Cytochrome P450 2B6
Details
- Name
- Cytochrome P450 2B6
- Synonyms
- 1,4-cineole 2-exo-monooxygenase
- 1.14.13.-
- CYPIIB6
- Cytochrome P450 IIB1
- Gene Name
- CYP2B6
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006839|Cytochrome P450 2B6 MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI PPTYQIRFLPR
- Number of residues
- 491
- Molecular Weight
- 56277.81
- Theoretical pI
- 8.44
- GO Classification
- Functionsarachidonic acid epoxygenase activity / heme binding / iron ion binding / monooxygenase activity / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen / oxygen binding / steroid hydroxylase activityProcessescellular ketone metabolic process / drug metabolic process / epoxygenase P450 pathway / exogenous drug catabolic process / oxidation-reduction process / small molecule metabolic process / steroid metabolic process / xenobiotic metabolic processComponentscytoplasm / endoplasmic reticulum membrane / intracellular membrane-bounded organelle
- General Function
- Steroid hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
- Pfam Domain Function
- p450 (PF00067)
- Transmembrane Regions
- Not Available
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0019435|Cytochrome P450 2B6 (CYP2B6) ATGGAACTCAGCGTCCTCCTCTTCCTTGCACTCCTCACAGGACTCTTGCTACTCCTGGTT CAGCGCCACCCTAACACCCATGACCGCCTCCCACCAGGGCCCCGCCCTCTGCCCCTTTTG GGAAACCTTCTGCAGATGGATAGAAGAGGCCTACTCAAATCCTTTCTGAGGTTCCGAGAG AAATATGGGGACGTCTTCACGGTACACCTGGGACCGAGGCCCGTGGTCATGCTGTGTGGA GTAGAGGCCATACGGGAGGCCCTTGTGGACAAGGCTGAGGCCTTCTCTGGCCGGGGAAAA ATCGCCATGGTCGACCCATTCTTCCGGGGATATGGTGTGATCTTTGCCAATGGAAACCGC TGGAAGGTGCTTCGGCGATTCTCTGTGACCACTATGAGGGACTTCGGGATGGGAAAGCGG AGTGTGGAGGAGCGGATTCAGGAGGAGGCTCAGTGTCTGATAGAGGAGCTTCGGAAATCC AAGGGGGCCCTCATGGACCCCACCTTCCTCTTCCAGTCCATTACCGCCAACATCATCTGC TCCATCGTCTTTGGAAAACGATTCCACTACCAAGATCAAGAGTTCCTGAAGATGCTGAAC TTGTTCTACCAGACTTTTTCACTCATCAGCTCTGTATTCGGCCAGCTGTTTGAGCTCTTC TCTGGCTTCTTGAAATACTTTCCTGGGGCACACAGGCAAGTTTACAAAAACCTGCAGGAA ATCAATGCTTACATTGGCCACAGTGTGGAGAAGCACCGTGAAACCCTGGACCCCAGCGCC CCCAAGGACCTCATCGACACCTACCTGCTCCACATGGAAAAAGAGAAATCCAACGCACAC AGTGAATTCAGCCACCAGAACCTCAACCTCAACACGCTCTCGCTCTTCTTTGCTGGCACT GAGACCACCAGCACCACTCTCCGCTACGGCTTCCTGCTCATGCTCAAATACCCTCATGTT GCAGAGAGAGTCTACAGGGAGATTGAACAGGTGATTGGCCCACATCGCCCTCCAGAGCTT CATGACCGAGCCAAAATGCCATACACAGAGGCAGTCATCTATGAGATTCAGAGATTTTCC GACCTTCTCCCCATGGGTGTGCCCCACATTGTCACCCAACACACCAGCTTCCGAGGGTAC ATCATCCCCAAGGACACAGAAGTATTTCTCATCCTGAGCACTGCTCTCCATGACCCACAC TACTTTGAAAAACCAGACGCCTTCAATCCTGACCACTTTCTGGATGCCAATGGGGCACTG AAAAAGACTGAAGCTTTTATCCCCTTCTCCTTAGGGAAGCGGATTTGTCTTGGTGAAGGC ATCGCCCGTGCGGAATTGTTCCTCTTCTTCACCACCATCCTCCAGAACTTCTCCATGGCC AGCCCCGTGGCCCCAGAAGACATCGATCTGACACCCCAGGAGTGTGGTGTGGGCAAAATA CCCCCAACATACCAGATCCGCTTCCTGCCCCGCTGA
- Chromosome Location
- 19
- Locus
- 19q13.2
- External Identifiers
Resource Link UniProtKB ID P20813 UniProtKB Entry Name CP2B6_HUMAN GenBank Protein ID 181296 GenBank Gene ID M29874 HGNC ID HGNC:2615 - General References
- Yamano S, Nhamburo PT, Aoyama T, Meyer UA, Inaba T, Kalow W, Gelboin HV, McBride OW, Gonzalez FJ: cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver. Biochemistry. 1989 Sep 5;28(18):7340-8. [Article]
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
- Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM: The DNA sequence and biology of human chromosome 19. Nature. 2004 Apr 1;428(6982):529-35. [Article]
- Miles JS, McLaren AW, Wolf CR: Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages. Nucleic Acids Res. 1989 Oct 25;17(20):8241-55. [Article]
- Thum T, Borlak J: Gene expression in distinct regions of the heart. Lancet. 2000 Mar 18;355(9208):979-83. [Article]
- Miyazawa M, Shindo M, Shimada T: Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes. Xenobiotica. 2001 Oct;31(10):713-23. [Article]
- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
- Gay SC, Shah MB, Talakad JC, Maekawa K, Roberts AG, Wilderman PR, Sun L, Yang JY, Huelga SC, Hong WX, Zhang Q, Stout CD, Halpert JR: Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution. Mol Pharmacol. 2010 Apr;77(4):529-38. doi: 10.1124/mol.109.062570. Epub 2010 Jan 8. [Article]
