Hyperuricemia (DBCOND0004938)

Identifiers

Synonyms
Hyperuricaemia / Hyperuricemia (disorder) / Hyperuricaemic / Uric acid retention

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Allopurinol
A xanthine oxidase inhibitor used to reduce urinary and serum uric acid concentrations in patients with gout, recurrent calcium oxalate calculi, and various malignancies.
Lesinurad
A uric acid 1 transporter inhibitor typically used in combination with a xanthine oxidase inhibitor to treat hyperuricemia associated with gout in patients with inadequate control of uric acid levels with xanthine oxidase inhibitor monotherapy.
Probenecid
A medication used to treat gouty arthritis, tophaceous gout, and hyperuricemia.
Rasburicase
A recombinant form of urate-oxidase enzyme used to treat hyperuricemia following chemotherapy for leukemias and non-Hodgkin's lymphoma.
Sulfinpyrazone
A platelet inhibitory and uricosuric agent used to inhibit thrombotic and embolic processes and to manage the chronic phases of gout .
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT01052987
Study of Tranilast Alone or in Combination With Allopurinol in Subjects With Hyperuricemiatreatment2completed
NCT01519687
Study of Levotofisopam 50 mg Three Times a Day (TID) Administered for 7 Days on Hyperuricemia and Gouttreatment2unknown_status
NCT00978653
The Effect of Uric Acid Decrement on Endothelial Function in Patients With Chronic Renal FailurescreeningNot Availablecompleted
NCT03927677
The Effect of Colchicine on the Pharmacokinetic Profile of LC350189 in Healthy Aldults.treatment1completed
NCT01038947
Safety and Efficacy Study of Intramuscular Uricase-PEG 20treatment1unknown_status
NCT04801745
Vegan Diet, Amla Fruits and Uric AcidNo drug interventionstreatmentNot Availablerecruiting
NCT02837198
Study of FYU-981 in Hyperuricemia (Effect on Two Hyperuricemic Types)basic_science2completed
NCT02282683
Long-term Prednisone Use for End-stage Heart Failuretreatment2 / 3unknown_status
NCT05168683
Scintigraphy Study in Healthy Volunteers to Characterize the Performance of ALLN-346 Tabletsother1completed
NCT03899883
Uric Acid Lowering Trial in Youth Onset T2Dtreatment2recruiting
NCT06463561
CPAP Effect on Lipid Profile and Hyperuricemia in Patients With Dyslipidemia and Moderate-severe Obstructive Sleep ApneaNo drug interventionstreatment4recruiting
NCT02338128
The Cardiovascular Protective Effects of Febuxostat in Peritoneal Dialysis PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT03185793
Dose-finding and Safety Study of SHR4640 in Subjects With Hyperuricemiatreatment2completed
NCT05586971
Tigulixostat, Phase 3 Study, Allopurinol Controlled in Gout Patientstreatment3recruiting
NCT02956278
The Effects of BCRP Q141K on Allopurinol Pharmacokinetics and Dynamicsbasic_science4completed
NCT03691688
The Long Term Effect of Low Dose Aspirin on Uric Acid in Chinese Patients With Coronary Artery Diseaseļ¼ˆAURORAļ¼‰Not AvailableNot Availableunknown_status
NCT06084585
The Efficacy of Amway Uric Acid Lowering Product on HyperuricemiaNo drug interventionssupportive_careNot Availablerecruiting
NCT04399915
Effect of Oxalate and Urate Metabolism on CKD EvolutionNo drug interventionsNot AvailableNot Availablerecruiting
NCT03534037
Urate Lowering Therapies and Left Ventricular Diastolic Dysfunctiontreatment4unknown_status
NCT00607152
Rasburicase (Fasturtec) Registration Trialtreatment3terminated
NCT00997542
Allopurinol in Chronic Heart Failuretreatment4completed
NCT04987242
