Orthopaedic Related Pain (Musculoskeletal Pain)

Also known as: Musculoskeletal Pain Disorder / Pain, Musculoskeletal / Painful musculoskeletal conditions / Musculoskeletal Pain / Musculoskeletal pain (finding) / [D]Musculoskeletal pain (context-dependent category) / [D]Musculoskeletal pain / Rheumatic pain (disorder)

DrugDrug NameDrug Description
DB00316AcetaminophenAn analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent.
DB06774CapsaicinA topical analgesic agent used for the symptomatic relief of neuropathic pain associated with post-herpetic neuralgia, as well as other muscle and joint pain.
DB09214DexketoprofenFor short-term treatment of mild to moderate pain, including dysmenorrhoea, musculoskeletal pain and toothache .
DB09212LoxoprofenLoxoprofen is non-steroidal anti-inflammatory medication (NSAID) indicated for pain and inflammation related to musculoskeletal and joint disorders. In addition to its effects on pain, it is an antipyretic and anti-inflammatory...
DB04743NimesulideFor the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.
DB00936Salicylic acidAn acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts.
DB11582ThiocolchicosideThiocolchicoside is a skeletal muscle-relaxant drug used in the treatment of orthopedic, traumatic and rheumatologic disorders . It is indicated as an adjuvant drug in the treatment of painful muscle...
DrugDrug NameTargetType
DB00316AcetaminophenProstaglandin G/H synthase 1target
DB00316AcetaminophenProstaglandin G/H synthase 2target
DB00316AcetaminophenCytochrome P450 1A2enzyme
DB00316AcetaminophenCytochrome P450 2E1enzyme
DB00316AcetaminophenP-glycoprotein 1transporter
DB00316AcetaminophenCytochrome P450 2D6enzyme
DB00316AcetaminophenCytochrome P450 2A6enzyme
DB00316AcetaminophenCytochrome P450 3A4enzyme
DB00316AcetaminophenUDP-glucuronosyltransferase 1-1enzyme
DB00316AcetaminophenUDP-glucuronosyltransferase 1-6enzyme
DB00316AcetaminophenUDP-glucuronosyltransferase 1-9enzyme
DB00316AcetaminophenUDP-glucuronosyltransferase 2B15enzyme
DB00316AcetaminophenSulfotransferase 1A1enzyme
DB00316AcetaminophenSulfotransferase 1A3/1A4enzyme
DB00316AcetaminophenArylamine N-acetyltransferase 2enzyme
DB00316AcetaminophenProstaglandin E synthase 3target
DB00316AcetaminophenTransient receptor potential cation channel subfamily V member 1target
DB00316AcetaminophenSerum albumincarrier
DB00316AcetaminophenFatty-acid amide hydrolase 1enzyme
DB00316AcetaminophenGlutathione S-transferase Penzyme
DB00316AcetaminophenGlutathione S-transferase Mu 1enzyme
DB06774CapsaicinCytochrome P450 3A4enzyme
DB06774CapsaicinProstaglandin G/H synthase 2enzyme
DB06774CapsaicinMyeloperoxidaseenzyme
DB06774CapsaicinCytochrome P450 1A2enzyme
DB06774CapsaicinCytochrome P450 2E1enzyme
DB06774CapsaicinAmine oxidase [flavin-containing] Aenzyme
DB06774CapsaicinDopamine beta-hydroxylaseenzyme
DB06774CapsaicinGlutamine synthetaseenzyme
DB06774CapsaicinCholinesteraseenzyme
DB06774CapsaicinTransient receptor potential cation channel subfamily V member 1target
DB06774CapsaicinProhibitin-2target
DB09214DexketoprofenProstaglandin G/H synthase 1target
DB09214DexketoprofenProstaglandin G/H synthase 2target
DB09214DexketoprofenProstaglandin G/H synthase 1enzyme
DB09214DexketoprofenProstaglandin G/H synthase 2enzyme
DB09212LoxoprofenProstaglandin G/H synthase 2target
DB09212LoxoprofenProstaglandin G/H synthase 1target
DB09212LoxoprofenCarbonyl reductase [NADPH] 1enzyme
DB09212LoxoprofenCytochrome P450 3A Subfamilyenzyme
DB09212LoxoprofenUDP-glucuronosyltransferase 2B7enzyme
DB04743NimesulideProstaglandin G/H synthase 2target
DB04743NimesulideGroup IIE secretory phospholipase A2target
DB04743NimesulideLactotransferrintarget
DB04743NimesulideCytochrome P450 3A4enzyme
DB00936Salicylic acidSerum albumincarrier
DB00936Salicylic acidProstaglandin G/H synthase 1target
DB00936Salicylic acidProstaglandin G/H synthase 2target
DB00936Salicylic acidAldo-keto reductase family 1 member C1target
DB00936Salicylic acidSolute carrier family 22 member 6transporter
DB00936Salicylic acidSolute carrier family 22 member 10transporter
DB00936Salicylic acidSolute carrier family 22 member 8transporter
DB00936Salicylic acidSolute carrier family 22 member 11transporter
DB00936Salicylic acidSolute carrier organic anion transporter family member 2B1transporter
DB00936Salicylic acidMonocarboxylate transporter 1transporter
DB00936Salicylic acidSolute carrier family 22 member 7transporter
DB00936Salicylic acidCytochrome P450 2C9enzyme
DB11582ThiocolchicosideGABA(A) Receptortarget
DB11582ThiocolchicosideGlycine receptor subunit alpha-1target
DB11582ThiocolchicosideTumor necrosis factor ligand superfamily member 11target
DrugDrug NamePhaseStatusCount
DB00316Acetaminophen0Withdrawn1
DB00956Hydrocodone0Withdrawn1
DB11228Methylcellulose0Withdrawn1
DB09061Cannabidiol1Completed1
DB00482Celecoxib1Completed1
DB00586Diclofenac1Recruiting1
DB01009Ketoprofen1Completed1
DB00316Acetaminophen2Completed1
DB00318Codeine2Completed1
DB00476Duloxetine2Completed1
DB01628Etoricoxib2Recruiting1
DB00956Hydrocodone2Completed1
DB01050Ibuprofen2Completed1
DB00497Oxycodone2Completed1
DB02789Pregnenolone2Completed1
DB00201Caffeine3Completed1
DB00924Cyclobenzaprine3Active Not Recruiting1
DB00924Cyclobenzaprine3Completed1
DB01009Ketoprofen3Active Not Recruiting1
DB01009Ketoprofen3Completed2
DB12335Tanezumab3Active Not Recruiting1
DB00316Acetaminophen4Completed2
DB00316Acetaminophen4Recruiting1
DB00297Bupivacaine4Completed1
DB00297Bupivacaine4Not Yet Recruiting1
DB09214Dexketoprofen4Completed2
DB00668Epinephrine4Completed1
DB01221Ketamine4Not Yet Recruiting1
DB01002Levobupivacaine4Recruiting1
DB00281Lidocaine4Completed1
DB01283Lumiracoxib4Completed1
DB00497Oxycodone4Recruiting1
DB00863Ranitidine4Completed1
DB12620Nerve Growth FactorNot AvailableActive Not Recruiting1