Non-statin Hypolipidemic Agents Indicated for Hyperlipidemia
- Non-statin Hypolipidemic Agents Indicated for Hyperlipidemia
- Accession Number
Agents that have been assigned indications for the lowering of serum lipid levels that do not belong in the statin (aka. Hydroxymethylglutaryl-CoA Reductase Inhibitors) drug class. Not included in this category are agents that may lower lipid levels via action at off-targets or through other means (i.e. agents that are not intended or indicated to lower serum lipid levels).
Drug Drug Description Alirocumab A PCSK9 inhibitor used as an adjunct to manage heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease in patients who require additional lowering of LDL-cholesterol (LDL-C). Bempedoic acid A drug used in conjunction with lifestyle modification and/or other agents for the treatment of refractory hypercholesterolemia. Bezafibrate A lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder. Cholestyramine A bile acid sequestrant used as an adjunct in the reduction of elevated serum cholesterol in patients with primary hypercholesterolemia, and for the relief of pruritus associated with partial biliary obstruction. Colesevelam A bile acid sequestrant used to lower LDL-C in adults with hyperlipidemia and pediatric patients with heterozygous familial hypercholesterolemia, and to improve glycemic control in type 2 diabetes. Colestipol A bile acid sequestrant used as an adjunct to diet and exercise to reduce LDL-C cholesterol levels in patients with primary hypercholesterolemia. Evolocumab A PCSK9 (proprotein convertase subtilisin kexin type 9) inhibitor antibody used as an adjunct to LDL cholesterol reducing therapies, aiding in the prevention of cardiovascular events and cardiovascular revascularization procedures. Ezetimibe A cholesterol absorption inhibitor used to lower total cholesterol, LDL-C, Apo-B, and non-HDL-C in primary hyperlipidemia and familial cholesterolemia. Fenofibrate A peroxisome proliferator receptor alpha activator used to lower LDL-C, total-C, triglycerides, and Apo B, while increasing HDL-C in hypercholesterolemia, dyslipidemia, and hypertriglyceridemia. Fenofibric acid A fibrate used to treat severe hypertriglyceridemia, primary hypercholesterolemia, or mixed dyslipidemia. Gemfibrozil A lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia. Inclisiran A PCSK9-targeting short interfering RNA (siRNA) that lowers plasma LDL-cholesterol levels. Lomitapide A microsomal triglyceride transfer protein inhibitor used to lower cholesterol associated with homozygous familial hypercholesterolemia (HoFH), reducing risk of cardiovascular events such as myocardial infarction and stroke. Mipomersen An oligonucleotide drug used for the treatment of homozygous familial hypercholesterolemia. Niacin A B vitamin used to treat hypertriglyceridemia and pellagra.
- Drugs & Drug Targets