Marginal Zone Lymphoma (MZL)

Also known as: MZL / Marginal Zone Lymphomas / Marginal Lymphoma / Lymphoma, Marginal Zone / Marginal Zone Lymphoma / Marginal zone B-cell lymphoma (morphologic abnormality) / Marginal zone lymphoma (disorder) / Primary cutaneous marginal zone B-cell lymphoma (disorder) / Primary cutaneous marginal zone B-cell lymphoma (morphologic abnormality) / Bronchus-associated lymphoid tissue lymphoma / BALT lymphoma / Small cell B-cell lymphoma / Nodal marginal zone B-cell lymphoma (disorder) / Nodal marginal zone B-cell lymphoma / Monocytoid B-cell lymphoma (disorder) / Nodal marginal zone B-cell lymphomas / Nodal marginal zone B-cell lymphoma NOS / Nodal marginal zone B-cell lymphoma (morphologic abnormality) / Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma] / Lymphoma, B-Cell, Marginal Zone / MALT lymphoma / Mucosa-associated lymphoma (disorder) / Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (disorder) / Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (morphologic abnormality)

Drug	Drug Name	Drug Description
DB09053	Ibrutinib	An antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia.
DB00480	Lenalidomide	A thalidomide derivative used to treat multiple myeloma and anemia in low to intermediate risk myelodysplastic syndrome.
DB15035	Zanubrutinib	A kinase inhibitor used to treat mantle cell lymphoma, a type of B-cell non-Hodgkin lymphoma, in adults who previously received therapy.

Drug	Drug Name	Target	Type
DB09053	Ibrutinib	Tyrosine-protein kinase BTK	target
DB09053	Ibrutinib	Cytochrome P450 3A4	enzyme
DB09053	Ibrutinib	Cytochrome P450 3A5	enzyme
DB09053	Ibrutinib	Albumin	carrier
DB09053	Ibrutinib	alpha1-acid glycoprotein	carrier
DB09053	Ibrutinib	Cytochrome P450 2D6	enzyme
DB00480	Lenalidomide	Prostaglandin G/H synthase 2	target
DB00480	Lenalidomide	Tumor necrosis factor ligand superfamily member 11	target
DB00480	Lenalidomide	Cadherin-5	target
DB00480	Lenalidomide	Protein cereblon	target
DB00480	Lenalidomide	ATP-dependent translocase ABCB1	transporter
DB00480	Lenalidomide	Tumor necrosis factor	target
DB15035	Zanubrutinib	Cytochrome P450 3A4	enzyme
DB15035	Zanubrutinib	ATP-dependent translocase ABCB1	transporter
DB15035	Zanubrutinib	Cytochrome P450 2B6	enzyme
DB15035	Zanubrutinib	Tyrosine-protein kinase BTK	target
DB15035	Zanubrutinib	Epidermal growth factor receptor	target
DB15035	Zanubrutinib	Receptor tyrosine-protein kinase erbB-2	target
DB15035	Zanubrutinib	Receptor tyrosine-protein kinase erbB-4	target
DB15035	Zanubrutinib	Tyrosine-protein kinase ITK/TSK	target
DB15035	Zanubrutinib	Cytoplasmic tyrosine-protein kinase BMX	target
DB15035	Zanubrutinib	Tyrosine-protein kinase JAK2	target
DB15035	Zanubrutinib	Tyrosine-protein kinase Tec	target
DB15035	Zanubrutinib	Tyrosine-protein kinase Blk	target
DB15035	Zanubrutinib	Tyrosine-protein kinase JAK3	target
