Vulvo Vaginal Atrophy (DBCOND0055337)

Identifiers

Synonyms
Vulvo-vaginal Atrophy / Atrophy;Vaginal / Vaginal Atrophy / Vulvovaginal Atrophy / Atrophic vulvovaginitis / Vulvovaginitis atrophy / Vulvovaginitis atrophic / Atrophic vulvovaginitis (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Drospirenone
A progestin used in oral contraceptive pills for the prevention of pregnancy and other conditions.
Estradiol
An estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate.
Estriol
A weak estrogen used to treat vaginal dryness and estrogen deficiency conditions, such as vaginitis and vulvar itching.
Estrone
An estrogen used to treat perimenopausal and postmenopausal symptoms.
Medroxyprogesterone acetate
A progestin used as a contraceptive and in the treatment of secondary amenorrhea, abnormal uterine bleeding, pain from endometriosis, endometrial and renal carcinomas, paraphilia in males, and GnRH-dependent precocious puberty.
Norethisterone
A synthetic second-generation progestin used for contraception, prevention of endometrial hyperplasia in hormone replacement therapy, and in the treatment of other hormone-mediated illnesses such as endometriosis.
Promestriene
A synthetic estrogen applied topically for the treatment of vulvovaginal atrophic symptoms and to speed wound healing following vulvovaginal surgery or trauma (e.g. post-partum).
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT01502527
A Twelve Week Study to Investigate the Efficacy of Femarelle®, for the Treatment of Post Menopausal Vaginal AtrophyNo drug interventionstreatmentNot Availablecompleted
NCT03857893
New Non-Hormonal Treatment by Radiofrequency for Vulvo-Vaginal AtrophyNo drug interventionstreatmentNot Availableterminated
NCT03833726
Light Emitting Diode for theTreatment of Genitourinary Syndrome of Menopause Associated With Breast Cancer TreatmentNo drug interventionstreatmentNot Availablecompleted
NCT04902794
Light Emitting Diode in the Treatment of Genitourinary Syndrome of MenopauseNo drug interventionstreatmentNot Availablerecruiting
NCT05398172
Clinical Evaluation of Fractional Bi-Polar Radio-Frequency for Symptoms of Vulvovaginal AtrophyNo drug interventionstreatmentNot Availablecompleted
NCT05457972
Postpartum Vaginal Estrogen for Breastfeeding Patientstreatment4not_yet_recruiting
NCT03996603
Investigation of Microbiomes of Postmenopausal Women Looking for Outcomes and Response to Estrogen Therapybasic_science4completed
NCT01753102
Efficacy and Safety Of Spil's Estradiol Vaginal Tablettreatment3terminated
NCT01256684
DHEA Against Vaginal Atrophy - 3-Month Efficacy Studytreatment3completed
NCT04493333
Vaginal Dehydroepiandrosterone (DHEA) in Postmenopausal Breast Cancer Survivors on Aromatase Inhibitorssupportive_care2terminated
NCT05379153
Testing Laser Therapy for Treatment of Vaginal Dryness in Survivors of Breast Cancer, The Revitalize TrialNo drug interventionssupportive_care3not_yet_recruiting
NCT03238053
Laser Treatment of Genito-urinary Syndrome in WomenNo drug interventionssupportive_careNot Availablenot_yet_recruiting
NCT04717245
Comparative Study: Vaginal Promestriene Use, Fractional CO2 LASER and Radiofrequency in the Vaginal Atrophy TreatmenttreatmentNot Availablecompleted
NCT06353945
Perceived Effectiveness of the Vaginal Moisturizer Investigational Product Under Normal Conditions of Use.No drug interventionstreatmentNot Availablenot_yet_recruiting
NCT03754205
Vaginal CO2 Laser and the Genitourinary Syndrome of MenopauseNo drug interventionstreatmentNot Availableunknown_status
NCT03738605
Vaginal Laser Therapy in Breast Cancer SurvivorsNo drug interventionstreatmentNot Availableunknown_status
NCT04081805