An Inpatient Study of ALLN-346 (Engineered Urate Oxidase) in Hyperuricemic Subjects (Study 201)treatment2completed
NCT03495999
Hyperuricemia and Left Ventricular Diastolic FunctionNo drug interventionsNot AvailableNot Availableterminated
NCT03934099
A Study to Assess Efficay and Safety of LC350189 Different Doses in Gout Patients With Hyperuricemiatreatment2completed
NCT03906006
A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ABP-671 in Healthy SubjectsNo drug interventionstreatment1completed
NCT05226013
Tolerance, Pharmacokinetics / Pharmacodynamics (PK / PD) and Immunogenicity of Pegylated Uric Acid Oxidase for Injection in Healthy Adults and Hyperuricemia Volunteerstreatment1unknown_status
NCT00422318
Treatment of Hyperuricemia in Patients With Heart Failuretreatment4completed
NCT04236219
ALLN-346 Single Ascending Dose (SAD) Study in Healthy Volunteerstreatment1completed
NCT00230217
Study of Rasburicase as Treatment or Prevention of Hyperuricemia Associated With Tumor Lysis Syndrome in Patients With Relapsed or Refractory Lymphoma, Leukemia, or Solid Tumor Malignancyprevention4completed
NCT05434858
Imagery as Biomarker of GoutNo drug interventionspreventionNot Availablerecruiting
NCT02190786
Phase II Exploratory Clinical Study of KUX-1151No drug interventionsNot Available2completed
NCT01336686
Safety and Efficacy Study of MBX-102 in Treatment of Hyperuricemia in Patients With Gouttreatment2completed
NCT05119686
Phase 2b Evaluation of Efficacy and Safety of AR882 in Gout PatientsNo drug interventionstreatment2completed
NCT01532622
Impact of Blueberries on Uric Acid and Quality of LifeNo drug interventionstreatmentNot Availablecompleted
NCT01830725
Purine Metabolism Enzyme SNP to Uric Acid ProductionNo drug interventionsNot AvailableNot Availablecompleted
NCT02502565
Musculoskeletal Ultrasound in Asymptomatic HyperuricemiaNo drug interventionsNot AvailableNot Availableunknown_status
NCT01407874
A Randomized, Double-Blind, Dose-Response Study of the Safety and Uric Acid Effects of Oral Ulodesine Added to Allopurinol in Subjects With Gout and Concomitant Moderate Renal Insufficiencytreatment2completed
NCT02891031
The Effects of Rhus Coriaria L. on Serum Uric Acid LevelsNo drug interventionstreatmentNot Availableunknown_status
NCT00868673
The Role Of Fructose and Uric Acid In the Development of Obesity and Metabolic SyndromeNo drug interventionsscreeningNot Availablecompleted
NCT05474560
Febuxostat Versus Allopurinol on Hepatic Steatosis in MAFLD Patientstreatment4completed
NCT04987294
Phase IIa Study of ALLN-346 (Engineered Urate Oxidase) in Subjects With Hyperuricemia, Gout and Chronic Kidney Diseasetreatment2terminated
NCT02213562
Effect of Chrysanthemum Flower Oil and Its Dose-dependency on HyperuricemiaNo drug interventionspreventionNot Availablecompleted
NCT02600780
Zurig (Febuxostat) 40mg Efficacy and Safety Trialtreatment4completed
NCT03636529
Tart Cherry Juice and Markers of Inflammation, CVD, and DiabetesNo drug interventionstreatmentNot Availablecompleted
NCT04463940
Xanthine Oxidase and Uric Acid Origin in Preeclamptic WomenNo drug interventionsNot AvailableNot Availableunknown_status
NCT04161872
Nutraceutical on HyperuricemiaNo drug interventionstreatment4completed
NCT02008968
Effect of Allopurinol Treatment on Insulin ResistancepreventionNot Availableunknown_status
NCT05954169
Pharmacokinetic/Pharmacokinetic and Safety Studies of SHR4640 in Subjects With Moderate Renal Insufficiency and Healthy Subjectstreatment1completed
NCT01363869
