Hormonal Contraception therapy (DBCOND0113074)

Identifiers

Synonyms

Contraception therapy / Hormonal Contraception / Uses combined oral contraception (finding)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Desogestrel	A synthetic progestin used in contraception, often in combination with ethinyl estradiol.	Progesterone receptortarget Estrogen receptortarget Cytochrome P450 3A4enzyme Albumincarrier Sex hormone-binding globulincarrier Cytochrome P450 2C9enzyme UDP-glucuronosyltransferase 1A1enzyme
Dienogest	An oral progestin used for the treatment of endometriosis as monotherapy or contraception in combination with ethinylestradiol.	Cytochrome P450 3A4enzyme Progesterone receptortarget Androgen receptortarget
Drospirenone	A progestin used in oral contraceptive pills for the prevention of pregnancy and other conditions.	Progesterone receptortarget Mineralocorticoid receptortarget Androgen receptortarget Prostaglandin G/H synthase 2enzyme Serum paraoxonase/arylesterase 1enzyme Glucocorticoid receptortarget Cytochrome P450 3A4enzyme
Estradiol	An estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate.	Estrogen receptortarget Nuclear receptor subfamily 1 group I member 2target Sex hormone-binding globulincarrier Estrogen receptor betatarget Cytochrome P450 1A2enzyme UDP-glucuronosyltransferase 1A1enzyme Albumincarrier Fatty acid-binding protein, intestinalcarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 3transporter ATP-binding cassette sub-family C member 10transporter Solute carrier family 22 member 11transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 1C1transporter Neuronal acetylcholine receptor subunit alpha-4target G-protein coupled estrogen receptor 1target ATP synthase subunit atarget Beclin-1target UDP-glucuronosyltransferase 2B15enzyme Catechol O-methyltransferaseenzyme UDP-glucuronosyltransferases (UGTs)enzyme Aromataseenzyme
Ethinylestradiol	An estradiol used as a contraceptive.	Estrogen receptortarget Nuclear receptor subfamily 1 group I member 2target Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme Bile salt export pumptransporter Hepatic sodium/bile acid cotransportertransporter ATP-binding cassette sub-family C member 2transporter ATP-dependent translocase ABCB1transporter UDP-glucuronosyltransferase 1A1enzyme Cytochrome P450 2C19enzyme UDP-glucuronosyltransferase 1A4enzyme UDP-glucuronosyltransferase 1A9enzyme Cytochrome P450 2C9enzyme Cytochrome P450 1A2enzyme Sulfotransferase 1E1enzyme Sulfotransferase 1A3enzyme Cytochrome P450 3A5enzyme UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 1A3enzyme Catechol O-methyltransferaseenzyme Solute carrier organic anion transporter family member 1A2transporter Albumincarrier Sex hormone-binding globulincarrier
Etonogestrel	A long-acting synthetic derived progestin contraceptive used in various devices such as contraceptive rings and intradermal implants.	Progesterone receptortarget Cytochrome P450 3A4enzyme Albumincarrier Sex hormone-binding globulincarrier
Medroxyprogesterone acetate	A progestin used as a contraceptive and in the treatment of secondary amenorrhea, abnormal uterine bleeding, pain from endometriosis, endometrial and renal carcinomas, paraphilia in males, and GnRH-dependent precocious puberty.	Progesterone receptortarget Estrogen receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A1enzyme Albumincarrier ATP-dependent translocase ABCB1target GABA(A) Receptortarget ATP-dependent translocase ABCB1transporter
Norethindrone enanthate	A synthetic progestogen indicated for contraceptive therapy.	Cytochrome P450 3A4enzyme
Norethisterone	A synthetic second-generation progestin used for contraception, prevention of endometrial hyperplasia in hormone replacement therapy, and in the treatment of other hormone-mediated illnesses such as endometriosis.	Progesterone receptortarget ATP-dependent translocase ABCB1transporter Cytochrome P450 2C19enzyme Albumincarrier Sex hormone-binding globulincarrier Aldo-keto reductase family 1 member C4enzyme 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme 3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme Aldo-keto reductase family 1 member D1enzyme Cytochrome P450 3A4enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2A6enzyme Glucocorticoid receptortarget Androgen receptortarget
Segesterone acetate	Segesterone acetate in combination with ethinyl estradiol is indicated for use by females of reproductive potential to prevent pregnancy as a combination hormonal contraceptive (CHC). It induces contraception for thirteen...	Glucocorticoid receptortarget Progesterone receptortarget Androgen receptortarget Cytochrome P450 3A4enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02529683	Study of Nuvaring Acceptability, Adherence and Biological Effects Among HIV-negative Women in Kenya	Ethinylestradiol Etonogestrel	Not Available	Not Available	completed
NCT06222749	Oxytocin and Reward Processing in Women	Oxytocin	basic_science	Not Available	recruiting
NCT06223126	Stress Reactivity and Hormonal Contraception	No drug interventions	Not Available	Not Available	enrolling_by_invitation
NCT03660046	Contraceptive Hormones, Immunity, and Microbiome Evaluation	Copper Etonogestrel Levonorgestrel Medroxyprogesterone acetate	Not Available	Not Available	recruiting