Sickle Cell Disease (SCD) (DBCOND0128712)

Identifiers

Synonyms
Sickle Cell SC Disease / Sickle Cell Disorders / Sickle Cells Disease / Sickle-cell Disease (SCD) / Sickle-Cell Disease / Sickle Cell Disorder / Sickle Cell Disease / SC Disease / Sickle-cell disease without crisis / Sickle-cell anemia, unspecified / Sickle-cell anaemia, unspecified / Sickle-cell disorders / Sickle cell anaemia / Anaemia sickle cell / Sickle-cell anaemia / Sickle cell disease NOS / Sickling disorder due to hemoglobin S (disorder) / Sickle-cell anemia / Sickle cell anemia / Sickle cell-hemoglobin SS disease (disorder) / Anemia sickle cell / Anemia, Sickle Cell / Sickle-cell/Hb-C disease / Sickle-cell/Hb-C disease without crisis / Hemoglobin SC Disease / Sickle cell-hemoglobin C disease (disorder) / Sickle cell Hb-C disease / Haemoglobin SC disease / Hb-SC / Double heterozygous sickling disorders / Double heterozygous sickling disorder (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Crizanlizumab
A monoclonal antibody that targets selectin to reduce the frequency of vasooclusive crises in patients with sickle cell disease.
Exagamglogene autotemcel
An autologous CRISPR-Cas9 modified hematopoietic stem cell therapy for the treatment of patients with sickle cell disease and recurrent vaso-occlusive crises.
No drug targets
Hydroxyurea
An antimetabolite used to treat sickle cell anemia crisis, resistant chronic myeloid leukemia, and Locally advanced squamous cell carcinomas of the head and neck (excluding the lip).
Lovotibeglogene autotemcel
An autologous CD34+ cell therapy used to treat sickle cell disease by providing a functional copy of the beta-globin gene
Piracetam
A nootropic cyclic GABA derivative used in myoclonus, sickle cell disease, alcohol dependence, and as a general cognitive enhancer.
No drug targets
Voxelotor
A drug used to inhibit the polymerization of hemoglobin S, preventing the painful and sometimes lethal vaso-occlusive crises associated with sickle cell disease.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT04579926
PINPOINT: Gaming Technology for SCD PainNo drug interventionssupportive_careNot Availablecompleted
NCT06396403
The Role of Red Cell Characteristics, Angiogenesis, Viscosity and Oxygenation in the Pathophysiology of Sickle Cell Related RetinopathyNo drug interventionsNot AvailableNot Availablerecruiting
NCT05904093
Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Diseasebasic_science1enrolling_by_invitation
NCT02433158
Safety of Rivipansel (GMI-1070) in the Treatment of One or More Vaso-Occlusive Crises in Hospitalized Subjects With Sickle Cell Diseasetreatment3terminated
NCT01601340
Effects of HQK-1001 in Patients With Sickle Cell Diseasetreatment2terminated
NCT04201210
A Trial to Assess Haploidentical T-depleted Stem Cell Transplantation in Patients With SCDNo drug interventionstreatment2recruiting
NCT01356485
Safety Study of MP4CO in Adult Sickle Cell PatientsNot Available1completed
NCT04134299
To Assess Safety, Tolerability and Physiological Effects on Structure and Function of AXA4010 in Subjects With Sickle Cell DiseaseNo drug interventionsbasic_scienceNot Availablecompleted
NCT01925001
Phase 2 Study of MP4CO to Treat Vaso-occlusive Sickle Crisistreatment2withdrawn
NCT01322269
A Study of HQK-1001 in Patients With Sickle Cell Diseasetreatment2completed
NCT06019208
GenoMed4ALL: Improving SCD Classification and Prognosis by AINo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT02972138
Vitamin D and Bisphosphonates in the Treatment of Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT04156893
RH Genotype Matched RBC TransfusionsNo drug interventionstreatment1 / 2recruiting
NCT02274415
Immunogenicity Study of an Anti-pneumococcal Vaccination Strategy in Patients With Sickle Cells Diseasebasic_science2completed
NCT06665997
Clinical and Biomarker Effects of Depot Medroxyprogesterone Acetate in Females with Sickle Cell Diseasetreatment4not_yet_recruiting
NCT03474965
Study of Dose Confirmation and Safety of Crizanlizumab in Pediatric Sickle Cell Disease Patientstreatment2active_not_recruiting
NCT03814746
Study of Two Doses of Crizanlizumab Versus Placebo in Adolescent and Adult Sickle Cell Disease Patientstreatment3active_not_recruiting
NCT03264989
Pharmacokinetics and Pharmacodynamics Study of SEG101 (Crizanlizumab) in Sickle Cell Disease (SCD) Patients With Vaso- Occlusive Crisis (VOC)treatment2completed
NCT04053764
Study Exploring the Effect of Crizanlizumab on Kidney Function in Patients With Chronic Kidney Disease Caused by Sickle Cell Diseasetreatment2completed
NCT06619093
Relationship Between Biological Phenotype, Clinical Severity of Sickle Cell Disease, and Blood CoagulationNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT06619197
Exploratory Study on Global Reflexology in Sickle Cell DiseaseNo drug interventionssupportive_careNot Availablenot_yet_recruiting
NCT05565092
Safety, Efficacy, Pharmacokinetic, and Pharmacodynamic Study of ALXN1820 in Adult Participants With Sickle Cell DiseaseNo drug interventionstreatment2terminated
NCT03478917
Early Diagnosis of Sickle Acute Chest Syndrome Using a Combination of Plasma Bimarkers and Chest ImagingNo drug interventionsNot AvailableNot Availablecompleted
NCT04662931
An Indian Multi-centric Phase IV Study to Assess the Safety of Crizanlizumab in Sickle Cell Disease Patientstreatment4completed
NCT04413539
Evaluation of Impact of Disease on Quality of Life, Education and Socio-professional Integration of Adults and Parents of Children Living With Sickle- Cell Disease in FranceNo drug interventionsNot AvailableNot Availablecompleted
NCT02193191
Escalation of Plerixafor for Mobilization of CD34+ Hematopoietic Progenitor Cells and Evaluation of Globin Gene Transfer in Patients With Sickle Cell Diseasetreatment1active_not_recruiting
NCT03049475
Pathophysiology of Acute Pain in Patients With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT00047996
Blood Collection for Research Related to Certain Diseases Involving Blood VesselsNo drug interventionsNot AvailableNot Availablerecruiting
NCT00011648
Secondary Pulmonary Hypertension in Adults With Sickle Cell AnemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT03383913
HRV-B for Symptom Management in Sickle Cell PatientsNo drug interventionstreatmentNot Availablecompleted
NCT00542230
Blood Sampling for Research Related to Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT03715972
Cerebrovascular Reserve and White Matter Disease in Patients with Chronic AnemiaNot AvailableNot Availablecompleted
NCT03745287
A Safety and Efficacy Study Evaluating CTX001 in Subjects With Severe Sickle Cell Diseasetreatment2 / 3active_not_recruiting
NCT03629678
Using Patient-Centered Guidelines in a Technology Platform to Improve Health Care in Adults With Sickle Cell DiseaseNo drug interventionspreventionNot Availablecompleted
NCT03720626
MAP to Provide Access to Crizanlizumab, for Sickle Cell Disease PatientsNot AvailableNot Availableavailable
NCT04610866
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivattreatment1 / 2active_not_recruiting
NCT03763656
Pharmacokinetics of Oral Hydroxyurea Solutiontreatment1 / 2completed
NCT05431088
A Phase 2/3 Study in Adult and Pediatric Participants With SCDtreatment2 / 3active_not_recruiting
NCT05405114
Research Study Investigating How Well NDec Works in People With Sickle Cell Diseasetreatment2recruiting
NCT05383911
Empowering Adolescents and Young Adults With Sickle Cell Disease as Partners in Treatment Decision Making (EMPOWER-AYA)No drug interventionssupportive_careNot Availablenot_yet_recruiting
NCT04987489
A Study of Etavopivat in Patients With Thalassemia or Sickle Cell Diseasetreatment2recruiting
NCT04912869
A Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of Crovalimab for the Management of Acute Uncomplicated Vaso-Occlusive Episodes (VOE) in Participants With Sickle Cell Disease (SCD).treatment1recruiting
NCT05953584
A Phase 2 Open-label Study to Evaluate the Activity of Etavopivat on Transcranial Doppler Velocities in Pediatric Patients With Sickle Cell Disease Who Are at Increased Risk for Primary Stroketreatment2recruiting
NCT06145282
Non-myeloablative Haploidentical HCT Study for Patients With Sickle Cell Disease, Including Compromised Organ Functiontreatment1 / 2recruiting
NCT06313398
Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labelingother0recruiting
NCT06397118
Prevention of Malnutrition in Children with Sickle Cell DiseaseNo drug interventionspreventionNot Availablenot_yet_recruiting
NCT06399107
Investigation Into the Use of BAH243 Lentiviral Vector for Gene Therapy in Treating Sickle Cell DiseaseNo drug interventionstreatment1 / 2recruiting
NCT06664541
Decision-Making and Quality of Life Surrounding Hematologic Disease and Gene TherapyNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT06612268
A Research Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Diseasetreatment3not_yet_recruiting
NCT06662812
Characteristics and Treatment Patterns of Patients With Sickle Cell Disease in Globin Research Network for Data and Discovery RegistryNo drug interventionsNot AvailableNot Availablecompleted
NCT06662825
Real World Patient Characteristics and Treatment Patterns From Crizanlizumab Use: Preliminary Analysis From Select Sickle Cell CentersNo drug interventionsNot AvailableNot Availablecompleted
NCT01757418
Intravenous Gammaglobulin for Sickle Cell Pain Crisestreatment1 / 2recruiting
NCT04406818
Metabolic and Hemodynamic Reserve in Pediatric SCAbasic_scienceNot Availablerecruiting
NCT03150433
Sleep and Pain in Sickle Cell DiseaseNo drug interventionstreatmentNot Availablecompleted
NCT04657822
Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab Studytreatment4recruiting
NCT05031780
A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With Sickle Cell Disease (RISE UP)treatment2 / 3recruiting
NCT04776850
Pre-transplant Immunosuppression and Donor Stem Cell Transplant for the Treatment of Severe Hemoglobinopathiestreatment0withdrawn
NCT05861453
Pharmacokinetics, Pharmacodynamics and Safety of Epeleuton in Patients With Sickle Cell Diseasetreatment2recruiting
NCT06477289
Peripheral Arterial Tonometry and Neurocognition in Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT06650813
Adapting the FACETS Program to Sickle Cell DiseaseNo drug interventionspreventionNot Availablenot_yet_recruiting
NCT06650059
Cohort Study of Sickle Cell Patients Evaluating Analgesic Strategies and Their ConsequencesNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT02720679
Investigation of the Genetics of Hematologic DiseasesNo drug interventionsNot AvailableNot Availablerecruiting
NCT00012545
Collection and Storage of Umbilical Cord Stem Cells for Treatment of Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT03937817
Collection of Human Biospecimens for Basic and Clinical Research Into Globin VariantsNo drug interventionsNot AvailableNot Availablerecruiting
NCT03904134
Clinical Transplant-Related Long-term Outcomes of Alternative Donor Allogeneic Transplantation (BMT CTN 1702)No drug interventionstreatmentNot Availableactive_not_recruiting
NCT03958643
Best Noninvasive Predictor of Renal Function in Assessing Adult Sickle NephropathyNo drug interventionsNot AvailableNot Availablecompleted
NCT05329649
Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Severe Sickle Cell Disease (SCD)treatment3recruiting
NCT05583721
Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PETdiagnostic2recruiting
NCT06286046
A Study of Mitapivat in Participants With Sickle Cell Disease and Nephropathytreatment2not_yet_recruiting
NCT06442761
SCD Stem Cell Mobilization and Apheresis Using Motixafortideother1recruiting
NCT06506461
Gene Editing For Sickle Cell Diseasetreatment1not_yet_recruiting
NCT06647979
Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Severe Β-HemoglobinopathiesNo drug interventionstreatment1not_yet_recruiting
NCT02140554
A Study Evaluating the Safety and Efficacy of Lovo-cel in Severe Sickle Cell DiseaseNo drug interventionstreatment1 / 2completed
NCT03353584
Effect of Virtual Reality Technology for Pain Management of Vaso-Occlusive Crisis in Patients With Sickle Cell DiseaseNo drug interventionssupportive_careNot Availablerecruiting
NCT04819841
Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell DiseaseNo drug interventionstreatment1 / 2recruiting
NCT05169580
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of FTX-6058No drug interventionstreatment1recruiting
NCT04853576
A Study Evaluating the Safety and Efficacy of EDIT-301 in Participants With Severe Sickle Cell Disease (RUBY)No drug interventionstreatment1 / 2active_not_recruiting
