Solute carrier organic anion transporter family member 1B1
Details
- Name
- Solute carrier organic anion transporter family member 1B1
- Synonyms
- Liver-specific organic anion transporter 1
- LST-1
- LST1
- OATP-2
- OATP-C
- OATP1B1
- OATP2
- OATPC
- SLC21A6
- Sodium-independent organic anion-transporting polypeptide 2
- Solute carrier family 21 member 6
- Gene Name
- SLCO1B1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010701|Solute carrier organic anion transporter family member 1B1 MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFE ISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGY YRYSKETNINSSENSTSTLSTCLINQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNML RGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYV DLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTPNKPQKERKASLSLHVLE TNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVF KYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLS FYLLYFFILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGIT YISPCLAGCKSSSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAI QVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCI KWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSSLVLYIILIYAMKKKYQEKDINASE NGSVMDEANLESLNKNKHFVPSAGADSETHC
- Number of residues
- 691
- Molecular Weight
- 76447.99
- Theoretical pI
- 8.68
- GO Classification
- Functionsbile acid transmembrane transporter activity / sodium-independent organic anion transmembrane transporter activityProcessesanion transmembrane transport / bile acid and bile salt transport / bile acid metabolic process / organic anion transport / small molecule metabolic process / sodium-independent organic anion transport / transmembrane transportComponentsbasolateral plasma membrane / integral component of plasma membrane / membrane / plasma membrane
- General Function
- Sodium-independent organic anion transmembrane transporter activity
- Specific Function
- Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
- Pfam Domain Function
- Transmembrane Regions
- 29-48 68-88 95-119 169-197 217-237 256-280 332-353 374-397 402-425 538-560 570-595 630-647
- Cellular Location
- Basolateral cell membrane
- Gene sequence
>lcl|BSEQ0010702|Solute carrier organic anion transporter family member 1B1 (SLCO1B1) ATGGACCAAAATCAACATTTGAATAAAACAGCAGAGGCACAACCTTCAGAGAATAAGAAA ACAAGATACTGCAATGGATTGAAGATGTTCTTGGCAGCTCTGTCACTCAGCTTTATTGCT AAGACACTAGGTGCAATTATTATGAAAAGTTCCATCATTCATATAGAACGGAGATTTGAG ATATCCTCTTCTCTTGTTGGTTTTATTGACGGAAGCTTTGAAATTGGAAATTTGCTTGTG ATTGTATTTGTGAGTTACTTTGGATCCAAACTACATAGACCAAAGTTAATTGGAATCGGT TGTTTCATTATGGGAATTGGAGGTGTTTTGACTGCTTTGCCACATTTCTTCATGGGATAT TACAGGTATTCTAAAGAAACTAATATCAATTCATCAGAAAATTCAACATCGACCTTATCC ACTTGTTTAATTAATCAAATTTTATCACTCAATAGAGCATCACCTGAGATAGTGGGAAAA GGTTGTTTAAAGGAATCTGGGTCATACATGTGGATATATGTGTTCATGGGTAATATGCTT CGTGGAATAGGGGAGACTCCCATAGTACCATTGGGGCTTTCTTACATTGATGATTTCGCT AAAGAAGGACATTCTTCTTTGTATTTAGGTATATTGAATGCAATAGCAATGATTGGTCCA ATCATTGGCTTTACCCTGGGATCTCTGTTTTCTAAAATGTACGTGGATATTGGATATGTA GATCTAAGCACTATCAGGATAACTCCTACTGATTCTCGATGGGTTGGAGCTTGGTGGCTT AATTTCCTTGTGTCTGGACTATTCTCCATTATTTCTTCCATACCATTCTTTTTCTTGCCC CAAACTCCAAATAAACCACAAAAAGAAAGAAAAGCTTCACTGTCTTTGCATGTGCTGGAA ACAAATGATGAAAAGGATCAAACAGCTAATTTGACCAATCAAGGAAAAAATATTACCAAA AATGTGACTGGTTTTTTCCAGTCTTTTAAAAGCATCCTTACTAATCCCCTGTATGTTATG TTTGTGCTTTTGACGTTGTTACAAGTAAGCAGCTATATTGGTGCTTTTACTTATGTCTTC AAATACGTAGAGCAACAGTATGGTCAGCCTTCATCTAAGGCTAACATCTTATTGGGAGTC ATAACCATACCTATTTTTGCAAGTGGAATGTTTTTAGGAGGATATATCATTAAAAAATTC AAACTGAACACCGTTGGAATTGCCAAATTCTCATGTTTTACTGCTGTGATGTCATTGTCC TTTTACCTATTATATTTTTTCATACTCTGTGAAAACAAATCAGTTGCCGGACTAACCATG ACCTATGATGGAAATAATCCAGTGACATCTCATAGAGATGTACCACTTTCTTATTGCAAC TCAGACTGCAATTGTGATGAAAGTCAATGGGAACCAGTCTGTGGAAACAATGGAATAACT TACATCTCACCCTGTCTAGCAGGTTGCAAATCTTCAAGTGGCAATAAAAAGCCTATAGTG