Atherosclerotic Cardiovascular Diseases

Also known as: Atherosclerotic Cardiovascular Disease / Atheromatosis / Atherosclerotic heart disease of native coronary artery / Atherosclerosis / Atherosclerosis (morphologic abnormality) / Arteriosclerotic vascular disease (disorder) / Arteriosclerosis / Arteriosclerosis (morphologic abnormality) / Vascular sclerosis (morphologic abnormality)

Drug	Drug Name	Drug Description
DB00945	Acetylsalicylic acid	A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events.
DB14901	Inclisiran	A PCSK9-targeting short interfering RNA (siRNA) that lowers plasma LDL-cholesterol levels.
DB01098	Rosuvastatin	An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.

Drug	Drug Name	Target	Type
DB00945	Acetylsalicylic acid	Prostaglandin G/H synthase 1	target
DB00945	Acetylsalicylic acid	Prostaglandin G/H synthase 2	target
DB00945	Acetylsalicylic acid	Aldo-keto reductase family 1 member C1	target
DB00945	Acetylsalicylic acid	Solute carrier family 22 member 6	transporter
DB00945	Acetylsalicylic acid	ATP-dependent translocase ABCB1	transporter
DB00945	Acetylsalicylic acid	Cytochrome P450 2C19	enzyme
DB00945	Acetylsalicylic acid	Cytochrome P450 2C9	enzyme
DB00945	Acetylsalicylic acid	5'-AMP-activated protein kinase	target
DB00945	Acetylsalicylic acid	Endothelin-1 receptor	target
DB00945	Acetylsalicylic acid	Cellular tumor antigen p53	target
DB00945	Acetylsalicylic acid	Endoplasmic reticulum chaperone BiP	target
DB00945	Acetylsalicylic acid	Ribosomal protein S6 kinase alpha-3	target
DB00945	Acetylsalicylic acid	NF-kappa-B inhibitor alpha	target
DB00945	Acetylsalicylic acid	Tumor necrosis factor-inducible gene 6 protein	target
DB00945	Acetylsalicylic acid	Caspase-1	target
DB00945	Acetylsalicylic acid	Caspase-3	target
DB00945	Acetylsalicylic acid	Inhibitor of nuclear factor kappa-B kinase subunit beta	target
DB00945	Acetylsalicylic acid	Extracellular signal-regulated kinase (ERK)	target
DB00945	Acetylsalicylic acid	G1/S-specific cyclin-D1	target
DB00945	Acetylsalicylic acid	Myc proto-oncogene protein	target
DB00945	Acetylsalicylic acid	Proliferating cell nuclear antigen	target
DB00945	Acetylsalicylic acid	Cyclin A	target
DB00945	Acetylsalicylic acid	UDP-glucuronosyltransferase 1-6	enzyme
DB00945	Acetylsalicylic acid	Arylamine N-acetyltransferase 2	enzyme
DB00945	Acetylsalicylic acid	Organic anion transporter 3	transporter
DB00945	Acetylsalicylic acid	Sialidase-1	target
DB00945	Acetylsalicylic acid	3-hydroxy-3-methylglutaryl-coenzyme A reductase	target
DB14901	Inclisiran	Proprotein convertase subtilisin/kexin type 9	target
DB01098	Rosuvastatin	3-hydroxy-3-methylglutaryl-coenzyme A reductase	target
DB01098	Rosuvastatin	Cytochrome P450 2C9	enzyme
DB01098	Rosuvastatin	ATP-binding cassette sub-family C member 4	transporter
DB01098	Rosuvastatin	Solute carrier organic anion transporter family member 1A2	transporter
DB01098	Rosuvastatin	Solute carrier organic anion transporter family member 1B3	transporter
DB01098	Rosuvastatin	Solute carrier organic anion transporter family member 2B1	transporter
DB01098	Rosuvastatin	Cystine/glutamate transporter	transporter
DB01098	Rosuvastatin	Solute carrier organic anion transporter family member 1B1	transporter
DB01098	Rosuvastatin	Bile salt export pump	transporter
DB01098	Rosuvastatin	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
DB01098	Rosuvastatin	Albumin	carrier
DB01098	Rosuvastatin	ATP-binding cassette sub-family C member 2	transporter
DB01098	Rosuvastatin	Organic anion transporter 3	transporter
DB01098	Rosuvastatin	Hepatic sodium/bile acid cotransporter	transporter
DB01098	Rosuvastatin	Integrin alpha-L	target

Drug	Drug Name	Phase	Status	Count
DB00945	Acetylsalicylic acid	Not Available	Completed	1
DB00945	Acetylsalicylic acid	Not Available	Recruiting	1
DB06630	Anacetrapib	Not Available	Completed	1
DB01076	Atorvastatin	Not Available	Recruiting	2
DB01076	Atorvastatin	Not Available	Unknown Status	1
DB09303	Evolocumab	Not Available	Completed	1
DB00973	Ezetimibe	Not Available	Completed	1
DB00973	Ezetimibe	Not Available	Recruiting	1
DB14901	Inclisiran	Not Available	Active Not Recruiting	1
DB14901	Inclisiran	Not Available	Completed	1
DB08860	Pitavastatin	Not Available	Recruiting	1
DB01098	Rosuvastatin	Not Available	Recruiting	1
DB13961	Fish oil	1	Not Yet Recruiting	1
DB00331	Metformin	1	Not Yet Recruiting	1
DB01098	Rosuvastatin	1 / 2	Recruiting	1
DB09303	Evolocumab	2	Completed	2
DB09303	Evolocumab	2	Unknown Status	1
DB14901	Inclisiran	2	Completed	2
DB18728	Olezarsen	2	Completed	1
DB12520	Plozalizumab	2	Withdrawn	1
DB12849	Clazakizumab	2 / 3	Recruiting	1
DB09302	Alirocumab	3	Completed	1
DB06630	Anacetrapib	3	Active Not Recruiting	1
DB00335	Atenolol	3	Completed	1
DB11936	Bempedoic acid	3	Completed	4
DB00999	Hydrochlorothiazide	3	Completed	1
DB14901	Inclisiran	3	Active Not Recruiting	2
DB14901	Inclisiran	3	Completed	2
DB14901	Inclisiran	3	Recruiting	1
DB00563	Methotrexate	3	Completed	1
DB14890	Obicetrapib	3	Active Not Recruiting	2
DB00275	Olmesartan	3	Completed	1
DB19001	Olpasiran	3	Active Not Recruiting	1
DB00052	Somatotropin	3	Unknown Status	1
DB00945	Acetylsalicylic acid	4	Completed	1
DB00125	Arginine	4	Terminated	1
DB01076	Atorvastatin	4	Active Not Recruiting	1
DB01076	Atorvastatin	4	Completed	1
DB09303	Evolocumab	4	Completed	2
DB09303	Evolocumab	4	Not Yet Recruiting	1
DB17310	Heme arginate	4	Terminated	1
DB14901	Inclisiran	4	Not Yet Recruiting	1