NCT05618301
Motixafortide and Natalizumab to Mobilize CD34+ Hematopoietic Stem Cells for Gene Therapies in Sickle Cell Disease (SCD)treatment1recruiting
NCT06635902
Intravenous L-Citrulline for Vaso-occlusive Pain Episode in Sickle Cell Diseasetreatment2recruiting
NCT03664830
Safety of Blood Stem Cell Mobilization With Plerixafor in Patients With Sickle Cell Diseasetreatment1active_not_recruiting
NCT04349189
Venous Thrombosis Biomarkers in Sickle Cell Disease and Sickle Cell TraitNo drug interventionsNot AvailableNot Availablecompleted
NCT05075824
A Study Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Crovalimab as Adjunct Treatment in Prevention of Vaso-Occlusive Episodes (VOE) in Sickle Cell Disease (SCD)treatment2active_not_recruiting
NCT04188509
Open-Label Extension of Voxelotortreatment3active_not_recruiting
NCT04170348
Daily Vitamin D for Sickle-cell Respiratory Complicationsprevention2active_not_recruiting
NCT05457790
Feasibility and Preliminary Efficacy of Acceptance and Commitment Therapy (ACT) for Sleep Disturbances in Adults With Sickle Cell Disease (SCD)No drug interventionssupportive_careNot Availablerecruiting
NCT05211037
Screening for Renal Complications in Children and Young Adults With Major Sickle Cell DiseaseNo drug interventionsdiagnosticNot Availablerecruiting
NCT04624659
A Study of Etavopivat in Adults and Adolescents With Sickle Cell Disease (HIBISCUS)treatment2 / 3recruiting
NCT05045820
Integrative Medicine in Pain Management in Sickle Cell DiseaseNo drug interventionstreatmentNot Availablerecruiting
NCT04817670
Study to Assess Efficacy and Safety of VIT-2763 (Vamifeport) in Subjects With Sickle Cell Diseasetreatment2completed
NCT04935879
A Study to Assess the Safety and Efficacy of Inclacumab in Participants With Sickle Cell Disease Experiencing Vaso-occlusive Crisestreatment3completed
NCT05098028
Pharmacokinetics and Pharmacodynamics of Rifaximin Novel Formulations in Patients With Sickle Cell Diseasetreatment2completed
NCT04774536
Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients with Severe Sickle Cell DiseaseNo drug interventionstreatment1 / 2recruiting
NCT05353647
A Gene Transfer Study Inducing Fetal Hemoglobin in Sickle Cell Disease (GRASP, BMT CTN 2001)No drug interventionstreatment2recruiting
NCT05153967
Cooperative Assessment of Late Effects for SCD Curative TherapiesNo drug interventionsNot AvailableNot Availablerecruiting
NCT05170412
Dietary Intake and Dietary Behaviors in Adults With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT05348915
A Study to Evaluate the Long-term Safety of Inclacumab Administered to Participants With Sickle Cell Diseasetreatment3active_not_recruiting
NCT05561140
Resolution of Sickle Cell Leg Ulcers With Voxelotortreatment3active_not_recruiting
NCT05640271
Tocilizumab for Acute Chest Syndrometreatment2recruiting
NCT05451940
Hydroxyurea and EPO in Sickle Cell Diseasetreatment1 / 2active_not_recruiting
NCT05725902
Study of the Effect of Etavopivat on Cerebral Hemodynamic Response in Children With Sickle Cell Diseasetreatment2recruiting
NCT06139510
Predictors of Pain in Sickle Cell DiseaseNo drug interventionsdiagnosticNot Availablerecruiting
NCT06198712
A Study to Evaluate the Pharmacokinetics and Safety of Etavopivat in Pediatric Patients With Sickle Cell Diseasetreatment1 / 2recruiting
NCT06374238
Peer Support for Adolescents and Emerging Adults with Sickle Cell PainNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT06363760
A Long-Term Follow-Up Study of Participants With Sickle Cell Disease or Transfusion Dependent β-Thalassemia Who Received EDIT-301No drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT06581627
A Research Study Looking at a Single Dose of Etavopivat in Healthy Chinese Participantstreatment1recruiting
NCT06511453
Acupressure in Patients With Sickle Cell DiseaseNo drug interventionstreatmentNot Availablerecruiting
NCT06213402
RADeep Multicenter European Epidemiological Platform for Patients Diagnosed With Rare Anemia Disorders (RADs)No drug interventionsNot AvailableNot Availablerecruiting
NCT04983264
A Study to Evaluate GBT021601-012 Single Dose and Multiple Dose in Participants With Sickle Cell Disease (SCD)No drug interventionstreatment1completed
NCT06318143
mAnaging siCkle CELl disEase Through incReased AdopTion of hydroxyurEa in NigeriaNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT05143021
Sickle Cell Disease Obstetric Multi-Disciplinary Care ProgrammeNo drug interventionsNot AvailableNot Availablerecruiting
NCT04157179
Cerebral Oxygen Metabolism in ChildrenNo drug interventionsbasic_scienceNot Availablerecruiting
NCT03709303
Motivations, Expectations, and Decision-making of Sickle Cell Patients in Clinical ResearchNo drug interventionsNot AvailableNot Availablecompleted
NCT04031521
Near Infrared Spectroscopy in Sickle Cell Pediatric PatientsNo drug interventionsNot AvailableNot Availablewithdrawn
NCT05084521
Interest of Famotidine in Children With Sickle Cell Diseasetreatment2 / 3recruiting
NCT05228821
Voxelotor Brain Oxygenation and Neurocognitive Studytreatment4withdrawn
NCT02776202
HLA-Identical Sibling Donor Bone Marrow Transplantation for Individuals With Severe Sickle Cell Disease Using a Reduced Intensity Conditioning Regimentreatment2unknown_status
NCT02960503
Macrolide Therapy to Improve Forced Expiratory Volume in 1 Second in Adults With Sickle Cell Diseaseother1 / 2withdrawn
NCT02675790
Moderate Dose Hydroxyurea for Secondary Stroke Prevention in Children With Sickle Cell Disease in Sub-Saharan Africaprevention3completed
NCT02448121
Autologous Bone Marrow Stem Cell Transplantation for Osteonecrosis in Sickle Cell DiseaseNo drug interventionstreatment1 / 2unknown_status
NCT02384590
Cognitive Behavioral Therapy and Real-time Self-management Intervention for SCD Via Mobile ApplicationsNo drug interventionstreatmentNot Availablecompleted
NCT02061202
Inhaled Mometasone to Reduce Painful Episodes in Patients With Sickle Cell Diseasetreatment2completed
NCT01833702
Use of a Mobile-based App for SCD PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT01673243
Parent Willingness to Participate in Tobacco Trials in the Pediatric Clinical SettingNo drug interventionsNot AvailableNot Availablecompleted
NCT01566890
Microvascular Blood Flow in Sickle Cell AnemiadiagnosticNot Availablecompleted
NCT01077921
Study of Propranolol as Anti-Adhesive Therapy in Sickle Cell Disease (SCD)treatment2completed
NCT00773890
TRF-1101 Assessment in Sickle Cell DiseaseNo drug interventionstreatment1 / 2terminated
NCT00434902
Evaluation of the Prevalence of Pulmonary Hypertension in Adult Patients With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availableunknown_status
NCT00066079
Home Based Massage and Relaxation for Sickle Cell PainNo drug interventionstreatment2completed
NCT06546670
A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell DiseaseNo drug interventionstreatment1 / 2recruiting
NCT06529042
SCRIPT: Sickle Cell Risk in Pregnancy ToolNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT06526117
Stroke Prevention in Nigeria 2 Trialprevention4recruiting
NCT06464458
Optimizing the Management of Sickle Cell Patients on Hydroxyurea: The Value of Therapeutic Pharmacological MonitoringNo drug interventionstreatmentNot Availablerecruiting
NCT06417411
LEARNER- Low dosE AspiRiN prEterm tRial (Angola)prevention1 / 2recruiting
NCT06385886
Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT06171217
Realizing Effectiveness Across Continents With Hydroxyureatreatment2recruiting
NCT06110754
Development and Adaptation of I-STRONG for SCDNo drug interventionssupportive_careNot Availablerecruiting
NCT06023199
Assessing Physical Function in Sickle Cell Patients Taking Voxelotortreatment2recruiting
NCT06016634
Alendronate for Osteonecrosis in Adults With Sickle Cell Diseasetreatment2recruiting
NCT05998824
COVID-19 Vaccination Hesitancy in Adults With Sickle Cell DiseaseNo drug interventionstreatmentNot Availablerecruiting
NCT05780775
Lipid Balance in Adult Sickle Cell PatientsNo drug interventionsbasic_scienceNot Availablerecruiting
NCT05775224
ASH Research Collaborative Data HubNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT05718687
A GBT021601 ADME Microtracer Study in Healthy VolunteersNo drug interventionsother1completed
NCT05506358
Evaluation of Low-cost Techniques for Detecting Sickle Cell Disease and β-thalassemia in Nepal and CanadaNo drug interventionsdiagnosticNot Availablecompleted
NCT05494541
Characteristics of Patients With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT05469828
Crizanlizumab Improves Tissue Oxygen Supply Demand Matching in Patients With Sickle Cell Anemiatreatment1 / 2not_yet_recruiting
NCT05384756
TMLI and Alemtuzumab for Treatment of Sickle Cell Diseasetreatment1recruiting
NCT05289700
Hyperbaric-oxygen Therapy (HBOT) Versus Placebo for Treating Vaso-Occlusive Crisis (VOC) in Sickle Cell Disease (SCD)No drug interventionstreatment3recruiting
NCT05285917
Promoting Utilization and Safety of Hydroxyurea Using Precision in Africatreatment3recruiting
NCT05283148
Sickle Cell Disease (SCD) Bone Pain StudyNo drug interventionsdiagnosticNot Availablecompleted
NCT05407805
A Study to Learn About Sickle Cell Disease In Adult PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT04930445
Oxbryta® Product Registry An Observational Study Designed to Evaluate the Effect of Oxbryta in Individuals With SCDNot AvailableNot Availablerecruiting
NCT04930328
Retrospective Real World Oxbryta® Data Collection and Analysis StudyNot AvailableNot Availablecompleted
NCT04917783
Health Literacy - Neurocognitive Screening in Pediatric SCDNo drug interventionshealth_services_researchNot Availablecompleted
NCT04906707
Home-Based Intervention for Chronic Pain in Adults With Sickle Cell DiseaseNo drug interventionstreatmentNot Availablecompleted
NCT04877054
Pilot Evaluation of a Motivational Interviewing Intervention Targeting Adherence Behaviors in Youth With Sickle Cell DiseaseNo drug interventionstreatmentNot Availablecompleted
NCT04864041
Evaluation of Left Ventricular Function by Speckle Tracking Echocardiography in Patient Hospitalised in Intensive Care Unit for Vaso-occlusive CrisisNo drug interventionsNot AvailableNot Availableunknown_status
NCT04817345
Peripheral Blood Stem Cell Collection From Patients With Sickle Cell Disease (SCD) Using Plerixaforsupportive_care2withdrawn
NCT04800809
The Afolabi Stroke Registry for Children and Young Adults With SCD in Northern NigeriaNo drug interventionsNot AvailableNot Availablecompleted
NCT04793854
Sickle Cell Disease, Neurocognitive Disorders, Social ParticipationNo drug interventionsNot AvailableNot Availablecompleted
NCT04756375
Evaluation of Virtual Reality to Save Morphinic in the Treatment of Vaso-occlusive Seizures of Sickle Cell Patients Consulting in the Emergency RoomNo drug interventionssupportive_careNot Availablecompleted
NCT04983654
Functional and Mechanistic Characterization of Limb Ulcers in Patients With Sickle Cell DiseaseNo drug interventionsbasic_scienceNot Availablecompleted
NCT04707235
ESCORT-HU Extension: European Sickle Cell Disease Cohort - Hydroxyurea - Extension StudyNot AvailableNot Availableactive_not_recruiting
NCT04667325
Evaluation of Therapeutic Adherence to Inciting Spirometry in Sickle Cell PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT04676113
Obesity in Pediatric Sickle Cell Disease: A New PhenomenonNo drug interventionsNot AvailableNot Availablecompleted
NCT04675645
Adherence to HU and HRQOL in Patients With Sickle Cell Disease: An Intervention Study Using HU-Go AppNo drug interventionssupportive_careNot Availablecompleted
NCT06264700
Applying Directly Observed Therapy to Hydroxyurea to Realize EffectivenessNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT05736419
A Study of Immune Suppression Treatment for People With Sickle Cell Disease or β-Thalassemia Who Are Going to Receive an Allogeneic Hematopoietic Cell Transplantation (HCT)treatment2recruiting
NCT04602728
Building Adaptive Coping and Knowledge to Improve Daily LifeNo drug interventionssupportive_careNot Availablecompleted
NCT04586985
Safety, Tolerability and Pharmacokinetics of FTX-6058treatment1completed
NCT04476277
Red Cell Half Life Determination in Patients With and Without Sickle Cell Diseasebasic_science0completed
NCT04362293
Reduced Intensity Transplantation for Severe Sickle Cell Diseasetreatment2suspended
NCT05730205
Effects of the Contraceptive Implant in Women With Sickle Cell Diseasetreatment4recruiting