TTTTACAACTGCAGTTGTTTGGAAGTAACTGGTCTCCAGAACAGAAATTACTCAGCCCAT TTGGGTGAATGCCCAAGAGATGATGCTTGTACAAGGAAATTTTACTTTTTTGTTGCAATA CAAGTCTTGAATTTATTTTTCTCTGCACTTGGAGGCACCTCACATGTCATGCTGATTGTT AAAATTGTTCAACCTGAATTGAAATCACTTGCACTGGGTTTCCACTCAATGGTTATACGA GCACTAGGAGGAATTCTAGCTCCAATATATTTTGGGGCTCTGATTGATACAACGTGTATA AAGTGGTCCACCAACAACTGTGGCACACGTGGGTCATGTAGGACATATAATTCCACATCA TTTTCAAGGGTCTACTTGGGCTTGTCTTCAATGTTAAGAGTCTCATCACTTGTTTTATAT ATTATATTAATTTATGCCATGAAGAAAAAATATCAAGAGAAAGATATCAATGCATCAGAA AATGGAAGTGTCATGGATGAAGCAAACTTAGAATCCTTAAATAAAAATAAACATTTTGTC CCTTCTGCTGGGGCAGATAGTGAAACACATTGTTAA
- Chromosome Location
- 12
- Locus
- 12p
- External Identifiers
Resource Link UniProtKB ID Q9Y6L6 UniProtKB Entry Name SO1B1_HUMAN GenBank Protein ID 5051630 GenBank Gene ID AF060500 GenAtlas ID SLCO1B1 HGNC ID HGNC:10959 - General References
- Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, Nomura H, Unno M, Suzuki M, Naitoh T, Matsuno S, Yawo H: Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem. 1999 Jun 11;274(24):17159-63. [Article]
- Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. [Article]
- Konig J, Cui Y, Nies AT, Keppler D: A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am J Physiol Gastrointest Liver Physiol. 2000 Jan;278(1):G156-64. [Article]
- Konig J, Cui Y, Nies AT, Keppler D: Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. J Biol Chem. 2000 Jul 28;275(30):23161-8. [Article]
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- van de Steeg E, Stranecky V, Hartmannova H, Noskova L, Hrebicek M, Wagenaar E, van Esch A, de Waart DR, Oude Elferink RP, Kenworthy KE, Sticova E, al-Edreesi M, Knisely AS, Kmoch S, Jirsa M, Schinkel AH: Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. J Clin Invest. 2012 Feb;122(2):519-28. doi: 10.1172/JCI59526. Epub 2012 Jan 9. [Article]
- Yao J, Hong W, Huang J, Zhan K, Huang H, Hong M: N-Glycosylation dictates proper processing of organic anion transporting polypeptide 1B1. PLoS One. 2012;7(12):e52563. doi: 10.1371/journal.pone.0052563. Epub 2012 Dec 20. [Article]
- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
- Tirona RG, Leake BF, Merino G, Kim RB: Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans. J Biol Chem. 2001 Sep 21;276(38):35669-75. Epub 2001 Jul 26. [Article]
- Michalski C, Cui Y, Nies AT, Nuessler AK, Neuhaus P, Zanger UM, Klein K, Eichelbaum M, Keppler D, Konig J: A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter. J Biol Chem. 2002 Nov 8;277(45):43058-63. Epub 2002 Aug 23. [Article]
- Nozawa T, Nakajima M, Tamai I, Noda K, Nezu J, Sai Y, Tsuji A, Yokoi T: Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis. J Pharmacol Exp Ther. 2002 Aug;302(2):804-13. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB04348 Taurocholic acid approved, experimental unknown substrateinhibitorinducer Details DB02659 Cholic Acid approved unknown substrateinhibitorinducer Details DB00199 Erythromycin approved, investigational, vet_approved no substrateinhibitor Details DB01045 Rifampicin approved unknown inhibitor Details DB00286 Conjugated estrogens approved unknown substrateinhibitor Details DB00655 Estrone approved unknown inhibitor Details DB00783 Estradiol approved, investigational, vet_approved unknown inhibitor Details DB01232 Saquinavir approved, investigational unknown inhibitor Details DB00503 Ritonavir approved, investigational unknown inhibitor Details DB00220 Nelfinavir approved unknown inhibitor Details DB00224 Indinavir approved unknown inhibitor Details DB01892 Hyperforin nutraceutical unknown inhibitor Details DB00091 Cyclosporine approved, investigational, vet_approved unknown substrateinhibitor Details DB00908 Quinidine approved, investigational unknown inhibitor Details DB00345 Aminohippuric acid approved, investigational unknown inhibitor Details DB00583 