DB15035	Zanubrutinib	Protein-tyrosine kinase 6	target
DB15035	Zanubrutinib	Tyrosine-protein kinase Fgr	target
DB15035	Zanubrutinib	Tyrosine-protein kinase FRK	target
DB15035	Zanubrutinib	Tyrosine-protein kinase Lck	target
DB15035	Zanubrutinib	Tyrosine-protein kinase TXK	target
DB15035	Zanubrutinib	Cytochrome P450 3A Subfamily	enzyme

Drug	Drug Name	Phase	Status	Count
DB00188	Bortezomib	Not Available	Terminated	1
DB16741	Bortezomib D-mannitol	Not Available	Terminated	1
DB00531	Cyclophosphamide	Not Available	Terminated	1
DB11952	Duvelisib	Not Available	Not Yet Recruiting	1
DB04958	Epratuzumab	Not Available	Completed	1
DB08935	Obinutuzumab	Not Available	Recruiting	1
DB16272	Orelabrutinib	Not Available	Recruiting	1
DB09037	Pembrolizumab	Not Available	Recruiting	1
DB00635	Prednisone	Not Available	Terminated	1
DB00073	Rituximab	Not Available	Completed	1
DB00073	Rituximab	Not Available	Recruiting	2
DB00073	Rituximab	Not Available	Terminated	1
DB15035	Zanubrutinib	Not Available	Recruiting	1
DB10319	Streptococcus pneumoniae type 1 capsular polysaccharide antigen	0	Completed	1
DB10329	Streptococcus pneumoniae type 10a capsular polysaccharide antigen	0	Completed	1
DB10330	Streptococcus pneumoniae type 11a capsular polysaccharide antigen	0	Completed	1
DB10331	Streptococcus pneumoniae type 12f capsular polysaccharide antigen	0	Completed	1
DB10332	Streptococcus pneumoniae type 14 capsular polysaccharide antigen	0	Completed	1
DB10333	Streptococcus pneumoniae type 15b capsular polysaccharide antigen	0	Completed	1
DB10334	Streptococcus pneumoniae type 17f capsular polysaccharide antigen	0	Completed	1
DB10335	Streptococcus pneumoniae type 18c capsular polysaccharide antigen	0	Completed	1
DB10337	Streptococcus pneumoniae type 19a capsular polysaccharide antigen	0	Completed	1
DB10336	Streptococcus pneumoniae type 19f capsular polysaccharide antigen	0	Completed	1
DB10320	Streptococcus pneumoniae type 2 capsular polysaccharide antigen	0	Completed	1
DB10338	Streptococcus pneumoniae type 20 capsular polysaccharide antigen	0	Completed	1
DB10339	Streptococcus pneumoniae type 22f capsular polysaccharide antigen	0	Completed	1
DB10340	Streptococcus pneumoniae type 23f capsular polysaccharide antigen	0	Completed	1
DB10321	Streptococcus pneumoniae type 3 capsular polysaccharide antigen	0	Completed	1
DB10341	Streptococcus pneumoniae type 33f capsular polysaccharide antigen	0	Completed	1
DB10322	Streptococcus pneumoniae type 4 capsular polysaccharide antigen	0	Completed	1
DB10323	Streptococcus pneumoniae type 5 capsular polysaccharide antigen	0	Completed	1
DB10324	Streptococcus pneumoniae type 6b capsular polysaccharide antigen	0	Completed	1
DB10325	Streptococcus pneumoniae type 7f capsular polysaccharide antigen	0	Completed	1
DB10326	Streptococcus pneumoniae type 8 capsular polysaccharide antigen	0	Completed	1