Effects of Green Tea on Level of Serum Uric Acid in Healthy IndividualsNo drug interventionstreatmentNot Availablecompleted
NCT04070846
Mass Balance Study of [14C]LC350189 in Healthy Volunteerstreatment1completed
NCT04066712
Renal PK Study of LC350189treatment1completed
NCT05913310
Efficacy and Safety of Kui-Yuan Chewable Tablets in Patients With HyperuricemiaNo drug interventionstreatment4not_yet_recruiting
NCT02944214
Compare the Renal Protective Effects of Febuxostat and Benzbromarone in CKD Chinese PatientstreatmentNot Availableunknown_status
NCT04886050
Relative Bioavailability Study to Assess an LC350189 Tablet Compared to an LC350189 Capsule in Healthy Adultstreatment1completed
NCT03425708
Effect of Hyperuricaemia on Chronic Renal Diseasetreatment4unknown_status
NCT04586803
Study on the Bioavailability of Three Different Prescription Processes of SHR4640 Tablets in Healthy Volunteersbasic_science1unknown_status
NCT03211403
Multiple Doses Study of SHR4640 in Male Subjects With High Serum Uric Acid Levelother1completed
NCT02462421
Pharmacogenetics of SGLT2 Inhibitorsbasic_science4terminated
NCT06439602
Phase 3 Evaluation of Efficacy and Safety of AR882 in Gout PatientsNo drug interventionstreatment3recruiting
NCT06119802
Prediction of UA/SOD Ratio as a Biomarker of Oxidative Stress in Atrial FibrillationNo drug interventionsNot AvailableNot Availablerecruiting
NCT04953533
Research and Development of a New Technology for Detection of Abnormal Excretion of Intestinal Uric Acid Involved in the Incidence of GoutNo drug interventionsNot AvailableNot Availableunknown_status
NCT05253833
Phase 2 to Assess Efficacy and Safety in AR882 Alone or in Combination With Allopurinol in Patients With Tophaceous Gouttreatment2active_not_recruiting
NCT00174954
Magnetic Resonance Imaging in Subjects With Gouty TophiNo drug interventionsNot AvailableNot Availablecompleted
NCT03473951
The Relationship Among, Serum Uric Acid, Left Ventricular Hypertrophy and Metabolic SyndromeNo drug interventionsNot AvailableNot Availableunknown_status
NCT04352153
Role of Uralyt-U in Patients With HyperuricemiatreatmentNot Availableunknown_status
NCT00302653
Rasburicase in Tumor Lysis Syndrometreatment4completed
NCT01818505
The Influence of Antiphospholipid Antibodies on the Relationship Between Hyperurecemia, Gout and Metabolic SyndromeNo drug interventionsNot AvailableNot Availableunknown_status
NCT05504083
Evaluate the Efficacy and Safety of D-0120 in Primary Hyperuricemia Patientstreatment2recruiting
NCT04072471
Post-Authorisation Safety Study of LesinuradNot AvailableNot Availablewithdrawn
NCT00563771
Rasburicase for Treatment of Hyperuricemia in Children and Adolescence Patients With Tumor Lysis Syndrometreatment4completed
NCT00230178
Rasburicase Versus Allopurinol in Tumor Patients at Risk for Hyperuricemia and Tumor Lysis Syndromeprevention3completed
NCT04144088
Traditional Chinese Medicine in the Treatment of Patients With Hyperuricemia.No drug interventionsbasic_science2completed
NCT03865407
Uric Acid Reduction as a Novel Treatment for Pediatric Chronic Kidney Diseasetreatment2terminated
NCT03218709
The Intervention of Multi-vitamin With Minerals to Hyperuricemiatreatment4unknown_status
NCT04157959
The Drug-Drug Interaction of SHR4640 and Febuxostat in Patients With Hyperuricemiatreatment1unknown_status
NCT00921375
Safety and Efficacy of TULY (Rasburicase) in Prevention and Treatment of Malignancy-associated HyperuricemiaNo drug interventionsprevention3completed
NCT06056570
