Petit Mal Epilepsy (DBCOND0030469)

Identifiers

Synonyms

Absence seizure / Absence Seizures / Petit mal / Seizure, Absence / Absence Epilepsy / Epilepsy, Absence / Petit mal epilepsy / Convulsion petit mal / Petit mal convulsion / Generalised onset non-motor seizure / Generalized onset non-motor seizure / Epilepsy petit mal / Absence seizure (finding)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Ethosuximide	An anticonvulsant used to treat petit mal seizures.	Voltage-dependent T-type calcium channel subunit alpha-1Gtarget Cytochrome P450 3A4enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A Subfamilyenzyme
Phenytoin	An anticonvulsant drug used in the prophylaxis and control of various types of seizures.	Sodium channel protein type 5 subunit alphatarget Sodium channel protein type 1 subunit alphatarget Cytochrome P450 2C8enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2B6enzyme Cytochrome P450 3A5enzyme Albumincarrier Cytochrome P450 3A4enzyme Solute carrier organic anion transporter family member 1C1transporter ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 3A7enzyme Nuclear receptor subfamily 1 group I member 2target Sodium channel regulatory subunit beta-1target Sodium channel protein type 3 subunit alphatarget UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1-6enzyme UDP-glucuronosyltransferase 1A9enzyme Thyroxine-binding globulincarrier Voltage-gated inwardly rectifying potassium channel KCNH2target Voltage-dependent L-type calcium channeltarget Sodium channel protein type 2 subunit alphatarget Sodium channel protein type 8 subunit alphatarget GABA(A) Receptortarget Cytochrome P450 1A2enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2E1enzyme Epoxide hydrolase 1enzyme UDP-glucuronosyltransferase 1A4enzyme Catechol O-methyltransferaseenzyme NAD(P)H dehydrogenase [quinone] 1enzyme Cytochrome P450 2C18enzyme
Valproic acid	An anticonvulsant used to control complex partial seizures and both simple and complex absence seizures.	Histone deacetylase 9target Short/branched chain specific acyl-CoA dehydrogenase, mitochondrialtarget Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme Organic cation/carnitine transporter 2transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Monocarboxylate transporter 1transporter Solute carrier family 22 member 7transporter Cytochrome P450 3A5enzyme UDP-glucuronosyltransferase 1A9enzyme Prostaglandin G/H synthase 1enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme UDP-glucuronosyltransferase 1A4enzyme UDP-glucuronosyltransferase 1A8enzyme UDP-glucuronosyltransferase 1A10enzyme UDP-glucuronosyltransferase 1-6enzyme UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 2B15enzyme 2-oxoglutarate dehydrogenase complex component E1target Succinate-semialdehyde dehydrogenase, mitochondrialtarget Sodium channel proteintarget Histone deacetylase 2target Peroxisome proliferator-activated receptor alphatarget Peroxisome proliferator-activated receptor deltatarget Peroxisome proliferator-activated receptor gammatarget Albumincarrier UDP-glucuronosyltransferase 1A1enzyme Solute carrier organic anion transporter family member 2B1transporter Histone deacetylasetarget Cyclin-dependent kinase inhibitor 1target Hepatocyte growth factortarget Ornithine decarboxylasetarget Programmed cell death 1 ligand 1target 4-aminobutyrate aminotransferase, mitochondrialtarget Glycogen synthase kinase-3 alphatarget
Valpromide	A valproic acid derivative used to treat epilepsy and as adjunct therapy for psychomotor agitation, depression, and manic episodes of bipolar disorder.	Limonene-1,2-epoxide hydrolasetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04439656	Detecting Absence Seizures Using Eye Tracking	No drug interventions	Not Available	Not Available	completed
NCT04615442	ECV - Epihunter Clinical Validation	No drug interventions	diagnostic	Not Available	completed
NCT06310772	Assessing Comorbidities in Epilepsy Using Eye Movement Recordings	No drug interventions	Not Available	Not Available	recruiting
NCT00545012	A Safety and Efficacy Follow-up Study With Levetiracetam in Children (4-17 Years Old) Suffering From Absence Seizures	Levetiracetam	treatment	2	completed
NCT06093490	Detecting Absence Seizures Using Hyperventilation and Eye Movement Recordings	No drug interventions	Not Available	Not Available	recruiting
NCT00144872	LAMICTAL (Lamotrigine) For The Treatment Of Absence Seizures	Lamotrigine	treatment	1	completed
NCT00088452	Childhood Absence Epilepsy Rx PK-PD-Pharmacogenetics Study	Ethosuximide Lamotrigine Valproic acid	treatment	3	completed
NCT04274179	Ketogenic Diet for New-Onset Absence Epilepsy	Ethosuximide Lamotrigine Valproic acid	treatment	3	recruiting
NCT06401538	BMB-101 in Absence Epilepsy and DEE	No drug interventions	treatment	2	not_yet_recruiting
NCT02954107	Longitudinal Early Epilepsy Study	No drug interventions	Not Available	Not Available	unknown_status
NCT00210574	A Pilot Study of Topiramate in Childhood Absence Epilepsy	Topiramate	treatment	2	completed
NCT02766595	Does Body Positioning Affect the Yield of Hyperventilation in Routine Pediatric Electroencephalography - EEG Studies?	No drug interventions	diagnostic	Not Available	unknown_status
NCT04799795	Objective EEG Bed Side Assessment of Impaired Conscious Awareness in Epilepsy	No drug interventions	Not Available	Not Available	recruiting