DB10327	Streptococcus pneumoniae type 9n capsular polysaccharide antigen	0	Completed	1
DB10328	Streptococcus pneumoniae type 9v capsular polysaccharide antigen	0	Completed	1
DB13906	Aloe vera leaf	1	Completed	1
DB09312	Antilymphocyte immunoglobulin (horse)	1	Completed	1
DB00098	Antithymocyte immunoglobulin (rabbit)	1	Completed	1
DB00126	Ascorbic acid	1	Completed	1
DB00928	Azacitidine	1	Terminated	1
DB17387	BR101801	1	Active Not Recruiting	1
DB06769	Bendamustine	1	Active Not Recruiting	1
DB06769	Bendamustine	1	Completed	1
DB06769	Bendamustine	1	Withdrawn	1
DB19293	CDX-301	1	Completed	1
DB01413	Cefepime	1	Completed	1
DB12483	Copanlisib	1	Active Not Recruiting	1
DB00531	Cyclophosphamide	1	Active Not Recruiting	2
DB00531	Cyclophosphamide	1	Recruiting	2
DB00531	Cyclophosphamide	1	Withdrawn	1
DB00997	Doxorubicin	1	Withdrawn	1
DB00099	Filgrastim	1	Completed	1
DB00196	Fluconazole	1	Completed	1
DB01073	Fludarabine	1	Active Not Recruiting	1
DB01073	Fludarabine	1	Completed	1
DB01073	Fludarabine	1	Recruiting	2
DB09462	Glycerin	1	Completed	1
DB18458	IMMU-114	1	Terminated	1
DB09053	Ibrutinib	1	Withdrawn	1
DB09054	Idelalisib	1	Completed	1
DB00480	Lenalidomide	1	Terminated	1
DB16222	Loncastuximab tesirine	1	Completed	1
DB16225	Magrolimab	1	Completed	1
DB16620	Methopterin	1	Completed	1
DB00563	Methotrexate	1	Completed	1
DB02701	Nicotinamide	1	Completed	1
DB09035	Nivolumab	1	Active Not Recruiting	1
DB08935	Obinutuzumab	1	Completed	1
DB08935	Obinutuzumab	1	Recruiting	1
DB00338	Omeprazole	1	Completed	1
DB09037	Pembrolizumab	1	Completed	1
DB17472	Pirtobrutinib	1	Not Yet Recruiting	1
DB00635	Prednisone	1	Withdrawn	1
DB00912	Repaglinide	1	Completed	1
DB00073	Rituximab	1	Completed	1
DB00073	Rituximab	1	Withdrawn	1
DB00864	Tacrolimus	1	Completed	1
DB12887	Tazemetostat	1	Completed	2
DB18806	Temuterkib	1	Withdrawn	1
DB11850	Ublituximab	1	Terminated	2
DB11581	Venetoclax	1	Completed	1
DB11581	Venetoclax	1	Recruiting	2
DB11581	Venetoclax	1	Terminated	1
DB00541	Vincristine	1	Withdrawn	1
DB00162	Vitamin A	1	Completed	1
DB15157	Voruciclib	1	Recruiting	1
DB15035	Zanubrutinib	1	Recruiting	1
DB18457	Zilovertamab vedotin	1	Completed	1
DB15773	anti-OX40 antibody BMS 986178	1	Active Not Recruiting	1
DB11703	Acalabrutinib	1 / 2	Active Not Recruiting	1
DB16741	Bortezomib D-mannitol	1 / 2	Withdrawn	1
DB00631	Clofarabine	1 / 2	Completed	1
DB00531	Cyclophosphamide	1 / 2	Active Not Recruiting	1
DB00531	Cyclophosphamide	1 / 2	Completed	1
DB00997	Doxorubicin	1 / 2	Active Not Recruiting	1
DB00997	Doxorubicin	1 / 2	Completed	1
DB12121	Entospletinib	1 / 2	Completed	1
DB16672	Epcoritamab	1 / 2	Active Not Recruiting	2
DB16672	Epcoritamab	1 / 2	Terminated	1
DB00441	Gemcitabine	1 / 2	Active Not Recruiting	1
DB09053	Ibrutinib	1 / 2	Active Not Recruiting	1
DB09053	Ibrutinib	1 / 2	Completed	1
DB09054	Idelalisib	1 / 2	Completed	1
DB17331	Imvotamab	1 / 2	Terminated	1
DB00480	Lenalidomide	1 / 2	Active Not Recruiting	1
