Premature Ovarian Failure (POF) (DBCOND0053948)

Identifiers

Synonyms
Premature Ovarian Failure, / Ovarian Failure, Premature / Premature Ovarian Failure / Primary ovarian failure / Primary Ovarian Insufficiency / Premature ovarian failure (disorder) / Ovarian failure primary / Primary ovarian failure (disorder) / Premature menopause / Asymptomatic premature menopause / Menopause, Premature / Menopause premature / Early menopause / Climacterium praecox / Premature menopause (finding) / Ovarian failure / Ovarian failure (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Conjugated estrogens
A mixture of estrogens used in estrogen replacement therapy for menopause and hypoestrogenism, used in the treatment of various malignancies, and used in the treatment of postmenopausal osteoporosis.
Esterified estrogens
A female hormone used to treat conditions related to estrogen deficiency and moderate to severe vasomotor menopausal symptoms in women.
Estradiol
An estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate.
Estradiol valerate
An estradiol prodrug used to treat some effects of menopause, hypoestrogenism, androgen dependant carcinoma of the prostate, and in combination products for endometriosis and contraception.
Estrone sulfate
An estrogen used as monotherapy or in several combination hormone replacement products for managing menopause symptoms and hormone disorders.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT01742533
Stem Cell Therapy Combined Hormone Replacement Therapy in Patients With Premature Ovarian Failuretreatment1 / 2unknown_status
NCT00471731
Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian FailureNo drug interventionsNot AvailableNot Availablecompleted
NCT04009473
Stem Cell Therapy and Growth Factor Ovarian in Vitro ActivationNo drug interventionstreatment1 / 2unknown_status
NCT02780791
Maturation of Follicles After Transplantation of Ovarian Tissue Into the Pelvic Wall and the OvaryNo drug interventionstreatmentNot Availableterminated
NCT01023178
Comparison of Transdermal and Oral Estrogens in Adolescent Girls With Ovarian FailuretreatmentNot Availablecompleted
NCT04031456
Autologous PRP Infusion May Restore Ovarian Function and May Promote Folliculogenesis in POI Patientstreatment2 / 3recruiting
NCT05443282
Ovarian Reserve and Matrix MetalloproteinasesNo drug interventionsNot AvailableNot Availablecompleted
NCT03535480
Autologous Bone Marrow Stem Cell Ovarian Transplantation to Restore Ovarian Function in Premature Ovarian Failuretreatment4unknown_status
NCT02086318
A New Algorithm to Predict Ovarian AgeNo drug interventionsNot AvailableNot Availableunknown_status
NCT01411644
Pheno- & Genotyping POF (WHO III)No drug interventionsNot AvailableNot Availableunknown_status
NCT04881695
Evaluation of Child Desire in Young Women With Premature Ovarian FailureNo drug interventionsNot AvailableNot Availableunknown_status
NCT02151890
Pregnancy After Stem Cell Transplantation in Premature Ovarian FailureNo drug interventionstreatment1 / 2completed
NCT05462379
Autologous Heterotopic Fresh Ovarian Graft in Woman With LACC Eligible for Pelvic Radiotherapy Treatment.No drug interventionstreatment1 / 2recruiting
NCT05740579
The Danish TURNER Cryopreservation StudyNo drug interventionsotherNot Availablerecruiting
NCT00295087
X-Chromosome Inactivation Status and Premature Ovarian FailureNo drug interventionsNot AvailableNot Availablecompleted
NCT02644447
Transplantation of HUC-MSCs With Injectable Collagen Scaffold for POFNo drug interventionstreatment1 / 2completed
NCT01129947
The Use of DHEA in Women With Premature Ovarian FailureNo drug interventionstreatment0withdrawn
NCT04149028
Platelet Rich Plasma Injection Into Ovary of Patients With Premature Ovarian InsufficiencyNo drug interventionstreatmentNot Availablecompleted
NCT00732693
Evaluation of Physiologic and Standard Sex Steroid Replacement Regimens in Women With Premature Ovarian Failuretreatment4completed