Levocarnitine approved, investigational unknown inhibitor Details DB00877 Sirolimus approved, investigational unknown inhibitor Details DB00641 Simvastatin approved unknown substrateinhibitor Details DB00227 Lovastatin approved, investigational unknown substrateinhibitor Details DB01076 Atorvastatin approved no substrateinhibitor Details DB00197 Troglitazone approved, investigational, withdrawn unknown inhibitor Details DB00412 Rosiglitazone approved, investigational unknown inhibitor Details DB01132 Pioglitazone approved, investigational unknown inhibitor Details DB00762 Irinotecan approved, investigational unknown inhibitor Details DB00520 Caspofungin approved unknown inhibitor Details DB00175 Pravastatin approved no substrate Details DB01393 Bezafibrate approved, investigational unknown inhibitor Details DB06151 Acetylcysteine approved, investigational unknown inhibitor Details DB00661 Verapamil approved unknown inhibitor Details DB00917 Dinoprostone approved unknown substrate Details DB01053 Benzylpenicillin approved, vet_approved unknown substrate Details DB00563 Methotrexate approved unknown substrate Details DB00279 Liothyronine approved, vet_approved unknown substrate Details DB00439 Cerivastatin approved, withdrawn unknown substrateinhibitor Details DB00275 Olmesartan approved, investigational unknown substrate Details DB00669 Sumatriptan approved, investigational unknown substrate Details DB01092 Ouabain approved unknown substrateinhibitor Details DB00390 Digoxin approved unknown substrateinhibitor Details DB00859 Penicillamine approved unknown substrate Details DB00177 Valsartan approved, investigational unknown substrateinhibitor Details DB06721 Gimatecan investigational unknown substrate Details DB01583 Liotrix approved unknown substrate Details DB06210 Eltrombopag approved unknown inhibitor Details DB00973 Ezetimibe approved unknown substrate Details DB02691 Glycocholic acid experimental, investigational unknown Details DB05804 Prasterone sulfate investigational unknown Details DB00451 Levothyroxine approved unknown inhibitor Details DB00509 Dextrothyroxine approved, investigational unknown Details DB00950 Fexofenadine approved, investigational unknown substrate Details DB08855 Leukotriene C4 experimental, investigational unknown Details DB08856 DADLE experimental unknown Details DB08857 Bamet-UD2 experimental unknown Details DB08858 cis-Diamminechlorocholylglycinateplatinum(II) experimental unknown Details DB01095 Fluvastatin approved unknown substrateinhibitor Details DB08860 Pitavastatin approved unknown substrateinhibitor Details DB06589 Pazopanib approved unknown inhibitor Details DB06772 Cabazitaxel approved unknown inhibitor Details DB08864 Rilpivirine approved unknown inhibitor Details DB08884 Gadoxetic acid approved unknown substrate Details DB06626 Axitinib approved, investigational no substrateinhibitor Details DB08912 Dabrafenib approved, investigational unknown inhibitor Details DB00912 Repaglinide approved, investigational unknown substrate Details DB00688 Mycophenolate mofetil approved, investigational unknown substrate Details DB01098 Rosuvastatin approved unknown substrateinhibitor Details DB06290 Simeprevir approved unknown substrateinhibitor Details DB04850 Posizolid investigational unknown inhibitor Details DB01211 Clarithromycin approved unknown Details DB09054 Idelalisib approved no inhibitor Details DB09272 Eluxadoline approved, investigational unknown substrateinhibitor Details DB09292 Sacubitril approved unknown inhibitor Details DB09102 Daclatasvir approved, investigational unknown inhibitor Details DB05239 Cobimetinib approved, investigational unknown substrateweak inhibitor Details DB11362 Selexipag approved no substrate Details DB06403 Ambrisentan approved, investigational unknown substrate