT120 in Adult Patients With Stable Sickle Cell Disease (SCD) treatment 1 completed NCT01793740
Cognitive Rehabilitation in Sickle Cell Disease No drug interventions treatment Not Available completed NCT01801423
Sickle Cell Disease - Stroke Prevention in Nigeria Trial No drug interventions treatment Not Available completed NCT01800526
A Pilot Study of N-acetylcysteine in Patients With Sickle Cell Disease treatment 1 / 2 completed NCT01794000
A Study of Prasugrel in Pediatric Participants With Sickle Cell Disease (SCD) No drug interventions treatment 3 terminated NCT01771731
Vaporized Cannabis for Chronic Pain Associated With Sickle Cell Disease treatment 1 / 2 completed NCT01718054
Vascular Function Intervention Trial in Sickle Cell Disease No drug interventions treatment 2 / 3 unknown_status NCT01639950
Validating Pain Scales in Children and Young Adults No drug interventions Not Available Not Available completed NCT01597401
A Single Dose Study of the Safety, Blood Levels and Biological Effects of Aes-103 Compared to Placebo in Subjects With Stable Sickle Cell Disease No drug interventions treatment 1 completed NCT01602809
Microvessels and Heart Problems in Sickle Cell Disease No drug interventions Not Available Not Available completed NCT01547793
Carbon Monoxide Levels and Sickle Cell Disease Severity No drug interventions Not Available Not Available completed NCT01569971
Adolescent, Caregiver, and Young Adult Perspectives of the Transition From Pediatric to Adult Care for Sickle Cell Disease: A Preliminary Evaluation of the Sickle Cell Disease Transition Program No drug interventions Not Available Not Available completed NCT01499888
Ph I/II Study of Allogeneic SCT for Clinically Aggressive Sickle Cell Disease (SCD) No drug interventions treatment 1 / 2 active_not_recruiting NCT01461837
Haplo T-Cell Depleted Transplantation in High-Risk Sickle Cell Disease No drug interventions treatment 2 active_not_recruiting NCT01443728
Vitamin D for Sickle-cell Respiratory Complications No drug interventions treatment 2 completed NCT01419977
Treatment of Sickle Cell Patients Hospitalized in Pain Crisis With Prophylactic Dose Low-molecular-weight Heparin (LMWH) Versus Placebo No drug interventions treatment 2 completed NCT01411280
Ameliorating Attention Problems in Children With Sickle Cell Disease (SCD) treatment 3 completed NCT01369160
Curative Versus Disease-Modifying Therapies in Children With Severe Sickle Cell Disease No drug interventions Not Available Not Available completed NCT01374165
Safety and Pharmacokinetics of SANGUINATE™ in Sickle Cell Disease (SCD) Patients No drug interventions Not Available Not Available withdrawn NCT01276587
Study of Vitamin D in Children With Sickle Cell Disease No drug interventions treatment 1 / 2 completed NCT01256281
Regional Anesthesia for Sickle Cell Crisis Using Ultrasound in The Emergency Department: Phase I No drug interventions treatment 1 terminated NCT01245179
Study of Panobinostat (LBH589) in Patients With Sickle Cell Disease No drug interventions treatment 1 recruiting NCT01239901
Iron Mediated Vascular Disease in Sickle Cell Anemia Patients No drug interventions Not Available Not Available completed NCT01114776
Multi-Center Study of Iron Overload: Pilot Study No drug interventions Not Available Not Available completed NCT01105923
Study of an Intervention to Improve Problem List Accuracy and Use No drug interventions diagnostic Not Available unknown_status NCT01096121
Angiotensin-converting Enzyme Inhibitors and Early Sickle Cell Renal Disease in Children No drug interventions treatment Not Available terminated NCT01048905
Glutamine Therapy for Hemolysis-Associated Pulmonary Hypertension No drug interventions treatment 2 completed NCT01044901
Cardiovascular Complications of Sickle Cell Disease No drug interventions Not Available Not Available completed NCT01049854
CD34+Selection for Partially Matched Family or Matched Unrelated Adult Donor Transplant No drug interventions treatment 2 completed NCT01033227
Safety and Efficacy of Sodium Nitrite in Sickle Cell Disease treatment 1 / 2 terminated NCT00999245
THE IMPROVE TRIAL: Improving Pain Management and Outcomes With Various Strategies of Patient-Controlled Analgesia (PCA) No drug interventions treatment 3 terminated NCT00968162
Sickle Cell Disease Conditioning for Bone Marrow Transplant treatment 1 completed NCT00895154
A Rehabilitation Program in Children With Sickle Cell Disease and Cognitive Deficits: a Pilot Study No drug interventions treatment Not Available completed NCT00880373
Ibuprofen and Opioid (Morphine or Diamorphine) for Acute Pain in Sickle Cell Disease - Sickle With Ibuprofen & Morphine treatment 4 terminated NCT00842621
Long Term Effects of Erythrocyte Lysis No drug interventions Not Available Not Available completed NCT00842088