Open Label PK, PD and DDI of Dotinurad and Allopurinol in Gout Patients With Hyperuricemiatreatment1 / 2recruiting
NCT00741442
A Study of RDEA806 in Hyperuricemic Subjects With Symptomatic Gouttreatment2completed
NCT04165499
Effect of the Consumption of a Combination of Plant Extracts (BSL_EP026) on Serum Uric Acid.No drug interventionstreatment0completed
NCT01984749
Febuxostat for Cerebral and caRdiorenovascular Events prEvEntion stuDytreatmentNot Availableunknown_status
NCT03921736
Reversal of an Unfavorable Effect of Hydrochlorothiazide Compared to Angiotensin Converting Enzyme Inhibitor on Serum Uric Acid and Oxypurines Levels by Estrogen-progestin Therapy in Hypertensive Postmenopausal Women.treatment4completed
NCT05574036
Comparative Study Between Febuxostat Versus Vitamin E in Non-alcoholic Steatohepatitis Patients With Hyperuricemiatreatment2recruiting
NCT00995618
Study of Tranilast Alone or in Combination With Febuxostat in Patients With Hyperuricemiatreatment2completed
NCT02959918
Multi-Dose Safety/Pharmacodynamic Study of SEL-212/SEL-037 in Subjects With Symptomatic Gout & Elevated Blood Uric Acidtreatment2completed
NCT01881919
Effect of Quercetin Supplements on Healthy Males: a Four-Week Randomized Cross-Over TrialNo drug interventionsbasic_science0completed
NCT01021241
Safety and Efficacy Study of Intravenous Uricase-PEG 20treatment1unknown_status
NCT06501534
A Dose Finding Study to Assess Efficacy and Safety of IBI128 in Chinese Gout Subjectstreatment2not_yet_recruiting
NCT04139824
The Effect of Naproxen on the Pharmacokinetic Profile of LC350189 in Healthy Adultstreatment1completed
NCT04622124
A Safety and Tolerability Study of FCN-207 in Healthy VolunteersNo drug interventionstreatment1completed
NCT04938024
Hmong Microbiome ANd Gout, Obesity, Vitamin C (HMANGO-C)No drug interventionstreatmentNot Availablecompleted
NCT04040816
Placebo Controlled, Multiple Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SAP-001 in Gout PatientsNo drug interventionstreatment2completed
NCT03648996
Sex-related Differences in Arterial Stiffness in Type 2 Diabetics: Role of Uric Acidtreatment2completed
NCT05586958
Tigulixostat, Phase 3 Study, Placebo Controlled in Gout Patientstreatment3recruiting
NCT00288158
Primary Prevention of Hypertension in Obese Adolescentstreatment2completed
NCT02252835
Evaluate the PK, PD, and Safety of Arhalofenate in Combination With Febuxostat for Hyperuricemia in Patients With Gouttreatment2completed
NCT04829435
Study 102: Multiple Ascending Dose Study of ALLN-346 (Engineered Urate Oxidase)treatment1completed
NCT03149939
Use of Febuxostat in Hyperuricemia Among Hemodialysis PatientstreatmentNot Availablecompleted
NCT03118739
Intensive Uric Acid Lowering With Verinurad and Febuxostat in Patients With Albuminuriatreatment2completed
NCT04199325
Probiotics for Gout / Hyperuricemia: A Randomized, Intervention, Parallel Controlled, Multicenter Clinical TrialtreatmentNot Availablerecruiting
NCT04799925
Hyperuricemia and Diabetic NephropathyNot AvailableNot Availableunknown_status
NCT04966325
Thorough QT (TQT) Study to Evaluate the Effect of LC350189 on Cardiac Repolarization in Healthy Male and Female Subjectstreatment0completed
NCT02557126
Study of URC102 to Assess the Safety and Efficacy in Gout PatientsNo drug interventionstreatment2completed
NCT03569020
The Diet Gout TrialNo drug interventionstreatmentNot Availablecompleted
NCT04180982
A Safety and Efficacy Study of SHR4640 and Febuxostat in Subjects With Hyperuricemiatreatment2unknown_status
NCT04060173
