Restless Legs Syndrome (RLS) (DBCOND0032885)

Identifiers

Synonyms
Restless Legs Syndrome / Restless Leg Syndrome (RLS) / Restless Leg Disorder / Restless Leg Syndrome / Restless Legs / RLS / Ekbom syndrome / Willis-Ekbom disease / Restless legs (disorder) / Legs restless / Syndrome restless legs

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Carbamazepine
An anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia.
Clonazepam
A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, and seizures.
Gabapentin enacarbil
A gabapentin prodrug used to treat Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).
Iron
An essential element commonly used for the treatment of patients with documented iron deficiency.
Levodopa
A dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT00256854
Converting From Ropinirole Immediate Release (IR) To Ropinirole Controlled-Release for RLS (Restless Legs Syndrome)treatment3completed
NCT01823770
Effect of Rotigotine Patch Treatment on Cardiovascular Markers in Idiopathic Restless Legs Syndrometreatment4completed
NCT01981941
Post-marketing Study of Gabapentin Enacarbil to Evaluate the Effect in Restless Leg Syndrome (RLS) Patients With Moderate Renal Impairmenttreatment4completed
NCT00363857
A Clinical Research Study Testing Ropinirole Treatment for Restless Legs Syndrometreatment3completed
NCT02397057
Placebo-Controlled Study to Investigate the Efficacy & Safety of Injectafer in the Treatment of RLStreatment3completed
NCT03053427
A Study of Oral Dosing of Gabapentin Enacarbil in Japanese Restless Legs Syndrome Patientstreatment4completed
NCT01382901
Intravenous (IV) Iron Preparation (VIT-45) in the Treatment of Restless Legs Syndrome (RLS)treatment2completed
NCT02826681
Randomized, Placebo-controlled Trial of Ferric Carboxymaltose in RLS Patients With Iron-deficiency Anemiatreatment2terminated
NCT00748098
Polysomnography Study of GSK1838262 Extended Release Tablets Versus Placebo in RLS and Associated Sleep Disturbancetreatment3completed
NCT00373542
12-week Polysomnography Study of Ropinirole Controlled Release for Restless Legs Syndrometreatment4completed
NCT01411124
Study to Assess the Effect of Gabapentin Enacarbil on Simulated Driving in Healthy Subjectstreatment1completed
NCT01494766
Efficacy of Tyrosine in Restless Legs SyndromeNo drug interventionstreatmentNot Availablecompleted
NCT00314860
RLS In Adults: Comparing Immediate Release Formulation With Extended Release Formulation Of Ropiniroletreatment3completed
NCT00627003
A Study to Evaluate the Efficacy and Safety of Cabergoline Compared With Placebo for the Treatment of RLStreatment3completed
NCT00676403
Lyrica Dose Response Study With Restless Legs Syndrome (RLS) Patientstreatment2completed
NCT04759703
Treatment of Restless Legs Symptoms With Pramipexole to Improve the Outcomes of Protracted Opioid Withdrawal in OUDtreatment2 / 3recruiting
NCT01192503
Safety and Efficacy of Rasagiline in Restless Legs Syndrometreatment2 / 3terminated
NCT04144790
Impact of Iron Supplementation Treatment on Brain Iron ConcentrationsNo drug interventionsNot AvailableNot Availablerecruiting
NCT01569464
Rotigotine Effect on All-day Functioning and Quality of Life in Subjects With Moderate to Severe Restless Legs Syndrome (RLS)treatment3completed
NCT00375284
A 6 Week Trial to Study the Efficacy and Safety of a Starting Dose 0.25 mg Pramipexole (Mirapex) in Patients With RLStreatment4completed
NCT03249779
Treatment of RLS/WED Symptoms Through Sensory Counter-stimulationNo drug interventionstreatmentNot Availablecompleted
NCT03728933
A Study of Rotigotine Patch in Adolescent Subjects With Restless Legs Syndrome of Unknown Causetreatment3terminated
NCT01823354