Phase 1/2 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of HQK-1001 Administered Daily in Patients With Sickle Cell Disease No drug interventions treatment 1 / 2 completed NCT00804362
Validation of the Sickle Cell Disease Pain Burden Interview No drug interventions Not Available Not Available completed NCT00784082
Inflammatory Response to Hydroxyurea Therapy in Sickle Cell Disease Not Available Not Available completed NCT00748423
Effect of Inhaled Nitric Oxide in Acute Chest Syndrome (INOSTA Study) No drug interventions treatment 2 / 3 completed NCT00749515
Pilot Study for Patients With Poor Response to Deferasirox No drug interventions treatment 4 completed NCT00730314
Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood Cells No drug interventions treatment 1 / 2 completed NCT00639392
Phase 1 Study of Zoledronic Acid in Sickle Cell Disease No drug interventions Not Available 1 / 2 withdrawn NCT00578344
Bone Marrow Transplantation, Hemoglobinopathies, SCALLOP No drug interventions treatment Not Available terminated NCT00560261
Evaluation of the Lung Capillary Blood Volume in Children With Sickle Cell Disease No drug interventions diagnostic 3 completed NCT00513864
Assessment of Opioid Analgesia in Sickle Cell No drug interventions basic_science 4 withdrawn NCT00492531
Sildenafil Therapy for Pulmonary Hypertension and Sickle Cell Disease treatment 2 terminated NCT00408447
Stem Cell Transplant in Sickle Cell Disease and Thalassemia No drug interventions treatment 2 active_not_recruiting NCT00393250
Hypnosis to Manage Pain and Symptoms in Patients With Sickle Cell Disease No drug interventions treatment 3 completed NCT00350844
Hydroxyurea for Children and Young Adults With Sickle Cell Disease and Pulmonary Hypertension No drug interventions treatment 1 / 2 terminated NCT00343954
PK and PD Responses to Oral L-Citrulline in Patients With Sickle Cell Disease No drug interventions treatment 1 unknown_status NCT00263562
Steroid Treatment for Sickle Cell Pain Crisis No drug interventions treatment 3 terminated NCT00235391
Expanded Access of Deferasirox to Patients With Congenital Disorders of Red Blood Cells and Chronic Iron Overload treatment 3 completed NCT00257543
SALT: Alternative Donor Bone Marrow and Cord Blood Transplantation for High Risk Sickle Cell Disease No drug interventions treatment 0 terminated NCT00226083
Study of Blood Platelets in Sickle Cell Disease No drug interventions Not Available Not Available withdrawn NCT00176852
Stem Cell Transplant for Hemoglobinopathy No drug interventions treatment 2 / 3 completed NCT00178464
Aspirin Prophylaxis in Sickle Cell Disease No drug interventions treatment 1 completed NCT00142051
Inhaled Nitric Oxide for Pediatric Painful Sickle Crisis No drug interventions treatment 2 terminated NCT00127543
Kid Cards: Teaching Kids About Medicines No drug interventions other Not Available withdrawn NCT00072826
Atorvastatin Therapy to Improve Endothelial Function in Sickle Cell Disease treatment 1 completed NCT00040677
A Study of the Efficacy and Safety of ICA-17043 (With or Without Hydroxyurea) in Patients With Sickle Cell Anemia. No drug interventions treatment 2 completed NCT00041574
Hospital-Based Program for Treatment of Severe Cardiopulmonary Disease With Inhaled Nitric Oxide treatment 2 terminated NCT04057521
Coordinated HEalthcare for Complex Kids No drug interventions health_services_research Not Available completed NCT04058197
Deferoxamine for Sickle Cell Chronic Leg Ulcer Treatment No drug interventions treatment 1 / 2 withdrawn NCT04053803
An Extension Study of IMR-687 in Adult Patients With Sickle Cell Anemia No drug interventions treatment 2 active_not_recruiting NCT04041180
Impact on the Length of Stay in Incentive Spirometry and Pain in the Decompensation of Sickle Cell Disease: . No drug interventions Not Available Not Available completed NCT06565026
CS-101 in Patients With Sickle Cell Disease No drug interventions treatment 0 recruiting NCT06581627
A Research Study Looking at a Single Dose of Etavopivat in Healthy Chinese Participants No drug interventions treatment 1 recruiting NCT06580067
The Feasibility of the Pray Until Something Happens (PUSH) Intervention-OUTPATIENT No drug interventions treatment Not Available not_yet_recruiting NCT06562439
Testing the Sickle Cell Caregiver Collaboration for Child Development (SCCCD) Intervention No drug interventions prevention Not Available not_yet_recruiting NCT06555939
Promoting Resilience Among Adolescents and Young Adults With Sickle Cell Disease No drug interventions treatment Not Available not_yet_recruiting NCT06503458
A Low-Interventional Study of an Electronic Sickle Cell Disease Patient Reported Outcomes in Sickle Cell Participants No drug interventions Not Available Not Available terminated NCT06477289
