Cytochrome P450 2B6

Details

Name
Cytochrome P450 2B6
Synonyms
  • 1,4-cineole 2-exo-monooxygenase
  • 1.14.13.-
  • CYPIIB6
  • Cytochrome P450 IIB1
Gene Name
CYP2B6
UniProtKB Entry
P20813Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0006839|Cytochrome P450 2B6
MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE
KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR
WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC
SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE
INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT
ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS
DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL
KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI
PPTYQIRFLPR
Number of residues
491
Molecular Weight
56277.81
Theoretical pI
8.44
GO Classification
Functions
anandamide 11,12 epoxidase activity / anandamide 14,15 epoxidase activity / anandamide 8,9 epoxidase activity / estrogen 2-hydroxylase activity / testosterone 16-alpha-hydroxylase activity / testosterone 16-beta-hydroxylase activity
Processes
xenobiotic catabolic process
General Function
A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids (PubMed:12865317, PubMed:21289075). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:21289075). Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2 (PubMed:12865317, PubMed:21289075). Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs (PubMed:11695850, PubMed:22909231). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850)
Specific Function
anandamide 11,12 epoxidase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0019435|Cytochrome P450 2B6 (CYP2B6)
ATGGAACTCAGCGTCCTCCTCTTCCTTGCACTCCTCACAGGACTCTTGCTACTCCTGGTT
CAGCGCCACCCTAACACCCATGACCGCCTCCCACCAGGGCCCCGCCCTCTGCCCCTTTTG
GGAAACCTTCTGCAGATGGATAGAAGAGGCCTACTCAAATCCTTTCTGAGGTTCCGAGAG
AAATATGGGGACGTCTTCACGGTACACCTGGGACCGAGGCCCGTGGTCATGCTGTGTGGA
GTAGAGGCCATACGGGAGGCCCTTGTGGACAAGGCTGAGGCCTTCTCTGGCCGGGGAAAA
ATCGCCATGGTCGACCCATTCTTCCGGGGATATGGTGTGATCTTTGCCAATGGAAACCGC
TGGAAGGTGCTTCGGCGATTCTCTGTGACCACTATGAGGGACTTCGGGATGGGAAAGCGG
AGTGTGGAGGAGCGGATTCAGGAGGAGGCTCAGTGTCTGATAGAGGAGCTTCGGAAATCC
AAGGGGGCCCTCATGGACCCCACCTTCCTCTTCCAGTCCATTACCGCCAACATCATCTGC
TCCATCGTCTTTGGAAAACGATTCCACTACCAAGATCAAGAGTTCCTGAAGATGCTGAAC
TTGTTCTACCAGACTTTTTCACTCATCAGCTCTGTATTCGGCCAGCTGTTTGAGCTCTTC
TCTGGCTTCTTGAAATACTTTCCTGGGGCACACAGGCAAGTTTACAAAAACCTGCAGGAA
ATCAATGCTTACATTGGCCACAGTGTGGAGAAGCACCGTGAAACCCTGGACCCCAGCGCC
CCCAAGGACCTCATCGACACCTACCTGCTCCACATGGAAAAAGAGAAATCCAACGCACAC
AGTGAATTCAGCCACCAGAACCTCAACCTCAACACGCTCTCGCTCTTCTTTGCTGGCACT
GAGACCACCAGCACCACTCTCCGCTACGGCTTCCTGCTCATGCTCAAATACCCTCATGTT
GCAGAGAGAGTCTACAGGGAGATTGAACAGGTGATTGGCCCACATCGCCCTCCAGAGCTT
CATGACCGAGCCAAAATGCCATACACAGAGGCAGTCATCTATGAGATTCAGAGATTTTCC
GACCTTCTCCCCATGGGTGTGCCCCACATTGTCACCCAACACACCAGCTTCCGAGGGTAC
ATCATCCCCAAGGACACAGAAGTATTTCTCATCCTGAGCACTGCTCTCCATGACCCACAC
TACTTTGAAAAACCAGACGCCTTCAATCCTGACCACTTTCTGGATGCCAATGGGGCACTG
AAAAAGACTGAAGCTTTTATCCCCTTCTCCTTAGGGAAGCGGATTTGTCTTGGTGAAGGC
ATCGCCCGTGCGGAATTGTTCCTCTTCTTCACCACCATCCTCCAGAACTTCTCCATGGCC
AGCCCCGTGGCCCCAGAAGACATCGATCTGACACCCCAGGAGTGTGGTGTGGGCAAAATA
CCCCCAACATACCAGATCCGCTTCCTGCCCCGCTGA
Chromosome Location
19
Locus
19q13.2
External Identifiers
ResourceLink
UniProtKB IDP20813
UniProtKB Entry NameCP2B6_HUMAN
GenBank Protein ID181296
GenBank Gene IDM29874
GeneCard IDCYP2B6
HGNC IDHGNC:2615
PDB ID(s)3IBD, 3QOA, 3QU8, 3UA5, 4I91, 4RQL, 4RRT, 4ZV8, 5UAP, 5UDA, 5UEC, 5UFG, 5WBG
KEGG IDhsa:1555
IUPHAR/Guide To Pharmacology ID1324
NCBI Gene ID1555
General References