Executive Dysfunction in Restless Legs Syndrome: Clinical Correlates and Outcome After Therapeutic ManagementNo drug interventionsotherNot Availablerecruiting
NCT00479154
Botulinum Toxin to Treat Restless Legs Syndrometreatment1 / 2completed
NCT00136045
Three Different Transdermal Doses of Rotigotine in Subjects With Idiopathic Restless Leg Syndrometreatment3completed
NCT00133198
Efficacy and Safety of Pramipexole Compared to Placebo in the Treatment of Restless Legs Syndrome (RLS)treatment3completed
NCT00654498
Pramipexole in Out-patients With Idiopathic Restless Legs Syndrome (IRLS)treatment3completed
NCT01332305
Dose-Response and Pharmacokinetics of Gabapentin Enacarbil (GEn [XP13512 / GSK1838262]) in Restless Legs Syndrometreatment2completed
NCT00357097
The Effects Of Ropinirole On Mood Or Mild Depression In Patients With Moderate To Severe Restless Legs Syndrometreatment3completed
NCT04700683
Noninvasive Peripheral Nerve Stimulation for Restless Legs SyndromeNo drug interventionsdevice_feasibilityNot Availablecompleted
NCT00051961
Effect of Ropinirole on Spinal Cord Reflexes and Restless Legs SyndromeNo drug interventionsNot AvailableNot Availablecompleted
NCT00867893
Suggested Immobilization Test (SIT) Test for Early Detection of Restless Legs Syndrome (RLS) Augmentation - Proof of ConceptNo drug interventionsNot AvailableNot Availablecompleted
NCT04853771
The Effect of Progressive Muscle Relaxation Exercise Training Given to Pregnant Women With Restless Leg SyndromeNo drug interventionstreatmentNot Availablecompleted
NCT01976871
Switching From Oral Dopamine Agonists to Rotigotinetreatment4completed
NCT03457571
Clinical Observational Study: IBD Patients With Restless-legs-syndrome and Iron Deficiency SyndromeNo drug interventionsNot AvailableNot Availablecompleted
NCT02658188
Long-term Efficacy and Safety of Gabapentin Enacarbil in Japanese Restless Legs Syndrome Patientstreatment3completed
NCT03708237
Effectiveness of Ropinirole and Gabapentin for the Treatment of RLS in Patients on Maintenance HDtreatment2terminated
NCT00895232
Iron Sucrose In The Treatment of Restless Legs Syndrome: Safety of Three Dose Regimens as Evaluated by Clinical Assessmentstreatment2completed
NCT01861652
Vasculaire Leg Compression Device for the Treatment of Restless Legs Syndrome - A Prospective Clinical StudyNo drug interventionstreatmentNot Availablewithdrawn
NCT04316052
Aerobic And Strength Training Exercises For Restless Leg Syndrome In Patients With DiabetesNo drug interventionstreatmentNot Availablecompleted
NCT01537042
A Sleep Laboratory Study to Investigate the Safety and Efficacy of the Rotigotine Skin Patch in Subjects With Restless Legs Syndrome and End-Stage Renal Disease Requiring Hemodialysistreatment3completed
NCT00472199
Long-term Efficacy, Safety and Tolerability of Pramipexole in Patients With Idiopathic Moderate to Severe Restless Legs Syndrome (RLS)treatment4completed
NCT06076499
A Post-Market Study for Long-Term Effectiveness and Safety of the NTX100 for RLSNo drug interventionsNot AvailableNot Availablerecruiting
NCT00949806
Restless Legs Syndrome Treatment With Botulinum ToxinNo drug interventionstreatment2completed
NCT00626418
The Effects of Aplindore on the Treatment of Signs and Symptoms of Restless Legs Syndrometreatment2completed
NCT01332318
Simulated Driving Study in Restless Legs Syndrometreatment2completed
NCT06570941
Benefits of a Cannabidiolic Acid Topical Cream for the Treatment of Restless Leg Syndrometreatment1 / 2active_not_recruiting
NCT00200941
Efficacy and Safety Study of Topiramate to Treat Restless Legs Syndromeeducational_counseling_training4completed
NCT00621517
Bupropion and Restless Legs Syndrometreatment2 / 3completed
NCT00356096
Phase IV Trial With Pramipexole to Evaluate Safety and Efficacy in Patients With RLS Associated With Mood Disturbancestreatment4completed