DB00480	Lenalidomide	1 / 2	Completed	1
DB00480	Lenalidomide	1 / 2	Recruiting	1
DB18866	Nemtabrutinib	1 / 2	Active Not Recruiting	1
DB08935	Obinutuzumab	1 / 2	Completed	1
DB00526	Oxaliplatin	1 / 2	Active Not Recruiting	1
DB09037	Pembrolizumab	1 / 2	Active Not Recruiting	1
DB00552	Pentostatin	1 / 2	Withdrawn	1
DB17472	Pirtobrutinib	1 / 2	Active Not Recruiting	1
DB12240	Polatuzumab vedotin	1 / 2	Recruiting	1
DB00635	Prednisone	1 / 2	Active Not Recruiting	1
DB00635	Prednisone	1 / 2	Completed	1
DB00073	Rituximab	1 / 2	Active Not Recruiting	2
DB00073	Rituximab	1 / 2	Completed	1
DB00073	Rituximab	1 / 2	Recruiting	1
DB00073	Rituximab	1 / 2	Withdrawn	1
DB17130	Spanlecortemlocel	1 / 2	Completed	1
DB14922	Tislelizumab	1 / 2	Active Not Recruiting	1
DB15320	Toll-like receptor 9	1 / 2	Completed	1
DB11850	Ublituximab	1 / 2	Completed	1
DB16657	Vecabrutinib	1 / 2	Terminated	1
DB11581	Venetoclax	1 / 2	Active Not Recruiting	1
DB00541	Vincristine	1 / 2	Active Not Recruiting	1
DB00541	Vincristine	1 / 2	Completed	1
DB15035	Zanubrutinib	1 / 2	Active Not Recruiting	1
DB18403	Zilovertamab	1 / 2	Active Not Recruiting	1
DB11703	Acalabrutinib	2	Active Not Recruiting	1
DB11703	Acalabrutinib	2	Recruiting	1
DB11703	Acalabrutinib	2	Terminated	1
DB00437	Allopurinol	2	Recruiting	1
DB13906	Aloe vera leaf	2	Terminated	1
DB09312	Antilymphocyte immunoglobulin (horse)	2	Terminated	1
DB00098	Antithymocyte immunoglobulin (rabbit)	2	Terminated	1
DB00126	Ascorbic acid	2	Terminated	1
DB11595	Atezolizumab	2	Completed	1
DB13915	Axicabtagene ciloleucel	2	Active Not Recruiting	1
DB00928	Azacitidine	2	Terminated	1
DB06769	Bendamustine	2	Recruiting	1
DB06769	Bendamustine	2	Withdrawn	1
DB00188	Bortezomib	2	Recruiting	1
DB00188	Bortezomib	2	Terminated	1
DB16741	Bortezomib D-mannitol	2	Completed	1
DB16741	Bortezomib D-mannitol	2	Recruiting	1
DB16741	Bortezomib D-mannitol	2	Terminated	1
DB08870	Brentuximab vedotin	2	Withdrawn	1
DB01008	Busulfan	2	Completed	1
DB00958	Carboplatin	2	Terminated	1
DB08889	Carfilzomib	2	Terminated	1
DB12483	Copanlisib	2	Active Not Recruiting	1
DB00531	Cyclophosphamide	2	Active Not Recruiting	2
DB00531	Cyclophosphamide	2	Completed	1
DB00531	Cyclophosphamide	2	Recruiting	2
DB00091	Cyclosporine	2	Active Not Recruiting	1
DB06210	Eltrombopag	2	Terminated	1
DB00445	Epirubicin	2	Recruiting	1
DB00773	Etoposide	2	Terminated	1
DB01073	Fludarabine	2	Active Not Recruiting	2
DB01073	Fludarabine	2	Completed	1
DB01073	Fludarabine	2	Recruiting	1
DB00441	Gemcitabine	2	Terminated	1
DB16371	Glofitamab	2	Recruiting	1
DB09462	Glycerin	2	Terminated	1
DB00078	Ibritumomab tiuxetan	2	Completed	1
DB09053	Ibrutinib	2	Active Not Recruiting	1
DB09053	Ibrutinib	2	Completed	1
DB09053	Ibrutinib	2	Withdrawn	1
DB09054	Idelalisib	2	Active Not Recruiting	1
DB09054	Idelalisib	2	Completed	1
DB01181	Ifosfamide	2	Terminated	1
DB05003	Imexon	2	Completed	1