Details DB11575 Grazoprevir approved no substrate Details DB09137 Technetium Tc-99m mebrofenin approved no substrate Details DB13139 Levosalbutamol approved, investigational no substrate Details DB13153 Levomenol approved, experimental unknown substrate Details DB11613 Velpatasvir approved, investigational no inhibitortransporter Details DB05521 Telaprevir approved, withdrawn unknown inhibitor Details DB09198 Lobeglitazone experimental no inhibitor Details DB12026 Voxilaprevir approved, investigational no substrateinhibitor Details DB13874 Enasidenib approved, investigational unknown inhibitor Details DB13878 Pibrentasvir approved, investigational unknown inhibitor Details DB13879 Glecaprevir approved, investigational unknown substrateinhibitor Details DB12070 Letermovir approved, investigational no substrate Details DB12332 Rucaparib approved, investigational unknown inhibitor Details DB13952 Estradiol acetate approved, investigational, vet_approved unknown inhibitor Details DB13953 Estradiol benzoate approved, investigational, vet_approved unknown inhibitor Details DB13954 Estradiol cypionate approved, investigational, vet_approved unknown inhibitor Details DB13955 Estradiol dienanthate approved, investigational, vet_approved unknown inhibitor Details DB13956 Estradiol valerate approved, investigational, vet_approved unknown inhibitor Details DB11901 Apalutamide approved, investigational unknown inducer Details DB09297 Paritaprevir approved, investigational unknown substrateinhibitor Details DB00975 Dipyridamole approved unknown inhibitor Details DB01072 Atazanavir approved, investigational unknown inhibitor Details DB00541 Vincristine approved, investigational unknown inhibitor Details DB12319 Benzbromarone investigational, withdrawn unknown inhibitor Details DB08862 Cholecystokinin approved, investigational unknown substrateinhibitor Details DB00255 Diethylstilbestrol approved, investigational unknown inhibitor Details DB01645 Genistein investigational unknown inhibitor Details DB00602 Ivermectin approved, investigational, vet_approved unknown inhibitor Details DB01115 Nifedipine approved unknown inhibitor Details DB01051 Novobiocin approved, investigational, vet_approved unknown inhibitor Details DB00646 Nystatin approved, vet_approved unknown inhibitor Details DB11869 Valspodar investigational unknown inhibitor Details DB00206 Reserpine approved, investigational unknown inhibitor Details DB09298 Silibinin experimental, investigational unknown inhibitor Details DB00795 Sulfasalazine approved unknown inhibitor Details DB00932 Tipranavir approved, investigational unknown inhibitor Details DB01601 Lopinavir approved unknown inhibitor Details DB01264 Darunavir approved unknown inhibitor Details DB00328 Indomethacin approved, investigational unknown inhibitor Details DB00701 Amprenavir approved, investigational unknown inhibitor Details DB00586 Diclofenac approved, vet_approved unknown inhibitor Details DB04216 Quercetin experimental, investigational unknown inhibitor Details DB00622 Nicardipine approved, investigational unknown inhibitor Details DB00396 Progesterone approved, vet_approved unknown inhibitor Details DB00570 Vinblastine approved unknown inhibitor Details DB00468 Quinine approved unknown inhibitor Details DB01026 Ketoconazole approved, investigational unknown inhibitor Details DB13919 Candesartan experimental unknown inhibitor Details DB09065 Cobicistat approved unknown inhibitor Details DB00976 Telithromycin approved unknown inhibitor Details DB01590 Everolimus approved unknown inhibitor Details DB00203 Sildenafil approved, investigational unknown inhibitor Details DB00864 Tacrolimus approved, investigational unknown inhibitor Details DB00398 Sorafenib approved, investigational unknown inhibitor Details DB04868 Nilotinib