NCT00152958
A Study in Patients Suffering From Idiopathic Restless Legs Syndrome Who Responded to a Preceding, 6-month Treatment With Open-label Pramipexole Including Titration (0.125, 0.25, 0.5, 0.75 mg Orally q.n.)treatment3completed
NCT01521663
Safety and Efficacy Study of IPX159 in Restless Legs Syndrome (RLS)No drug interventionstreatment2completed
NCT05695963
Ecological Momentary Assessment in Patients With Restless Legs SyndromeNo drug interventionsotherNot Availablerecruiting
NCT05214963
Noninvasive Peripheral Nerve Stimulation for Medication-Naive and Medication-Refractory RLSNo drug interventionstreatmentNot Availablecompleted
NCT00239486
Dose Finding Study of Pramipexole (Sifrol) in Patients With Idiopathic Restless Legs Syndrome (RLS)treatment2completed
NCT04906486
Autonomic Assessment in Patients With Restless Legs SyndromeNo drug interventionsNot AvailableNot Availablecompleted
NCT00498186
Long-term Open-label Trial in Idiopathic Restless Legs Syndrome (RLS)treatment2completed
NCT01327339
REQUIP RLS Post Marketing SurveillanceNot AvailableNot Availablecompleted
NCT02559739
Sleep Deficiency and Stroke OutcomeNo drug interventionsNot AvailableNot Availablecompleted
NCT00367822
Transdermal Lisuride: a Trial for the Treatment of Patients With Restless Legs Syndrome (RLS)treatment3completed
NCT05003648
Treating Leg Symptoms in Women With X-linked Adrenoleukodystrophytreatment4recruiting
NCT00275457
Efficacy and Safety of Pramipexole (PPX) in Moderate to Severe Idiopathic Restless Legs Syndrome (RLS) Patientstreatment3completed
NCT02138357
Butrans for Treatment of Restless Legs Syndrometreatment4withdrawn
NCT01498120
Long-Term Follow-Up Study for Safety, Efficacy and Tolerability of Rotigotine in Adolescents With Restless Legs Syndrometreatment2completed
NCT04610827
Oral Iron Frequency for Childhood Restless Leg Syndrome/Periodic Limb Movement Disordertreatment4terminated
NCT06324760
Alpha-lipoic Acid Combined With B Vitamins Shows Promise for Treating Restless Legs SyndromeNo drug interventionsNot AvailableNot Availablecompleted
NCT04141891
Advancing Understanding of Transportation OptionsNo drug interventionshealth_services_researchNot Availablecompleted
NCT00258492
Restless Legs Syndrome Exercise InterventionNo drug interventionstreatment1 / 2unknown_status
NCT03834792
Adverse Long-term Consequences of Sleep Disordered Breathing: The Ottawa Hospital (TOH) Sleep DatabaseNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT00996944
Clinical Evaluation of Ropinirole IR (Immediate Release) Tablets in Patients Who Are Diagnosed With Symptomatic Restless Legs Syndrome (RLS) Associated With Chronic Kidney Disease (CKD) Managed With Haemodialysis (Including Haemofiltration and Haemodiafiltration)treatment2terminated
NCT01386944
Effect on RLS Symptom Severity After Switching to Neupro® in Patients Who Previously Experienced AugmentationNo drug interventionsNot AvailableNot Availablecompleted
NCT03849001
Impact of Acute Leg Cycling at Various Intensities on RLS Severity in Persons With MSNo drug interventionstreatmentNot Availablewithdrawn
NCT05851001
Effects of Progressive Muscle Relaxation Exercises During PregnancyNo drug interventionssupportive_careNot Availablecompleted
NCT01061372
12-Week Efficacy And Safety Of Pregabalin In Treating Restless Legs Syndrome (RLS) Subjectstreatment3withdrawn
NCT02484768
IV Iron Treatment of Restless Legs Syndrometreatment2withdrawn
NCT01937169
Targeting Dopamine Therapy in RLStreatmentNot Availableunknown_status
NCT00199446
Study of Istradefylline (KW-6002) for the Treatment of Restless Legs Syndrometreatment2completed
NCT00584246
Pregabalin (Lyrica) for the Treatment of Restless Legs Syndrometreatment4withdrawn