- Shah MB, Pascual J, Zhang Q, Stout CD, Halpert JR: Structures of cytochrome P450 2B6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: insight into inhibitor binding and rearrangement of active site side chains. Mol Pharmacol. 2011 Dec;80(6):1047-55. doi: 10.1124/mol.111.074427. Epub 2011 Aug 29. [Article]
- Shah MB, Wilderman PR, Pascual J, Zhang Q, Stout CD, Halpert JR: Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules. Biochemistry. 2012 Sep 18;51(37):7225-38. doi: 10.1021/bi300894z. Epub 2012 Sep 4. [Article]
- Haas DW, Ribaudo HJ, Kim RB, Tierney C, Wilkinson GR, Gulick RM, Clifford DB, Hulgan T, Marzolini C, Acosta EP: Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study. AIDS. 2004 Dec 3;18(18):2391-400. [Article]
- Carr DF, la Porte CJ, Pirmohamed M, Owen A, Cortes CP: Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort. J Antimicrob Chemother. 2010 Sep;65(9):1889-93. doi: 10.1093/jac/dkq260. Epub 2010 Jul 17. [Article]
- Elens L, Vandercam B, Yombi JC, Lison D, Wallemacq P, Haufroid V: Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients. Pharmacogenomics. 2010 Sep;11(9):1223-34. doi: 10.2217/pgs.10.94. [Article]
- Ariyoshi N, Miyazaki M, Toide K, Sawamura Yi, Kamataki T: A single nucleotide polymorphism of CYP2b6 found in Japanese enhances catalytic activity by autoactivation. Biochem Biophys Res Commun. 2001 Mar;281(5):1256-60. [Article]
- Lang T, Klein K, Fischer J, Nussler AK, Neuhaus P, Hofmann U, Eichelbaum M, Schwab M, Zanger UM: Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver. Pharmacogenetics. 2001 Jul;11(5):399-415. [Article]
- Jinno H, Tanaka-Kagawa T, Ohno A, Makino Y, Matsushima E, Hanioka N, Ando M: Functional characterization of cytochrome P450 2B6 allelic variants. Drug Metab Dispos. 2003 Apr;31(4):398-403. [Article]
- Saito S, Iida A, Sekine A, Kawauchi S, Higuchi S, Ogawa C, Nakamura Y: Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population. J Hum Genet. 2003;48(5):249-70. Epub 2003 Apr 29. [Article]
- Lamba V, Lamba J, Yasuda K, Strom S, Davila J, Hancock ML, Fackenthal JD, Rogan PK, Ring B, Wrighton SA, Schuetz EG: Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression. J Pharmacol Exp Ther. 2003 Dec;307(3):906-22. Epub 2003 Oct 9. [Article]
- Lang T, Klein K, Richter T, Zibat A, Kerb R, Eichelbaum M, Schwab M, Zanger UM: Multiple novel nonsynonymous CYP2B6 gene polymorphisms in Caucasians: demonstration of phenotypic null alleles. J Pharmacol Exp Ther. 2004 Oct;311(1):34-43. Epub 2004 Jun 9. [Article]
- Solus JF, Arietta BJ, Harris JR, Sexton DP, Steward JQ, McMunn C, Ihrie P, Mehall JM, Edwards TL, Dawson EP: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. Pharmacogenomics. 2004 Oct;5(7):895-931. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB02974 4-(4-Chlorophenyl)Imidazole experimental unknown Details DB04664 Cyclohexyl-pentyl-maltoside experimental unknown Details DB04794 Bifonazole approved, investigational unknown Details DB00333 Methadone approved unknown substrateinducer Details DB00531 Cyclophosphamide approved, investigational unknown substrateinducer Details DB00532 Mephenytoin approved, investigational, withdrawn unknown substrate Details DB00625 Efavirenz approved, investigational unknown substrateinducer Details DB01104 Sertraline approved unknown substrateinhibitor Details DB01156 Bupropion approved unknown substrate Details DB01181 Ifosfamide approved unknown substrate Details DB00184 Nicotine approved unknown substrate Details DB00208 Ticlopidine approved unknown inhibitor Details DB00220 Nelfinavir approved no inhibitor Details DB00238 Nevirapine approved unknown substrateinducer Details DB00252 Phenytoin approved, vet_approved no substrateinducer Details DB00454 Meperidine approved no substrate Details DB00503 Ritonavir approved, investigational no inhibitorinducer Details DB00564 Carbamazepine approved, investigational unknown substrateinducer Details DB00758 Clopidogrel approved unknown substrateinhibitor Details DB00818 Propofol approved, investigational, vet_approved unknown substrate Details DB00849 Methylphenobarbital approved unknown substrate Details DB01037 Selegiline approved, investigational, vet_approved unknown