LASER and Radiofrequency for Treatment of Vaginal Vulvar Atrophy (VVA) in Women Treated for Breast Cancer (EPMLARF-arm2)treatmentNot Availablerecruiting
NCT06028009
PRP Injections for Genitourinary Syndrome of MenopauseNo drug interventionstreatmentNot Availablerecruiting
NCT00238732
Study Evaluating Bazedoxifene/Conjugated Estrogen Combinations in Vasomotor Symptoms Associated With Menopausediagnostic3completed
NCT06136975
Low-level Laser Therapy for Genitourinary Syndromes and Stress Urinary IncontinenceNo drug interventionsNot AvailableNot Availablecompleted
NCT01846442
Topical DHEA Against Vaginal Atrophytreatment3completed
NCT04574999
Study to Determine Efficacy & Safety of a Low Concentration Estriol (0.005%) in Postmenopausal Vaginal Atrophy.treatment3completed
NCT04910906
Non-Interventional Multicentre Post-market Study of Ectoin® Vaginal Gel for Symptomatic Treatment of Vaginal AtrophyNo drug interventionsNot AvailableNot Availablecompleted
NCT00429806
DHEA Bioavailability Following Administration of Vaginal Suppositories in Post-Menopausal Women With Vaginal Atrophytreatment1completed
NCT04079218
Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trialtreatment4completed
NCT00803335
The Effects of Local Vaginal Estrogen in Postmenopausal Women With Pelvic Organ Prolapsetreatment3completed
NCT06514586
The Efficacy of Topical Vaginal Oxytocin Gel in Postmenopausal Women With Vulvovaginal Atrophytreatment3not_yet_recruiting
NCT03998722
Evaluation of VagiVital® for Treatment of Vaginal AtrophyNo drug interventionstreatmentNot Availablecompleted
NCT03520426
Evaluation of Efficacy and Safety of Votiva for Vaginal RejuvenationNo drug interventionstreatmentNot Availableunknown_status
NCT03493126
Vaginal Estrogen on Postpartum Atrophy, Perineal Pain, and Sexual Functiontreatment4completed
NCT03770065
Exploratory Study on Two Different Doses of VML-0001 on the Effects on Vaginal pH in Healthy Post-Menopausal WomenNo drug interventionsNot AvailableNot Availablecompleted
NCT06207227
Clinical Performance and Safety of the VITA AV Clinical SystemNo drug interventionstreatmentNot Availablecompleted
NCT02571127
Evaluate the Efficacy, Safety and Tolerability of a Non-hormonal Intravaginal Gel in Postmenopausal Women With Symptoms of Vaginal Dryness.No drug interventionstreatment4unknown_status
NCT04492176
A Clinical Clinical Observation of CO2 Fractional Laser in Female Vaginal RepairNo drug interventionstreatmentNot Availablecompleted
NCT01358760
Dehydroepiandrosterone (DHEA) Against Vaginal Atrophytreatment3completed
NCT04807894
Prevention of Recurrent UTI Using Vaginal Testosterone Versus Placebo Placebotreatment4recruiting
NCT03547089
A Prospective Trial to Assess Breast Cancer Survivors and Vaginal Atrophy Treatment OutcomesNo drug interventionstreatmentNot Availablesuspended
NCT01987804
Dose-relationship of Vaginally Administrated Oxytocin in Postmenopausal Womentreatment2completed
NCT06391372
Effect of Local Estriol Treatment Before Vaginal Repair Surgerytreatment3not_yet_recruiting
NCT05654610
Real-world Evidence Study on the Performance and Safety of Halova OvulesNo drug interventionsNot AvailableNot Availablecompleted
NCT05463081
Clinical Trial of "Magic Gyno" Laser DeviceNo drug interventionssupportive_careNot Availablecompleted
NCT00607295
Efficacy and Safety of Clino-san on Vaginal Dryness of Breast Cancer PatientsNo drug interventionssupportive_care3completed
NCT03316950
Radiofrequency and Hybrid Fractional Laser for Vaginal RejuvenationNo drug interventionstreatmentNot Availablecompleted
NCT05953090
VALOR: Vaginal Atrophy & Long-term Observation of RecoveryNo drug interventionstreatmentNot Availablerecruiting
NCT06000202