  1. Yamano S, Nhamburo PT, Aoyama T, Meyer UA, Inaba T, Kalow W, Gelboin HV, McBride OW, Gonzalez FJ: cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver. Biochemistry. 1989 Sep 5;28(18):7340-8. [Article]
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  3. Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM: The DNA sequence and biology of human chromosome 19. Nature. 2004 Apr 1;428(6982):529-35. [Article]
  4. Miles JS, McLaren AW, Wolf CR: Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages. Nucleic Acids Res. 1989 Oct 25;17(20):8241-55. [Article]
  5. Thum T, Borlak J: Gene expression in distinct regions of the heart. Lancet. 2000 Mar 18;355(9208):979-83. [Article]
  6. Miyazawa M, Shindo M, Shimada T: Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes. Xenobiotica. 2001 Oct;31(10):713-23. [Article]
  7. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
  8. Gay SC, Shah MB, Talakad JC, Maekawa K, Roberts AG, Wilderman PR, Sun L, Yang JY, Huelga SC, Hong WX, Zhang Q, Stout CD, Halpert JR: Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution. Mol Pharmacol. 2010 Apr;77(4):529-38. doi: 10.1124/mol.109.062570. Epub 2010 Jan 8. [Article]
  9. Shah MB, Pascual J, Zhang Q, Stout CD, Halpert JR: Structures of cytochrome P450 2B6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: insight into inhibitor binding and rearrangement of active site side chains. Mol Pharmacol. 2011 Dec;80(6):1047-55. doi: 10.1124/mol.111.074427. Epub 2011 Aug 29. [Article]
  10. Shah MB, Wilderman PR, Pascual J, Zhang Q, Stout CD, Halpert JR: Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules. Biochemistry. 2012 Sep 18;51(37):7225-38. doi: 10.1021/bi300894z. Epub 2012 Sep 4. [Article]
  11. Haas DW, Ribaudo HJ, Kim RB, Tierney C, Wilkinson GR, Gulick RM, Clifford DB, Hulgan T, Marzolini C, Acosta EP: Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study. AIDS. 2004 Dec 3;18(18):2391-400. [Article]
  12. Carr DF, la Porte CJ, Pirmohamed M, Owen A, Cortes CP: Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort. J Antimicrob Chemother. 2010 Sep;65(9):1889-93. doi: 10.1093/jac/dkq260. Epub 2010 Jul 17. [Article]
  13. Elens L, Vandercam B, Yombi JC, Lison D, Wallemacq P, Haufroid V: Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients. Pharmacogenomics. 2010 Sep;11(9):1223-34. doi: 10.2217/pgs.10.94. [Article]
  14. Ariyoshi N, Miyazaki M, Toide K, Sawamura Yi, Kamataki T: A single nucleotide polymorphism of CYP2b6 found in Japanese enhances catalytic activity by autoactivation. Biochem Biophys Res Commun. 2001 Mar;281(5):1256-60. [Article]
  15. Lang T, Klein K, Fischer J, Nussler AK, Neuhaus P, Hofmann U, Eichelbaum M, Schwab M, Zanger UM: Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver. Pharmacogenetics. 2001 Jul;11(5):399-415. [Article]
  16. Jinno H, Tanaka-Kagawa T, Ohno A, Makino Y, Matsushima E, Hanioka N, Ando M: Functional characterization of cytochrome P450 2B6 allelic variants. Drug Metab Dispos. 2003 Apr;31(4):398-403. [Article]
  17. Saito S, Iida A, Sekine A, Kawauchi S, Higuchi S, Ogawa C, Nakamura Y: Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population. J Hum Genet. 2003;48(5):249-70. Epub 2003 Apr 29. [Article]
  18. Lamba V, Lamba J, Yasuda K, Strom S, Davila J, Hancock ML, Fackenthal JD, Rogan PK, Ring B, Wrighton SA, Schuetz EG: Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression. J Pharmacol Exp Ther. 2003 Dec;307(3):906-22. Epub 2003 Oct 9. [Article]
  19. Lang T, Klein K, Richter T, Zibat A, Kerb R, Eichelbaum M, Schwab M, Zanger UM: Multiple novel nonsynonymous CYP2B6 gene polymorphisms in Caucasians: demonstration of phenotypic null alleles. J Pharmacol Exp Ther. 2004 Oct;311(1):34-43. Epub 2004 Jun 9. [Article]
