Atrial Fibrillation or Flutter (DBCOND0077970)

Identifiers

Synonyms

Atrial fibrillation/atrial flutter ( AFIB/AFL ) / Atrial flutter/fibrillation / Atrial fibrillation/flutter / Atrial Fibrillation and Flutter / Atrial Fibrillation Fluttering / Atrial Fibrillation or Atrial Flutter / Atrial flutter/ fibrillation / Atrial fibrillation and flutter (disorder) / Atrial fibrillation / Atrial fibrillation (disorder) / Auricular fibrillation / Fibrillation atrial / AFib

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Digitoxin	A cardiac glycoside used in the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure.	Sodium/potassium-transporting ATPase subunit alpha-1target Albumincarrier Cholesterol side-chain cleavage enzyme, mitochondrialenzyme Cytochrome P450 3A4enzyme Solute carrier organic anion transporter family member 1A2transporter Solute carrier organic anion transporter family member 4C1transporter ATP-dependent translocase ABCB1transporter Sodium/potassium-transporting ATPase subunit alpha-2target Sodium/potassium-transporting ATPase subunit alpha-3target Sodium/potassium-transporting ATPase subunit beta-1target Sodium/potassium-transporting ATPase subunit beta-2target Sodium/potassium-transporting ATPase subunit beta-3target
Hydroquinidine	A medication indicated in the maintenance of a normal sinus rhythm, as well as the treatment and prevention of abnormal rhythm.	No drug targets
Quinidine	A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias.	Sodium channel protein type 5 subunit alphatarget Alpha-1-acid glycoprotein 1carrier Potassium voltage-gated channel subfamily H member 2target Potassium channel subfamily K member 1target Potassium channel subfamily K member 6target Cytochrome P450 1A2enzyme Cytochrome P450 2E1enzyme Cytochrome P450 1A1enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Organic cation/carnitine transporter 2transporter ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Organic anion transporter 3transporter ATP-binding cassette sub-family C member 2transporter Solute carrier family 22 member 4transporter Solute carrier organic anion transporter family member 1B1transporter Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme Alpha-1A adrenergic receptortarget Alpha-1B adrenergic receptortarget Alpha-1D adrenergic receptortarget Bile salt export pumptransporter Cytochrome P450 2C8enzyme Albumincarrier
Sotalol	A methane sulfonanilide beta adrenergic antagonist used to treat life-threatening ventricular arrhythmias and to maintain sinus rhythm in atrial fibrillation or flutter.	Potassium voltage-gated channel subfamily H member 2target Beta-1 adrenergic receptortarget Beta-2 adrenergic receptortarget Cytochrome P450 2D6enzyme
Verapamil	A non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension.	ATP-sensitive inward rectifier potassium channel 11target Voltage-dependent T-type calcium channel subunit alpha-1Gtarget Potassium voltage-gated channel subfamily H member 2target Voltage-dependent L-type calcium channel subunit alpha-1Ctarget Cytochrome P450 1A2enzyme Cytochrome P450 3A5enzyme Voltage-dependent N-type calcium channel subunit alpha-1Btarget Voltage-dependent P/Q-type calcium channel subunit alpha-1Atarget Sodium-dependent serotonin transportertarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Solute carrier family 22 member 1transporter ATP-binding cassette sub-family C member 3transporter ATP-binding cassette sub-family C member 4transporter Organic cation/carnitine transporter 2transporter Solute carrier organic anion transporter family member 1A2transporter ATP-binding cassette sub-family C member 10transporter Solute carrier family 22 member 4transporter Solute carrier organic anion transporter family member 1B1transporter Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme Alpha-1A adrenergic receptortarget Alpha-1B adrenergic receptortarget Alpha-1D adrenergic receptortarget Albumincarrier Alpha-1-acid glycoprotein 1carrier Cytochrome P450 2C18enzyme Cytochrome P450 2E1enzyme Multidrug resistance-associated protein 1transporter Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Voltage-dependent T-type calcium channel subunit alpha-1Htarget Voltage-dependent calcium channeltarget ATP-dependent translocase ABCB1target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02454283	Safety and Efficacy of Vanoxerine for the Conversion of Subjects With Recent Onset Atrial Fibrillation or Flutter to Normal Sinus Rhythm	Vanoxerine	treatment	3	terminated