NCT00656110
Neuroma Injections to Treat Restless Legs Syndrome - RCTtreatmentNot Availableunknown_status
NCT03539081
Spinal Cord Stimulation for Restless Legs SyndromeNo drug interventionsbasic_scienceNot Availablecompleted
NCT02248155
Observational Study of Sifrol® in Patients With Primary Restless Legs Syndrome (RLS)Not AvailableNot Availablecompleted
NCT05321355
Mainz Register of Patients With Sleep DisordersNo drug interventionsNot AvailableNot Availablerecruiting
NCT00298623
XP13512 (GSK1838262) Versus Placebo in Patients With Restless Legs Syndrome.treatment3completed
NCT01675323
Glutamate, Hyperarousal and Restless Legs SyndromeNo drug interventionsNot AvailableNot Availablecompleted
NCT02025608
Autonomic Function and Cardiovascular Risk in Restless Legs Syndromeother4completed
NCT04698343
Noninvasive Peripheral Nerve Stimulation for Restless Legs Syndrome During Opioid Medication ReductionNo drug interventionstreatmentNot Availablecompleted
NCT05007743
Effects of Transcutaneous Vagus Nerve Stimulation in Chronic Pain Patients and Healthy ControlsNo drug interventionsbasic_scienceNot Availableactive_not_recruiting
NCT04303143
Hypnosis and Direct Autonomic Experience Influence on Chronic SymptomsNo drug interventionsNot AvailableNot Availableunknown_status
NCT01967303
Restless Legs Syndrome in Stroke PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT04887103
The Effect of Hot Water Application in Pregnant Women With Restless Legs Syndrome: A Randomised Controlled StudyNo drug interventionssupportive_careNot Availablecompleted
NCT00530790
Clinical Evaluation of Ropinirole CR-RLS ( SK&F101468)Tablets in Restless Legs Syndrometreatment2completed
NCT00247364
A Double Blind Crossover Trial of Levetiracetam (Keppra®) and Placebo in the Treatment of Restless Legs Syndrome (RLS)treatment2completed
NCT05985421
Gut Microbiota and Bacterial Translocation in Restless Legs SyndromeNo drug interventionsNot AvailableNot Availablerecruiting
NCT00329602
Long-term Study Of Ropinirole In Restless Legs Syndrometreatment4completed
NCT00721279
Sifrol (Pramipexole) Onset of Action and Impact: a 12-weeks Observational Study in Patients With Primary Restless Legs SyndromeNot AvailableNot Availablecompleted
NCT01125033
Study of Vitamin C, Vitamin E and Their Combination to Treat Restless Legs Syndrome in Hemodialysis Patientstreatment2 / 3completed
NCT02499354
Pilot Study: Randomized, Placebo-controlled Comparator Trial of IV vs Oral Iron Treatment of RLS With IDA. (IVOR-IDA)treatment2completed
NCT03817554
Pramipexole for Restless Leg Syndrome in Peritoneal Dialysis Patientstreatment4terminated
NCT01633151
Validation Study for an Unobtrusive Online Sleep Measurement SystemNo drug interventionsNot AvailableNot Availablecompleted
NCT00246051
Comprehensive Police Fatigue Management ProgramNo drug interventionsdiagnosticNot Availablecompleted
NCT03345953
Clinical Trial Assessing the Efficacy and Safety of BP1.4979 in Restless Legs Syndrometreatment2terminated
NCT00942253
Exercise Training in Dialysis Patients With Restless Legs Syndrome (RLS)No drug interventionssupportive_care2completed
NCT02526277
A Study on the Use of the MMF07 Foot Massager and Heat Therapy Treatments for Restless Leg SyndromeNo drug interventionsotherNot Availablecompleted
NCT00625547
A Study to Determine the Efficacy and Safety of Cabergoline for the Treatment of Patients With RLStreatment3completed
NCT00152997
Pramipexole (BI-Sifrol®) Orally Once Daily for 6 Weeks in Patients With Primary Restless Legs Syndrometreatment2completed
NCT00539461
Non-interventional Observational Study of Pramipexole in Restless Legs Syndrome: Impact on Quality of LifeNo drug interventionsNot AvailableNot Availablecompleted
NCT02670161