  20. Solus JF, Arietta BJ, Harris JR, Sexton DP, Steward JQ, McMunn C, Ihrie P, Mehall JM, Edwards TL, Dawson EP: Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. Pharmacogenomics. 2004 Oct;5(7):895-931. [Article]

Associated Data

Bio-Entities
Bio-EntityType
Cytochrome P450 2B6 (Humans)protein
primary
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
4-(4-Chlorophenyl)ImidazoleexperimentalunknowntargetDetails
Cyclohexyl-pentyl-maltosideexperimentalunknowntargetDetails
Bifonazoleapproved, investigationalunknowntargetDetails
MethadoneapprovedunknownenzymesubstrateinducerDetails
Cyclophosphamideapproved, investigationalunknownenzymesubstrateinducerDetails
Mephenytoinapproved, investigational, withdrawnunknownenzymesubstrateDetails
Efavirenzapproved, investigationalunknownenzymesubstrateinducerDetails
SertralineapprovedunknownenzymesubstrateinhibitorDetails
BupropionapprovedunknownenzymesubstrateDetails
IfosfamideapprovedunknownenzymesubstrateDetails
NicotineapprovedunknownenzymesubstrateDetails
TiclopidineapprovedunknownenzymeinhibitorDetails
NelfinavirapprovednoenzymeinhibitorDetails
NevirapineapprovedunknownenzymesubstrateinducerDetails
Phenytoinapproved, vet_approvednoenzymesubstrateinducerDetails
MeperidineapprovednoenzymesubstrateDetails
Ritonavirapproved, investigationalnoenzymeinhibitorinducerDetails
Carbamazepineapproved, investigationalunknownenzymesubstrateinducerDetails
ClopidogrelapprovednoenzymesubstrateinhibitorDetails
Propofolapproved, investigational, vet_approvedunknownenzymesubstrateDetails
MethylphenobarbitalapprovedunknownenzymesubstrateDetails
Selegilineapproved, investigational, vet_approvedunknownenzymesubstrateinhibitorDetails
Memantineapproved, investigationalunknownenzymeinhibitorDetails
OrphenadrineapprovedunknownenzymeinhibitorDetails
AmlodipineapprovedunknownenzymesubstrateinhibitorDetails
TamoxifenapprovedunknownenzymesubstrateinhibitorDetails
Valproic acidapproved, investigationalunknownenzymesubstrateDetails
Cinnarizineapproved, investigationalunknownenzymesubstrateDetails
Sorafenibapproved, investigationalunknownenzymeinhibitorDetails
Thiotepaapproved, investigationalunknownenzymeinhibitorDetails
Phenobarbitalapproved, investigationalunknownenzymeinducerDetails
RifampinapprovedunknownenzymeinducerDetails
Promethazineapproved, investigationalunknownenzymesubstrateDetails
Ketamineapproved, vet_approvedunknownenzymesubstrateDetails
Fosphenytoinapproved, investigationalunknownenzymeinducerDetails
Desipramineapproved, investigationalunknownenzymeinhibitorDetails
Doxorubicinapproved, investigationalnoenzymeinhibitorDetails
Clotrimazoleapproved, vet_approvedunknownenzymeinhibitorinducerDetails
Itraconazoleapproved, investigationalnoenzymeinhibitorDetails
Raloxifeneapproved, investigationalunknownenzymeinhibitorDetails
Diazepamapproved, illicit, investigational, vet_approvedunknownenzymesubstrateDetails
SimvastatinapprovedunknownenzymeinhibitorinducerDetails
Cerivastatinapproved, withdrawnunknownenzymeinducerDetails
AtorvastatinapprovednoenzymeinducerDetails
SeratrodastexperimentalunknownenzymesubstrateDetails
DextromethorphanapprovedunknownenzymesubstrateDetails
PhencyclidineillicitunknownenzymeinhibitorDetails
Benzphetamineapproved, illicitunknownenzymesubstrateDetails
1-(biphenyl-4-ylmethyl)-1H-imidazoleexperimentalunknowntargetDetails
ArtemetherapprovedunknownenzymesubstrateinducerDetails
AmitriptylineapprovedunknownenzymesubstrateDetails
Amprenavirapproved, investigationalunknownenzymeinhibitorDetails
Cisaprideapproved, investigational, withdrawnunknownenzymesubstrateDetails