Peripheral Arterial Tonometry and Neurocognition in Sickle Cell Disease No drug interventions Not Available Not Available recruiting NCT06374238
Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain No drug interventions treatment Not Available not_yet_recruiting NCT06363760
A Long-Term Follow-Up Study of Participants With Sickle Cell Disease or Transfusion Dependent β-Thalassemia Who Received EDIT-301 No drug interventions Not Available Not Available not_yet_recruiting NCT06351462
Comparative Health Status and Quality of Life of Patients With Sickle Cell Disease (SCD) Who Underwent Matched-sibling Hematopoietic Stem Cell Transplantation Versus Non Transplanted SCD Case-control Patients No drug interventions other Not Available not_yet_recruiting NCT06358638
Sickle Cell Disease Transplant Using a Nonmyeloablative Approach for Patients With Anti-donor Red Cell AntibodY No drug interventions treatment 2 recruiting NCT06251843
Support Strategies for Parents During the First Year Following Their Child's Diagnosis of Sickle Cell Disorder No drug interventions Not Available Not Available not_yet_recruiting NCT06260891
Zinc Supplementation in Sickle Cell Disease No drug interventions other 2 not_yet_recruiting NCT06198712
A Study to Evaluate the Pharmacokinetics and Safety of Etavopivat in Pediatric Patients With Sickle Cell Disease No drug interventions treatment 1 / 2 recruiting NCT06139510
Predictors of Pain in Sickle Cell Disease No drug interventions diagnostic Not Available not_yet_recruiting NCT06035939
SMYLS Multi-site Trial No drug interventions prevention Not Available recruiting NCT05981365
Voxelotor CYP and Transporter Cocktail Interaction Study No drug interventions basic_science 1 completed NCT05983055
Steroid Injection for Sickle Cell Arthropathy Pain Therapy No drug interventions Not Available Not Available completed NCT05810181
Gene Therapy Communication: Use of a Needs Assessment to Drive Decision-AIDS for Gene Therapy for Rare Diseases (GENETX) No drug interventions Not Available Not Available recruiting NCT05799118
Study of the Role of Genetic Modifiers in Hemoglobinopathies No drug interventions Not Available Not Available recruiting NCT05789355
Effect of NUV001 Supplementation in Patients Suffering From Sickle Cell Disease (SCD) No drug interventions treatment Not Available active_not_recruiting NCT05791591
Safety and Efficacy of Orally Administered NUV001 Nutraceutical Supplement in Sickle Cell Disease Patients No drug interventions other Not Available active_not_recruiting NCT05649280
Safety Evaluation of DREPADOM - Home Care Services and Hospitalizations for Sickle Cell Disease Patients No drug interventions Not Available Not Available completed NCT05632289
Osteopathic Manipulation in the Management of Pain Associated With Sickel Cell Disease No drug interventions other Not Available recruiting NCT05530239
Nano-rheological Biomarkers for Patients With Sickle Cell Disease (SCD) Versus Control Subjects (Other Constitutional Red Blood Cell Diseases and Healthy Subjects) No drug interventions Not Available Not Available not_yet_recruiting NCT05477563
Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With Transfusion-Dependent β-Thalassemia and Severe Sickle Cell Disease No drug interventions treatment 3 recruiting NCT05389891
Hemoglobinopathy Nursing Program and Pediatric Nursing Students No drug interventions treatment Not Available completed NCT05377372
Early Life Exposures Among Children with Sickle Cell Disease No drug interventions prevention Not Available not_yet_recruiting NCT05359991
Exercise in Child Health No drug interventions basic_science Not Available recruiting NCT05170412
Dietary Intake and Dietary Behaviors in Adults With Sickle Cell Disease No drug interventions Not Available Not Available recruiting NCT05153967
Cooperative Assessment of Late Effects for SCD Curative Therapies No drug interventions Not Available Not Available recruiting NCT05012631
Losartan for Diffuse Myocardial Fibrosis in Sickle Cell Disease No drug interventions treatment 2 recruiting NCT04912869
A Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of Crovalimab for the Management of Acute Uncomplicated Vaso-Occlusive Episodes (VOE) in Participants With Sickle Cell Disease (SCD). No drug interventions treatment 1 recruiting NCT04819841
Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell Disease No drug interventions treatment 1 / 2 recruiting NCT04776850
Pre-transplant Immunosuppression and Donor Stem Cell Transplant for the Treatment of Severe Hemoglobinopathies No drug interventions treatment 0 withdrawn NCT04987489
A Study of Etavopivat in Patients With Thalassemia or Sickle Cell Disease No drug interventions treatment 2 recruiting NCT04657822
Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab Study No drug interventions treatment 4 recruiting NCT04610866
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat No drug interventions treatment 1 / 2 active_not_recruiting NCT04594031
US Phase I Study of ECT-001-CB in Patients With Sickle-Cell Disease No drug interventions treatment 1 withdrawn NCT04523376
Pilot Study PBSCT With TCRab Depletion For Hemoglobinopathies No drug interventions treatment Not Available active_not_recruiting NCT04514510
Fixed Dose Flavonoid Isoquercetin on Thrombo-Inflammatory Biomarkers in Subjects With Stable Sickle Cell Disease No drug interventions basic_science 2 completed NCT04474626
Isoquercetin in Sickle Cell Anemia No drug interventions treatment 2 withdrawn NCT04474314
A Study of IMR-687 in Subjects With Sickle Cell Disease No drug interventions treatment 2 terminated NCT04388241
Preliminary Feasibility and Efficacy of Behavioral Intervention to Reduce Pain-Related Disability in Pediatric SCD No drug interventions treatment Not Available completed NCT04380610
Improving Scientific Rigor of Renal Clinical Endpoints for Sickle Cell Anemia No drug interventions Not Available Not Available recruiting NCT04244240
Links Between Cognitive Functions and Clinical, Biological and Neuroradiological Outcomes in Adults With Sickle Cell Disease. No drug interventions Not Available Not Available recruiting NCT04207320
Haploidentical Hematopoietic Stem Cell Transplantation (HSCT) for Patients With Severe Sickle Cell Disease No drug interventions treatment Not Available recruiting NCT04173026
Dissemination and Implementation of Stroke Prevention Looking at the Care Environment No drug interventions other Not Available completed NCT04099966
AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion No drug interventions treatment 2 recruiting NCT04093986
Hydroxyurea Exposure Limiting Pregnancy and Follow-Up Lactation No drug interventions Not Available Not Available recruiting NCT04084080
Sickle Cell Disease and CardiovAscular Risk - Red Cell Exchange Trial (SCD-CARRE) No drug interventions treatment 3 recruiting NCT04080167
Integration of mHEALTH Into the Care of Patients With Sickle Cell Disease to Increase Hydroxyurea Utilization No drug interventions health_services_research Not Available completed NCT04015401
Neuropathic Pain in Jamaicans With Sickle Cell Disease No drug interventions Not Available Not Available completed NCT03997760
A Study of SHP655 (rADAMTS13) in Sickle Cell Disease No drug interventions treatment 1 completed NCT03976180
High-flow Oxygen for Vaso-occlusive Pain Crisis No drug interventions other Not Available unknown_status NCT03937817
Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants No drug interventions Not Available Not Available recruiting NCT03904134
Clinical Transplant-Related Long-term Outcomes of Alternative Donor Allogeneic Transplantation (BMT CTN 1702) No drug interventions treatment Not Available active_not_recruiting NCT03805581
Defibrotide in Sickle Cell Disease-Related Acute Chest Syndrome No drug interventions treatment 2 completed NCT03789591
Hydroxyurea Optimization Through Precision Study No drug interventions prevention 3 recruiting NCT00047996
Blood Collection for Research Related to Certain Diseases Involving Blood Vessels No drug interventions Not Available Not Available recruiting NCT03715972
Cerebrovascular Reserve and White Matter Disease in Patients With Chronic Anemia No drug interventions Not Available Not Available completed NCT03720626
MAP to Provide Access to Crizanlizumab, for Sickle Cell Disease Patients No drug interventions Not Available Not Available available NCT04691323
The Longitudinal Relationship of HU Adherence to HRQOL, Barriers to Adherence and Habit in SCD. No drug interventions supportive_care Not Available active_not_recruiting NCT04684381
Pharmacokinetics and Safety of Endari (L-glutamine) in Sickle Cell Disease Patients No drug interventions basic_science 4 completed NCT03708731
Exploring Adherence Monitoring in Sickle Cell Disease No drug interventions Not Available Not Available active_not_recruiting NCT03704922
Age of Blood in Sickle Cell Transfusion No drug interventions treatment 2 / 3 completed NCT03694548
Acceptability, Feasibility and Safety of a Yoga Program for Chronic Pain in Sickle Cell Disease No drug interventions supportive_care Not Available terminated NCT03653676
Sickle Cell Pro-Inflammatory Response to Interval Training Study No drug interventions Not Available Not Available unknown_status NCT03621826
Evaluating Barriers to Stroke Screening and Prevention in Children With Sickle Cell Disease No drug interventions Not Available Not Available completed NCT03609814
