Refractory Hodgkin Lymphoma

Also known as: Refractory Hodgkin's lymphoma / Hodgkin Disease Refractory / Hodgkin's disease refractory / Refractory Hodgkin Disease / Refractory Hodgkin's disease / Refractory Hodgkin lymphoma (disorder) / Hodgkin's disease NOS refractory

Drug	Drug Name	Drug Description
DB06769	Bendamustine	An antineoplastic nitrogen mustard agent used in the treatment of indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed following rituximab therapy.
DB00958	Carboplatin	A alkylating agent used to treat advanced ovarian cancer.
DB00262	Carmustine	An alkylating agent used in the treatment of various malignancies, including brain tumours and multiple myeloma, among others.
DB01206	Lomustine	An alkylating agent used as a part of chemotherapeutic regimens for the treatment of primary and metastatic brain tumors as well as refractory or relapsed Hodgkin's disease in addition to surgical and/or radiotherapeutic treatments.

Drug	Drug Name	Target	Type
DB06769	Bendamustine	Cytochrome P450 1A2	enzyme
DB00958	Carboplatin	DNA	target
DB00958	Carboplatin	High affinity copper uptake protein 1	transporter
DB00958	Carboplatin	Protein SLC31A2	transporter
DB00958	Carboplatin	Xanthine dehydrogenase/oxidase	enzyme
DB00958	Carboplatin	Myeloperoxidase	enzyme
DB00958	Carboplatin	Glutathione S-transferase theta-1	enzyme
DB00958	Carboplatin	Metallothionein-1A	enzyme
DB00958	Carboplatin	Metallothionein-2	enzyme
DB00958	Carboplatin	Superoxide dismutase [Cu-Zn]	enzyme
DB00958	Carboplatin	Glutathione S-transferase P	enzyme
DB00958	Carboplatin	Glutathione S-transferase Mu 1	enzyme
DB00958	Carboplatin	NAD(P)H dehydrogenase [quinone] 1	enzyme
DB00958	Carboplatin	Copper-transporting ATPase 1	transporter
DB00958	Carboplatin	Copper-transporting ATPase 2	transporter
DB00958	Carboplatin	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
DB00958	Carboplatin	ATP-binding cassette sub-family C member 2	transporter
DB00262	Carmustine	Glutathione reductase, mitochondrial	target
DB00262	Carmustine	DNA	target
DB00262	Carmustine	RNA	target
DB01206	Lomustine	DNA	target
DB01206	Lomustine	Cytochrome P450 3A4	enzyme
DB01206	Lomustine	Cytochrome P450 2D6	enzyme
DB01206	Lomustine	Stathmin-4	target

Drug	Drug Name	Phase	Status	Count
DB00531	Cyclophosphamide	0	Completed	1
DB00091	Cyclosporine	0	Completed	1
DB01073	Fludarabine	0	Completed	1
DB00688	Mycophenolate mofetil	0	Completed	1
DB09035	Nivolumab	0	Recruiting	1
DB09037	Pembrolizumab	0	Recruiting	1
DB12001	Abemaciclib	1	Terminated	1
DB05812	Abiraterone	1	Terminated	1
DB00316	Acetaminophen	1	Active Not Recruiting	1
DB08916	Afatinib	1	Terminated	1
DB00062	Albumin human	1	Terminated	1
DB05220	Alisertib	1	Completed	1
DB09495	Avobenzone	1	Terminated	1
DB05015	Belinostat	1	Suspended	1
DB06769	Bendamustine	1	Active Not Recruiting	1
DB00112	Bevacizumab	1	Terminated	1
DB01128	Bicalutamide	1	Terminated	1
DB00188	Bortezomib	1	Terminated	1
DB16741	Bortezomib D-mannitol	1	Terminated	1
DB08870	Brentuximab vedotin	1	Completed	1
DB08870	Brentuximab vedotin	1	Terminated	1
DB01008	Busulfan	1	Active Not Recruiting	1
DB06772	Cabazitaxel	1	Terminated	1
DB08875	Cabozantinib	1	Terminated	1
DB01101	Capecitabine	1	Terminated	1
