Anaphylaxis (DBCOND0001820)

Identifiers

Synonyms
Anaphylaxis reactions / Anaphylactic / Anaphylaxis reaction / Anaphylactic-type reactions / Anaphylactic Reaction / Anaphylactic responses / Anaphylactic symptoms / Anaphylactic reactions / Systemic anaphylaxis / Systemic anaphylactic reaction / Anaphylaxis (disorder) / Anaphylactic shock, unspecified / Anaphylactic shock / Allergic shock / Shock due to anaphylaxis (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Carbinoxamine
A first generation antihistamine used to treat allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, allergic reactions, and mild allergic reactions.
Cyproheptadine
A combined serotonin and histamine antagonist used in the treatment of allergic symptoms, for appetite stimulation, and off-label in the treatment of serotonin syndrome.
Dimetindene
A 1st generation selective H1 antagonist used topically as an antipruritic and orally to treat allergies.
Diphenhydramine
A H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.
Epinephrine
A hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma.
Hydrocortisone phosphate
A corticosteroid used to treat congenital adrenal hyperplasia, for emergency asthma treatment, hypersensitivity, and inflammation.
Pheniramine
An antihistamine used to treat allergic rhinitis and pruritus.
Prednisolone hemisuccinate
A corticosteroid indicated in the treatment of anaphylaxis, asthma, edema, organ rejection, and other indications.
Promethazine
A first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT04475003
Health Literacy Among Caregivers of Children With IgE-mediated Allergy With Risk of AnaphylaxisNo drug interventionsNot AvailableNot Availableunknown_status
NCT05210543
Acquisition and Long-term Observation of Patients With Severe Allergic ReactionsNo drug interventionsNot AvailableNot Availablerecruiting
NCT05135377
Canadian Anaphylaxis Network- Predicting Recurrence After Emergency Presentation for Allergic REactionNo drug interventionsNot AvailableNot Availablerecruiting
NCT01361347
Safety of Oral Immunotherapy for Cow's Milk Allergy in School-aged ChildrenNo drug interventionstreatment4completed
NCT02958605
Smartphone Apps for Pediatric ResuscitationNo drug interventionstreatmentNot Availablecompleted
NCT06065137
Standardised Drug Provocation Testing in Perioperative HypersensitivityNo drug interventionsdiagnosticNot Availablerecruiting
NCT06205134
Comparative Bioavailability of Intranasal Epinephrinetreatment1 / 2completed
NCT00163735
Potential Allergens in Wine: Double-blind Placebo-controlled TrialNo drug interventionsdiagnosticNot Availablecompleted
NCT04696822
Bioavailability of Nasal Epinephrinetreatment1completed
NCT03406325
Mast Cell Activation Test in Allergic DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT02028065
A Study to Evaluate the Incidence of Hypersensitivity After Administration of Sugammadex in Healthy Participants (MK-8616-101)treatment1completed
NCT04615065
Acutelines: a Large Data-/Biobank of Acute and Emergency MedicineNo drug interventionsNot AvailableNot Availablerecruiting
NCT06445374
Effects of Inhaled Epinephrine on Systemic Allergic Reactions During Allergy Testing Immunotherapy or Oral Challengestreatment1recruiting
NCT03182491
Mechanisms of AnaphylaxisNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT01776489
Evaluation of the Sphingolipid Metabolite S1P as a Novel Biomarker in Food AllergyNo drug interventionsNot AvailableNot Availableunknown_status
NCT03942692
What is the Allergy Follow-up for Children After Anaphylactic Reaction? AFCAR : Allergy Follow-up for Children After Anaphylactic ReactionNo drug interventionsNot AvailableNot Availablecompleted
NCT05112367