Quality Improvement and Practice Based Research in Neurology Using the EMRNo drug interventionstreatment4enrolling_by_invitation
NCT05196828
Extension Study Evaluating NTX100 Neuromodulation System for Medication-Refractory Primary RLSNo drug interventionstreatmentNot Availablecompleted
NCT05573711
Restless Legs Syndrome in People With Neuromyelitis Optica Spectrum DisorderNo drug interventionsNot AvailableNot Availablerecruiting
NCT04711993
Investigation of the Effects of Different Exercise Programs in Patients With Restless Legs Syndrome.No drug interventionstreatmentNot Availablecompleted
NCT00135993
Four Different Transdermal Doses of Rotigotine in Subjects With Idiopathic Restless Legs Syndrometreatment3completed
NCT01495793
Dose Escalating Study of Rotigotine in Pediatric Subjects With Restless Legs Syndromeother2completed
NCT03852771
REST Study (CompRESsion Therapy for RLS)No drug interventionstreatmentNot Availableterminated
NCT06468371
Exercise Training Versus Ropinirole in Treating Restless Legs Syndrome Among Hemodialysis PatientstreatmentNot Availablecompleted
NCT06156007
Effect of Progressive Muscle Relaxation Exercises in Menopausal Women Experiencing RLS.No drug interventionstreatmentNot Availablecompleted
NCT00144209
Assess Efficacy and Safety of the Dopamine Agonist Pramipexole Versus Levodopa / Benserazide (Madopar® DR) in Patients With Restless Legs Syndrometreatment3completed
NCT00207285
Sleep Disorders Management, Health and Safety in PoliceNo drug interventionsdiagnosticNot Availablecompleted
NCT02256215
Vitamin D in the Treatment of Primary Restless Legs Syndrometreatment2 / 3unknown_status
NCT02642315
The Effect of Horizant (Gabapentin Enacarbil) on AugmentationtreatmentNot Availablecompleted
NCT03570515
Yoga vs. Education for Restless Legs Syndrome: a Feasibility StudyNo drug interventionsotherNot Availablecompleted
NCT01109537
Altered Brain GABA and Glutamate in Restless Legs SyndromeNo drug interventionsNot AvailableNot Availablecompleted
NCT02929732
Analysis of Sympathetic Activity in Willis-Ekbom DiseaseNo drug interventionsbasic_scienceNot Availablerecruiting
NCT00365352
XP13512 vs. Placebo in Patients With Restless Legs Syndrome.treatment3completed
NCT02264600
Apelin in Willis Ekbom DiseaseNo drug interventionsNot AvailableNot Availableunknown_status
NCT01174459
Survey on Long-Term Use of BI-Sifrol® Tablets in Patients With Restless Legs SyndromeNo drug interventionsNot AvailableNot Availablecompleted
NCT00333359
XP13512 (Gabapentin Enacarbil) Extension Study in Patients With Restless Legs Syndrome.treatment3completed
NCT02248142
Observational Study of Sifrol® in Patients With Primary Restless Legs Syndrome (RLS)Not AvailableNot Availablecompleted
NCT00275236
A Sleep Lab Trial to Investigate the Efficacy and Safety of Transdermal Rotigotine in Subjects With Idiopathic Restless Legs Syndrometreatment3completed
NCT01887613
Specified Drug Use-Results Survey of RegniteNot AvailableNot Availablecompleted
NCT02231918
Study to Investigate Pharmacokinetics (PK) of Pramipexole in Pediatric Patients Who Are Individually Optimized to Stable Pramipexole Doses for the Treatment of Idiopathic Restless Legs Syndrome (RLS)treatment2completed
NCT03076541
Cardiovascular Variability, Heart Rate Response, and Electromyogram Power Associated With Periodic Leg Movements.No drug interventionsNot AvailableNot Availablecompleted
NCT00355641
Long-Term Safety Of Ropinirole XR In Patients With Restless Legs Syndrometreatment3completed
NCT01138124
Gabapentin and Risk of Pancreatic Cancer and Renal Cancer (GPRD)Not AvailableNot Availablecompleted
NCT01476124
Drug Drug Interaction Study With Gabapentin Enacarbil and Morphinetreatment1completed
NCT05350124