NCT04400487
Actigraphy Improvement With Voxelotor (ActIVe) Studytreatment4completed
NCT04264871
Is the Preoperative Preparation of Sickle Cell Patients Optimal: Assessment of Practices and Post-operative ComplicationsNo drug interventionsNot AvailableNot Availableunknown_status
NCT04190888
Sickle Cell Uric Acid (SCUA) - Cohort RepositoryNo drug interventionsNot AvailableNot Availablecompleted
NCT04156399
Acupuncture for Adults With Sickle Cell Disease (SCD): A Feasibility StudyNo drug interventionsbasic_scienceNot Availableterminated
NCT03989986
iPeer2Peer Program for Youth With Sickle Cell DiseaseNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT03975699
Implications of a Paediatrician-psychologist Tandem for Sickle Cell Disease Care and Impact on Cognitive FunctioningNo drug interventionsNot AvailableNot Availablecompleted
NCT03948516
Sickle Cell Disease, HemechipNo drug interventionsNot AvailableNot Availablecompleted
NCT03938324
Peer i-Coaching for Activated Self-Management Optimization in Adolescents and Young Adults With Chronic ConditionsNo drug interventionssupportive_careNot Availablecompleted
NCT03944447
Outcomes Mandate National Integration With Cannabis as Medicinetreatment2recruiting
NCT03943615
Expanded Access to Voxelotor for Patients With Sickle Cell Disease Who Have No Alternative Treatment OptionsNot AvailableNot Availableno_longer_available
NCT03908385
Hemoglobin Desaturation in Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT03903133
Endothelial Monocyte-activating Polypeptide-II in Egyptian Sickle Patientssupportive_care4completed
NCT03825341
Hydroxyurea Therapy: Optimizing Access in Pediatric Populations Everywheretreatment2terminated
NCT04688411
An mHealth Strategy to Improve Medication Adherence in Adolescents With Sickle Cell DiseaseNo drug interventionssupportive_careNot Availablerecruiting
NCT03682211
Intranasal Fentanyl Versus Intravenous Morphine in the Treatment of Severe Painful Sickle Cell Crises in Childrentreatment4completed
NCT03653247
A Study to Assess the Safety, Tolerability, and Efficacy of BIVV003 for Autologous Hematopoietic Stem Cell Transplantation in Patients With Severe Sickle Cell Diseasetreatment1 / 2active_not_recruiting
NCT03644953
Hydroxyurea and Transfusiontreatment2completed
NCT03615924
Effect of Ticagrelor vs. Placebo in the Reduction of Vaso-occlusive Crises in Pediatric Patients With Sickle Cell Diseasetreatment3terminated
NCT03599609
Central Nervous System Vascular Changes in Adult Sickle Cell Disease and the Effect of Treatment With Simvastatinprevention1 / 2unknown_status
NCT03528434
Zinc for Infection Prevention in Sickle Cell Anemia (ZIPS)No drug interventionspreventionNot Availablecompleted
NCT03214354
Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling Donortreatment2recruiting
NCT04628585
Long-term Follow-up of Subjects With Sickle Cell Disease Treated With Ex Vivo Gene TherapyNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT04629430
Effects of Prebiotics on Gut Microbiome in Patients Undergoing HSCTNo drug interventionstreatmentNot Availablecompleted
NCT04839354
Sickle Cell Disease Treatment With Arginine Therapy (STArT) Trialtreatment3active_not_recruiting
NCT05255445
Red Blood Cell - IMProving trAnsfusions for Chronically Transfused RecipientsNo drug interventionsNot AvailableNot Availablecompleted
NCT05445128
Study of MGTA-145 and Plerixafor in Patients With Sickle Cell Diseasetreatment2terminated
NCT05228834
Voxelotor Neurocognitive Function Studytreatment3terminated
NCT05519852
Pilates Physical Activity in Sickle Cell DiseaseNo drug interventionstreatmentNot Availableunknown_status
NCT05228756
SCD Fit Homebase ProgramNo drug interventionsotherNot Availablewithdrawn
NCT05748717
Arterial Function Parameters and Transcranial Doppler Velocity in Paediatric Patients With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT06287099
Clinical Study of BRL-101 in the Treatment of Sickle Cell DiseaseNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT04301336
Different Treatment Modalities in the Management of the Painful Crisis in Pediatric Sickle- Cell Anemiatreatment2 / 3completed
NCT05519111
Cannabinoids for the Reduction of Inflammation and Sickle Cell Related Painsupportive_care2recruiting
NCT04416178
Sickle Cell Disease and the Genomic and Gene Therapy Needs of StakeholdersNo drug interventionsNot AvailableNot Availablecompleted
NCT03128515
Optimizing Hydroxyurea Therapy in Children With SCA In Malaria Endemic Areastreatment3completed
NCT03431935
Predictors and Outcomes in Patients With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT03417947
Vitamin D Supplementation in Children With Sickle Cell DiseaseNo drug interventionsother3completed
NCT03405688
Transfusion in Sickle Cell Disease: Screening of Sickle Cell Disease Trait in Blood DonorsNo drug interventionsdiagnosticNot Availablecompleted
NCT03421756
Stem Cell Transplant in Patients With Severe Sickle Cell Diseasetreatment0terminated
NCT03263559
Haploidentical Bone Marrow Transplantation in Sickle Cell Patients (BMTCTN1507)treatment2active_not_recruiting
NCT03344900
Re-Aiming at Hydroxyurea Adherence for Sickle Cell With mHealthNo drug interventionsNot AvailableNot Availablecompleted
NCT03333486
Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancertreatment2active_not_recruiting
NCT03327428
Sickle-cell Disease Registry of the GPOHNo drug interventionsNot AvailableNot Availablerecruiting
NCT06301893
Uganda Sickle Surveillance Study (US-3)No drug interventionsNot AvailableNot Availablerecruiting
NCT03298399
Mesenchymal Stromal Cells for Haplo Hematopoietic Cell Transplantation for Sickle Cell DiseaseNo drug interventionstreatment1withdrawn
NCT03293641
Zinc Supplementation in Children With Sickle Cell Disease in Western KenyapreventionNot Availablecompleted
NCT03285178
A Study of the Effect of IW-1701 (Olinciguat), a Stimulator of Soluble Guanylate Cyclase (sGC), on Patients With Sickle Cell Disease (SCD)treatment2completed
NCT03253211
Disseminating NIH Evidence Based Sickle Cell Recommendations in North CarolinaNo drug interventionsNot AvailableNot Availablecompleted
NCT03114137
Heart Arteries and Sickle Cell Disease / Coeur Artères DREpanocytoseNo drug interventionsNot AvailableNot Availableunknown_status
NCT03105271
Acute Kidney Injury in Patients With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT05714098
Gerofit Exercise Intervention for Older Adults With Sickle Cell Disease (SICKLE-FIT Study)No drug interventionstreatmentNot Availablerecruiting
NCT05434000
Primary Prevention of Stroke in Children With Sickle Cell Anaemia in Nigeria in the CommunityscreeningNot Availablerecruiting
NCT02770534
Evaluating Thromboelastography (TEG) and ETP in Sickle AdultsNo drug interventionsNot AvailableNot Availablecompleted
NCT02785848
Identifying Barriers and Strategies to Support Self-efficacy for Medication Adherence With Text MessagingNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT02824406
Cerebrovascular Reserve Measurements in Sickle Cell DiseaseNot AvailableNot Availableunknown_status
NCT02851615
Improving Self-Management in Adolescents With Sickle Cell DiseaseNo drug interventionstreatmentNot Availablecompleted
NCT02867800
Abatacept for GVHD Prophylaxis After Hematopoietic Stem Cell Transplantation for Pediatric Sickle Cell Diseasetreatment1completed
NCT02887118
Dense Red Blood Cells in Sickle Cell ChildrenNo drug interventionsNot AvailableNot Availableterminated
NCT02922296
Glucose Metabolism in Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT03006718
SCD-PROMIS: A Software Platform to Enhance Self-efficacy and Patient-provider Engagement for Patients With Sickle Cell PainNo drug interventionsotherNot Availablecompleted
NCT03041909
An Extension Study to Further Evaluate the Safety, Tolerability of GBT440 in Patients With Sickle Cell Disease Who Participated in the Study GBT440-001other2completed
NCT02987725
Laboratory-based Hypnosis Intervention on Pain Responsivity in Adolescents With Sickle Cell DiseaseNo drug interventionssupportive_careNot Availablecompleted
NCT06158945
The Role of Endothelin 1 as a Marker of Renal Impairment in Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT02698761
A Comprehensive Care Plan for Pediatric Patients With Vaso-Occlusive CrisesNo drug interventionssupportive_careNot Availableterminated
NCT02578017
ElectroNic Hydroxyurea AdhereNCE: A Strategy to Improve Hydroxyurea Adherence in Patients With Sickle Cell DiseaseNo drug interventionsotherNot Availablecompleted
NCT02449616
Evaluation of Repeat Administration of Purified Poloxamer 188treatment3completed
NCT02443545
Long-term Safety and Efficacy of Ferriprox® in Iron Overloaded Patients With Sickle Cell Disease or Other Anemiastreatment4terminated
NCT02536170
Arginine Therapy for Sickle Cell Disease Paintreatment2completed
NCT02560935
Primary Prevention of Stroke in Children With SCD in Sub-Saharan Africa IIprevention3completed
NCT02386657
Single-center Prospective Evaluation of Sickle Cell Patient Care in the CHU Brugmann Emergency DepartmentNo drug interventionsNot AvailableNot Availablecompleted
NCT02394899
Improving Parental Psychosocial Functioning and Early Developmental Outcomes in Children With Sickle Cell DiseaseNo drug interventionspreventionNot Availablecompleted
NCT02411396
Comparison of Patient Centered Outcomes for People With Sickle Cell Disease in the Acute Care SettingNo drug interventionsNot AvailableNot Availablecompleted
NCT02410811
Novel Cardiac Magnetic Resonance Imaging to Define a Unique Restrictive Cardiomyopathy in Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT02482298
A Study to Assess the Effect of Ticagrelor in Reducing the Number of Days With Pain in Patients With Sickle Cell Diseaseprevention2completed
NCT02306993
Sickle Cell Hemoglobinopathies and Bone HealthNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT02326597
Decision Aid for Therapeutic Options In Sickle Cell DiseaseNo drug interventionshealth_services_researchNot Availablecompleted
NCT02501447
Feasibility of a Stress Reduction Intervention Study in Sickle Cell DiseaseNo drug interventionstreatmentNot Availablecompleted
NCT02504619
Allogeneic SCT of CordIn™, in Patients With HemoglobinopathiesNo drug interventionstreatment1 / 2terminated
NCT02373241
Preventing Sickle Cell Kidney Diseasetreatment2terminated
NCT02197845
Enhancing Use of Hydroxyurea In Sickle Cell Disease Using Patient NavigatorsNo drug interventionshealth_services_researchNot Availablecompleted
NCT02179359
Hematopoietic Stem Cell Transplant for High Risk HemoglobinopathiesNo drug interventionstreatmentNot Availablerecruiting
NCT02065596
Hematopoietic Stem Cell Transplant for Sickle Cell Diseasetreatment1completed
NCT02098993
Feasibility Study of Unfractionated Heparin in Acute Chest Syndrometreatment2terminated
NCT02041299
Efficacy and Safety of Ferriprox® in Patients With Sickle Cell Disease or Other Anemiastreatment4terminated
NCT02013375
SCD-Haplo: Phase II Study of HLA-Haploidentical SCT for Aggressive SCDtreatment2terminated
NCT02042222
Novel Dose Escalation to Predict Treatment With Hydroxyureatreatment0completed
NCT01976416
Novel Use Of Hydroxyurea in an African Region With Malariatreatment3completed
NCT01913548
Multi-Center Study of Iron Overload: Survey Study (MCSIO)No drug interventionsNot AvailableNot Availablecompleted
NCT01849016
N-Acetylcysteine in Patients With Sickle Cell Diseaseprevention3completed
NCT01848925
Study of SANGUINATE™ Versus Hydroxyurea in Sickle Cell Disease (SCD) Patientstreatment1completed
NCT01736657
Evaluation of Spectra Optia Red Blood Cell Exchange in Sickle Cell PatientsNo drug interventionstreatmentNot Availablecompleted
NCT01685515
Study of Decitabine and Tetrahydrouridine (THU) in Patients With Sickle Cell Diseasetreatment1completed
NCT01732718
Effect of Atorvastatin on Endothelial Dysfunction and Albuminuria in Sickle Cell Diseasetreatment2completed
NCT01591187
The Feasibility of Text Messaging to Assess Secondhand Smoke Exposure Among Youngsters With Cancer or Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT01565954
Sleep Respiratory Disorders Evaluation in Sickle Cell Disease ChildrenNo drug interventionsNot AvailableNot Availablecompleted
NCT01522196
A Study of Varespladib Infusion in Subjects With Sickle Cell Disease.prevention2terminated
NCT01518218
Effectiveness of Laying-on-of-hands for Sickle Cell DiseaseNo drug interventionssupportive_care2completed
NCT01476696
A Study of Prasugrel in Pediatric Participants With Sickle Cell Diseasetreatment2completed
NCT01393847
