Hormone Replacement Therapy (DBCOND0029389)

Identifiers

Synonyms

HRT / Hormone replacement therapy / Hormone replacement therapy (procedure) / Administration of hormone (procedure)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Cyproterone acetate	A steroid used in combination with ethinyl estradiol to treat women with severe acne and symptoms of androgenization. Also used alone at much higher doses for palliative treatment of patients with prostate cancer	Androgen receptortarget Prostate-specific antigentarget Cytochrome P450 3A4enzyme Aromataseenzyme
Estradiol	An estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate.	Estrogen receptortarget Nuclear receptor subfamily 1 group I member 2target Sex hormone-binding globulincarrier Estrogen receptor betatarget Cytochrome P450 1A2enzyme UDP-glucuronosyltransferase 1A1enzyme Albumincarrier Fatty acid-binding protein, intestinalcarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 3transporter ATP-binding cassette sub-family C member 10transporter Solute carrier family 22 member 11transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 1C1transporter Neuronal acetylcholine receptor subunit alpha-4target G-protein coupled estrogen receptor 1target ATP synthase subunit atarget Beclin-1target UDP-glucuronosyltransferase 2B15enzyme Catechol O-methyltransferaseenzyme UDP-glucuronosyltransferases (UGTs)enzyme Aromataseenzyme
Estradiol valerate	An estradiol prodrug used to treat some effects of menopause, hypoestrogenism, androgen dependant carcinoma of the prostate, and in combination products for endometriosis and contraception.	Estrogen receptortarget Nuclear receptor subfamily 1 group I member 2target Sex hormone-binding globulincarrier Estrogen receptor betatarget Cytochrome P450 1A2enzyme UDP-glucuronosyltransferase 1A1enzyme Albumincarrier Fatty acid-binding protein, intestinalcarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Solute carrier family 22 member 3transporter Solute carrier organic anion transporter family member 2B1transporter Solute carrier organic anion transporter family member 1A2transporter ATP-binding cassette sub-family C member 10transporter Solute carrier family 22 member 11transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 1C1transporter Solute carrier organic anion transporter family member 4A1transporter Neuronal acetylcholine receptor subunit alpha-4target Nuclear receptor coactivator 2target G-protein coupled estrogen receptor 1target ATP synthase subunit atarget Beclin-1target 17-beta-hydroxysteroid dehydrogenase type 2target Estrogen-related receptor gammatarget
Lactobacillus acidophilus	Not Annotated	No drug targets
Medrogestone	A progestin used as an adjunct to control secondary amenorrhea and dysfunctional bleeding in adolescent and adult females, and treat endometrial shedding in menopausal women.	Albumincarrier Progesterone receptortarget Sex hormone-binding globulincarrier Corticosteroid-binding globulincarrier Cytochrome P450 3A4enzyme
Nomegestrol acetate	Nomegestrol acetate, also known as NOMAC, is a progestin used in oral contraceptives, menopausal hormone therapy, and for the treatment of gynecological disorders.	Cytochrome P450 3A4enzyme Estrogen receptortarget
Norethisterone	A synthetic second-generation progestin used for contraception, prevention of endometrial hyperplasia in hormone replacement therapy, and in the treatment of other hormone-mediated illnesses such as endometriosis.	Progesterone receptortarget ATP-dependent translocase ABCB1transporter Cytochrome P450 2C19enzyme Albumincarrier Sex hormone-binding globulincarrier Aldo-keto reductase family 1 member C4enzyme 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme 3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme Aldo-keto reductase family 1 member D1enzyme Cytochrome P450 3A4enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2A6enzyme Glucocorticoid receptortarget Androgen receptortarget
Prasterone enantate	An estrogen indicated for hormone replacement therapy in postmenopausal women.	No drug targets