DB15244	Iopofosine I-131	2	Recruiting	1
DB09570	Ixazomib	2	Active Not Recruiting	1
DB00480	Lenalidomide	2	Recruiting	3
DB00480	Lenalidomide	2	Terminated	1
DB16222	Loncastuximab tesirine	2	Recruiting	1
DB01042	Melphalan	2	Completed	1
DB15434	Mosunetuzumab	2	Recruiting	2
DB00075	Muromonab	2	Recruiting	1
DB00688	Mycophenolate mofetil	2	Active Not Recruiting	1
DB00688	Mycophenolate mofetil	2	Completed	1
DB00688	Mycophenolate mofetil	2	Recruiting	1
DB02701	Nicotinamide	2	Terminated	1
DB08935	Obinutuzumab	2	Active Not Recruiting	1
DB08935	Obinutuzumab	2	Completed	1
DB08935	Obinutuzumab	2	Recruiting	8
DB06650	Ofatumumab	2	Completed	1
DB16272	Orelabrutinib	2	Recruiting	4
DB09037	Pembrolizumab	2	Active Not Recruiting	1
DB17472	Pirtobrutinib	2	Not Yet Recruiting	1
DB12240	Polatuzumab vedotin	2	Recruiting	1
DB00635	Prednisone	2	Recruiting	1
DB00073	Rituximab	2	Active Not Recruiting	4
DB00073	Rituximab	2	Completed	3
DB00073	Rituximab	2	Not Yet Recruiting	2
DB00073	Rituximab	2	Recruiting	3
DB00073	Rituximab	2	Terminated	3
DB00073	Rituximab	2	Withdrawn	1
DB00877	Sirolimus	2	Recruiting	1
DB00864	Tacrolimus	2	Completed	1
DB00864	Tacrolimus	2	Terminated	1
DB15044	Tafasitamab	2	Active Not Recruiting	1
DB04572	Thiotepa	2	Active Not Recruiting	1
DB00135	Tyrosine	2	Recruiting	1
DB11850	Ublituximab	2	Completed	1
DB14989	Umbralisib	2	Completed	2
DB14989	Umbralisib	2	Terminated	1
DB11581	Venetoclax	2	Active Not Recruiting	1
DB11581	Venetoclax	2	Completed	1
DB11581	Venetoclax	2	Not Yet Recruiting	1
DB00162	Vitamin A	2	Terminated	1
DB02546	Vorinostat	2	Terminated	1
DB18245	Zandelisib	2	Terminated	1
DB15035	Zanubrutinib	2	Completed	2
DB15035	Zanubrutinib	2	Recruiting	2
DB06769	Bendamustine	2 / 3	Terminated	1
DB11850	Ublituximab	2 / 3	Terminated	1
DB14989	Umbralisib	2 / 3	Terminated	1
DB06769	Bendamustine	3	Completed	1
DB06769	Bendamustine	3	Recruiting	1
DB06769	Bendamustine	3	Terminated	1
DB06769	Bendamustine	3	Withdrawn	1
DB19176	Boclatixafortide gallium Ga-68	3	Recruiting	1
DB00531	Cyclophosphamide	3	Completed	2
DB00531	Cyclophosphamide	3	Terminated	1
DB00997	Doxorubicin	3	Completed	2
DB11952	Duvelisib	3	Withdrawn	1
DB09053	Ibrutinib	3	Active Not Recruiting	1
DB00480	Lenalidomide	3	Active Not Recruiting	1
DB00480	Lenalidomide	3	Recruiting	3
DB15434	Mosunetuzumab	3	Recruiting	1
DB08935	Obinutuzumab	3	Recruiting	1
DB08935	Obinutuzumab	3	Withdrawn	1
DB16684	Odronextamab	3	Recruiting	1
DB14867	Parsaclisib	3	Withdrawn	1
DB00635	Prednisone	3	Completed	2
DB00635	Prednisone	3	Terminated	1
DB00073	Rituximab	3	Active Not Recruiting	3
DB00073	Rituximab	3	Completed	3
DB00073	Rituximab	3	Recruiting	3
DB00073	Rituximab	3	Terminated	1
DB00073	Rituximab	3	Withdrawn	2
DB15044	Tafasitamab	3	Active Not Recruiting	1
DB00541	Vincristine	3	Completed	2
DB00541	Vincristine	3	Terminated	1
DB18245	Zandelisib	3	Terminated	1
DB15035	Zanubrutinib	3	Recruiting	1