Nitric Oxide and Sickle Cell PainNo drug interventionsNot AvailableNot Availableterminated
NCT01389024
Hydroxyurea to Prevent Brain Injury in Sickle Cell Diseaseprevention2completed
NCT01380197
Choosing Opioid Management for Pain and Analyzing Acute Chest Syndrome (ACS) Rates Equallytreatment3completed
NCT01316549
Study of Fludarabine Drug Exposure in Pediatric Bone Marrow TransplantationNot AvailableNot Availablecompleted
NCT01331148
High Dose Vitamin D for Sickle Cell Diseaseprevention2completed
NCT01319851
Alefacept and Allogeneic Hematopoietic Stem Cell TransplantationtreatmentNot Availableterminated
NCT01220115
A 3-year, Prospective, Non-interventional, Multicenter Registry in Sickle Cell Disease (SCD) PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT01242878
MACS Study - Microparticles and Coagulation in Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availableunknown_status
NCT01197417
Intravenous Magnesium for Sickle Cell Vasoocclusive Crisistreatment2 / 3completed
NCT01195818
Albuminuria Reduction With Renin Angiotensin System Inhibitors in SCA PatientsNo drug interventionspreventionNot Availablecompleted
NCT01136941
Trial of Zileuton CR in Children and Adults With Sickle Cell Diseasetreatment1completed
NCT01142219
L-Arginine and Sickle Cell Diseasetreatment3completed
NCT01119833
Study of GMI-1070 for the Treatment of Sickle Cell Pain Crisistreatment2completed
NCT00834899
A Safety Study of Eptifibatide in Patients With Sickle Cell Diseasetreatment1 / 2terminated
NCT00761085
Methadone in Pediatric and Adult Sickle Cell PatientstreatmentNot Availablecompleted
NCT00711698
Comparison of Patient Controlled Analgesia (PCA) Versus Bolus Narcotic Therapy for the Treatment of Vaso-Occlusive Crisis (VOC)No drug interventionstreatment2withdrawn
NCT00663507
Kidney Transplantation in Patients With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availableterminated
NCT00595530
Low-Dose Ketamine Infusion for Children With Sickle Cell Disease-Related Paintreatment2terminated
NCT00590148
Assessing Function in Pediatric Patients With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT00512577
Transfusion Alternatives Pre-operatively in Sickle Cell Disease (TAPS)No drug interventionstreatment3terminated
NCT00445978
A Phase 2 Study of the Effects of 6R-BH4 in Subjects With Sickle Cell Diseasetreatment2completed
NCT00451919
The Link Between Anemia and Deficits in Memory and Attention in Individuals With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT00427661
A Pilot Study of HSCT for Patients With High-risk Hemoglobinopathy Using a Nonmyeloablative Preparative RegimenNo drug interventionstreatmentNot Availablecompleted
NCT00386048
Pain Management Protocol for Pediatric Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT00305175
Long Term Effects of Hydroxyurea Therapy in Children With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT00270478
Hydroxyurea and Erythropoietin to Treat Sickle Cell Anemiatreatment1completed
NCT00152113
Haploidentical Stem Cell Transplant for Patients With Sickle Cell Disease and Prior Stroke or Abnormal Transcranial UltrasoundNo drug interventionstreatment1completed
NCT00153985
Allogeneic Stem Cell Transplantation Following Chemotherapy in Patients With Hemoglobinopathiestreatment2completed
NCT05732922
ORCHARD- Optimising Home Assessment of Rural PatientsNo drug interventionssupportive_careNot Availablenot_yet_recruiting
NCT06155500
Long-term Follow-up (LTFU) of Patients Treated With Genome-edited Autologous Hematopoietic Stem and Progenitor Cells (HSPC)No drug interventionsNot AvailableNot Availablerecruiting
NCT06578507
Pharmacokinetics, Efficacy and Safety of Twice Daily Dosing Regimen of Hydroxycarbamide Dispersible Tablets in Children With Sickle Cell Diseasetreatment2not_yet_recruiting
NCT06579703
Ketorolac for Acute Vaso-Occlusive Crisis in Pediatric Sickle Cell Diseasetreatment4not_yet_recruiting
NCT06563440
Development and Evaluation of an Information Management System and Communication System for Population-wide Point-of-care Infant Sickle Cell Disease ScreeningNo drug interventionshealth_services_researchNot Availablenot_yet_recruiting
NCT06561061
Zinc for Infection Prevention in Sickle Cell Anemia-2 (ZIPS-2)prevention2 / 3not_yet_recruiting
NCT06539169
FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare DiseasesNo drug interventionsNot AvailableNot Availablerecruiting
NCT06497153
Lung Ultrasound in Pediatric Acute Chest SyndromeNo drug interventionsNot AvailableNot Availablerecruiting
NCT06367192
School Readiness Intervention for Preschool Children With Sickle Cell DiseaseNo drug interventionstreatmentNot Availablerecruiting
NCT06184126
Virtual Reality Devices as an Adjunct to Usual Care for Patients With Sickle Cell Disease Experiencing Vaso-Occlusive CrisesNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT06147414
Development of Non-Invasive Prenatal Diagnosis for Single Gene DisordersNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT06074198
Sickle Cell Children's Exercise Study (SuCCESs)No drug interventionstreatmentNot Availablerecruiting
NCT06072287
The Living With a Long-Term Condition StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT05951205
Evaluation of Efficacy and Safety of a Single Dose of Exa-cel in Participants With Severe Sickle Cell Disease, βS/βC Genotypetreatment3not_yet_recruiting
NCT05632354
GBT021601-022: A Study of GBT021601 in Participants With Sickle Cell Disease (SCD)No drug interventionstreatment2 / 3recruiting
NCT05635266
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research InitiativesNo drug interventionsNot AvailableNot Availablerecruiting
NCT05646888
Inflammation, Platelets and Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT05470998
L-Arginine in Children Having Sickle Cell Disease With Increased Tricuspid Regurgitant Jet Velocitytreatment3recruiting
NCT05470270
Acceptability of a New Paediatric Formulation of Hydroxycarbamide in Children With Sickle Cell Disease.treatment2completed
NCT05392101
Low Dose Iron Chelation as TReatment of Oxidative Damage in Sickle Cell Diseasebasic_science2completed
NCT05376046
Study of Erythrocyte Parameters and Hypercoagulability in Sickle Cell Disease (SCD-TGA)Not AvailableNot Availablerecruiting
NCT05392894
RElated Haplo-DonoR Haematopoietic stEm Cell Transplantation for Adults With Severe Sickle Cell DiseaseNo drug interventionstreatment3recruiting
NCT05371184
Glutamine Role in Preventing Vaso-occlusive Crisis Among SCD Patientsprevention4completed
NCT05315908
COVID-19 Testing in Underserved and Vulnerable PopulationsNo drug interventionsotherNot Availableterminated
NCT05292781
CHOICES3: Sickle Cell Disease Parenting CHOICESNo drug interventionspreventionNot Availablerecruiting
NCT05261711
AB1 in Adult Patients With Sickle Cell Disease (SCD)No drug interventionstreatment1 / 2suspended
NCT05153044
Severe Acute Respiratory Syndrome CoV 2 COVID-19 Survey and Vaccination Coverage in the Sickle Cell Population in Ile-De-FranceNo drug interventionsotherNot Availableunknown_status
NCT05099874
Feasibility and Efficacy of Attentional-Control Training in Sickle Cell DiseaseNo drug interventionstreatmentNot Availablerecruiting
NCT05081349
Hydoxycarbamide and L-Carnitine Therapy in Sickle Cell Anemiatreatment4completed
NCT05053932
Long-term Comparative Cerebrovascular Outcome After Transplantation vs Standard Care in Sickle Cell AnemiaNo drug interventionsNot AvailableNot Availablerecruiting
NCT04911049
Prevalence and Pathophysiology of Systemic Arterial Pressure Abnormalities in Childhood Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availableunknown_status
NCT04925492
PET Imaging of Vaso-Occlusive Crisis (VOC) in SCDNo drug interventionsscreening1recruiting
NCT04917120
Observational Prospective Study Measuring the Impact of the Use of a Hypnotic Script Associated With Virtual Reality on the Pain of the Child's Sickle Cell During a Vaso-occlusive CrisisNo drug interventionssupportive_careNot Availableunknown_status
NCT04906447
Hybrid Effectiveness-Implementation Trial of Guided Relaxation and Acupuncture for Chronic Sickle Cell Disease PainNo drug interventionstreatment2recruiting
NCT04927247
A Study of a Single Dose of Inclacumab to Reduce Re-admission in Participants With Sickle Cell Disease and Recurrent Vaso-occlusive Crisestreatment3terminated
NCT04892160
Distracting Through Procedural Pain and DistressNo drug interventionssupportive_careNot Availablecompleted
NCT04808778
Stroke Prevention in Young Adults With Sickle Cell AnemiaNot AvailableNot Availableactive_not_recruiting
NCT04772391
Fitness Trial in Adults With Sickle Cell Disease (SCD Fit): A Feasibility StudyNo drug interventionsotherNot Availablecompleted
NCT04724421
Expanded Access Protocol for Adults and Pediatric Patients With Sickle Cell Disease Who Have No Alternative Treatment OptionsNot AvailableNot Availableavailable
NCT04754711
Interest of Nutritional Care of Children With Sickle Cell Disease on Bone Mineral Density and Body CompositionNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT04678037
Home-based Assessment of PRO Measures in SCD Using A Smartphone App Platform: A Feasibility StudyNo drug interventionssupportive_careNot Availablecompleted
NCT06439082
A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)treatment3not_yet_recruiting
NCT05139992
COVID-19 Vaccine Response in Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT04606160
Utilizing A Single Session Problem-Solving Intervention With Caregivers of Pediatric Patients Receiving Chronic Transfusion to Treat Sickle Cell DiseaseNo drug interventionsotherNot Availablecompleted
NCT06274203
High Dose Vitamin D Supplementation in Children With Sickle Cell DiseasetreatmentNot Availablecompleted
NCT04584528
Implementing an Individualized Pain Plan (IPP) for ED Treatment of VOE's in Sickle Cell DiseaseNo drug interventionstreatmentNot Availablecompleted
NCT04574050
SELF-BREATHE RCT for Chronic BreathlessnessNo drug interventionstreatmentNot Availablecompleted
NCT04587661
Designing an Implementation Strategy for Delivering Routine Mental Health Screening and TreatmentNo drug interventionstreatmentNot Availableterminated
NCT04541875
Medication Adherence and Non-adherence in Adults With Rare DiseaseNo drug interventionsNot AvailableNot Availablewithdrawn
NCT04505969
A Study Aimed to Assess the Needs of Subjects With Sickle Cell Disease and Healthcare Professionals Managing Sickle Cell Disease Patients in Selected Nigerian CentresNo drug interventionsNot AvailableNot Availablecompleted
NCT04484272
A Stress and Pain Self-management m-Health App for Adult Outpatients With Sickle Cell DiseaseNo drug interventionstreatmentNot Availablerecruiting
NCT04443907
Study of Safety and Efficacy of Genome-edited Hematopoietic Stem and Progenitor Cells in Sickle Cell Disease (SCD)No drug interventionstreatment1active_not_recruiting
NCT04335721
A Voxelotor for Sickle Cell Anemia Patients at Highest Risk for Progression of Chronic Kidney Diseasetreatment1 / 2recruiting
NCT04293185
A Study Evaluating Gene Therapy With BB305 Lentiviral Vector in Sickle Cell DiseaseNo drug interventionstreatment3recruiting
NCT04293172
Study to Evaluate the Effect of Ticagrelor Versus Placebo in Reducing Vaso-Occlusive Crises Rate in Pediatric Patients With Sickle Cell Disease.treatment3withdrawn
NCT04285827
Safety of Single Doses of CSL889 in Adult Patients With Sickle Cell Diseasetreatment1completed
NCT04289311
SMYLS: A Self-management Program for Youth Living With Sickle Cell DiseaseNo drug interventionssupportive_careNot Availablecompleted
NCT04398628
ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic DisordersNo drug interventionsNot AvailableNot Availablerecruiting
NCT04614610
Lidocaine Intravenous in the Emergency Department For Sickle Cell Crisistreatment2not_yet_recruiting
NCT04247594
Dose Escalation Study to Evaluate the Safety, Tolerability, PK and PD of Voxelotor in Patients With SCDtreatment2terminated
NCT04218084
Study to Evaluate the Effect of GBT440 on TCD in Pediatrics With Sickle Cell Diseasetreatment3active_not_recruiting
NCT04208529
A Long-term Follow-up Study in Participants Who Received CTX001other3enrolling_by_invitation
NCT04205123
Biological, Genetic and Environmental Involved in the Complications of Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT04181944
Qualitative Survey of Potential Exercise Activity in Adults With Sickle Cell Anemia (SCA)No drug interventionsotherNot Availablecompleted
NCT04166526
A Pilot Study on Neuroimaging in SCD: Part of The Boston Consortium to Cure Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT04150757
