Dry Mouth

Also known as: Drying of salivary secretions / Dryness of the mouth / Dryness of mouth / Mouth Dryness / Xerostomia / Hyposalivation / Dry mouth or salivation / Mouth dry / Hypoptyalism / (Dry mouth) or (salivary hyposecretion) / Hyposecretion of salivary gland (disorder) / Aptyalia / Salivary hyposecretion / Salivary hyposecretion [Ambiguous] / Saliva decreased / Aptyalism / Dryness oral / Oral dryness / Xerostomia (disorder) / Asialia / Mouth became dry / Reduced salivation (finding)

DrugDrug NameDrug Description
DB01143AmifostineA cytoprotective adjuvant used for reduction in the cumulative renal toxicity in patients with ovarian cancer and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.
DB01164Calcium chlorideAn ionic compound used for the treatment of hypocalcemia and hyperkalemia, and as an antidote to magnesium intoxication due to overdosage of magnesium sulfate.
DB00185CevimelineA muscarinic agonist with parasympathomimetic activities that is used for the symptomatic treatment of dry mouth in patients with Sjögren's Syndrome.
DB09462GlycerinIt is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.
DB01085PilocarpineA muscarinic cholinergic agonist used on the eye to treat elevated intraocular pressure, various types of glaucoma, and to induce miosis. Also available orally to treat symptoms of dry mouth associated with Sjogren's syndrome and radiotherapy.
DB00761Potassium chlorideA potassium salt used to treat hypokalemia.
DrugDrug NameTargetType
DB01143AmifostineAlkaline phosphatase, placental-liketarget
DB01143AmifostineAlkaline phosphatase, tissue-nonspecific isozymeenzyme
DB01164Calcium chlorideProtein S100-A13target
DB00185CevimelineMuscarinic acetylcholine receptor M1target
DB00185CevimelineMuscarinic acetylcholine receptor M3target
DB00185CevimelineCytochrome P450 3A4enzyme
DB00185CevimelineCytochrome P450 2D6enzyme
DB00185CevimelineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB09462GlycerinGroup IIE secretory phospholipase A2target
DB09462GlycerinInositol-3-phosphate synthase 1target
DB09462GlycerinAlcohol dehydrogenase 1Btarget
DB09462GlycerinInositol 1,4,5-trisphosphate receptor type 1target
DB09462GlycerinGlycodelintarget
DB09462GlycerinAlpha-N-acetylgalactosaminidasetarget
DB09462GlycerinADP-ribosylation factor 1target
DB09462GlycerinBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1target
DB09462GlycerinDNA mismatch repair protein MutLtarget
DB09462GlycerinRibonucleoside-diphosphate reductase 1 subunit betatarget
DB09462GlycerinA/G-specific adenine glycosylasetarget
DB09462GlycerintRNA (cytosine(38)-C(5))-methyltransferasetarget
DB09462GlycerinCytochrome P450 2E1enzyme
DB09462GlycerinRetinal dehydrogenase 1enzyme
DB09462GlycerinPeroxisome proliferator-activated receptor deltatarget
DB09462GlycerinMaleylacetoacetate isomerasetarget
DB09462GlycerinAquaporin-7transporter
DB09462GlycerinAquaporin-9transporter
DB09462GlycerinGlycerol uptake facilitator proteintransporter
DB01085PilocarpineMuscarinic acetylcholine receptor M1target
DB01085PilocarpineMuscarinic acetylcholine receptor M2target
DB01085PilocarpineCytochrome P450 2A6enzyme
DB01085PilocarpineMuscarinic acetylcholine receptor M3target
DB01085PilocarpineCytochrome P450 3A4enzyme
DB01085PilocarpineMuscarinic acetylcholine receptor M4target
DB00761Potassium chlorideSolute carrier family 12 member 2target
DB00761Potassium chlorideSolute carrier family 12 member 1target
DB00761Potassium chlorideSolute carrier family 12 member 5target
DB00761Potassium chlorideSolute carrier family 12 member 6target
DB00761Potassium chlorideSolute carrier family 12 member 7target
DB00761Potassium chlorideSolute carrier family 12 member 4target
DB00761Potassium chlorideSolute carrier family 12 member 2transporter
DB00761Potassium chlorideSolute carrier family 12 member 1transporter
DB00761Potassium chlorideSolute carrier family 12 member 5transporter
DB00761Potassium chlorideSolute carrier family 12 member 6transporter
DB00761Potassium chlorideSolute carrier family 12 member 7transporter
DB00761Potassium chlorideSolute carrier family 12 member 4transporter
DrugDrug NamePhaseStatusCount
DB00185Cevimeline0Completed2
DB01590Everolimus0Terminated1
DB08921(4R)-limonene1Recruiting1
DB01373Calcium1Completed1
DB00515Cisplatin1Recruiting1
DB09145Water1 / 2Completed1
DB01143Amifostine2Completed1
DB01143Amifostine2Terminated1
DB00958Carboplatin2Completed1
DB00515Cisplatin2Terminated1
DB01234Dexamethasone2Terminated1
DB05152NGX2672Completed1
DB01229Paclitaxel2Completed1
DB01708Prasterone2Completed1
DB11656Rebamipide2Completed1
DB00073Rituximab2Completed1
DB01041Thalidomide2Completed1
DB01164Calcium chloride2 / 3Terminated1
DB11059Carboxymethylcellulose2 / 3Terminated1
DB09414Dipotassium phosphate2 / 3Terminated1
DB09407Magnesium chloride2 / 3Terminated1
DB12751Malic acid2 / 3Completed1
DB01085Pilocarpine2 / 3Completed1
DB00761Potassium chloride2 / 3Terminated1
DB09153Sodium chloride2 / 3Terminated1
DB01638Sorbitol2 / 3Terminated1
DB06756Betaine3Completed1
DB16555Lactoferrin3Completed1
DB13260Lysozyme3Completed1
DB09484Sodium fluorophosphate3Completed1
DB01956Taurine3Completed1
DB11195Xylitol3Completed1
DB00185Cevimeline4Completed1
DB04272Citric acid4Completed1
DB01085Pilocarpine4Completed1
DB01085Pilocarpine4Unknown Status1
DB09484Sodium fluorophosphate4Withdrawn1
DB00185CevimelineNot AvailableCompleted1
DB01611HydroxychloroquineNot AvailableCompleted1
DB12751Malic acidNot AvailableRecruiting1
DB01085PilocarpineNot AvailableCompleted6