Clobazamapproved, illicitnoenzymesubstrateDetails
ClomethiazoleinvestigationalunknownenzymesubstrateDetails
Clotiazepamapproved, illicitunknownenzymesubstrateDetails
ColchicineapprovedunknownenzymeinhibitorDetails
Dexamethasoneapproved, investigational, vet_approvedunknownenzymeinducerDetails
Diclofenacapproved, vet_approvedunknownenzymesubstrateDetails
Domperidoneapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Epinastineapproved, investigationalunknownenzymesubstrateDetails
EstroneapprovedunknownenzymesubstrateDetails
EthanolapprovedunknownenzymeinhibitorDetails
Ethylmorphineexperimental, illicitunknownenzymesubstrateDetails
Flunitrazepamapproved, illicitunknownenzymesubstrateDetails
Fluoxetineapproved, vet_approvedunknownenzymesubstrateDetails
Fluvoxamineapproved, investigationalunknownenzymeinhibitorDetails
Halothaneapproved, vet_approvedunknownenzymesubstrateDetails
ImipramineapprovedunknownenzymesubstrateDetails
Isofluraneapproved, vet_approvedunknownenzymesubstrateinducerDetails
KetobemidoneinvestigationalunknownenzymesubstrateDetails
Ketoconazoleapproved, investigationalunknownenzymeinhibitorDetails
Lidocaineapproved, vet_approvedunknownenzymesubstrateDetails
LopinavirapprovedunknownenzymeinhibitorDetails
Malathionapproved, investigationalunknownenzymesubstrateDetails
Metamizoleapproved, investigational, withdrawnunknownenzymeinducerDetails
Methoxyfluraneapproved, investigational, vet_approved, withdrawnunknownenzymesubstrateDetails
MethyltestosteroneapprovedunknownenzymesubstrateDetails
Mexiletineapproved, investigationalunknownenzymesubstrateDetails
Mianserinapproved, investigationalunknownenzymesubstrateDetails
Miconazoleapproved, investigational, vet_approvedunknownenzymeinhibitorDetails
Modafinilapproved, investigationalunknownenzymeinhibitorinducerDetails
Nicardipineapproved, investigationalunknownenzymeinducerDetails
NifedipineapprovedunknownenzymeinducerDetails
Paroxetineapproved, investigationalunknownenzymeinhibitorDetails
Perhexilineapproved, investigationalunknownenzymesubstrateDetails
Permethrinapproved, investigationalunknownenzymesubstrateinducerDetails
Antipyrineapproved, investigationalunknownenzymesubstrateDetails
Quinidineapproved, investigationalunknownenzymeinhibitorDetails
RopivacaineapprovednoenzymesubstrateDetails
Roxithromycinapproved, investigational, withdrawnnoenzymeinhibitorDetails
Sevofluraneapproved, vet_approvedunknownenzymesubstrateDetails
SulfaphenazoleapprovedunknownenzymeinhibitorDetails
SulfinpyrazoneapprovedunknownenzymeinducerDetails
Temazepamapproved, investigationalunknownenzymesubstrateDetails
Testosteroneapproved, investigationalunknownenzymesubstrateDetails
MethimazoleapprovedunknownenzymeinhibitorDetails
Tramadolapproved, investigationalunknownenzymesubstrateDetails
Troglitazoneapproved, investigational, withdrawnunknownenzymeinducerDetails
VerapamilapprovedunknownenzymesubstrateactivatorDetails
Tretinoinapproved, investigational, nutraceuticalunknownenzymesubstrateDetails
Nilotinibapproved, investigationalunknownenzymeinducerDetails
Armodafinilapproved, investigationalunknownenzymeinducerDetails
LoperamideapprovedunknownenzymesubstrateDetails
BanoxantroneinvestigationalunknownenzymesubstrateDetails
Nitric OxideapprovedunknownenzymeinhibitorDetails
CisplatinapprovedunknownenzymeinhibitorDetails
PrasugrelapprovednoenzymesubstrateDetails
Lorcaserinapproved, withdrawnnoenzymesubstrateDetails
RilpivirineapprovedunknownenzymeinhibitorDetails
RegorafenibapprovedunknownenzymeinhibitorDetails
EnzalutamideapprovednoenzymeinhibitorDetails
Ospemifeneapproved, investigationalunknownenzymesubstrateDetails