substrateinhibitor Details DB01043 Memantine approved, investigational unknown inhibitor Details DB01173 Orphenadrine approved unknown inhibitor Details DB00381 Amlodipine approved unknown substrateinhibitor Details DB00675 Tamoxifen approved unknown substrateinhibitor Details DB00313 Valproic acid approved, investigational unknown substrate Details DB00568 Cinnarizine approved, investigational unknown substrate Details DB00398 Sorafenib approved, investigational unknown inhibitor Details DB04572 Thiotepa approved, investigational unknown inhibitor Details DB01174 Phenobarbital approved, investigational unknown inducer Details DB01045 Rifampicin approved unknown inducer Details DB00762 Irinotecan approved, investigational unknown substrate Details DB01069 Promethazine approved, investigational unknown substrate Details DB01221 Ketamine approved, vet_approved unknown substrate Details DB01320 Fosphenytoin approved, investigational unknown inducer Details DB01151 Desipramine approved, investigational unknown inhibitor Details DB00997 Doxorubicin approved, investigational unknown inhibitor Details DB00257 Clotrimazole approved, vet_approved unknown inhibitorinducer Details DB01167 Itraconazole approved, investigational unknown inhibitor Details DB00481 Raloxifene approved, investigational unknown inhibitor Details DB00829 Diazepam approved, illicit, investigational, vet_approved unknown substrate Details DB00641 Simvastatin approved unknown inhibitorinducer Details DB00439 Cerivastatin approved, withdrawn unknown inducer Details DB01076 Atorvastatin approved no inducer Details DB06739 Seratrodast experimental unknown substrate Details DB00514 Dextromethorphan approved unknown substrate Details DB03575 Phencyclidine illicit unknown inhibitor Details DB00865 Benzphetamine approved, illicit unknown substrate Details DB08369 1-(biphenyl-4-ylmethyl)-1H-imidazole experimental unknown Details DB06697 Artemether approved unknown substrateinducer Details DB00321 Amitriptyline approved unknown substrate Details DB00701 Amprenavir approved, investigational unknown inhibitor Details DB00604 Cisapride approved, investigational, withdrawn unknown substrate Details DB00349 Clobazam approved, illicit unknown substrate Details DB06470 Clomethiazole investigational unknown substrate Details DB01559 Clotiazepam approved, illicit unknown substrate Details DB01394 Colchicine approved unknown inhibitor Details DB01234 Dexamethasone approved, investigational, vet_approved unknown inducer Details DB00586 Diclofenac approved, vet_approved unknown substrate Details DB01184 Domperidone approved, investigational, vet_approved unknown substrate Details DB00751 Epinastine approved, investigational unknown substrate Details DB00655 Estrone approved unknown substrate Details DB00898 Ethanol approved unknown inhibitor Details DB01466 Ethylmorphine experimental, illicit unknown substrate Details DB01544 Flunitrazepam approved, illicit unknown substrate Details DB00472 Fluoxetine approved, vet_approved unknown substrate Details DB00176 Fluvoxamine approved, investigational unknown inhibitor Details DB01159 Halothane approved, vet_approved unknown substrate Details DB00458 Imipramine approved unknown substrate Details DB00753 Isoflurane approved, vet_approved unknown substrateinducer Details DB06738 Ketobemidone investigational unknown substrate Details DB01026 Ketoconazole approved, investigational unknown inhibitor Details DB00281 Lidocaine approved, vet_approved unknown substrate Details DB01601 Lopinavir approved unknown inhibitor Details DB00772 Malathion approved, investigational unknown substrate Details DB04817 Metamizole approved, investigational, withdrawn unknown inducer Details DB01028 Methoxyflurane approved, investigational, vet_approved unknown substrate Details DB06710 Methyltestosterone approved unknown substrate Details DB00379 Mexiletine approved, investigational unknown substrate Details DB06148 Mianserin approved, investigational unknown substrate Details DB01110 Miconazole approved, investigational, vet_approved unknown inhibitor Details DB00745 Modafinil approved, investigational unknown inhibitorinducer Details