approved, investigational unknown inhibitor Details DB11586 Asunaprevir approved, investigational, withdrawn unknown substrateinhibitor Details DB11979 Elagolix approved, investigational unknown substrate Details DB13867 Fluticasone approved, experimental no inhibitor Details DB08906 Fluticasone furoate approved no inhibitor Details DB00588 Fluticasone propionate approved no inhibitor Details DB09078 Lenvatinib approved, investigational unknown inhibitor Details DB05928 Dovitinib investigational unknown inhibitor Details DB08880 Teriflunomide approved unknown inhibitor Details DB02703 Fusidic acid approved, investigational unknown Details DB11753 Rifamycin approved, investigational no inhibitor Details DB11581 Venetoclax approved, investigational unknown inhibitor Details DB11855 Revefenacin approved, investigational no substrate Details DB09279 Fimasartan investigational unknown substrate Details DB00834 Mifepristone approved, investigational no inhibitor Details DB00257 Clotrimazole approved, vet_approved unknown substrateinhibitor Details DB00214 Torasemide approved no substrate Details DB13867 Fluticasone approved, experimental unknown inhibitor Details DB08906 Fluticasone furoate approved unknown Details DB09299 Tenofovir alafenamide approved no substrate Details DB00481 Raloxifene approved, investigational unknown substrate Details DB00394 Beclomethasone dipropionate approved, investigational unknown inhibitor Details DB12978 Pexidartinib approved, investigational unknown inhibitor Details DB12500 Fedratinib approved, investigational unknown inhibitor Details DB11757 Istradefylline approved, investigational unknown inhibitor Details DB01241 Gemfibrozil approved unknown inhibitor Details DB04855 Dronedarone approved no inhibitor Details DB15444 Elexacaftor approved, investigational unknown inhibitor Details DB14962 Trastuzumab deruxtecan approved, investigational unknown Details DB15091 Upadacitinib approved, investigational no inhibitor Details DB15328 Ubrogepant approved, investigational unknown substrateinhibitor Details DB01211 Clarithromycin approved unknown inhibitor Details DB12941 Darolutamide approved, investigational unknown inhibitor Details DB00588 Fluticasone propionate approved unknown inhibitor Details DB12457 Rimegepant approved, investigational unknown inhibitor Details DB11837 Osilodrostat approved, investigational unknown inhibitor Details DB11936 Bempedoic acid approved, investigational unknown inhibitor Details DB01708 Prasterone approved, investigational, nutraceutical unknown substrate Details DB14761 Remdesivir approved, investigational unknown substrateinhibitor Details DB09038 Empagliflozin approved unknown substrate Details DB09274 Artesunate approved, investigational unknown inhibitor Details DB12674 Lurbinectedin approved, investigational unknown inhibitor Details DB11796 Fostemsavir approved, investigational unknown inhibitor Details DB15719 Belantamab mafodotin approved unknown substrate Details DB15822 Pralsetinib approved, investigational no inhibitor Details DB06448 Lonafarnib approved, investigational no inhibitor Details DB06137 Tirbanibulin approved, investigational no inhibitor Details DB11632 Opicapone approved, investigational no inhibitor Details DB08995 Diosmin approved, investigational unknown inhibitor Details DB11886 Infigratinib approved, investigational no inhibitor Details DB12151 Brincidofovir approved, investigational no substrateinhibitor Details DB16703 Belumosudil approved, investigational no inhibitor Details DB15463 Belzutifan approved, investigational no substrate Details DB12265 Fexinidazole approved, investigational unknown inhibitor Details DB16098 Atogepant approved, investigational no substrateinhibitor Details DB06176 Romidepsin approved, investigational no inhibitor Details