Generalized Tonic-Clonic Seizures (DBCOND0050096)

Identifiers

Synonyms

Tonic-Clonic Seizures / Grand mal epileptic seizure / Generalised tonic-clonic seizure / Seizure grand mal / Grand mal seizure / Centrencephalic epilepsies / Tonic-clonic Seizure / Generalized tonic-clonic Seizure / Generalised tonic-clonic seizures / Generalized Tonic Clonic Seizures / Generalized tonic clonic seizure / Grand mal Seizures / Grand mal Generalized tonic-clonic seizure / Seizures, Tonic-Clonic / Generalized tonic-clonic Seizures / Centrencephalic epilepsy / Tonic-clonic epileptic seizure (finding) / Other generalized epilepsy and epileptic syndromes / Grand mal fit / Grand mal epileptic fit / Generalized onset tonic-clonic epileptic seizure (finding)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Acetazolamide	A carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma.	Carbonic anhydrase 1target Aquaporin-1target Carbonic anhydrase 14target Solute carrier family 22 member 6transporter Carbonic anhydrase 2target Carbonic anhydrase 3target Carbonic anhydrase 4target Cytochrome P450 3A4enzyme Carbonic anhydrase 7target Carbonic anhydrase 12target
Carbamazepine	An anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia.	Voltage-gated sodium channel alpha subunittarget Cytochrome P450 2C8enzyme Cytochrome P450 2B6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 3A5enzyme UDP-glucuronosyltransferase 2B7enzyme RalA-binding protein 1transporter ATP-binding cassette sub-family C member 2transporter Neuronal acetylcholine receptor subunit alpha-4target Nuclear receptor subfamily 1 group I member 2target UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1-6enzyme UDP-glucuronosyltransferase 1A7enzyme
Ethotoin	A hydantoin antiepileptic used to control tonic-clonic and complex partial seizures.	Sodium channel protein type 5 subunit alphatarget Nuclear receptor subfamily 1 group I member 2target Thyroxine-binding globulincarrier
Phenytoin	An anticonvulsant drug used in the prophylaxis and control of various types of seizures.	Sodium channel protein type 5 subunit alphatarget Sodium channel protein type 1 subunit alphatarget Cytochrome P450 2C8enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2B6enzyme Cytochrome P450 3A5enzyme Albumincarrier Cytochrome P450 3A4enzyme Solute carrier organic anion transporter family member 1C1transporter ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 3A7enzyme Nuclear receptor subfamily 1 group I member 2target Sodium channel regulatory subunit beta-1target Sodium channel protein type 3 subunit alphatarget UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1-6enzyme UDP-glucuronosyltransferase 1A9enzyme Thyroxine-binding globulincarrier Voltage-gated inwardly rectifying potassium channel KCNH2target Voltage-dependent L-type calcium channeltarget Sodium channel protein type 2 subunit alphatarget Sodium channel protein type 8 subunit alphatarget GABA(A) Receptortarget Cytochrome P450 1A2enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2E1enzyme Epoxide hydrolase 1enzyme UDP-glucuronosyltransferase 1A4enzyme Catechol O-methyltransferaseenzyme NAD(P)H dehydrogenase [quinone] 1enzyme Cytochrome P450 2C18enzyme
Primidone	An antiepileptic used to treat grand mal, psychomotor, and focal epileptic seizures.	Gamma-aminobutyric acid receptor subunit alpha-1target Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Gamma-aminobutyric acid receptor subunit alpha-2target Gamma-aminobutyric acid receptor subunit alpha-3target Gamma-aminobutyric acid receptor subunit alpha-4target Gamma-aminobutyric acid receptor subunit alpha-5target Gamma-aminobutyric acid receptor subunit alpha-6target Neuronal acetylcholine receptor subunit alpha-4target Neuronal acetylcholine receptor subunit alpha-7target Glutamate receptor 2target Glutamate receptor ionotropic, kainate 2target GABA(A) Receptortarget Transient receptor potential cation channel subfamily M member 3transporter Cytochrome P450 2E1enzyme Cytochrome P450 1A2enzyme UDP-glucuronosyltransferases (UGTs)enzyme
Topiramate	An anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines.	Gamma-aminobutyric acid receptor subunit alpha-1target Voltage-gated sodium channel alpha subunittarget Carbonic anhydrase 2target Carbonic anhydrase 4target Kainate receptorstarget Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme Carbonic anhydrase 1target Carbonic anhydrase 3target Voltage gated L-type calcium channeltarget Voltage-dependent R-type calcium channeltarget Albumincarrier ATP-dependent translocase ABCB1transporter 5'-AMP-activated protein kinasetransporter Glutamate receptor ionotropic, kainate 1target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05718817	An Open-label Study of XEN1101 in Epilepsy	No drug interventions	treatment	3	enrolling_by_invitation
NCT01747915	A Safety, Efficacy and Tolerability Trial of Pregabalin as Add-On Treatment in Pediatric and Adult Subjects With Primary Generalized Tonic-Clonic (i.e., Grand Mal) Seizures.	Pregabalin	treatment	3	completed
NCT01228747	A Double-blind, Placebo-controlled Study of Levetiracetam in Epilepsy Patients With Generalized Tonic-clonic Seizures (Except Partial Seizures Evolving to Secondarily Generalized Seizures)	Levetiracetam	treatment	3	completed
NCT01398956	An Open Label Study of L059 (Levetiracetam) in Japanese Epilepsy Subjects With Generalized Tonic-clonic Seizures	Levetiracetam	treatment	3	completed
NCT01292837	A Study of Levetiracetam in Japanese Pediatric Patients With Generalized Tonic-clonic Seizures	Levetiracetam	treatment	3	completed
NCT02371200	Detecting Generalized Tonic-Clonic Seizures With a Seizure Detection and Warning System in Epilepsy Patients	No drug interventions	Not Available	Not Available	completed
NCT02555410	Seizure Detection and Warning System in Epilepsy Patients	No drug interventions	Not Available	Not Available	completed
NCT00510783	IV Keppra in the Emergency Department for Prevention of Early Recurrent Seizures	Fosphenytoin Levetiracetam Phenytoin	treatment	4	completed
NCT05064878	A Study to Investigate the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder	Fenfluramine	treatment	3	recruiting
NCT03443388	Novel Helmet Design in Patients With Seizures	No drug interventions	prevention	Not Available	completed
NCT05147571	RNS System NAUTILUS Study	No drug interventions	treatment	3	active_not_recruiting
NCT04252846	A Study to Investigate Dosage, Effectiveness, and Safety of Perampanel When Used as First Add-on Therapy in Participants >=12 Years With Partial Onset Seizures With or Without Secondary Generalization or With Primary Generalized Tonic-Clonic Seizures Associated With Idiopathic Generalized Epilepsy	Perampanel	Not Available	Not Available	completed
NCT03283748	Detection of Motor Seizures Using WBAN	No drug interventions	diagnostic	Not Available	completed
NCT00266604	A Study to Evaluate the Dosing, Effectiveness and Safety of Topiramate for the Treatment of Epilepsy	Topiramate	treatment	4	completed