DB00622 Nicardipine approved, investigational unknown inducer Details DB01115 Nifedipine approved unknown inducer Details DB00715 Paroxetine approved, investigational unknown inhibitor Details DB01074 Perhexiline approved, investigational unknown substrate Details DB04930 Permethrin approved, investigational unknown substrateinducer Details DB01435 Antipyrine approved, investigational unknown substrate Details DB00908 Quinidine approved, investigational unknown inhibitor Details DB00296 Ropivacaine approved unknown substrate Details DB00778 Roxithromycin approved, investigational, withdrawn no inhibitor Details DB01236 Sevoflurane approved, vet_approved unknown substrate Details DB06729 Sulfaphenazole approved unknown inhibitor Details DB01138 Sulfinpyrazone approved unknown inducer Details DB00231 Temazepam approved, investigational unknown substrate Details DB00624 Testosterone approved, investigational unknown substrate Details DB00763 Methimazole approved unknown inhibitor Details DB00193 Tramadol approved, investigational unknown substrate Details DB00197 Troglitazone approved, investigational, withdrawn unknown inducer Details DB00661 Verapamil approved unknown substrateactivator Details DB00755 Tretinoin approved, investigational, nutraceutical unknown substrate Details DB04868 Nilotinib approved, investigational unknown inducer Details DB06413 Armodafinil approved, investigational unknown inducer Details DB00836 Loperamide approved unknown substrate Details DB04975 Banoxantrone investigational unknown substrate Details DB00435 Nitric Oxide approved unknown inhibitor Details DB00515 Cisplatin approved unknown inhibitor Details DB06209 Prasugrel approved no substrate Details DB04871 Lorcaserin approved no substrate Details DB08864 Rilpivirine approved unknown inhibitor Details DB08896 Regorafenib approved unknown inhibitor Details DB08899 Enzalutamide approved unknown inhibitor Details DB04938 Ospemifene approved, investigational unknown substrate Details DB09074 Olaparib approved unknown inducer Details DB09054 Idelalisib approved no inducer Details DB09068 Vortioxetine approved, investigational no substrate Details DB09280 Lumacaftor approved no inducer Details DB09570 Ixazomib approved, investigational unknown substrate Details DB06176 Romidepsin approved, investigational unknown substrate Details DB01589 Quazepam approved, illicit unknown inhibitor Details DB08865 Crizotinib approved unknown inhibitor Details DB05219 Crisaborole approved, investigational no inhibitor Details DB06595 Midostaurin approved, investigational unknown inducer Details DB11613 Velpatasvir approved, investigational no substrate Details DB05541 Brivaracetam approved, investigational no substrate Details DB09238 Manidipine approved, investigational unknown inhibitor Details DB13874 Enasidenib approved, investigational unknown substrateinhibitorinducer Details DB12070 Letermovir approved, investigational no inducer Details DB13943 Testosterone cypionate approved unknown substrate Details DB13944 Testosterone enanthate approved unknown substrate Details DB13946 Testosterone undecanoate approved, investigational unknown substrate Details DB13941 Piperaquine approved, experimental, investigational unknown inhibitor Details DB11642 Pitolisant approved, investigational unknown inducer Details DB11633 Isavuconazole approved, investigational unknown inducer Details DB11586 Asunaprevir approved, investigational, withdrawn no substrate Details DB11672 Curcumin approved, investigational unknown inhibitor Details DB13132 Artemisinin investigational no substrateinducer Details DB00582 Voriconazole approved unknown inhibitor Details DB14568 Ivosidenib approved, investigational unknown inducer Details DB00615 Rifabutin approved, investigational no inducer Details DB11753 Rifamycin approved, investigational no inhibitorinducer Details DB01201 Rifapentine approved, investigational no inducer Details DB08883 Perampanel approved unknown substrateinducer Details DB09078 Lenvatinib approved, investigational unknown inhibitor Details DB14635 Curcumin sulfate experimental unknown inhibitor Details DB01095 Fluvastatin approved unknown