NCT03069209
Autologous Bone Marrow-Derived Stem Cell Transplantation in Patients With Premature Ovarian Failure (POF)No drug interventionstreatment1 / 2unknown_status
NCT04306185
Ovarian Fragmentation Study (Crespo Medical Team)No drug interventionstreatmentNot Availableunknown_status
NCT02783937
Filgrastim for Premature Ovarian Insufficiencytreatment4completed
NCT03381300
Preservation of Ovarian Cortex Tissue in Girls With Turner SyndromeNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT06132542
Autologous ADMSC Transplantation in Patients With POINo drug interventionstreatment1not_yet_recruiting
NCT00370019
Effects of an Estrogen Replacement Therapy Skin Patch on Ovulation in Women With Premature Ovarian Failuretreatment2withdrawn
NCT00837616
Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolismtreatment4completed
NCT00119925
'SPRING'-Study: "Subfertility Guidelines: Patient Related Implementation in the Netherlands Among Gynaecologists"No drug interventionsNot AvailableNot Availableunknown_status
NCT03924648
Endocan Levels in Women With Premature Ovarian InsufficiencyNo drug interventionsNot AvailableNot Availablecompleted
NCT05838157
The Effect of HPV Vaccine on Menstrual Cycle in Women of Reproductive AgeNo drug interventionsNot AvailableNot Availablerecruiting
NCT00417157
Modified Natural Cycle Offers a Chance of Pregnancy in Patients With Poor Response and High Basal FSHNot AvailableNot Availablecompleted
NCT02779374
Autologous Bone Marrow Transplantation for Premature Ovarian InsufficiencyNo drug interventionstreatmentNot Availableterminated
NCT03474120
Prospective Genetic Study in Patients With Ovarian InsufficiencyNo drug interventionsNot AvailableNot Availableunknown_status
NCT02467231
Ovarian Reserve After Cancer: Longitudinal EffectsNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT00429494
GnRH Analogue for Ovarian Function Preservation in Hematopoietic Stem Cell Transplantation Patientstreatment2completed
NCT04536467
Prevention of Chemotherapy-Induced Ovarian Failure With Goserelin in Premenopausal Lymphoma Patientsprevention2enrolling_by_invitation
NCT05138367
Effects of UCA-PSCs in Women With POFNo drug interventionstreatment1completed
NCT01853501
Effects of ADSC Therapy in Women With POFNo drug interventionstreatment4unknown_status
NCT02912104
A Therapeutic Trial of Human Amniotic Epithelial Cells Transplantation for Primary Ovarian Failuretreatment1completed
NCT03207412
Human Amniotic Epithelial Cells Treatment for Ovarian InsufficiencytreatmentNot Availableunknown_status
NCT03480412
Second Step Protocol in Poor Ovarian Responder (POR)No drug interventionsNot AvailableNot Availableunknown_status
NCT03178695
Inovium Ovarian Rejuvenation TrialsNo drug interventionstreatment1completed
NCT04390308
Is There A Role For Mechanical Stimulation In Ovarian Follicular Activation?No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT02043743
Autologous Stem Cells Transplantation in Patients With Idiopathic and Drug Induced Premature Ovarian FailureNo drug interventionstreatment1 / 2unknown_status
NCT03412487
Ovarian Histopathology and Laparoscopic Assessment of Premature Ovarian FailureNo drug interventionsdiagnosticNot Availableunknown_status
NCT00619333
Inactive FSH in GalactosemiaNot AvailableNot Availableunknown_status
NCT00001951
Hormone Replacement in Young Women With Premature Ovarian FailureNo drug interventionstreatment2completed
NCT04767451
Levels of Selected Microelements in Premature Ovarian InsufficiencyNo drug interventionsNot AvailableNot Availableunknown_status
NCT06202547
Intra-ovarian Injection of MSC-EVs in Idiopathic Premature Ovarian Failuretreatment1 / 2recruiting
NCT00140998
Estrogen Treatment (Oral vs. Patches) in Turner Syndrometreatment3completed
NCT04922398