Study of Clofarabine and Fludarabine Drug Exposure in Pediatric Bone Marrow Transplantation (HCT) No drug interventions Not Available Not Available completed NCT03585543
Self-Management for Youth and Families Living With SCD - SMYLS No drug interventions supportive_care Not Available completed NCT03587272
Minimizing Toxicity in HLA-identical Related Donor Transplantation for Children With Sickle Cell Disease No drug interventions treatment 2 recruiting NCT03593395
LCI-HEM-SCD-ST3P-UP-001: The Sickle Cell Trevor Thompson Transition Project (ST3P-UP Study) No drug interventions health_services_research Not Available completed NCT03556657
MUSic Therapy to Improve Quality Of Life in Sickle Cell Disease (MUSIQOLS) No drug interventions treatment Not Available completed NCT03492931
PK Study of Ticagrelor in Children Aged Less Than 24 Months, With Sickle Cell Disease (HESTIA4) No drug interventions other 1 completed NCT04853576
A Study Evaluating the Safety and Efficacy of EDIT-301 in Participants With Severe Sickle Cell Disease (RUBY) No drug interventions treatment 1 / 2 recruiting NCT05020873
Prospective, Observational Study in Sickle Cell Disease Patients on Crizanlizumab Treatment in Middle East Countries and India No drug interventions Not Available Not Available terminated NCT04694976
Vitamin D Status in Children With Sickle Cell Disease Living in Lyon, France No drug interventions Not Available Not Available completed NCT05572294
Mindfulness and Yoga Therapy for Acute Pain in Sickle Cell Disease No drug interventions supportive_care Not Available completed NCT05456880
BEACON: A Study Evaluating the Safety and Efficacy of BEAM-101 in Patients With Severe Sickle Cell Disease No drug interventions treatment 1 / 2 recruiting NCT05451940
Hydroxyurea and EPO in Sickle Cell Disease No drug interventions treatment 1 / 2 recruiting NCT05203991
Avascular Bone Necrosis in Sickle Cell Disease: a Pediatric Study. No drug interventions Not Available Not Available completed NCT05210114
Cutaneous Hydration Assessment in SCD No drug interventions diagnostic Not Available recruiting NCT05561140
Resolution of Sickle Cell Leg Ulcers With Voxelotor No drug interventions treatment 3 active_not_recruiting NCT05336201
Cognitive Remediation Intervention to Prepare for Transition of Care No drug interventions supportive_care 2 recruiting NCT06345638
Sex Hormones and Inflammatory Biomarkers in Patients With Sickle Cell Disease No drug interventions Not Available Not Available enrolling_by_invitation NCT05687474
Baby Detect : Genomic Newborn Screening No drug interventions Not Available Not Available recruiting NCT05848531
Clonidine With Morphine in Patient Controlled Analgesia Pump in Vaso-Occlusive Crisis in Sickle Cell Disease Patient No drug interventions treatment 4 recruiting NCT05909657
Enablers and Barriers to Hydroxyurea Use for Sickle Cell Disease Jamaica No drug interventions Not Available Not Available recruiting NCT05833022
Patient Characteristics and Treatment Patterns From Early Crizanlizumab Use in Real-world Setting: Preliminary Analysis From Select Sickle Cell Centers No drug interventions Not Available Not Available completed NCT06287086
Clinical Study on the Safety and Efficacy of BRL-101 in the Treatment of Sickle Cell Disease No drug interventions treatment Not Available not_yet_recruiting NCT06286046
A Study of Mitapivat in Participants With Sickle Cell Disease and Nephropathy No drug interventions treatment 2 not_yet_recruiting NCT06293222
Patient and Public Involvement and Engagement in Research With Children and Young People With Sickle Cell Disorder and Their Families No drug interventions Not Available Not Available active_not_recruiting NCT04432623
The BENeFiTS Trial in Beta Thalassemia Intermedia No drug interventions treatment 1 / 2 recruiting NCT04426591
Red Blood Cell Survival in Sickle Cell Disease No drug interventions basic_science 1 recruiting NCT04349189
Venous Thrombosis Biomarkers in Sickle Cell Disease and Sickle Cell Trait No drug interventions Not Available Not Available active_not_recruiting NCT03119922
Quality of Care of Children With Sickle Cell Disease (SCD) Screened at Birth in France No drug interventions Not Available Not Available completed NCT03121001
Study of HLA-Haploidentical Stem Cell Transplantation to Treat Clinically Aggressive Sickle Cell Disease No drug interventions treatment 2 recruiting NCT03401125
Risk Factors for Allo-immunization in Sickle Cell Disease No drug interventions Not Available Not Available withdrawn NCT03368924
Implication of the Oxydative Stress in the Pathophysiology of Sickle Cell Anemia: No drug interventions basic_science Not Available completed NCT03367546
Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation (HaploHCT) Following Reduced Intensity Conditioning (RIC) for Selected High Risk Non-Malignant Diseases No drug interventions treatment 2 terminated NCT05405114