Intranasal Ketamine For Pain Control In Patients With Sickle Cell Disease And Vaso-occlusive Episode (VOE) In The PEDtreatment3unknown_status
NCT04156906
RHD Genotype Matched Red Cells for Anti-DNo drug interventionstreatment0recruiting
NCT04122378
Acupuncture for Pain in Sickle Cell DiseaseNo drug interventionsotherNot Availableactive_not_recruiting
NCT04109820
Effect of MitoQ on Platelet Function and Reactive Oxygen Species Generation in Patients With Sickle Cell AnemiaNo drug interventionsotherNot Availablerecruiting
NCT04046705
Comparison of Allogeneic Matched Related Haematopoietic Stem Cell Transplantation After a Reduced Intensity Conditioning Regimen With Standard of Care in Adolescents and Adults With Severe Sickle Cell DiseaseNo drug interventionstreatment3not_yet_recruiting
NCT04076683
Algorithm for Apherisis Monitoring and Prescription Assistance in Sickle Cell Patients (ALGODREP)No drug interventionssupportive_careNot Availablecompleted
NCT04075877
FOCUS for Pediatric Sickle Cell Disease and CancerNo drug interventionstreatmentNot Availableunknown_status
NCT04018937
Early Human Leukocyte Antigen (HLA) Matched Sibling Hematopoietic Stem Cell Transplantationtreatment2recruiting
NCT03997903
Imatinib for Pain in Sickle Cell Anemiabasic_science1 / 2recruiting
NCT04000165
A Dose-Finding Study of AG-348 in Sickle Cell Diseasebasic_science0completed
NCT03985501
DREPAMASSE Study - Evaluation of a Newborn Screening for Sickle Cell Disease by Tandem Mass SpectrometryNo drug interventionsNot AvailableNot Availablecompleted
NCT03977532
Study of a Red Blood Cell Deformability Parameter in Patients With Sickle Cell DiseaseNo drug interventionsotherNot Availablecompleted
NCT03978156
Dronabinol for Pain and Inflammation in Adults Living With Sickle Cell Diseasetreatment1terminated
NCT03964792
Safety and Efficacy of Gene Therapy of the Sickle Cell Disease by Transplantation of an Autologous CD34+ Enriched Cell Fraction That Contains CD34+ Cells Transduced ex Vivo With the GLOBE1 Lentiviral Vector Expressing the βAS3 Globin Gene in Patients With Sickle Cell Disease (DREPAGLOBE)No drug interventionstreatment1 / 2active_not_recruiting
NCT03975894
TAPS2 Transfusion Antenatally in Pregnant Women With SCDNo drug interventionstreatment2unknown_status
NCT03933397
Comparing Individualized vs. Weight Based Protocols to Treat Vaso-Occlusive Episodes in Sickle Cell Diseasetreatment3terminated
NCT03919266
Combined Use of a Respiratory Broad Panel Multiplex PCR and Procalcitonin to Reduce Antibiotics Exposure in Hospitalized Sickle-cell Adults With Acute Chest Syndrome.No drug interventionstreatmentNot Availablecompleted
NCT03899246
Sickle Cell Pain: Intervention With Capsaicin Exposuretreatment1completed
NCT03886753
Pharmacokinetic (PK) and Pharmacodynamics (PD) Study of Ilera Specific ProductsNo drug interventionsNot AvailableNot Availableterminated
NCT03903289
The Implementation of the Automated Erythrocytapheresis in Egyptian Sickle Cell Disease CenterNo drug interventionstreatmentNot Availablerecruiting
NCT03876821
Collect of Cord Blood From Subjects at Risk for Sickle Cell Disease, for the Purpose of Laboratory ResearchNo drug interventionsNot AvailableNot Availablecompleted
NCT03815695
A SAD/MAD to Assess the Safety, PK/PD of FT-4202 in Healthy Volunteers and Sickle Cell Disease Patientstreatment1completed
NCT03806452
SIKAMIC (SIklos on Kidney Function and AlbuMInuria Clinical Trial)treatment2completed
NCT03786549
Pediatric -Adult Care Transition Program of Patients With Sickle Cell DiseaseNo drug interventionshealth_services_researchNot Availablerecruiting
NCT03753854
Sleep Apnea in Sickle Cell DiseaseNo drug interventionsbasic_scienceNot Availableterminated
NCT03758950
Inhaled Mometasone to Promote Reduction in Vasoocclusive Events 2treatment2completed
NCT03716726
Sickle Cell Anemia WE CARENo drug interventionsscreeningNot Availablecompleted
NCT03719729
Rifaximin to Modify the Disease Course in Sickle Cell Diseasetreatment2unknown_status
NCT03111589
Monocytic Expression of Heme Oxidase-1 (HO-1) in Sickle Cell Patients and Correlation With the Humoral Immune Response to Vaccine and With Allo-immunization.basic_scienceNot Availablecompleted
NCT03648710
Community Health Workers and mHealth for Sickle Cell Disease CareNo drug interventionssupportive_careNot Availableactive_not_recruiting
NCT03655223
Early Check: Expanded Screening in NewbornsNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT03609840
Study of Thiotepa and TEPA Drug Exposure in Pediatric Hematopoietic Stem Cell Transplant PatientsNot AvailableNot Availablecompleted
NCT03609827
Study of Melphalan Drug Exposure in Pediatric Hematopoietic Stem Cell Transplant PatientsNot AvailableNot Availablecompleted
NCT03577691
Efficacy of a Decision Aid for Hydroxyurea in Sickle Cell DiseaseNo drug interventionssupportive_careNot Availableterminated
NCT03572036
Phosphodiesterase Type-5 Inhibitor Therapy in Sickle Cell People With Pulmonary HypertensionNo drug interventionsNot AvailableNot Availablecompleted
NCT03573882
Study to Assess the Effect of Long-term Treatment With Voxelotor in Participants Who Have Completed Treatment in Study GBT440-031treatment3active_not_recruiting
NCT03513328
Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantationtreatment1 / 2completed
NCT03492099
Assessing the Safety of Buprenorphine in People With Sickle Cell Diseasetreatment2completed
NCT03488264
Stigma, Self-management, & Quality of Life in SCDNo drug interventionsNot AvailableNot Availablecompleted
NCT03201874
iCanCope With Sickle Cell PainNo drug interventionstreatmentNot Availablecompleted
NCT04839159
Study of Biological Markers in Children With Sickle Cell DiseaseNo drug interventionsdiagnosticNot Availableunknown_status
NCT05253781
Low Dose Aspirin for Preventing Intrauterine Growth Restriction and Preeclampsia in Sickle Cell Pregnancy (PIPSICKLE)prevention3active_not_recruiting
NCT05249452
Adding Azathioprine/Hydroxyurea Preconditioning to Alemtuzumab/TBI to Reduce Risk of Graft Failure in MSD HSCT in Adult SCD PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT05197205
Nasopharyngeal Bacterial Carriage and Antibiotic Resistance in Children With Sickle Cell Disease in Ile-De-FranceNo drug interventionsscreeningNot Availableunknown_status
NCT05200338
Preservation and Transfer of HBV Immunity After Allogeneic HSCT for SCDotherNot Availablerecruiting
NCT05199766
Hemolysis Related Complications in SCD. A Phase II Study With Voxelotortreatment2recruiting
NCT05214105
The Predictive Capacity of Machine Learning Models for Progressive Kidney Disease in Individuals With Sickle Cell AnemiaNo drug interventionsNot AvailableNot Availablerecruiting
NCT05564845
Brain Structure and Neurocognitive Development in Sickle Cell Disease; a Longitudinal Cohort Study (BRICK Study)No drug interventionsNot AvailableNot Availablerecruiting
NCT05334576
Study of Crizanlizumab for Prevention of Silent Cerebral Infarcts in SCANo drug interventionspreventionNot Availablerecruiting
NCT05605366
Minocycline In Neurocognitive Outcomes - Sickle Cell Diseasetreatment1not_yet_recruiting
NCT05662098
Alternative Dosing And Prevention of Transfusions (ADAPT)treatment0recruiting
NCT05758766
Study on Use of Omega-3 Fatty Acids to Improve Outcomes in Individuals With Sickle Cell DiseaseNo drug interventionstreatmentNot Availablerecruiting
NCT05905770
Do Alemtuzumab Levels Predict T Cell Chimerism After MSD SCT for SCD?Not AvailableNot Availablerecruiting
NCT05837871
Genetic and Haematological Modifiers of SCD Severity in Kaduna State, Northern NigeriaNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT05894161
Efficacy of Designed Exercise Program on Pain and Quality of Sleeping in Patient With Sickle Cell Disease Anemia.No drug interventionstreatmentNot Availablecompleted
NCT04417673
Living With Sickle Cell Disease in the COVID-19 PandemicNo drug interventionsNot AvailableNot Availablecompleted
NCT03167450
Examining the Knowledge, Attitudes, and Beliefs of Sickle Cell Disease Patients, Parents of Patients With Sickle Cell Disease, and Providers Towards the Integration of CRISPR in Clinical CareNo drug interventionsNot AvailableNot Availablecompleted
NCT03462511
Hydroxyurea Adherence for Personal Best in Sickle Cell Disease (HABIT): Efficacy TrialNo drug interventionshealth_services_researchNot Availablecompleted
NCT03458897
Quantitative MRI for Patients With Sickle Cell Disease Undergoing Hematopoietic Cell TransplantNo drug interventionsdiagnosticNot Availablecompleted
NCT03405402
Transfusion in Sickle Cell Disease: Risk Factors for AlloimmunizationNo drug interventionsscreeningNot Availablecompleted
NCT03240731
HLA Haploidentical Bone Marrow Transplant in Patients With Severe Sickle Cell DiseaseNo drug interventionsother2active_not_recruiting
NCT06300723
Clinical Study of BRL-101 in Severe SCDNo drug interventionstreatmentNot Availableenrolling_by_invitation
NCT03401112
A Study of IMR-687 in Adult Participants With Sickle Cell Anemia (Homozygous HbSS or Sickle-β0 Thalassemia)treatment2completed
NCT03387033
Role of Virtual Reality (VR) in Patients With Sickle Cell Disease (SCD)No drug interventionsotherNot Availableterminated
NCT03368261
Epidemiology and Pathophysiological Mechanisms of HTAP in SS and SC Children in Martinique and Guadeloupe.No drug interventionsotherNot Availablecompleted
NCT03376893
Epidemiology of Silent and Overt Strokes in Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT04299594
Prevalence of Osteoporosis in Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT03250585
sPLA2 in EBC During Acute Chest SyndromeNo drug interventionsNot AvailableNot Availablecompleted
NCT03291613
Gaming Technology to Engage Adolescent Sickle Cell Patients in Pain ManagementNo drug interventionssupportive_careNot Availablecompleted
NCT03296345
Adjuvant Low-dose Ketamine in Pediatric Sickle Cell Vaso-occlusive Crisistreatment2completed
NCT03277547
Kidney Function in Sickle Cell AnemiaNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT03282656
Gene Transfer for Sickle Cell DiseaseNo drug interventionstreatment1active_not_recruiting
NCT03243812
Muscle Function and Its Biological and Physiological Determinants in Sickle Cell DiseaseNo drug interventionsbasic_scienceNot Availablecompleted
NCT03235011
Evaluation of Knowledge Among Adolescents With Sickle Cell Disease.No drug interventionsNot AvailableNot Availablecompleted
NCT02729350
The Feasibility of the PAINReportIt Guided Relaxation Intervention-INPATIENTNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT02757885
Transplantation for Patients With Sickle Cell Disease From Mismatched Family Donors of Bone Marrowtreatment2completed
NCT02824471
Sickle Cell Disease Biofluid Chip Technology (SCD BioChip)No drug interventionsNot AvailableNot Availablerecruiting
NCT02863068
Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcerstreatment2completed
NCT02850406
Study to Evaluate the Effect of GBT440 in Pediatrics With Sickle Cell Diseasetreatment2active_not_recruiting
NCT02909283
Sickle Cell Anemia and Cerebral Microcirculation : Multimodal ExplorationNo drug interventionsNot AvailableNot Availablecompleted
NCT02946905
Neurovascular Determinants of Cognitive Function in Adults With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT02947100
Omega-3 Fatty Acids in Sickle Cell Diseasetreatment1 / 2terminated
NCT02981329
Fetal Hemoglobin Induction Treatment Metformintreatment0completed
NCT03007849
A Pilot Study of Fecal Microbiome and Neutrophil Cellular Adhesion Molecules in Patients With Sickle Cell Disease (SCD)No drug interventionsNot AvailableNot Availableunknown_status
NCT03037021
Improving Sickle Cell Disease (SCD) Care Using Web-based GuidelinesNo drug interventionsNot AvailableNot Availablecompleted
NCT03077542
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Diseasetreatment1 / 2active_not_recruiting
NCT03029468
Computerized Cognitive Behavioral Therapy Assisted Life Management for Pain in Sickle Cell DiseaseNo drug interventionstreatmentNot Availablecompleted
NCT03012555
Vitamin D3 in Patients With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT03013426
A Phase Ib Study of NVX-508 in Sickle Cell DiseaseNo drug interventionstreatment1withdrawn
NCT02766465
Bone Marrow Transplantation vs Standard of Care in Patients With Severe Sickle Cell Disease (BMT CTN 1503)treatment2completed
NCT02973360
Dose-Finding Study of SC411 in Children With Sickle Cell Diseasetreatment2unknown_status
NCT02709681