Ovarian Injection of PRP (Platelet -Rich Plasma) Vs Normal Saline in Premature Ovarian Insufficiencytreatment1 / 2unknown_status
NCT04800705
Levels of Selected Macroelements in Premature Ovarian InsufficiencyNo drug interventionsNot AvailableNot Availableunknown_status
NCT00780897
Premature Ovarian Failure (Genetic and Physiopathologic Analysis)No drug interventionsNot AvailableNot Availableunknown_status
NCT05667428
A Multicenter Open-label Clinical Study on the Prevention of Premature Ovarian Failure After HSCTpreventionNot Availablenot_yet_recruiting
NCT06121388
Brain MRI Imaging Changes and Associated Factors on Cognition Function in Patients With Premature Ovarian FailureNo drug interventionsNot AvailableNot Availablerecruiting
NCT04237909
Effects of Intraovarian Platelet Rich Plasma in Women With Poor Ovarian Response and Premature Ovarian InsufficiencytreatmentNot Availablecompleted
NCT00006156
Feasibility Study for Development of an Early Test for Ovarian FailurediagnosticNot Availablecompleted
NCT03861715
Single Follicular Dexarelix for LH Suppression During Ovarian Stimulation in Oocyte Donors.No drug interventionsNot AvailableNot Availableunknown_status
NCT03816852
The Safety and Efficiency Study of Mesenchymal Stem Cell (19#iSCLife®-POI) in Premature Ovarian Insufficiencytreatment2suspended
NCT00001275
Ovarian Follicle Function in Patients With Primary Ovarian FailureNo drug interventionsNot AvailableNot Availablecompleted
NCT04675970
Long Term Follow up Patients With Premature Ovarian Failure ex Vivo Gene TherapyNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04381299
Will Autologous Platelet Rich Plasma Able To Restore Ovarian Function?No drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04189406
Turner Syndrome Minipuberty StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT00001306
Steroid Therapy in Autoimmune Premature Ovarian FailureNo drug interventionsNot AvailableNot Availablecompleted
NCT04815213
The Use of Expandeded Mesenchymal Stromal Cells (MSC) in Premature Ovarian Failure (POF) in Adult HumansNo drug interventionsother1unknown_status
NCT05890417
Evolution of Sexual Life Quality of Women With POI Before and After Introduction of Hormone Replacement TherapyNo drug interventionsotherNot Availablerecruiting
NCT05522634
A Clinical Study of Chinese Herbal Compound TJAOA101 in the Treatment of Premature Ovarian InsufficiencyNo drug interventionstreatment0not_yet_recruiting
NCT01187524
The Natural History of Reproductive and Overall Health in Girls and Women With a Pre-Mutation in the FMR1 Gene; Creation of a Patient RegistryNo drug interventionsNot AvailableNot Availableterminated
NCT03840824
Blood Spot Self-administered Test and AssayNo drug interventionsNot AvailableNot Availablecompleted
NCT00948857
Dehydroepiandrosterone (DHEA) Treatment and Premature Ovarian Failure (POF)No drug interventionstreatment2 / 3terminated
NCT00417066
Flexible GnRH Antagonist vs Flare up GnRH Agonist Protocol in Poor Responderstreatment4completed
NCT02372474
"It is a Real" The First Baby Of Autologous Stem Cell Therapy in Premature Ovarian FailureNo drug interventionstreatment1 / 2completed
NCT04071574
Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertilityhealth_services_research1 / 2completed
NCT06117982
The Impact of Granulocyte Colony Stimulating Factor on Premature Ovarian Insufficiencytreatment2recruiting
NCT02062931
Autologous Mesenchymal Stem Cells Transplantation In Women With Premature Ovarian FailureNo drug interventionstreatment1 / 2unknown_status
NCT03985462
Very Small Embryonic-like Stem Cells for OvaryNo drug interventionstreatment1 / 2withdrawn
NCT02696889
Rejuvenation of Premature Ovarian Failure With Stem CellsNo drug interventionstreatmentNot Availablecompleted
NCT02603744
Autologous Adipose Derived Mesenchymal Stromal Cells Transplantation in Women With Premature Ovarian Failure (POF)No drug interventionstreatment1 / 2unknown_status