Elastographic Improvement of Vaginal Atrophy Treated by Erbium Yag LaserNo drug interventionstreatmentNot Availablerecruiting
NCT03063684
Fractional / Pixel CO2 Laser Treatment of Vulvar Atrophy and Lichen SclerosusNo drug interventionsbasic_scienceNot Availablecompleted
NCT02937805
Effects of a Moisturizing Cream on Vaginal and Vulvar Mucous MembranesNo drug interventionstreatmentNot Availablecompleted
NCT05211505
Investigation of Efficacy and Tolerability of WO 2707, a MoistCream Cremolum, in Postmenopausal Women Suffering From Symptoms of Vaginal DrynessNo drug interventionstreatment4completed
NCT06564883
Hydration and Acceptability of the Genital and Skin Mucosa of a Vaginal Moisturizer in Menopausal WomenNo drug interventionstreatment3not_yet_recruiting
NCT04159493
A Randomized Controlled Phase 2 Study to Determine Lowest Efficacious Dose of Ovestin in Vulvar and Vaginal Atrophytreatment2withdrawn
NCT01256671
DHEA Against Vaginal Atrophy - Safety Study of 12 Monthstreatment3completed
NCT03939078
CO2 Laser in the Treatment of the GSM - (Genitourinary Syndrome of Menopause) Genitourinary Syndrome of MenopauseNo drug interventionsNot AvailableNot Availablecompleted
NCT05458375
Vaginal Estradiol Use in Pessary Caresupportive_care0terminated
NCT01432470
Study of Oxytocin to Treat Vaginal Atrophy in Postmenopausal Womentreatment2completed
NCT04735549
Vulvovaginal Atrophy Correction Using Neodymium Lasersupportive_careNot Availablecompleted
NCT02704741
Clinical Study of the CO2RE Laser Device Performance for Vaginal Atrophy TreatmentsNo drug interventionstreatmentNot Availableunknown_status
NCT02747641
Prospective, Open-Label, Single-Center, Non-Comparative Study to Assess the Use of Pixel CO2 Laser System (FemiLift) in the Treatment of Vulvovaginal Atrophy (VVA) in Postmenopausal Female SubjectsNo drug interventionstreatmentNot Availablecompleted
NCT05335317
Treatment of Vaginal Atrophy With Low Intensity Nanosecond Neodymium Lasersupportive_careNot Availablerecruiting
NCT05483634
Compare Vaginal Estrogen and Platelet-rich Plasma Over Women With Genitourinary Syndrome of MenopauseNot AvailableNot Availablenot_yet_recruiting
NCT03956563
Effect of Hybrid Laser 10600+1540 nm on GSMNo drug interventionstreatmentNot Availableunknown_status
NCT03178825
Hybrid Fractional Laser for Symptoms of Genitourinary Syndrome of MenopauseNo drug interventionstreatmentNot Availablecompleted
NCT05627791
Effects of Vaginal Oxytocin Gel on Vaginal Cytologic Parameters in Postmenopausal Womantreatment2 / 3terminated
NCT05898191
Effect of Laser Therapy on Vaginal TissueNo drug interventionsbasic_scienceNot Availableactive_not_recruiting
NCT01975129
A Pharmacokinetic Study of Vaginally and Intravenously Administered Oxytocintreatment2completed
NCT00453089
VG101 Phase I/II to Treat Vulvar and Vaginal Atrophy in Post-Menopausal WomenNo drug interventionstreatment1 / 2unknown_status
NCT02013544
Intravaginal Prasterone (DHEA) Against Vulvovaginal Atrophy Associated With Menopausetreatment3completed
NCT04659668
Evaluation of the Efficacy and Safety of the Dermal Filler for Female Intimate Area Hydration and Atrophy of the Vagina.No drug interventionstreatmentNot Availablecompleted
NCT04868812
Histological Modifications of Postmenopausal Vaginal Mucosa After Repeated Carbon Dioxide (CO2) Laser TreatmentNo drug interventionstreatmentNot Availablecompleted
NCT01899612
Vaginal Inflammation Markers in Postmenopausal Women With and Without Symptoms of Vaginal InflammationNo drug interventionsNot AvailableNot Availablecompleted
NCT02967510
Study Evaluating the Efficacy and Safety of Three Formulations of Ultra-low Dose Estriol Vaginal Gel (0.005%, 0.002%, 0.0008% Estriol Vaginal Gel) for the Treatment of Vaginal Dryness in Postmenopausal Women With Vulvovaginal Atrophytreatment2completed