DB00958	Carboplatin	1	Terminated	1
DB08889	Carfilzomib	1	Suspended	1
DB15694	Cedazuridine	1	Recruiting	1
DB00482	Celecoxib	1	Terminated	1
DB14006	Choline salicylate	1	Recruiting	1
DB05239	Cobimetinib	1	Terminated	1
DB12483	Copanlisib	1	Suspended	1
DB12483	Copanlisib	1	Terminated	1
DB00531	Cyclophosphamide	1	Unknown Status	1
DB00091	Cyclosporine	1	Completed	1
DB08912	Dabrafenib	1	Terminated	1
DB11963	Dacomitinib	1	Terminated	1
DB09331	Daratumumab	1	Suspended	1
DB12941	Darolutamide	1	Terminated	1
DB01254	Dasatinib	1	Terminated	1
DB00694	Daunorubicin	1	Terminated	1
DB01262	Decitabine	1	Recruiting	1
DB01234	Dexamethasone	1	Active Not Recruiting	1
DB01075	Diphenhydramine	1	Active Not Recruiting	1
DB00997	Doxorubicin	1	Terminated	1
DB11714	Durvalumab	1	Terminated	1
DB13874	Enasidenib	1	Terminated	1
DB11986	Entrectinib	1	Terminated	1
DB08899	Enzalutamide	1	Terminated	1
DB00530	Erlotinib	1	Terminated	1
DB01175	Escitalopram	1	Recruiting	1
DB01590	Everolimus	1	Terminated	2
DB15223	Flotetuzumab	1	Active Not Recruiting	1
DB01073	Fludarabine	1	Active Not Recruiting	1
DB01073	Fludarabine	1	Unknown Status	1
DB09502	Fludeoxyglucose (18F)	1	Suspended	1
DB13134	Fluorine F-18	1	Suspended	1
DB00544	Fluorouracil	1	Terminated	1
DB00441	Gemcitabine	1	Active Not Recruiting	1
DB00441	Gemcitabine	1	Suspended	1
DB01050	Ibuprofen	1	Active Not Recruiting	1
DB09054	Idelalisib	1	Terminated	1
DB00619	Imatinib	1	Terminated	1
DB06186	Ipilimumab	1	Terminated	1
DB00480	Lenalidomide	1	Unknown Status	1
DB09078	Lenvatinib	1	Terminated	1
DB00650	Leucovorin	1	Terminated	1
DB12130	Lorlatinib	1	Terminated	1
DB00678	Losartan	1	Terminated	1
DB00888	Mechlorethamine	1	Active Not Recruiting	1
DB00888	Mechlorethamine	1	Unknown Status	1
DB00688	Mycophenolate mofetil	1	Unknown Status	1
DB15721	Natural Killer Cell	1	Unknown Status	1
DB11828	Neratinib	1	Terminated	1
DB09035	Nivolumab	1	Active Not Recruiting	1
DB09035	Nivolumab	1	Recruiting	1
DB09035	Nivolumab	1	Suspended	1
DB09035	Nivolumab	1	Terminated	1
DB08935	Obinutuzumab	1	Suspended	1
DB09496	Octinoxate	1	Terminated	1
DB09074	Olaparib	1	Active Not Recruiting	1
DB09074	Olaparib	1	Terminated	1
DB09567	Olive oil	1	Not Yet Recruiting	1
DB00526	Oxaliplatin	1	Terminated	1
DB01229	Paclitaxel	1	Terminated	1
DB09073	Palbociclib	1	Terminated	1
DB06603	Panobinostat	1	Terminated	1
DB09037	Pembrolizumab	1	Suspended	1
DB09037	Pembrolizumab	1	Terminated	1
DB00738	Pentamidine	1	Completed	1
DB06366	Pertuzumab	1	Terminated	1
DB08901	Ponatinib	1	Terminated	1
DB00863	Ranitidine	1	Active Not Recruiting	1
DB08896	Regorafenib	1	Terminated	1
DB00073	Rituximab	1	Active Not Recruiting	1
DB00073	Rituximab	1	Suspended	1
DB00073	Rituximab	1	Unknown Status	1
DB06176	Romidepsin	1	Completed	1
DB06176	Romidepsin	1	Suspended	1
DB08877	Ruxolitinib	1	Terminated	1
DB11942	Selinexor	1	Recruiting	1
DB00877	Sirolimus	1	Terminated	1
DB00398	Sorafenib	1	Terminated	1
DB01268	Sunitinib	1	Terminated	1
DB00864	Tacrolimus	1	Unknown Status	1
DB08911	Trametinib	1	Terminated	1
DB00072	Trastuzumab	1	Suspended	1
DB05773	Trastuzumab emtansine	1	Terminated	1
DB00755	Tretinoin	1	Terminated	1
DB08881	Vemurafenib	1	Terminated	1
DB11581	Venetoclax	1	Terminated	1
DB00661	Verapamil	1	Completed	1