Research Study Investigating How Well NDec Works in People With Sickle Cell Disease No drug interventions treatment 2 recruiting NCT03352986
Substudy of CADRE: for People With Extreme Phenotype: BIOCADRE No drug interventions Not Available Not Available unknown_status NCT03288012
Sickle Cell Disease: Targeting Alloantibody Formation Reduction; Risk Factors, and Genetics No drug interventions Not Available Not Available unknown_status NCT03249831
A Blood Stem Cell Transplant for Sickle Cell Disease No drug interventions treatment 1 active_not_recruiting NCT03279094
Haploidentical Transplantation With Pre-Transplant Immunosuppressive Therapy for Patients With Sickle Cell Disease No drug interventions treatment 1 recruiting NCT03247218
A Phase - IIa - IIb, Trial to Study the Safety, Tolerability and Efficacy of Memantine as a Long-term Treatment of SCD No drug interventions treatment 2 unknown_status NCT03126695
A Study to Compare if the Uptake of Ticagrelor in the Body Differs When Different Tablets Are Administered No drug interventions other 1 completed NCT03132324
A Study to Evaluate Safety, Pharmacokinetic, and Biological Activity of INCB059872 in Subjects With Sickle Cell Disease No drug interventions treatment 1 terminated NCT03224429
Sickle Cell Disease (SCD) Decision Aid No drug interventions health_services_research Not Available completed NCT05033314
THromboprophylaxis In Sickle Cell Disease With Central Venous Catheters (THIS) No drug interventions prevention 3 recruiting NCT05036512
A Study to Evaluate GBT021601 in Single and Multiple Doses in Healthy Participants No drug interventions treatment 1 completed NCT02731157
Rejuvesol® Washed RBC in Sickle Cell Patients Requiring Frequent Transfusions No drug interventions other 4 completed NCT02729363
The Feasibility of the PAINReportIt Guided Relaxation Intervention-Outpatient No drug interventions treatment Not Available completed NCT02801292
Ketamine as an Adjuvant Therapy for Acute Vaso Occlusive Crisis in Pediatric Patients With Sickle Cell Disease No drug interventions treatment 3 unknown_status NCT02829580
Evaluation of Non-invasive Endothelial Function in Children Sickle by Vascular Ultrasound No drug interventions diagnostic Not Available completed NCT02868138
Study of Hydroxyurea to Treat Sickle Cell Disease No drug interventions Not Available Not Available completed NCT02998450
A Study of IMR-687 in Healthy Adult Volunteers No drug interventions treatment 1 completed NCT03036813
Study to Evaluate the Effect of Voxelotor Administered Orally to Patients With Sickle Cell Disease (GBT_HOPE) No drug interventions treatment 3 completed NCT03027258
Point-of-Delivery Prenatal Test Results Through mHealth to Improve Birth Outcome No drug interventions other Not Available unknown_status NCT03040908
New Hemolysis Parameters in Sickle Cell Disease No drug interventions Not Available Not Available unknown_status NCT02721472
Plasma DNA and Vascular Remodelling in Patients With Sickle Cell Disease No drug interventions diagnostic Not Available completed NCT03233269
BEATS 2: Music Therapy in Sickle Cell No drug interventions treatment Not Available completed NCT03226691
Peripheral Blood Stem Cell Collection for Sickle Cell Disease (SCD) Patients No drug interventions supportive_care 1 completed NCT02813850
Oxygen Therapy and Pregnancy in Sickle Cell Disease No drug interventions prevention 3 completed NCT02697240
A Phase 1 Study of Continuous Intravenous L-citrulline During Sickle Cell Pain Crisis or Acute Chest Syndrome No drug interventions treatment 1 completed NCT02659644
A Study of Oral L-citrulline in Sickle Cell Disease No drug interventions diagnostic 1 withdrawn NCT02522104
Evaluation of the Impact of Renal Function on the Pharmacokinetics of SIKLOS ® (DARH) No drug interventions other 4 completed NCT02619734
Autologous Bone Marrow Stem Cells for Chronic Leg Ulcer Treatment in Sickle Cell Disease No drug interventions treatment 1 unknown_status NCT02567695
A Single-Dose Relative Bioavailability Study Of GBT440 300 mg Capsules in Healthy Subjects No drug interventions treatment 1 completed NCT02447874
Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Disease No drug interventions treatment 1 / 2 recruiting NCT02608580
Survey in a Population of Sickle Cell Disease Patients to Evaluate the Transition Between the Queen Fabiola Children Hospital and the CHU Brugmann Hospital, and the Quality of the Hospital Care Within the CHU Brugmann Hospital. No drug interventions other Not Available completed NCT02604368
A Sickle CEll Disease ComplicatioN Trial No drug interventions treatment 3 unknown_status NCT02435901
HSCT For Patients With High Risk Hemoglobinopathies Using Reduced Intensity No drug interventions treatment 1 / 2 completed NCT02466555