OlaparibapprovedunknownenzymeinducerDetails
IdelalisibapprovednoenzymeinducerDetails
Vortioxetineapproved, investigationalnoenzymesubstrateDetails
LumacaftorapprovednoenzymeinducerDetails
Ixazomibapproved, investigationalunknownenzymesubstrateDetails
Romidepsinapproved, investigationalunknownenzymesubstrateDetails
Crizotinibapproved, investigationalunknownenzymeinhibitorDetails
Crisaboroleapproved, investigationalnoenzymeinhibitorDetails
Midostaurinapproved, investigationalunknownenzymeinducerDetails
Velpatasvirapproved, investigationalnoenzymesubstrateDetails
Brivaracetamapproved, investigationalnoenzymesubstrateDetails
Manidipineapproved, investigationalunknownenzymeinhibitorDetails
Enasidenibapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
Letermovirapproved, investigationalnoenzymeinducerDetails
Testosterone cypionateapprovedunknownenzymesubstrateDetails
Testosterone enanthateapprovedunknownenzymesubstrateDetails
Testosterone undecanoateapproved, investigationalunknownenzymesubstrateDetails
Piperaquineapproved, experimental, investigationalunknownenzymeinhibitorDetails
Pitolisantapproved, investigationalunknownenzymeinducerDetails
Isavuconazoleapproved, investigationalunknownenzymeinducerDetails
Asunaprevirapproved, investigational, withdrawnnoenzymesubstrateDetails
Curcuminapproved, investigationalunknownenzymeinhibitorDetails
ArtemisinininvestigationalnoenzymesubstrateinducerDetails
VoriconazoleapprovedunknownenzymeinhibitorDetails
Ivosidenibapproved, investigationalunknownenzymeinducerDetails
Rifabutinapproved, investigationalnoenzymeinducerDetails
Rifamycinapproved, investigationalnoenzymeinhibitorinducerDetails
Rifapentineapproved, investigationalnoenzymeinducerDetails
PerampanelapprovedunknownenzymesubstrateinducerDetails
Lenvatinibapproved, investigationalunknownenzymeinhibitorDetails
Curcumin sulfateexperimentalunknownenzymeinhibitorDetails
FluvastatinapprovedunknownenzymeinducerDetails
Dabrafenibapproved, investigationalnoenzymeinhibitorinducerDetails
VemurafenibapprovedunknownenzymeinducerDetails
Lorlatinibapproved, investigationalunknownenzymeinducerDetails
Triclabendazoleapproved, investigationalunknownenzymeinhibitorDetails
Esketamineapproved, investigationalunknownenzymesubstrateinducerDetails
Loratadineapproved, investigationalunknownenzymesubstrateDetails
Pexidartinibapproved, investigationalunknownenzymeinhibitorinducerDetails
Hydrocodoneapproved, illicit, investigationalunknownenzymesubstrateDetails
Istradefyllineapproved, investigationalunknownenzymesubstrateDetails
AzelastineapprovedunknownenzymeinhibitorDetails
DexloxiglumideinvestigationalunknownenzymesubstrateDetails
Trifaroteneapproved, investigationalunknownenzymesubstrateDetails
Abemaciclibapproved, investigationalunknownenzymeinhibitorDetails
Elexacaftorapproved, investigationalnoenzymeinhibitorDetails
Zanubrutinibapproved, investigationalnoenzymeinducerDetails
Voxelotorapproved, investigationalunknownenzymesubstrateDetails
Prednisoneapproved, vet_approvedunknownenzymeinducerDetails
Hydrocortisoneapproved, vet_approvedunknownenzymeinducerDetails
Cenobamateapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
BudesonideapprovedunknownenzymeinducerDetails
Methylprednisoloneapproved, vet_approvedunknownenzymeinducerDetails
Lemborexantapproved, investigationalunknownenzymeinducerDetails
Norgestimateapproved, investigationalunknownenzymesubstrateDetails
Osilodrostatapproved, investigationalunknownenzymesubstrateDetails
Betamethasoneapproved, vet_approvedunknownenzymeinducerDetails
Methylene blueapproved, investigationalunknownenzymeinhibitorDetails