DB08828	Vismodegib	1	Terminated	1
DB02546	Vorinostat	1	Active Not Recruiting	1
DB02546	Vorinostat	1	Terminated	1
DB13906	Aloe vera leaf	1 / 2	Completed	1
DB09312	Antilymphocyte immunoglobulin (horse)	1 / 2	Completed	1
DB00098	Antithymocyte immunoglobulin (rabbit)	1 / 2	Completed	1
DB00126	Ascorbic acid	1 / 2	Completed	1
DB06769	Bendamustine	1 / 2	Active Not Recruiting	1
DB02379	Beta-D-Glucose	1 / 2	Active Not Recruiting	1
DB02379	Beta-D-Glucose	1 / 2	Completed	2
DB08870	Brentuximab vedotin	1 / 2	Active Not Recruiting	1
DB01008	Busulfan	1 / 2	Completed	1
DB00958	Carboplatin	1 / 2	Active Not Recruiting	1
DB00262	Carmustine	1 / 2	Completed	2
DB00631	Clofarabine	1 / 2	Completed	1
DB00531	Cyclophosphamide	1 / 2	Active Not Recruiting	1
DB00531	Cyclophosphamide	1 / 2	Completed	2
DB00091	Cyclosporine	1 / 2	Completed	1
DB00987	Cytarabine	1 / 2	Completed	2
DB00773	Etoposide	1 / 2	Active Not Recruiting	1
DB00773	Etoposide	1 / 2	Completed	2
DB01073	Fludarabine	1 / 2	Completed	2
DB00441	Gemcitabine	1 / 2	Active Not Recruiting	1
DB00441	Gemcitabine	1 / 2	Completed	1
DB09462	Glycerin	1 / 2	Completed	1
DB01181	Ifosfamide	1 / 2	Active Not Recruiting	1
DB06186	Ipilimumab	1 / 2	Completed	1
DB00888	Mechlorethamine	1 / 2	Completed	2
DB00688	Mycophenolate mofetil	1 / 2	Completed	3
DB15721	Natural Killer Cell	1 / 2	Completed	1
DB02701	Nicotinamide	1 / 2	Completed	1
DB09035	Nivolumab	1 / 2	Active Not Recruiting	1
DB09035	Nivolumab	1 / 2	Completed	1
DB00073	Rituximab	1 / 2	Completed	1
DB00864	Tacrolimus	1 / 2	Completed	2
DB00162	Vitamin A	1 / 2	Completed	1
DB00074	Basiliximab	2	Recruiting	1
DB06769	Bendamustine	2	Active Not Recruiting	1
DB02379	Beta-D-Glucose	2	Active Not Recruiting	1
DB02379	Beta-D-Glucose	2	Recruiting	1
DB08870	Brentuximab vedotin	2	Active Not Recruiting	2
DB08870	Brentuximab vedotin	2	Completed	1
DB08870	Brentuximab vedotin	2	Recruiting	1
DB16411	Camidanlumab tesirine	2	Completed	1
DB00958	Carboplatin	2	Active Not Recruiting	1
DB00262	Carmustine	2	Recruiting	1
DB00531	Cyclophosphamide	2	Active Not Recruiting	1
DB00531	Cyclophosphamide	2	Completed	1
DB00091	Cyclosporine	2	Completed	1
DB00987	Cytarabine	2	Recruiting	1
DB01262	Decitabine	2	Recruiting	1
DB16137	Dezapelisib	2	Terminated	1
DB00773	Etoposide	2	Active Not Recruiting	1
DB00773	Etoposide	2	Recruiting	1
DB00099	Filgrastim	2	Recruiting	1
DB15223	Flotetuzumab	2	Withdrawn	1
DB01073	Fludarabine	2	Active Not Recruiting	1
DB01073	Fludarabine	2	Completed	1
DB09053	Ibrutinib	2	Active Not Recruiting	2
DB09053	Ibrutinib	2	Completed	1
DB01181	Ifosfamide	2	Active Not Recruiting	1
DB06186	Ipilimumab	2	Active Not Recruiting	1
DB12154	Itacitinib	2	Terminated	1
DB00688	Mycophenolate mofetil	2	Completed	1
DB09035	Nivolumab	2	Active Not Recruiting	3
DB09035	Nivolumab	2	Recruiting	1
DB09037	Pembrolizumab	2	Recruiting	1
DB12887	Tazemetostat	2	Active Not Recruiting	1
DB00755	Tretinoin	2	Recruiting	1
DB13076	Yttrium Y-90	2	Recruiting	1
DB08870	Brentuximab vedotin	2 / 3	Recruiting	1
DB09035	Nivolumab	2 / 3	Recruiting	1
DB09037	Pembrolizumab	2 / 3	Recruiting	1
DB00091	Cyclosporine	3	Completed	2
DB01073	Fludarabine	3	Completed	2
DB00688	Mycophenolate mofetil	3	Completed	2
DB00877	Sirolimus	3	Completed	1