Atherosclerotic Cardiovascular Diseases

Also known as: Atheromatosis / Atherosclerotic Cardiovascular Disease / Atherosclerosis / Arteriosclerosis

DrugDrug NameDrug Description
DB11936Bempedoic acidA drug used in conjunction with lifestyle modification and/or other agents for the treatment of refractory hypercholesterolemia.
DB09303EvolocumabA PCSK9 (proprotein convertase subtilisin kexin type 9) inhibitor antibody used as an adjunct to LDL cholesterol reducing therapies, aiding in the prevention of cardiovascular events and cardiovascular revascularization procedures.
DB01095FluvastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
DB01098RosuvastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
DrugDrug NameTargetType
DB11936Bempedoic acidATP-citrate synthasetarget
DB11936Bempedoic acidVery long-chain acyl-CoA synthetaseenzyme
DB11936Bempedoic acidSolute carrier organic anion transporter family member 1B1transporter
DB11936Bempedoic acidCanalicular multispecific organic anion transporter 2transporter
DB11936Bempedoic acidSolute carrier organic anion transporter family member 1B3transporter
DB11936Bempedoic acidUDP-glucuronosyltransferase 2B7enzyme
DB11936Bempedoic acidAcetyl-coenzyme A synthetase, cytoplasmicenzyme
DB11936Bempedoic acidNUAK family SNF1-like kinase 2enzyme
DB09303EvolocumabProprotein convertase subtilisin/kexin type 9enzyme
DB01095Fluvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB01095FluvastatinCytochrome P450 2C9enzyme
DB01095FluvastatinCytochrome P450 3A4enzyme
DB01095FluvastatinCytochrome P450 2C8enzyme
DB01095FluvastatinCytochrome P450 2D6enzyme
DB01095FluvastatinCytochrome P450 2C19enzyme
DB01095FluvastatinCytochrome P450 1A1enzyme
DB01095FluvastatinSolute carrier organic anion transporter family member 1B1transporter
DB01095FluvastatinSolute carrier organic anion transporter family member 1B3transporter
DB01095FluvastatinSolute carrier organic anion transporter family member 2B1transporter
DB01095FluvastatinSolute carrier family 15 member 1transporter
DB01095FluvastatinCytochrome P450 3A5enzyme
DB01095FluvastatinUDP-glucuronosyltransferase 1-1enzyme
DB01095FluvastatinUDP-glucuronosyltransferase 1-3enzyme
DB01095FluvastatinUDP-glucuronosyltransferase 2B7enzyme
DB01095FluvastatinCanalicular multispecific organic anion transporter 1transporter
DB01095FluvastatinCytochrome P450 2B6enzyme
DB01095FluvastatinHistone deacetylase 2target
DB01098Rosuvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB01098RosuvastatinCytochrome P450 2C9enzyme
DB01098RosuvastatinMultidrug resistance-associated protein 4transporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 1A2transporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 1B3transporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 2B1transporter
DB01098RosuvastatinCystine/glutamate transportertransporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 1B1transporter
DB01098RosuvastatinBile salt export pumptransporter
DB01098RosuvastatinATP-binding cassette sub-family G member 2transporter
DB01098RosuvastatinSerum albumincarrier
DB01098RosuvastatinCanalicular multispecific organic anion transporter 1transporter
DB01098RosuvastatinSolute carrier family 22 member 8transporter
DB01098RosuvastatinSodium/bile acid cotransportertransporter
DB01098RosuvastatinIntegrin alpha-Ltarget
DrugDrug NamePhaseStatusCount
DB09303Evolocumab2Active Not Recruiting1
DB09303Evolocumab2Not Yet Recruiting1
DB14901Inclisiran2Active Not Recruiting1
DB14901Inclisiran2Completed1
DB12520Plozalizumab2Withdrawn1
DB09302Alirocumab3Completed1
DB06630Anacetrapib3Active Not Recruiting1
DB00335Atenolol3Completed1
DB11936Bempedoic acid3Completed4
DB00999Hydrochlorothiazide3Completed1
DB14901Inclisiran3Recruiting1
DB00563Methotrexate3Completed1
DB00275Olmesartan3Completed1
DB00052Somatotropin3Unknown Status1
DB00945Acetylsalicylic acid4Recruiting1
DB00125Arginine4Terminated1
DB01076Atorvastatin4Recruiting1
DB09303Evolocumab4Recruiting2
DB00945Acetylsalicylic acidNot AvailableCompleted1
DB06630AnacetrapibNot AvailableCompleted1
DB01076AtorvastatinNot AvailableRecruiting1