NCT04039555
Clinical Study to Compare the Efficacy of Erbium-Yag Laser or CO2RE Intimate Laser With Sham (COER)No drug interventionstreatmentNot Availablecompleted
NCT02413008
A Clinical Trial to Assess the Safety of 0.005 % Estriol Vaginal Gel in Hormone Receptor-Positive Postmenopausal Women With Early Stage Breast Cancer in Treatment With Aromatase Inhibitor in the Adjuvant Settingtreatment2completed
NCT02460302
Vaginal Progesterone Versus Placebo for the Treatment of Vaginal Atrophytreatment2withdrawn
NCT02449902
TXV13-01 Estradiol Vaginal Softgel Capsules in Treating Postmenopausal Women With Symptoms of Vulvar and Vaginal Atrophytreatment2completed
NCT03557398
Efficacy and Safety of HYDEAL-D Vaginal Pessaries Application on the Treatment of Vaginal Atrophy in Post-menopause WomenNo drug interventionstreatmentNot Availablecompleted
NCT04607798
Multi-polar RF and PEMF for Treatment of Vulvovaginal AtrophyNo drug interventionstreatmentNot Availablecompleted
NCT04210583
RF and PEMF for Treatment of Vaginal Laxity and Mons Pubis and Labia for Improvement of Skin LaxityNo drug interventionsotherNot Availablecompleted
NCT05586711
Local DHEA and Estradiol on Dyspareunia in Postmenopausal Womentreatment4recruiting
NCT04746456
Vulvovaginal Atrophy Questionnaire (VVAQ): Psychometric Validation of a Novel PROMNo drug interventionsNot AvailableNot Availablerecruiting
NCT03044652
Investigation of Non-inferiority of Treatment of Vulvovaginal Dryness With WO2085 Moisturising Cream in Comparison to a Cream With 0.1% Estrioltreatment4completed
NCT02784613
Vulvoscopy Changes of the Vulva, Vestibule and Vagina With Daily Ospemifene in Women With Dyspareunia From VVAtreatment4completed
NCT05562518
GRACE-trial: a Randomized Active-controlled Trial for vulvovaGinal atRophy in breAst Cancer Patients on Endocrine Therapy.treatment4recruiting
NCT03666819
Carbon Dioxide Fractional Laser in Treating Participants With Stage 0-III Hormone Receptor-Positive Breast Cancer With Vulvovaginal AtrophyNo drug interventionstreatment2withdrawn
NCT01084616
Vaginal Microbiota Among Postmenopausal WomenNo drug interventionsNot AvailableNot Availablecompleted
NCT01816139
Multicenter Study to Evaluate Safety and Efficacy of WC3011 (Estradiol Vaginal Cream) in Postmenopausal Womentreatment3completed
NCT03593122
Investigation on the Efficacy of WO 2085 Moisturising Cream for Breast Cancer Patients Suffering From Vulvovaginal DrynessNo drug interventionstreatmentNot Availablecompleted
NCT04219722
Efficacy and Safety of Hyaluronic Acid Injection on Symptoms of Vulvovaginal Atrophy in Postmenopausal WomenNo drug interventionstreatmentNot Availablecompleted
NCT05418426
A Phase 1, Open-Label, Parallel Group Study to Evaluate the Pharmacokinetics and Safety of DARE-HRT1 in Healthy PostMenopausal Womenother1completed
NCT04021966
Use of Fractional CO2 Laser for the Treatment of Vulvovaginal Atrophy: a Double-blinded Randomized Placebo-controlled Clinical Trial.No drug interventionstreatmentNot Availablecompleted
NCT03823560
Performance and Safety of Class IIb MD Celegyn® in VVANo drug interventionstreatmentNot Availableunknown_status
NCT04579991
Effects of Visnadin, Ethyl Ximeninate, Coleus Barbatus and Millet in Emulgel on Sexual Function in Postmenopausal WomenNo drug interventionstreatmentNot Availablerecruiting
NCT02419729
Evaluation of Fractional CO2 Laser Treatment Efficacy and Comparison to Vaginal Estrogen Therapy in Postmenopausal Women With Vulvovaginal Atrophytreatment3completed
NCT03628092
Laser Therapy for Vulvovaginal Symptoms in Breast Cancer PatientsNo drug interventionstreatmentNot Availableunknown_status