Hydroxyurea in the Treatment of Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT02580565
Prevalence of Problematic Use of Equimolar Mixture of Oxygen and Nitrous Oxide and Analgesics in the Sickle-cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT02594462
Contraception in Women With Sickle Cell Diseasetreatment4completed
NCT02525107
Prevention of Vaso-occlusive Painful Crisis by Using Omega-3 Fatty Acid SupplementsNo drug interventionstreatment3unknown_status
NCT02620488
A Brief Laboratory-Based Hypnosis Session for Pain in Sickle Cell DiseaseNo drug interventionssupportive_careNot Availablecompleted
NCT02615847
Clinical Trial to Study the Safety and Tolerability of Memantin Mepha® in Sickle Cell Disease PatientsNo drug interventionstreatment2completed
NCT02651272
Macitentan in Pulmonary Hypertension of Sickle Cell Diseaseother2terminated
NCT02516579
European Sickle Cell Disease Cohort - HydroxyureaNot AvailableNot Availablecompleted
NCT02511769
Web-MAP Intervention for Youth With Sickle Cell DiseaseNo drug interventionstreatmentNot Availablecompleted
NCT02565082
Evaluation of the Hemostatic Potential in Sickle Cell Disease PatientsNo drug interventionsdiagnosticNot Availablecompleted
NCT02567682
Drug Interaction Study of GBT440 With Caffeine, S-warfarin, Omeprazole, and Midazolam in Healthy Subjectstreatment1completed
NCT02675959
Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell Diseasetreatment2recruiting
NCT02573714
Sub-dissociative Intranasal Ketamine for Pediatric Sickle Cell Pain CrisestreatmentNot Availableunknown_status
NCT02678143
Nonmyeloablative Conditioning for Mismatched Hematopoietic Stem Cell Transplantation for Severe Sickle Cell Diseasetreatment1terminated
NCT02447627
Study of Methodologies to Measure Blood Flow and Oxygenation in Adults With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT02539771
Sleep Study in Adult Patients With Major Sickle Cell Disease With Paroxysmal Nocturnal EventsNo drug interventionspreventionNot Availablecompleted
NCT02596087
Improving Quality by Maintaining Accurate Problems in the EHRNo drug interventionsotherNot Availablecompleted
NCT02380079
Dose-Escalation Study of SCD-101 in Sickle Cell DiseaseNo drug interventionstreatment1active_not_recruiting
NCT02314689
A Dose Escalation Study of Intravenous L-citrulline in Steady-state Sickle Cell Diseasetreatment1completed
NCT02630394
A Pilot Study of Azithromycin Prophylaxis for Acute Chest Syndrome in Sickle Cell Diseaseprevention1withdrawn
NCT02633397
A Multi-Center Study of Riociguat in Patients With Sickle Cell Diseasestreatment2completed
NCT02394431
Added Value of Speckle Tracking in the Evaluation of Patients With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT02475993
SMART Mobile Application Technology Utilization in the Treatment of Sickle Cell Disease Post Day Hospital DischargeNo drug interventionssupportive_careNot Availablecompleted
NCT02247843
Stem Cell Gene Therapy for Sickle Cell Diseasetreatment1 / 2active_not_recruiting
NCT02285088
A Study of the Safety, Blood Levels and Biological Effects of GBT440 in Healthy Subjects and Subjects With Sickle Cell Diseasetreatment1completed
NCT02270060
Music Therapy in Sickle Cell Pain Mixed Methods StudyNo drug interventionstreatmentNot Availablecompleted
NCT02273310
Families Taking Control (FTC): Family-based Problem-solving Intervention for Children With Sickle Cell DiseaseNo drug interventionspreventionNot Availablecompleted
NCT02225132
Assessment of Algorithm-Based Hydroxyurea Dosing on Fetal Hemoglobin Response, Acute Complications, and Organ Function in People With Sickle Cell Diseasetreatment1 / 2completed
NCT02212691
Functional Neuroimaging of Pain Using EEG and fMRINo drug interventionsNot AvailableNot Availablecompleted
NCT02222246
Comparing Acute Pain Management Protocols for Patients With Sickle Cell Diseasesupportive_care4completed
NCT02187445
Inhaled Corticosteroid Use to Prevent Acute Chest Syndrome Recurrence in Children Between 1 and 4 With Sickle Cell Disease: a Feasibility Trialprevention1completed
NCT02151526
A Study Evaluating the Safety and Efficacy of LentiGlobin BB305 Drug Product in β-Thalassemia Major (Also Referred to as Transfusion-dependent β-Thalassemia [TDT]) and Sickle Cell Diseasetreatment1 / 2completed
NCT02179177
Apixaban in Patients With Sickle Cell Diseaseprevention3terminated
NCT02149537
Risk Clinical Stratification of Sickle Cell Disease in Nigeria, Assessment of Efficacy/Safety of Hydroxyurea Treatmenttreatment4completed
NCT02133560
Use of Mobile Technology for Intensive Training in Medication ManagementNo drug interventionshealth_services_researchNot Availablecompleted
NCT02114515
PATient Navigator to rEduce ReadmissionsNo drug interventionshealth_services_researchNot Availablecompleted
NCT02105766
Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failuretreatment2recruiting
NCT02029742
Hydroxyurea Adherence for Personal Best in Sickle Cell Treatment: HABITNo drug interventionstreatmentNot Availablecompleted
NCT01989078
Losartan for Sickle Cell Kidney Diseasetreatment0completed
NCT02012777
Propanolol and Red Cell Adhesion Non-asthmatic Children Sickle Cell Diseasetreatment1terminated
NCT01987908
Evaluation of Different Dose Regimens of Aes-103 Given for 28 Days to Subjects With Stable Sickle Cell Diseasetreatment2terminated
NCT02007746
Liver Fibrosis in Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT01945073
Improving Disease Knowledge in Adolescents With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT01966367
CD34+ (Non-Malignant) Stem Cell Selection for Patients Receiving Allogeneic Stem Cell TransplantationNo drug interventionstreatment1 / 2active_not_recruiting
NCT01954927
Pain Management in Children and Young Adults With Sickle Cell Diseasetreatment2completed
NCT01932554
Abciximab (ReoPro) as a Therapeutic Intervention for Sickle Cell Vaso-Occlusive Pain Crisistreatment2withdrawn
NCT01950429
Evaluation of Sickle Cell Liver DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT01911871
Multicenter Observational Study on Myocardial Iron Overload in 3 Multitransfused PopulationsNo drug interventionsNot AvailableNot Availablecompleted
NCT01895361
Study to Assess Safety and Impact of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Pain CrisesNo drug interventionstreatment2completed
NCT01895998
Quantifying the Presence of Lung Disease and Pulmonary Hypertension in Children With Sickle Cell Diseasediagnostic1completed
NCT01877837
Stem Cell Transplantation for Sickle Cell Anemiatreatment3completed
NCT01879592
Molecular Phenotyping of Asthma in Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT01891812
Nitrous Oxide Analgesia Vaso-occlusive Crisistreatment2terminated
NCT01888614
Exhaled Carbon Monoxide as a Marker of Hemolysis in Sickle Cell Disease- an Exploratory StudyNo drug interventionsNot AvailableNot Availablewithdrawn
NCT01783691
Safety, Pharmacokinetic, and Pharmacodynamic Study of NKTT120 in Adult Patients With Stable Sickle Cell Disease (SCD)treatment1completed
NCT01793740
Cognitive Rehabilitation in Sickle Cell DiseaseNo drug interventionstreatmentNot Availablecompleted
NCT01801423
Sickle Cell Disease - Stroke Prevention in Nigeria TrialtreatmentNot Availablecompleted
NCT01800526
A Pilot Study of N-acetylcysteine in Patients With Sickle Cell Diseasetreatment1 / 2completed
NCT01794000
A Study of Prasugrel in Pediatric Participants With Sickle Cell Disease (SCD)treatment3terminated
NCT01771731
Vaporized Cannabis for Chronic Pain Associated With Sickle Cell Diseasetreatment1 / 2completed
NCT01718054
Vascular Function Intervention Trial in Sickle Cell Diseasetreatment2 / 3unknown_status
NCT01639950
Validating Pain Scales in Children and Young AdultsNo drug interventionsNot AvailableNot Availablecompleted
NCT01597401
A Single Dose Study of the Safety, Blood Levels and Biological Effects of Aes-103 Compared to Placebo in Subjects With Stable Sickle Cell Diseasetreatment1completed
NCT01602809
Microvessels and Heart Problems in Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT01547793
Carbon Monoxide Levels and Sickle Cell Disease SeverityNo drug interventionsNot AvailableNot Availablecompleted
NCT01569971
Adolescent, Caregiver, and Young Adult Perspectives of the Transition From Pediatric to Adult Care for Sickle Cell Disease: A Preliminary Evaluation of the Sickle Cell Disease Transition ProgramNo drug interventionsNot AvailableNot Availablecompleted
NCT01499888
Ph I/II Study of Allogeneic SCT for Clinically Aggressive Sickle Cell Disease (SCD)treatment1 / 2active_not_recruiting
NCT01461837
Haplo T-Cell Depleted Transplantation in High-Risk Sickle Cell DiseaseNo drug interventionstreatment2active_not_recruiting
NCT01443728
Vitamin D for Sickle-cell Respiratory Complicationstreatment2completed
NCT01419977
Treatment of Sickle Cell Patients Hospitalized in Pain Crisis With Prophylactic Dose Low-molecular-weight Heparin (LMWH) Versus Placebotreatment2completed
NCT01411280
Ameliorating Attention Problems in Children With Sickle Cell Disease (SCD)treatment3completed
NCT01369160
Curative Versus Disease-Modifying Therapies in Children With Severe Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT01374165
Safety and Pharmacokinetics of SANGUINATE™ in Sickle Cell Disease (SCD) PatientsNo drug interventionsNot AvailableNot Availablewithdrawn
NCT01276587
Study of Vitamin D in Children With Sickle Cell Diseasetreatment1 / 2completed
NCT01256281
Regional Anesthesia for Sickle Cell Crisis Using Ultrasound in The Emergency Department: Phase INo drug interventionstreatment1terminated
NCT01245179
Study of Panobinostat (LBH589) in Patients With Sickle Cell Diseasetreatment1recruiting
NCT01239901
Iron Mediated Vascular Disease in Sickle Cell Anemia PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT01114776
Multi-Center Study of Iron Overload: Pilot StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT01105923
Study of an Intervention to Improve Problem List Accuracy and UseNo drug interventionsdiagnosticNot Availableunknown_status
NCT01096121
Angiotensin-converting Enzyme Inhibitors and Early Sickle Cell Renal Disease in ChildrentreatmentNot Availableterminated
NCT01048905
Glutamine Therapy for Hemolysis-Associated Pulmonary Hypertensiontreatment2completed
NCT01044901
Cardiovascular Complications of Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT01049854
CD34+Selection for Partially Matched Family or Matched Unrelated Adult Donor Transplanttreatment2completed
NCT01033227
Safety and Efficacy of Sodium Nitrite in Sickle Cell Diseasetreatment1 / 2terminated
NCT00999245
THE IMPROVE TRIAL: Improving Pain Management and Outcomes With Various Strategies of Patient-Controlled Analgesia (PCA)No drug interventionstreatment3terminated
NCT00968162
Sickle Cell Disease Conditioning for Bone Marrow Transplanttreatment1completed
NCT00895154
A Rehabilitation Program in Children With Sickle Cell Disease and Cognitive Deficits: a Pilot StudyNo drug interventionstreatmentNot Availablecompleted
NCT00880373
Ibuprofen and Opioid (Morphine or Diamorphine) for Acute Pain in Sickle Cell Disease - Sickle With Ibuprofen & Morphinetreatment4terminated
NCT00842621
Long Term Effects of Erythrocyte LysisNo drug interventionsNot AvailableNot Availablecompleted
NCT00842088
Phase 1/2 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of HQK-1001 Administered Daily in Patients With Sickle Cell Diseasetreatment1 / 2completed
NCT00804362
Validation of the Sickle Cell Disease Pain Burden InterviewNo drug interventionsNot AvailableNot Availablecompleted
NCT00784082
Inflammatory Response to Hydroxyurea Therapy in Sickle Cell DiseaseNot AvailableNot Availablecompleted
NCT00748423
Effect of Inhaled Nitric Oxide in Acute Chest Syndrome (INOSTA Study)treatment2 / 3completed
NCT00749515
Pilot Study for Patients With Poor Response to Deferasiroxtreatment4completed
NCT00730314
Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood CellsNo drug interventionstreatment1 / 2completed
NCT00639392
Phase 1 Study of Zoledronic Acid in Sickle Cell DiseaseNot Available1 / 2withdrawn
NCT00578344
Bone Marrow Transplantation, Hemoglobinopathies, SCALLOPtreatmentNot Availableterminated
NCT00560261
Evaluation of the Lung Capillary Blood Volume in Children With Sickle Cell DiseaseNo drug interventionsdiagnostic3completed
NCT00513864
Assessment of Opioid Analgesia in Sickle Cellbasic_science4withdrawn
NCT00492531
Sildenafil Therapy for Pulmonary Hypertension and Sickle Cell Diseasetreatment2terminated
NCT00408447
Stem Cell Transplant in Sickle Cell Disease and Thalassemiatreatment2active_not_recruiting
NCT00393250