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ABP-671No drug interventionstreatment1completed
NCT05476627
Risk Factors and Multiomics Study of Chronic Kidney Disease Caused by Metabolic DiseasesNo drug interventionsNot AvailableNot Availablerecruiting
NCT01931527
Effect of Reducing Uric Acid on Insulin Sensitivity and Oxidative StatusotherNot Availablecompleted
NCT04012294
Effects of Allopurinol on Inflammation and Ultrasonographic Changes in People With Elevated Uric Acid But no Symptomstreatment3unknown_status
NCT02344862
Study of FYU-981 in Hyperuricemia With or Without Gouttreatment2completed
NCT06168929
Bioequivalence Study of 2 Sizes of SHR4640 Tablets Orally in Healthy Subjectstreatment1completed
NCT03473444
Prevalence of Hyperuricemia in PakistanNo drug interventionsNot AvailableNot Availableunknown_status
NCT00664144
Rasburicase for the Treatment/Prevention of Hyperuricemia in Adult Patients With Relapsing Aggressive Non Hodgkin's Lymphomatreatment2terminated
NCT00186940
Rasburicase Treatment for Chemotherapy or Malignancy-Induced Hyperuricemia in Asthma/Allergy PatientsNot AvailableNot Availablecompleted
NCT06310967
A Dose Escalation Study of IG3018 in Subjects With Hyperuricemia With or Without Chronic Kidney DiseaseNo drug interventionstreatment1 / 2not_yet_recruiting
NCT02416167
Study of FYU-981 in Hyperuricemia With or Without Gouttreatment2completed
NCT06189404
Effect of Tigulixostat on the Pharmacokinetics of Theophyllinebasic_science1completed
NCT06315569
The Effect of Exercise at Different Time Intervals on HyperuricemiaNo drug interventionspreventionNot Availablerecruiting
NCT01361646
Safety, Tolerability and Pharmacokinetic/Pharmacodynamic Characteristics of LC350189treatment1completed
NCT02290210
Phase 2 Study of URC102 to Assess the Efficacy and Safety in Gout PatientsNo drug interventionstreatment2completed
NCT03200210
Lowering-hyperuricemia Treatment on Cardiovascular Outcomes in Peritoneal Dialysis Patientstreatment4unknown_status
NCT00955981
Gout Dose Response Studytreatment2completed
NCT02338323
Compare the Renal Protective Effects of Febuxostat and BenzbromaronetreatmentNot Availablecompleted
NCT04638543
A Study to Assess the Efficacy, Safety, and Pharmacokinetics of ABP-671 in Patients With Gout or HyperuricemiaNo drug interventionstreatment2completed
NCT06315543
Effect of Increased Daily Water Intake in Patients With HyperuricemiaNo drug interventionstreatmentNot Availablerecruiting
NCT00919243
Prednisone for Heart Failure Patients With Hyperuricemiatreatment4completed
NCT05245890
Assocaiton Between Uric Acid Trajecteries and Remission of NAFLD in NAFLD IndividualsNo drug interventionsNot AvailableNot Availableunknown_status
NCT01265264
Study to Evaluate sUA Lowering Activity, Safety and Efficacy of Oral Ulodesine Added to Allopurinoltreatment2completed
NCT00756964
Lowering Serum Uric Acid to Prevent Acute Kidney Injuryprevention2completed
NCT01109121
Tranilast Plus Allopurinol in Patients With Moderate to Severe Gout (TAnGO)treatment2completed
NCT01416402
Open Label Safety/Efficacy Study of Arhalofenate in Combination With Febuxostat for Hyperuricemia in Gout Patientstreatment2completed
NCT03076684
Gender Differences in the Metabolic Effects of Uric Acidbasic_science0withdrawn
NCT04733079
Treat-to-target by Email During Urate-lowering Therapy in GoutNo drug interventionstreatmentNot Availablerecruiting
NCT00631579
Rasburicase as a Uricolytic Therapy for Hyperuricemia in Patients With Leukemia or Lymphomatreatment2completed