NCT03862859	The Danish Warfarin-Dialysis Study - Safety and Efficacy of Warfarin in Patients With Atrial Fibrillation on Dialysis	Warfarin	prevention	4	recruiting
NCT02623049	Direct Oral Anticoagulants Pharmacodynamics in Octogenarian Patients With Atrial Fibrillation	No drug interventions	Not Available	Not Available	unknown_status
NCT05509517	A Clinical Trial of the Use of Remote Heart Rhythm Monitoring With a Smartphone After Cardiac Surgery	No drug interventions	diagnostic	Not Available	completed
NCT06056557	Versatility of a Circular Multielectrode Catheter in the Individualized Recognition & Treatment of Atrial Fibrillation and Related Arrhythmias Using Pulsed Field Energy	No drug interventions	treatment	Not Available	active_not_recruiting
NCT06584266	Multimodal Cardiac Imaging Registry in Patients with Atrial Fibrillation	No drug interventions	Not Available	Not Available	recruiting
NCT03377465	Biomarkers, Hemodynamic and Echocardiographic Predictors of Ischemic Strokes and Their Influence on the Course and Prognosis	No drug interventions	prevention	Not Available	completed
NCT03707873	Effect of Targeted Education for Atrial Fibrillation Patients	No drug interventions	treatment	Not Available	completed
NCT02344901	ReAl-life Multicentre Survey Evaluating Stroke Prevention Strategies (RAMSES)	No drug interventions	Not Available	Not Available	completed
NCT05008601	Aino ECG Ambulatory Study	No drug interventions	Not Available	Not Available	completed
NCT03243604	cARdiotoxicity Profile of aBIraTeRone in prostAte Cancer : a pharmacoviGilancE Study	No drug interventions	Not Available	Not Available	completed
NCT04438395	Dielectric Tissue Imaging in Cavotricuspid Isthmus Ablation	No drug interventions	Not Available	Not Available	unknown_status
NCT03472495	Oral vs Intravenous Diltiazem for Rapid Atrial Fibrillation/Flutter Trial	Diltiazem	treatment	4	completed
NCT06187155	Impact of Education Level on Clinical Outcomes in Self-INR Managed Patients	No drug interventions	prevention	Not Available	recruiting
NCT04855890	HIgh Power Short Duration Radiofrequency Ablation or Cryoballoon Ablation for Paroxysmal Atrial Fibrillation	No drug interventions	treatment	Not Available	unknown_status
NCT02273609	INR Control and Atrial Fibrillation in Primary Care in Spain (PAULA)	Acenocoumarol Phylloquinone Warfarin	Not Available	Not Available	completed
NCT03911986	Risk-Based Screening for the Evaluation of Atrial Fibrillation Trial	No drug interventions	screening	Not Available	completed
NCT05009225	Clinical Decision Support for Atrial Fibrillation and Flutter	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT03488420	Canadian EdoxAban(Lixiana®) Registry in Patients With ATrial Fibrillation/Flutter With Confirmed ValvUlar HeaRt DiseasE	Edoxaban	Not Available	Not Available	active_not_recruiting
NCT03110627	Increasing Detection of Sub-Clinical Atrial Fibrillation in Defibrillator Patients With the Use of a VDD-ICD Lead	No drug interventions	diagnostic	Not Available	unknown_status
NCT05159180	Development of a New Impedance Mapping System for Ablation of Atrial Arrhythmias in Patients	No drug interventions	Not Available	Not Available	unknown_status
NCT03788044	Effect of Targeted Education for Atrial Fibrillation Patients (Application Substudy)	No drug interventions	treatment	Not Available	completed
NCT06452823	Efficacy and Safety of Catheter Ablation of Atrial Fibrillation in Patients With Thyroid Hormone Stabilization	No drug interventions	Not Available	Not Available	enrolling_by_invitation
NCT02986282	Ankle - Brachial Index Measurement in Atrial Fibrillation	No drug interventions	diagnostic	Not Available	completed
NCT02256683	Resolution of Left Atrial-Appendage Thrombus - Effects of Dabigatran in Patients With AF	Dabigatran Phenprocoumon	treatment	2	terminated
NCT02307188	Multipolar Mapping and Atrial Arrhythmias	No drug interventions	diagnostic	Not Available	completed