NCT04487392
Photobiomodulation Effect on Vulvovaginal Atrophy in Postmenopausal Women.treatment2withdrawn
NCT03271944
Fractional Handpiece With CO2 Laser: Fractional Ablative Laser Treatment of Vulvovaginal AtrophyNo drug interventionstreatmentNot Availableunknown_status
NCT03682601
Sexual Penetration Pain in Postmenopausal Women: A Topical Botanical Drug Treatmenttreatment2terminated
NCT01319968
Postpartum Dyspareunia Resulting From Vaginal AtrophyNot AvailableNot Availablecompleted
NCT03725410
Multi-polar RF and PEMF for Treatment of Symptoms Associated With Vulvovaginal AtrophyNo drug interventionstreatmentNot Availablecompleted
NCT06144814
A Comparison of Hyaluronic Acid and Estradiol Treatment in Vulvovaginal Atrophy.treatmentNot Availablecompleted
NCT03900143
Safety, Efficacy and Usage Compliance of the Silk'n Tightra DeviceNo drug interventionstreatmentNot Availablecompleted
NCT04355403
Performance and Safety of Hyalo Gyn Gel on the Treatment of Vaginal Atrophy in Postmenopausal WomenNo drug interventionstreatmentNot Availablecompleted
NCT03385551
Study to Evaluate Estradiol Vaginal Tablets vs Promestriene Vaginal CreamNot AvailableNot Availablecompleted
NCT04222647
Investigation of Efficacy and Tolerability of a Lactic Acid Containing Vaginal Suppository in Post-menopausal Women With VVANo drug interventionstreatment2completed
NCT01455597
Evaluate Long-Term Safety and Efficacy WC3011 (Estradiol Vaginal Cream)treatment3completed
NCT04607707
Women's Satisfaction and Adherence to Vulvovaginal Atrophy TreatmentsNo drug interventionsNot AvailableNot Availablecompleted
NCT04898556
Clinical Study to Evaluate the Efficacy of Prasterone Treatment for Atrophy Vulvovaginal in Postmenopausal Women With Vulvar / Vestibular Paintreatment3unknown_status
NCT03536585
Multi-polar RF and PEMF for Treatment of Vaginal Laxity and Mons Pubis and Labia for Improvement of Skin LaxityNo drug interventionstreatmentNot Availablecompleted
NCT04629885
Study to Evaluate Efficacy of Vagitocin in Postmenopausal Women With Vulvovaginal Atrophy Symptomstreatment2completed
NCT02670785
A Safety and Efficacy Study of Estradiol Vaginal Capsule in Postmenopausal Women With Vulvovaginal Atrophytreatment2completed
NCT01845649
Study to Evaluate Safety and Efficacy of WC3011 (Estradiol Vaginal Cream) in Postmenopausal Women With Dyspareuniatreatment3completed
NCT04232813
Evaluation of the Acceptability and Efficacy of 10 Micrograms of Estradiol Vaginal Tablets vs Promestriene Vaginal Creamtreatment3completed
NCT04766957
Pilot Clinical Trial of IDRACARE® in Moderate to Severe Symptoms of Vulvovaginal AtrophyNo drug interventionstreatmentNot Availablecompleted
NCT05367973
Study of DARE-HRT1 Over 12 Weeks in Healthy PostMenopausal WomenNo drug interventionstreatment1 / 2completed
NCT02253173
Estradiol Vaginal Softgel Capsules in Treating Symptoms of Vulvar and Vaginal Atrophy in Postmenopausal Womentreatment3completed
NCT03083262
High Tone Pelvic Floor DysfunctionNo drug interventionsNot AvailableNot Availablecompleted
NCT03782480
Examining Effects of Intrarosa in Women With Genitourinary Syndrome of Menopause/Vulvovaginal Atrophytreatment3unknown_status
NCT02085980
Clinical Investigation to Assess the Safety and Efficacy of the Laser for the Treatment of Vulvovaginal AtrophyNo drug interventionstreatmentNot Availablecompleted
NCT04887701
Non-hormonal Medical Device for Treatment of Vulvovaginal Atrophy (VVA) in Post-Menopausal WomenNo drug interventionstreatmentNot Availablecompleted
NCT03281655
Visnadine, Prenylflavonoids and Bovine Colostrum to Treat Vulvovaginal Atrophy in Postmenopausal Womentreatment2completed