Testosterone undecanoate	An androgen indicated for testosterone replacement therapy in adult males with primary hypogonadism and hypogonadotropic hypogonadism.	Androgen receptortarget Cytochrome P450 3A4enzyme Amine oxidase [flavin-containing] Aenzyme Cholesterol side-chain cleavage enzyme, mitochondrialenzyme Albumincarrier Sex hormone-binding globulincarrier Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier organic anion transporter family member 1A2transporter Organic anion transporter 3transporter Solute carrier family 22 member 7transporter ATP-dependent translocase ABCB1transporter Hepatic sodium/bile acid cotransportertransporter Solute carrier family 22 member 4transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2A13enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A43enzyme 3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme Solute carrier family 22 member 2transporter Multidrug and toxin extrusion protein 1transporter Solute carrier organic anion transporter family member 1B3transporter Aromataseenzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01210586	Tobacco Cessation in Postmenopausal Women	No drug interventions	treatment	Not Available	completed
NCT05774405	Short-term Effects of Transdermal Estradiol on Female COVID-19 Patients	Estradiol	treatment	2	completed
NCT04758871	Oral Versus Vaginal Progesterone for Luteal Phase Supplementation in Frozen Embryo Transfer Cycles	Dydrogesterone Progesterone	treatment	4	completed
NCT04453332	Effects of Hormone Replacement Therapy on Cardiovascular Risk and Body Composition Parameters	Estradiol Progesterone	treatment	Not Available	unknown_status
NCT06357442	Assessment of Endometrial Thickness Among Adolescent and Young Adult Patients on Estrogen Replacement Therapy Using Daily Oral Micronized Progesterone Versus the Etonogestrel Implant.	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT06372119	Letrozole-stimulated Cycle Strategy Versus Artificial Cycle Strategy (LETSACT)	No drug interventions	treatment	Not Available	recruiting
NCT00785317	Effects of Estradiol on Menopausal Breast	No drug interventions	treatment	4	unknown_status
NCT04742816	Renal Effects of Hormones/Biomarkers in Transgender PrEP Recipients	Iohexol	diagnostic	4	completed
NCT05168865	Letrozole Versus Hormonal Preparation in Frozen Cycles of PCOS Patients.	Estradiol Letrozole Progesterone	treatment	4	withdrawn
NCT06544473	Determining Dose Equivalence Between Oral and Transdermal Estrogen Treatment in Women With Turner Syndrome	Estradiol	treatment	4	recruiting
NCT04478760	Trans & Non-binary Reference Intervals While on Hormone Therapy Study	No drug interventions	Not Available	Not Available	recruiting
NCT06570460	Long Term Effects of Oral Versus Transdermal Estrogen Replacement Therapy in Turner Syndrome	Estradiol	treatment	4	recruiting
NCT00319072	Hormone Replacement Therapy (HRT) Website Tool	No drug interventions	educational_counseling_training	2	completed
NCT01023802	The Use of Molecular Breast Imaging in the Evaluation of Tumor Response to Neoadjuvant Therapy in Women With Breast Cancer	No drug interventions	Not Available	Not Available	completed
NCT01070979	Hormone Replacement Therapy for Use in Postmenopausal Women for Relief of Hot Flushes and Urogenital Symptoms.	No drug interventions	treatment	3	completed
NCT05166083	Investigation of the Perceptual and Acoustic Voice in Trans Man	No drug interventions	Not Available	Not Available	recruiting
NCT00012909	Development and Evaluation of a Hormone Replacement Therapy Decision-Aid	No drug interventions	Not Available	Not Available	completed
NCT05072756	Opinion of Brazilian Gynecologists on Hormone Therapy for Menopause and Prescriptive Habits	No drug interventions	Not Available	Not Available	completed
NCT04503915	Estrogen Supplementation Mode in HRT-FET Cycle: a RCT	No drug interventions	treatment	Not Available	unknown_status
NCT05122065	Menopausal Vaginal Microbiome	No drug interventions	Not Available	Not Available	unknown_status
NCT06353555	Efficacy of Thyroid Hormone Replacement for Secondary Hypothyroidism Following Intracerebral Hemorrhage	No drug interventions	treatment	Not Available	recruiting
NCT00463450	Efficacy of Gynodian® Depot in Women With Impaired Well-being	No drug interventions	treatment	3	completed