Hypnosis to Manage Pain and Symptoms in Patients With Sickle Cell DiseaseNo drug interventionstreatment3completed
NCT00350844
Hydroxyurea for Children and Young Adults With Sickle Cell Disease and Pulmonary Hypertensiontreatment1 / 2terminated
NCT00343954
PK and PD Responses to Oral L-Citrulline in Patients With Sickle Cell Diseasetreatment1unknown_status
NCT00263562
Steroid Treatment for Sickle Cell Pain CrisisNo drug interventionstreatment3terminated
NCT00235391
Expanded Access of Deferasirox to Patients With Congenital Disorders of Red Blood Cells and Chronic Iron Overloadtreatment3completed
NCT00257543
SALT: Alternative Donor Bone Marrow and Cord Blood Transplantation for High Risk Sickle Cell DiseaseNo drug interventionstreatment0terminated
NCT00226083
Study of Blood Platelets in Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablewithdrawn
NCT00176852
Stem Cell Transplant for Hemoglobinopathytreatment2 / 3completed
NCT00178464
Aspirin Prophylaxis in Sickle Cell Diseasetreatment1completed
NCT00142051
Inhaled Nitric Oxide for Pediatric Painful Sickle Crisistreatment2terminated
NCT00127543
Kid Cards: Teaching Kids About MedicinesNo drug interventionsotherNot Availablewithdrawn
NCT00072826
Atorvastatin Therapy to Improve Endothelial Function in Sickle Cell Diseasetreatment1completed
NCT00040677
A Study of the Efficacy and Safety of ICA-17043 (With or Without Hydroxyurea) in Patients With Sickle Cell Anemia.treatment2completed
NCT00041574
Hospital-Based Program for Treatment of Severe Cardiopulmonary Disease With Inhaled Nitric Oxidetreatment2terminated
NCT04057521
Coordinated HEalthcare for Complex KidsNo drug interventionshealth_services_researchNot Availablecompleted
NCT04058197
Deferoxamine for Sickle Cell Chronic Leg Ulcer Treatmenttreatment1 / 2withdrawn
NCT04053803
An Extension Study of IMR-687 in Adult Patients With Sickle Cell Anemiatreatment2active_not_recruiting
NCT04041180
Impact on the Length of Stay in Incentive Spirometry and Pain in the Decompensation of Sickle Cell Disease: .No drug interventionsNot AvailableNot Availablecompleted
NCT06565026
CS-101 in Patients With Sickle Cell DiseaseNo drug interventionstreatment0recruiting
NCT06580067
The Feasibility of the Pray Until Something Happens (PUSH) Intervention-OUTPATIENTNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT06562439
Testing the Sickle Cell Caregiver Collaboration for Child Development (SCCCD) InterventionNo drug interventionspreventionNot Availablenot_yet_recruiting
NCT06555939
Promoting Resilience Among Adolescents and Young Adults With Sickle Cell DiseaseNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT06503458
A Low-Interventional Study of an Electronic Sickle Cell Disease Patient Reported Outcomes in Sickle Cell ParticipantsNo drug interventionsNot AvailableNot Availableterminated
NCT06351462
Comparative Health Status and Quality of Life of Patients With Sickle Cell Disease (SCD) Who Underwent Matched-sibling Hematopoietic Stem Cell Transplantation Versus Non Transplanted SCD Case-control PatientsNo drug interventionsotherNot Availablenot_yet_recruiting
NCT06358638
Sickle Cell Disease Transplant Using a Nonmyeloablative Approach for Patients With Anti-donor Red Cell AntibodYtreatment2recruiting
NCT06251843
Support Strategies for Parents During the First Year Following Their Child's Diagnosis of Sickle Cell DisorderNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT06260891
Zinc Supplementation in Sickle Cell Diseaseother2not_yet_recruiting
NCT06035939
SMYLS Multi-site TrialNo drug interventionspreventionNot Availablerecruiting
NCT05981365
Voxelotor CYP and Transporter Cocktail Interaction Studybasic_science1completed
NCT05983055
Steroid Injection for Sickle Cell Arthropathy Pain TherapyNot AvailableNot Availablecompleted
NCT05810181
Gene Therapy Communication: Use of a Needs Assessment to Drive Decision-AIDS for Gene Therapy for Rare Diseases (GENETX)No drug interventionsNot AvailableNot Availablerecruiting
NCT05799118
Study of the Role of Genetic Modifiers in HemoglobinopathiesNo drug interventionsNot AvailableNot Availablerecruiting
NCT05789355
Effect of NUV001 Supplementation in Patients Suffering From Sickle Cell Disease (SCD)No drug interventionstreatmentNot Availableactive_not_recruiting
NCT05791591
Safety and Efficacy of Orally Administered NUV001 Nutraceutical Supplement in Sickle Cell Disease PatientsNo drug interventionsotherNot Availableactive_not_recruiting
NCT05649280
Safety Evaluation of DREPADOM - Home Care Services and Hospitalizations for Sickle Cell Disease PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT05632289
Osteopathic Manipulation in the Management of Pain Associated With Sickel Cell DiseaseNo drug interventionsotherNot Availablerecruiting
NCT05530239
Nano-rheological Biomarkers for Patients With Sickle Cell Disease (SCD) Versus Control Subjects (Other Constitutional Red Blood Cell Diseases and Healthy Subjects)No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT05477563
Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With Transfusion-Dependent β-Thalassemia and Severe Sickle Cell Diseasetreatment3recruiting
NCT05389891
Hemoglobinopathy Nursing Program and Pediatric Nursing StudentsNo drug interventionstreatmentNot Availablecompleted
NCT05377372
Early Life Exposures Among Children with Sickle Cell DiseaseNo drug interventionspreventionNot Availablenot_yet_recruiting
NCT05359991
Exercise in Child HealthNo drug interventionsbasic_scienceNot Availablerecruiting
NCT05012631
Losartan for Diffuse Myocardial Fibrosis in Sickle Cell Diseasetreatment2recruiting
NCT04594031
US Phase I Study of ECT-001-CB in Patients With Sickle-Cell DiseaseNo drug interventionstreatment1withdrawn
NCT04523376
Pilot Study PBSCT With TCRab Depletion For HemoglobinopathiesNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT04514510
Fixed Dose Flavonoid Isoquercetin on Thrombo-Inflammatory Biomarkers in Subjects With Stable Sickle Cell Diseasebasic_science2completed
NCT04474626
Isoquercetin in Sickle Cell Anemiatreatment2withdrawn
NCT04474314
A Study of IMR-687 in Subjects With Sickle Cell Diseasetreatment2terminated
NCT04388241
Preliminary Feasibility and Efficacy of Behavioral Intervention to Reduce Pain-Related Disability in Pediatric SCDNo drug interventionstreatmentNot Availablecompleted
NCT04380610
Improving Scientific Rigor of Renal Clinical Endpoints for Sickle Cell AnemiaNo drug interventionsNot AvailableNot Availablerecruiting
NCT04244240
Links Between Cognitive Functions and Clinical, Biological and Neuroradiological Outcomes in Adults With Sickle Cell Disease.No drug interventionsNot AvailableNot Availablerecruiting
NCT04207320
Haploidentical Hematopoietic Stem Cell Transplantation (HSCT) for Patients With Severe Sickle Cell DiseaseNo drug interventionstreatmentNot Availablerecruiting
NCT04173026
Dissemination and Implementation of Stroke Prevention Looking at the Care EnvironmentNo drug interventionsotherNot Availablecompleted
NCT04099966
AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletiontreatment2recruiting
NCT04093986
Hydroxyurea Exposure Limiting Pregnancy and Follow-Up LactationNo drug interventionsNot AvailableNot Availablerecruiting
NCT04084080
Sickle Cell Disease and CardiovAscular Risk - Red Cell Exchange Trial (SCD-CARRE)No drug interventionstreatment3recruiting
NCT04080167
Integration of mHEALTH Into the Care of Patients With Sickle Cell Disease to Increase Hydroxyurea UtilizationNo drug interventionshealth_services_researchNot Availablecompleted
NCT04015401
Neuropathic Pain in Jamaicans With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT03997760
A Study of SHP655 (rADAMTS13) in Sickle Cell Diseasetreatment1completed
NCT03976180
High-flow Oxygen for Vaso-occlusive Pain CrisisNo drug interventionsotherNot Availableunknown_status
NCT03805581
Defibrotide in Sickle Cell Disease-Related Acute Chest Syndrometreatment2completed
NCT03789591
Hydroxyurea Optimization Through Precision Studyprevention3recruiting
NCT04691323
The Longitudinal Relationship of HU Adherence to HRQOL, Barriers to Adherence and Habit in SCD.No drug interventionssupportive_careNot Availableactive_not_recruiting
NCT04684381
Pharmacokinetics and Safety of Endari (L-glutamine) in Sickle Cell Disease Patientsbasic_science4completed
NCT03708731
Exploring Adherence Monitoring in Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT03704922
Age of Blood in Sickle Cell TransfusionNo drug interventionstreatment2 / 3completed
NCT03694548
Acceptability, Feasibility and Safety of a Yoga Program for Chronic Pain in Sickle Cell DiseaseNo drug interventionssupportive_careNot Availableterminated
NCT03653676
Sickle Cell Pro-Inflammatory Response to Interval Training StudyNo drug interventionsNot AvailableNot Availableunknown_status
NCT03621826
Evaluating Barriers to Stroke Screening and Prevention in Children With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT03609814
Study of Clofarabine and Fludarabine Drug Exposure in Pediatric Bone Marrow Transplantation (HCT)Not AvailableNot Availablecompleted
NCT03585543
Self-Management for Youth and Families Living With SCD - SMYLSNo drug interventionssupportive_careNot Availablecompleted
NCT03587272
Minimizing Toxicity in HLA-identical Related Donor Transplantation for Children With Sickle Cell Diseasetreatment2recruiting
NCT03593395
LCI-HEM-SCD-ST3P-UP-001: The Sickle Cell Trevor Thompson Transition Project (ST3P-UP Study)No drug interventionshealth_services_researchNot Availablecompleted
NCT03556657
MUSic Therapy to Improve Quality Of Life in Sickle Cell Disease (MUSIQOLS)No drug interventionstreatmentNot Availablecompleted
NCT03492931
PK Study of Ticagrelor in Children Aged Less Than 24 Months, With Sickle Cell Disease (HESTIA4)other1completed
NCT05020873
Prospective, Observational Study in Sickle Cell Disease Patients on Crizanlizumab Treatment in Middle East Countries and IndiaNo drug interventionsNot AvailableNot Availableterminated
NCT04694976
Vitamin D Status in Children With Sickle Cell Disease Living in Lyon, FranceNot AvailableNot Availablecompleted
NCT05572294
Mindfulness and Yoga Therapy for Acute Pain in Sickle Cell DiseaseNo drug interventionssupportive_careNot Availablecompleted
NCT05456880
BEACON: A Study Evaluating the Safety and Efficacy of BEAM-101 in Patients With Severe Sickle Cell DiseaseNo drug interventionstreatment1 / 2recruiting
NCT05203991
Avascular Bone Necrosis in Sickle Cell Disease: a Pediatric Study.No drug interventionsNot AvailableNot Availablecompleted
NCT05210114
Cutaneous Hydration Assessment in SCDNo drug interventionsdiagnosticNot Availablerecruiting
NCT05336201
Cognitive Remediation Intervention to Prepare for Transition of CareNo drug interventionssupportive_care2recruiting
NCT06345638
Sex Hormones and Inflammatory Biomarkers in Patients With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT05687474
Baby Detect : Genomic Newborn ScreeningNo drug interventionsNot AvailableNot Availablerecruiting
NCT05848531
Clonidine With Morphine in Patient Controlled Analgesia Pump in Vaso-Occlusive Crisis in Sickle Cell Disease Patienttreatment4recruiting
NCT05909657
Enablers and Barriers to Hydroxyurea Use for Sickle Cell Disease JamaicaNo drug interventionsNot AvailableNot Availablerecruiting
NCT05833022
Patient Characteristics and Treatment Patterns From Early Crizanlizumab Use in Real-world Setting: Preliminary Analysis From Select Sickle Cell CentersNo drug interventionsNot AvailableNot Availablecompleted
NCT06287086
Clinical Study on the Safety and Efficacy of BRL-101 in the Treatment of Sickle Cell DiseaseNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT06293222
Patient and Public Involvement and Engagement in Research With Children and Young People With Sickle Cell Disorder and Their FamiliesNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04432623
The BENeFiTS Trial in Beta Thalassemia Intermediatreatment1 / 2recruiting
NCT04426591
Red Blood Cell Survival in Sickle Cell Diseasebasic_science1recruiting
NCT03119922
Quality of Care of Children With Sickle Cell Disease (SCD) Screened at Birth in FranceNo drug interventionsNot AvailableNot Availablecompleted
NCT03121001
Study of HLA-Haploidentical Stem Cell Transplantation to Treat Clinically Aggressive Sickle Cell Diseasetreatment2recruiting
NCT03401125
Risk Factors for Allo-immunization in Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablewithdrawn
NCT03368924
Implication of the Oxydative Stress in the Pathophysiology of Sickle Cell Anemia:No drug interventionsbasic_scienceNot Availablecompleted
NCT03367546
Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation (HaploHCT) Following Reduced Intensity Conditioning (RIC) for Selected High Risk Non-Malignant DiseasesNo drug interventionstreatment2terminated
NCT03352986
Substudy of CADRE: for People With Extreme Phenotype: BIOCADRENo drug interventionsNot AvailableNot Availableunknown_status
NCT03288012
Sickle Cell Disease: Targeting Alloantibody Formation Reduction; Risk Factors, and GeneticsNo drug interventionsNot AvailableNot Availableunknown_status
NCT03249831
A Blood Stem Cell Transplant for Sickle Cell Diseasetreatment1active_not_recruiting
NCT03279094
Haploidentical Transplantation With Pre-Transplant Immunosuppressive Therapy for Patients With Sickle Cell DiseaseNo drug interventionstreatment1recruiting
NCT03247218
A Phase - IIa - IIb, Trial to Study the Safety, Tolerability and Efficacy of Memantine as a Long-term Treatment of SCDtreatment2unknown_status
NCT03126695
A Study to Compare if the Uptake of Ticagrelor in the Body Differs When Different Tablets Are Administeredother1completed
NCT03132324
A Study to Evaluate Safety, Pharmacokinetic, and Biological Activity of INCB059872 in Subjects With Sickle Cell DiseaseNo drug interventionstreatment1terminated
NCT03224429
Sickle Cell Disease (SCD) Decision AidNo drug interventionshealth_services_researchNot Availablecompleted
NCT05033314
THromboprophylaxis In Sickle Cell Disease With Central Venous Catheters (THIS)prevention3recruiting
NCT05036512
A Study to Evaluate GBT021601 in Single and Multiple Doses in Healthy ParticipantsNo drug interventionstreatment1completed
NCT02731157
Rejuvesol® Washed RBC in Sickle Cell Patients Requiring Frequent Transfusionsother4completed
NCT02729363
The Feasibility of the PAINReportIt Guided Relaxation Intervention-OutpatientNo drug interventionstreatmentNot Availablecompleted
NCT02801292
Ketamine as an Adjuvant Therapy for Acute Vaso Occlusive Crisis in Pediatric Patients With Sickle Cell Diseasetreatment3unknown_status
NCT02829580
Evaluation of Non-invasive Endothelial Function in Children Sickle by Vascular UltrasoundNo drug interventionsdiagnosticNot Availablecompleted
NCT02868138
Study of Hydroxyurea to Treat Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT02998450
A Study of IMR-687 in Healthy Adult Volunteerstreatment1completed
NCT03036813
Study to Evaluate the Effect of Voxelotor Administered Orally to Patients With Sickle Cell Disease (GBT_HOPE)treatment3completed
NCT03027258
Point-of-Delivery Prenatal Test Results Through mHealth to Improve Birth OutcomeNo drug interventionsotherNot Availableunknown_status
NCT03040908
New Hemolysis Parameters in Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availableunknown_status
NCT02721472
Plasma DNA and Vascular Remodelling in Patients With Sickle Cell DiseaseNo drug interventionsdiagnosticNot Availablecompleted
NCT03233269
BEATS 2: Music Therapy in Sickle CellNo drug interventionstreatmentNot Availablecompleted
NCT03226691
Peripheral Blood Stem Cell Collection for Sickle Cell Disease (SCD) Patientssupportive_care1completed
NCT02813850
Oxygen Therapy and Pregnancy in Sickle Cell DiseaseNo drug interventionsprevention3completed
NCT02697240
A Phase 1 Study of Continuous Intravenous L-citrulline During Sickle Cell Pain Crisis or Acute Chest Syndrometreatment1completed
NCT02659644
A Study of Oral L-citrulline in Sickle Cell Diseasediagnostic1withdrawn
NCT02522104
Evaluation of the Impact of Renal Function on the Pharmacokinetics of SIKLOS ® (DARH)other4completed
NCT02619734
Autologous Bone Marrow Stem Cells for Chronic Leg Ulcer Treatment in Sickle Cell DiseaseNo drug interventionstreatment1unknown_status
NCT02567695
A Single-Dose Relative Bioavailability Study Of GBT440 300 mg Capsules in Healthy Subjectstreatment1completed
NCT02447874
Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Diseasetreatment1 / 2recruiting
NCT02608580
Survey in a Population of Sickle Cell Disease Patients to Evaluate the Transition Between the Queen Fabiola Children Hospital and the CHU Brugmann Hospital, and the Quality of the Hospital Care Within the CHU Brugmann Hospital.No drug interventionsotherNot Availablecompleted
NCT02604368
A Sickle CEll Disease ComplicatioN Trialtreatment3unknown_status
NCT02435901
HSCT For Patients With High Risk Hemoglobinopathies Using Reduced Intensitytreatment1 / 2completed
NCT02466555
Music Therapy in Sickle Cell Transition StudyNo drug interventionstreatmentNot Availablecompleted
NCT02316366
The Use of Warmed Saline in Vaso-occlusive EpisodesNo drug interventionstreatmentNot Availablecompleted
NCT02261480
A New Reagent Assay Examining Natural Parvovirus B19 Infection in Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT02227472
Working Memory and School Readiness in Preschool-Aged Children With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT02371720
Patient Centered Comprehensive Medication Adherence Management System in Patients With Sickle Cell DiseaseNo drug interventionshealth_services_researchNot Availablecompleted
NCT02239016
Screening Patients With Sickle Cell Disease for Kidney DamageNo drug interventionsNot AvailableNot Availablecompleted
NCT02200510
Patient-Provider Tools to Improve the Transition to Adult Care in Sickle Cell DiseaseNo drug interventionstreatmentNot Availablecompleted
NCT02143076
Medication Adherence in Youth With Sickle Cell Disease (SCD)No drug interventionsNot AvailableNot Availablecompleted
NCT02090881
Measurement of Cerebral Blood Flow Using Transcranial Doppler Ultrasound in Children With Sickle Cell DiseaseNo drug interventionsdiagnosticNot Availablecompleted
NCT02098863
Sickle Cell Clinical Research and Intervention ProgramNo drug interventionsNot AvailableNot Availablerecruiting
NCT01966731
Realizing Effectiveness Across Continents With Hydroxyurea (REACH)treatment1 / 2active_not_recruiting
NCT01959958
Evaluation of Nocturnal Enuresis and Barriers to Treatment Among Pediatric Patients With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT01940718
Androgen Regulation of Priapism in Sickle Cell Diseasetreatment0withdrawn
NCT01917708
Bone Marrow Transplant With Abatacept for Non-Malignant Diseasessupportive_care1completed
NCT01850108
Non-Myeloablative Conditioning and Bone Marrow TransplantationtreatmentNot Availableactive_not_recruiting
NCT01835496
Absorption, Metabolism, and Excretion of a Single Dose of Ferriprox® in Patients With Sickle Cell DiseaseNot Available1completed
NCT01737814
Evaluation of Purified Poloxamer 188 in Vaso-Occlusive Crisis of Sickle Cell Disease (EPIC)treatment3completed
NCT01758250
Microvascular and Fibrosis Imaging StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT01702246
Effect of Simvastatin Treatment on Vaso-occlusive Pain in Sickle Cell Diseasetreatment1 / 2completed
NCT01603160
Improving Emergency Department Management of Adults With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT01568710
Blood Flow and Pain Crises in People With Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT01565616
Bone Marrow Transplantation in Young Adults With Severe Sickle Cell Diseasetreatment2completed
NCT01511848
Study Of Efficacy,Safety of Combined Deferasirox and Deferiprone Versus Combined Deferiprone and Desferal In Conditions of Iron Overloadtreatment2 / 3unknown_status
NCT01534676
Effects of Transfusion of Older Stored Red CellsNo drug interventionstreatmentNot Availableterminated
NCT01430091
A Relative Bioavailability Study of a Prasugrel Orally Disintegrating Tablettreatment1completed
NCT01375608
Decitabine for High-Risk Sickle Cell Diseasetreatment2completed
NCT01316796
Topical Sodium Nitrite for Chronic Leg Ulcers in Adult Patients With Blood Disorderstreatment1completed
NCT01279616
A Reduced Toxicity Allogeneic Unrelated Donor Stem Cell Transplantation (SCT) for Severe Sickle Cell Diseasetreatment2terminated
NCT01294891
Microvascular and Cardiac Dysfunction in Paroxysmal Nocturnal Hemoglobinuria and Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT01241357
High-Tc Susceptometer to Monitor Transfusional Iron OverloadNo drug interventionsNot AvailableNot Availablecompleted
NCT01202812
A Randomized Trial of LOVAZA in Pediatric Sickle Cell Disease (SCD)No drug interventionstreatment2unknown_status
NCT01158794
Genes Influencing Iron Overload StateNo drug interventionsNot AvailableNot Availablecompleted
NCT01123863
The Brigance Assessment Of Individual Neurodevelopment In Young Children With Sickle Cell Disease- 2No drug interventionsNot AvailableNot Availablecompleted
NCT01123369
Spectralis HRA+OCT Imaging of the Retina With Autofluorescence in Sickle Cell DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT01090323
Evaluation of the Safety, Tolerability, Pharmacokinetics (PK) and Effects on Liver Iron Concentration of ICL670 Relative to Deferoxamine(DFO).treatment2completed
NCT01089439
Nitric Oxide Therapy for Acute Chest Syndrome in Sickle Cell Disease Childrentreatment2completed
NCT01085201
Adenosine 2A Agonist Lexiscan in Children and Adults With Sickle Cell Diseasetreatment1completed
NCT01058473
Psychometric Evaluation of the IPPAQ in Pediatric Patients With Sickle Cell Disease Hospitalized With Vasoocclusive PainNo drug interventionsNot AvailableNot Availablecompleted
NCT00957931
Allo-HCT MUD for Non-malignant Red Blood Cell (RBC) Disorders: Sickle Cell, Thal, and DBA: Reduced Intensity Conditioning, Co-tx MSCstreatment2completed
NCT01000155
Efficacy of Vorinostat to Induce Fetal Hemoglobin in Sickle Cell Diseasetreatment2terminated
NCT00940901
Sildenafil for Treatment of Priapism in Men With Sickle Cell Anemiatreatment2completed
NCT00972231
Iron Overload and Growth Velocity in Thalassemia and Sickle Cell AnemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT00951808
Preventing Acute Chest Syndrome by Transfusion Feasibility StudyNo drug interventionstreatmentNot Availablecompleted
NCT00911495
Study of Intravenous GMI-1070 in Adults With Sickle Cell Diseasetreatment1 / 2completed
NCT00850369
A Pilot Study of Chronic Red Blood Cell Transfusion in Sickle Cell Disease-Associated Pulmonary HypertensionNo drug interventionstreatment2withdrawn
NCT00777231
Phase I/II Pilot Study of Mixed Chimerism to Treat HemoglobinopathiesNo drug interventionstreatment1 / 2completed
NCT00745420
Evaluating the Safety and Effectiveness of Bone Marrow Transplants in Children With Sickle Cell Disease (BMT CTN 0601)No drug interventionstreatment2completed
NCT00695123
Screening for Subjects to Participate in Studies of Blood DisordersNo drug interventionsNot AvailableNot Availablecompleted
NCT00508989
Niacin to Improve Blood Flow in People With Sickle Cell Diseasetreatment2completed
NCT00508027
Simvastatin (Zocor) Therapy in Sickle Cell Diseasetreatment1 / 2completed
NCT00489281
Non-Myeloablative Bone Marrow Transplant for Patients With Sickle Cell Anemia and Other Blood Disorderstreatment2terminated
NCT00481039
Sickle Cell Anemia in an Arab Bedouin Village in the Northern IsraelNo drug interventionsNot AvailableNot Availablecompleted
NCT00434473
IMPACTS Trial: Investigation of the Modulation of Phospholipase in Acute Chest Syndromeprevention2completed
NCT00367523
Pulmonary Hypertension in Patients With Sickle Cell Disease in NigeriaNo drug interventionsNot AvailableNot Availablecompleted
NCT00294541
A Study Evaluating the Long-Term Safety of ICA-17043 in Sickle Cell Disease Patients With or Without Hydroxyurea Therapytreatment3terminated
NCT00252122
Pilot Study on the Effects of Intravenous Ketamine on Acute Pain Crisis in Patients With Sickle Cell Diseasetreatment4terminated
NCT00228631
Analysis of T-Cell Immune Reconstitution Following Allogeneic Hematopoietic BMT for Severe SCDNo drug interventionsNot AvailableNot Availablecompleted
NCT00186810
Stem Cell Transplantation With Identical Donors for Patients With Sickle Cell Diseasetreatment2completed
NCT00174538
Codeine in Sickle Cell Diseasetreatment1 / 2completed
NCT00102791
A Stratified Sickle Event Randomized Trial (ASSERT)treatment3terminated
NCT00110617
Study of Deferasirox Relative to Subcutaneous Deferoxamine in Sickle Cell Disease Patientstreatment2completed
NCT00061568
Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemiastreatment1 / 2active_not_recruiting
NCT04055818
A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Diseasetreatment1recruiting
NCT02515838
Sevuparin Infusion for the Management of Acute VOC in Subjects With SCDtreatment2completed
NCT02417298
Ketamine Infusion for Acute Sickle Cell Crisis in the Emergency DepartmenttreatmentNot Availableterminated
NCT03502421
Ketamine Sickle Cell Diseasetreatment3withdrawn