Music Therapy in Sickle Cell Transition Study No drug interventions treatment Not Available completed NCT02316366
The Use of Warmed Saline in Vaso-occlusive Episodes No drug interventions treatment Not Available completed NCT02261480
A New Reagent Assay Examining Natural Parvovirus B19 Infection in Sickle Cell Disease No drug interventions Not Available Not Available completed NCT02227472
Working Memory and School Readiness in Preschool-Aged Children With Sickle Cell Disease No drug interventions Not Available Not Available completed NCT02371720
Patient Centered Comprehensive Medication Adherence Management System in Patients With Sickle Cell Disease No drug interventions health_services_research Not Available completed NCT02239016
Screening Patients With Sickle Cell Disease for Kidney Damage No drug interventions Not Available Not Available completed NCT02200510
Patient-Provider Tools to Improve the Transition to Adult Care in Sickle Cell Disease No drug interventions treatment Not Available completed NCT02143076
Medication Adherence in Youth With Sickle Cell Disease (SCD) No drug interventions Not Available Not Available completed NCT02090881
Measurement of Cerebral Blood Flow Using Transcranial Doppler Ultrasound in Children With Sickle Cell Disease No drug interventions diagnostic Not Available completed NCT02098863
Sickle Cell Clinical Research and Intervention Program No drug interventions Not Available Not Available recruiting NCT01966731
Realizing Effectiveness Across Continents With Hydroxyurea (REACH) No drug interventions treatment 1 / 2 active_not_recruiting NCT01959958
Evaluation of Nocturnal Enuresis and Barriers to Treatment Among Pediatric Patients With Sickle Cell Disease No drug interventions Not Available Not Available completed NCT01940718
Androgen Regulation of Priapism in Sickle Cell Disease No drug interventions treatment 0 withdrawn NCT01917708
Bone Marrow Transplant With Abatacept for Non-Malignant Diseases No drug interventions supportive_care 1 completed NCT01850108
Non-Myeloablative Conditioning and Bone Marrow Transplantation No drug interventions treatment Not Available active_not_recruiting NCT01835496
Absorption, Metabolism, and Excretion of a Single Dose of Ferriprox® in Patients With Sickle Cell Disease No drug interventions Not Available 1 completed NCT01737814
Evaluation of Purified Poloxamer 188 in Vaso-Occlusive Crisis of Sickle Cell Disease (EPIC) No drug interventions treatment 3 completed NCT01758250
Microvascular and Fibrosis Imaging Study No drug interventions Not Available Not Available completed NCT01702246
Effect of Simvastatin Treatment on Vaso-occlusive Pain in Sickle Cell Disease No drug interventions treatment 1 / 2 completed NCT01603160
Improving Emergency Department Management of Adults With Sickle Cell Disease No drug interventions Not Available Not Available completed NCT01568710
Blood Flow and Pain Crises in People With Sickle Cell Disease No drug interventions Not Available Not Available completed NCT01565616
Bone Marrow Transplantation in Young Adults With Severe Sickle Cell Disease No drug interventions treatment 2 completed NCT01511848
Study Of Efficacy,Safety of Combined Deferasirox and Deferiprone Versus Combined Deferiprone and Desferal In Conditions of Iron Overload No drug interventions treatment 2 / 3 unknown_status NCT01534676
Effects of Transfusion of Older Stored Red Cells No drug interventions treatment Not Available terminated NCT01430091
A Relative Bioavailability Study of a Prasugrel Orally Disintegrating Tablet No drug interventions treatment 1 completed NCT01375608
Decitabine for High-Risk Sickle Cell Disease No drug interventions treatment 2 completed NCT01316796
Topical Sodium Nitrite for Chronic Leg Ulcers in Adult Patients With Blood Disorders No drug interventions treatment 1 completed NCT01279616
A Reduced Toxicity Allogeneic Unrelated Donor Stem Cell Transplantation (SCT) for Severe Sickle Cell Disease No drug interventions treatment 2 terminated NCT01294891
Microvascular and Cardiac Dysfunction in Paroxysmal Nocturnal Hemoglobinuria and Sickle Cell Disease No drug interventions Not Available Not Available completed NCT01241357
High-Tc Susceptometer to Monitor Transfusional Iron Overload No drug interventions Not Available Not Available completed NCT01202812
A Randomized Trial of LOVAZA in Pediatric Sickle Cell Disease (SCD) No drug interventions treatment 2 unknown_status NCT01158794
Genes Influencing Iron Overload State No drug interventions Not Available Not Available completed NCT01123863
The Brigance Assessment Of Individual Neurodevelopment In Young Children With Sickle Cell Disease- 2 No drug interventions Not Available Not Available completed NCT01123369