Epidemiology and Management of Pediatric Anaphylaxis and Allergy in the Pediatric Emergency Department of MontpellierNo drug interventionsNot AvailableNot Availableunknown_status
NCT02854969
Satisfaction of Patient With Anaphylaxis in the Use of a Medical DeviceNo drug interventionssupportive_careNot Availablecompleted
NCT04755881
SHARED Study (Saguenay Hospitals Anaphylaxis Rule for Early Discharge)No drug interventionsNot AvailableNot Availableterminated
NCT03523221
Use of Dexamethasone in Prevention of the Second Phase or a Biphasic Reaction of Anaphylaxistreatment1recruiting
NCT03366298
Pharmacokinetics of Intramuscular Adrenaline in Food--Allergic Teenagerstreatment4completed
NCT00657228
Intravenous Heparin as an Adjunct for the Treatment of Anaphylactic Reactions in an Emergency DepartmenttreatmentNot Availablewithdrawn
NCT04290507
Epidemiology and Outcome of Anaphylactic Shocks Admitted to Intensive Care UnitNo drug interventionsNot AvailableNot Availablecompleted
NCT01247415
Clinical Investigation on Allergic-like Reactions and Oculo-respiratory Syndrome After the H1N1 Pandemic VaccineNo drug interventionsNot AvailableNot Availableunknown_status
NCT00868842
Desensitization of Human Mast Cells: Mechanisms and Potential Utility for Preventing AnaphylaxisNo drug interventionsNot AvailableNot Availablecompleted
NCT02424136
PEAnut Anaphylaxis PredictorsNo drug interventionsdiagnosticNot Availablecompleted
NCT00047918
Blood Factors in Mastocytosis and Unexplained Anaphylaxis and FlushingNo drug interventionsNot AvailableNot Availablecompleted
NCT01326741
Clonal Mast Cell Disorders in Exercise-Induced AnaphylaxisNo drug interventionsNot AvailableNot Availableunknown_status
NCT04653324
A Registry for the Food Allergy CommunityNo drug interventionsNot AvailableNot Availablerecruiting
NCT04825158
Study of the Role of Hemostasis in Perioperative AnaphylaxisNo drug interventionsNot AvailableNot Availableunknown_status
NCT01432522
A Study for Absorption of Intranasal Epinephrine Compared to Conventional Intramuscular EpinephrinetreatmentNot Availablecompleted
NCT03953482
Evaluation of Medical Care and Patient's Knowledge About the Behavior to Take on Secondary Prevention of AnaphylaxisNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT00890162
A Randomized, Double-Blind, Placebo-Controlled Study of Omalizumab for Idiopathic Anaphylaxistreatment2completed
NCT03282929
Study to Explore the Pharmacokinetics and Pharmacodynamics of Epinephrine in Healthy Male and Female Subjects With Different Skin to Muscle Depth (STMD)No drug interventionstreatment1completed
NCT04207840
Study of Drug Exposure in Systemic Circulation of Primatene Mist by Oral Inhalation, Versus Epinephrine Injection by Intramuscular Injection and ProAir by Oral Inhalation in Healthy Individualstreatment4completed
NCT02640014
Oral Immunotherapy in Food Allergy in FinlandNo drug interventionstreatmentNot Availableunknown_status
NCT01217138
Make up for the Epinephrine AutoinjectorNo drug interventionsNot Available4completed
NCT05028257
Allergy and COVID-19 Vaccinestreatment3completed
NCT03640884
Post-marketing Safety Surveillance of Xueshuantong-Injection : a Registry StudyNo drug interventionsNot AvailableNot Availableunknown_status
NCT06013150
Study of Inhaled DMC-IH1 and Intramuscular (EpiPenĀ®) Epinephrine in Healthy Male and Female Participants.treatment1completed
NCT06405399
Design, Implementation and Evaluation of the Guided Observer Role in Clinical SimulationNo drug interventionsotherNot Availablecompleted
NCT02559960
Post-marketing Safety Surveillance of Breviscapine Powder-Injection : a Registry StudyNo drug interventionsNot AvailableNot Availablesuspended
NCT05152901
Study of Inhaled Epinephrine and Intramuscular Epinephrine Administered to Healthy Adultstreatment1completed