inducer Details DB08912 Dabrafenib approved, investigational unknown inhibitor Details DB08881 Vemurafenib approved unknown inducer Details DB12130 Lorlatinib approved, investigational unknown inducer Details DB12245 Triclabendazole approved, investigational unknown inhibitor Details DB11823 Esketamine approved, investigational unknown substrateinducer Details DB00455 Loratadine approved, investigational unknown substrate Details DB12978 Pexidartinib approved, investigational unknown inhibitorinducer Details DB00956 Hydrocodone approved, illicit, investigational unknown substrate Details DB11757 Istradefylline approved, investigational unknown substrate Details DB00972 Azelastine approved unknown inhibitor Details DB04856 Dexloxiglumide investigational unknown substrate Details DB12808 Trifarotene approved, investigational unknown substrate Details DB12001 Abemaciclib approved, investigational unknown inhibitor Details DB15444 Elexacaftor approved, investigational unknown inhibitor Details DB15035 Zanubrutinib approved, investigational no inducer Details DB14975 Voxelotor approved, investigational unknown substrate Details DB00635 Prednisone approved, vet_approved unknown inducer Details DB00741 Hydrocortisone approved, vet_approved unknown inducer Details DB06119 Cenobamate approved, investigational unknown substrateinhibitorinducer Details DB01222 Budesonide approved unknown inducer Details DB00959 Methylprednisolone approved, vet_approved unknown inducer Details DB11951 Lemborexant approved, investigational unknown inducer Details DB00957 Norgestimate approved, investigational unknown substrate Details DB11837 Osilodrostat approved, investigational unknown substrate Details DB00443 Betamethasone approved, vet_approved unknown inducer Details DB09241 Methylene blue approved, investigational unknown inhibitor Details DB14631 Prednisolone phosphate approved, vet_approved unknown inducer Details DB00714 Apomorphine approved, investigational unknown substrate Details DB14649 Dexamethasone acetate approved, investigational, vet_approved unknown inducer Details DB00574 Fenfluramine approved, illicit, investigational, withdrawn unknown substrate Details DB11932 Abametapir approved, investigational unknown inhibitor Details DB12499 Clascoterone approved, investigational no inhibitor Details DB06137 Tirbanibulin approved, investigational no inhibitor Details DB11853 Relugolix approved, investigational unknown Details DB11632 Opicapone approved, investigational no inhibitor Details DB00170 Menadione approved, nutraceutical unknown inhibitor Details DB00476 Duloxetine approved unknown inhibitor Details DB01086 Benzocaine approved, investigational unknown substrate Details DB08822 Azilsartan medoxomil approved, investigational no substrate Details DB00412 Rosiglitazone approved, investigational unknown inducer Details DB00986 Glycopyrronium approved, investigational, vet_approved unknown substrate Details DB08816 Ticagrelor approved unknown inducer Details DB15569 Sotorasib approved, investigational unknown inducer Details DB12151 Brincidofovir approved, investigational no inhibitor Details DB12265 Fexinidazole approved, investigational unknown substrateinhibitorinducer Details DB15011 Avacopan approved, investigational no inducer Details DB05667 Levoketoconazole approved, investigational no inhibitor Details DB14973 Abrocitinib approved, investigational no substrate Details DB16236 Mitapivat approved, investigational no inducer Details DB09061 Cannabidiol approved, investigational unknown substrateinhibitorinducer Details DB00470 Dronabinol approved, illicit no inhibitor Details DB14737 Cannabinol experimental, investigational unknown inhibitor Details DB14009 Medical Cannabis experimental, investigational unknown substrateinhibitorinducer Details DB05087 Ganaxolone approved, investigational no substrate Details DB01041 Thalidomide approved, investigational, withdrawn no substrateinducer Details DB14921 Mavacamten approved, investigational no inducer Details DB09185 Viloxazine approved, investigational, withdrawn no inhibitor Details DB12020 Tecovirimat approved, investigational no inducer Details