Spectralis HRA+OCT Imaging of the Retina With Autofluorescence in Sickle Cell Disease No drug interventions Not Available Not Available completed NCT01090323
Evaluation of the Safety, Tolerability, Pharmacokinetics (PK) and Effects on Liver Iron Concentration of ICL670 Relative to Deferoxamine(DFO). No drug interventions treatment 2 completed NCT01089439
Nitric Oxide Therapy for Acute Chest Syndrome in Sickle Cell Disease Children No drug interventions treatment 2 completed NCT01085201
Adenosine 2A Agonist Lexiscan in Children and Adults With Sickle Cell Disease No drug interventions treatment 1 completed NCT01058473
Psychometric Evaluation of the IPPAQ in Pediatric Patients With Sickle Cell Disease Hospitalized With Vasoocclusive Pain No drug interventions Not Available Not Available completed NCT00957931
Allo-HCT MUD for Non-malignant Red Blood Cell (RBC) Disorders: Sickle Cell, Thal, and DBA: Reduced Intensity Conditioning, Co-tx MSCs No drug interventions treatment 2 completed NCT01000155
Efficacy of Vorinostat to Induce Fetal Hemoglobin in Sickle Cell Disease No drug interventions treatment 2 terminated NCT00940901
Sildenafil for Treatment of Priapism in Men With Sickle Cell Anemia No drug interventions treatment 2 completed NCT00972231
Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia No drug interventions Not Available Not Available completed NCT00951808
Preventing Acute Chest Syndrome by Transfusion Feasibility Study No drug interventions treatment Not Available completed NCT00911495
Study of Intravenous GMI-1070 in Adults With Sickle Cell Disease No drug interventions treatment 1 / 2 completed NCT00850369
A Pilot Study of Chronic Red Blood Cell Transfusion in Sickle Cell Disease-Associated Pulmonary Hypertension No drug interventions treatment 2 withdrawn NCT00777231
Phase I/II Pilot Study of Mixed Chimerism to Treat Hemoglobinopathies No drug interventions treatment 1 / 2 completed NCT00745420
Evaluating the Safety and Effectiveness of Bone Marrow Transplants in Children With Sickle Cell Disease (BMT CTN 0601) No drug interventions treatment 2 completed NCT00695123
Screening for Subjects to Participate in Studies of Blood Disorders No drug interventions Not Available Not Available completed NCT00508989
Niacin to Improve Blood Flow in People With Sickle Cell Disease No drug interventions treatment 2 completed NCT00508027
Simvastatin (Zocor) Therapy in Sickle Cell Disease No drug interventions treatment 1 / 2 completed NCT00489281
Non-Myeloablative Bone Marrow Transplant for Patients With Sickle Cell Anemia and Other Blood Disorders No drug interventions treatment 2 terminated NCT00481039
Sickle Cell Anemia in an Arab Bedouin Village in the Northern Israel No drug interventions Not Available Not Available completed NCT00434473
IMPACTS Trial: Investigation of the Modulation of Phospholipase in Acute Chest Syndrome No drug interventions prevention 2 completed NCT00367523
Pulmonary Hypertension in Patients With Sickle Cell Disease in Nigeria No drug interventions Not Available Not Available completed NCT00294541
A Study Evaluating the Long-Term Safety of ICA-17043 in Sickle Cell Disease Patients With or Without Hydroxyurea Therapy No drug interventions treatment 3 terminated NCT00252122
Pilot Study on the Effects of Intravenous Ketamine on Acute Pain Crisis in Patients With Sickle Cell Disease No drug interventions treatment 4 terminated NCT00228631
Analysis of T-Cell Immune Reconstitution Following Allogeneic Hematopoietic BMT for Severe SCD No drug interventions Not Available Not Available completed NCT00186810
Stem Cell Transplantation With Identical Donors for Patients With Sickle Cell Disease No drug interventions treatment 2 completed NCT00174538
Codeine in Sickle Cell Disease No drug interventions treatment 1 / 2 completed NCT00102791
A Stratified Sickle Event Randomized Trial (ASSERT) No drug interventions treatment 3 terminated NCT00110617
Study of Deferasirox Relative to Subcutaneous Deferoxamine in Sickle Cell Disease Patients No drug interventions treatment 2 completed NCT00061568
Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias No drug interventions treatment 1 / 2 active_not_recruiting NCT00011648
Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia No drug interventions Not Available Not Available completed NCT04055818
A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease No drug interventions treatment 1 recruiting NCT02515838
Sevuparin Infusion for the Management of Acute VOC in Subjects With SCD No drug interventions treatment 2 completed NCT02417298
Ketamine Infusion for Acute Sickle Cell Crisis in the Emergency Department No drug interventions treatment Not Available terminated NCT03502421
Ketamine Sickle Cell Disease No drug interventions treatment 3 withdrawn