Prednisolone phosphateapproved, vet_approvedunknownenzymeinducerDetails
Apomorphineapproved, investigationalunknownenzymesubstrateDetails
Dexamethasone acetateapproved, investigational, vet_approvedunknownenzymeinducerDetails
Fenfluramineapproved, illicit, investigational, withdrawnunknownenzymesubstrateDetails
Abametapirapproved, investigationalunknownenzymeinhibitorDetails
Clascoteroneapproved, investigationalnoenzymeinhibitorDetails
Tirbanibulinapproved, investigationalnoenzymeinhibitorDetails
Relugolixapproved, investigationalunknownenzymeDetails
Opicaponeapproved, investigationalnoenzymeinhibitorDetails
Menadioneapproved, nutraceuticalunknownenzymeinhibitorDetails
DuloxetineapprovedunknownenzymeinhibitorDetails
Benzocaineapproved, investigationalunknownenzymesubstrateDetails
Azilsartan medoxomilapproved, investigationalnoenzymesubstrateDetails
Rosiglitazoneapproved, investigationalunknownenzymeinducerDetails
Glycopyrroniumapproved, investigational, vet_approvedunknownenzymesubstrateDetails
TicagrelorapprovedunknownenzymeinducerDetails
Sotorasibapproved, investigationalunknownenzymeinducerDetails
Brincidofovirapproved, investigationalnoenzymeinhibitorDetails
Fexinidazoleapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
Avacopanapproved, investigationalnoenzymeinducerDetails
Levoketoconazoleapproved, investigationalnoenzymeinhibitorDetails
Abrocitinibapproved, investigationalnoenzymesubstrateDetails
Mitapivatapproved, investigationalnoenzymeinducerDetails
Cannabidiolapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
Dronabinolapproved, illicitnoenzymeinhibitorDetails
Cannabinolexperimental, investigationalunknownenzymeinhibitorDetails
Medical Cannabisexperimental, investigationalunknownenzymesubstrateinhibitorinducerDetails
Ganaxoloneapproved, investigationalnoenzymesubstrateDetails
Thalidomideapproved, investigational, withdrawnnoenzymesubstrateinducerDetails
Mavacamtenapproved, investigationalnoenzymeinducerDetails
Viloxazineapproved, investigational, withdrawnnoenzymeinhibitorDetails
Tecovirimatapproved, investigationalnoenzymeinducerDetails
StiripentolapprovedunknownenzymeinhibitorinducerDetails
Baloxavir marboxilapproved, investigationalunknownenzymeinhibitorDetails
Deucravacitinibapproved, investigationalunknownenzymesubstrateDetails
Telotristat ethylapproved, investigationalnoenzymeinducerDetails
Thiosulfuric acidapproved, investigationalunknownenzymeinducerDetails
Vonoprazanapproved, investigationalunknownenzymesubstrateDetails
ResveratrolinvestigationalnoenzymeinhibitorDetails
Adagrasibapproved, investigationalunknownenzymesubstrateDetails
Olutasidenibapproved, investigationalunknownenzymeinducerDetails
Pirtobrutinibapproved, investigationalunknownenzymeinhibitorinducerDetails
Sparsentanapproved, investigationalunknownenzymeinducerDetails
Tezacaftorapproved, investigationalnoenzymeinhibitorDetails
BrinzolamideapprovedunknownenzymesubstrateDetails
Vadadustatapproved, investigationalunknownenzymeinducerDetails
Palovaroteneapproved, investigationalnoenzymeinducerDetails
Momelotinibapproved, investigationalunknownenzymeinhibitorDetails
Encorafenibapproved, investigationalnoenzymeinhibitorinducerDetails
Repotrectinibapproved, investigationalnoenzymeinducerDetails
Nirogacestatapproved, investigationalnoenzymeinducerDetails
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Givinostatapproved, investigationalnoenzymeinducerDetails
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Mavorixaforapproved, investigationalunknownenzymeinhibitorDetails
Vorasidenibapproved, investigationalunknownenzymesubstrateinducerDetails