The Effect of Vitamin C and E Therapy on Restless Leg Syndrome in Patients With End Stage Renal Disease on Haemodialysistreatment3unknown_status
NCT03992196
A Follow-up Study of Rotigotine Patch in Adolescent Subjects With Restless Legs Syndrometreatment3terminated
NCT04462796
The Effect of Magnesium Citrate Supplementation in Restless Legs Syndrome (RLS)No drug interventionsotherNot Availablerecruiting
NCT00557258
Cross-Sectional Study: Prevalence of Restless Legs Syndrome in Patients With Unpleasant Sensations of the LegsNo drug interventionsNot AvailableNot Availablecompleted
NCT00311363
Long-Term Study of Gabapentin Enacarbil (GEn, XP13512) vs. Placebo in Patients With Restless Legs Syndrome.treatment3completed
NCT00530530
ASP8825 - Study in Patients With Restless Legs Syndrometreatment2completed
NCT03806530
DIalysis Symptom COntrol-Restless Legs Syndrome Trialtreatment3completed
NCT04145674
A Proof of Concept, Phase 2, Double-blind, Randomized Trial With d-Methadone Product Versus Placebotreatment2recruiting
NCT05044520
Clinical Features Associated With Restless Legs Syndrome.No drug interventionsNot AvailableNot Availablerecruiting
NCT05698420
Investigation of the Effects of Medium Cut-off Dialyzers Versus High-Flux Dialyzers on Clinical and Laboratory Parameters of Prevalent Hemodialysis PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT00389831
Efficacy, Safety and Tolerability of Rotigotine Nasal Spray for the Acute Treatment of RLS Symptomstreatment2completed
NCT00479531
Sequential Compression Devices for Treatment of Restless Legs SyndromeNo drug interventionstreatment3completed
NCT00349531
A Phase IV Trial With Pramipexole to Investigate the Effects on RLS Symptoms and Sleep Disturbance in Patients With RLStreatment4completed
NCT04161027
RCT for Pregabalin in Restless Legs Syndrome in South Koreatreatment3completed
NCT00834327
Efficacy and Safety Study of Aplindore in Patients With Restless Legs SyndromeNo drug interventionstreatment2terminated
NCT06481176
Blood Changes After Exercise in Restless Legs SyndromeNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT05581576
Pitolisant in Refractory Restless Legs Syndrometreatment4recruiting
NCT00991276
Polysomnography Study Of Pregabalin And Pramipexole Versus Placebo In Patients With Restless Legs Syndrome And Associated Sleep Disturbancetreatment3completed
NCT00344994
SWITCH:Restless Legs Patients Switched to Ropinirole From Pramipexoletreatment4completed
NCT00422994
A Study To Investigate The Effects Of End Stage Renal Disease And Hemodialysis On The Pharmacokinetics Of Ropinirolediagnostic1completed
NCT02011191
Biotin Deficiency and Restless Legs SyndromeNo drug interventionstreatmentNot Availablecompleted
NCT01170091
Safety and Effect of Mirapex(Pramipexole) Tablet Among Korean RLSNo drug interventionsNot AvailableNot Availablecompleted
NCT04706091
Efficacy of Suvorexant in Patients With Effectively Treated Restless Legs Syndrome and Persistent Chronic Insomniatreatment4completed
NCT01528462
Sleep Disorders Managed and Assessed Rapidly in Transient Ischemic Attack (TIA) and In Early StrokeNo drug interventionsNot AvailableNot Availablecompleted
NCT00225862
A Clinical Research Study Evaluating Ropinirole Treatment For Restless Legs Syndrome (RLS)treatment3completed
NCT05787080
Massage, Oxidative and Antioxidant Enzymes in Hemodialysis Patients With Restless Legs Syndrome(RLS)No drug interventionssupportive_careNot Availablecompleted
NCT00197080
Ropinirole XR (Extended Release) In Patients With Restless Legs Syndrometreatment3completed
NCT04827329
Anesthetic Management of Patients With Chronic Sleep DisordersNo drug interventionsNot AvailableNot Availablecompleted
NCT00887289
Non-interventional Observational Study on the Influence of Pramipexole on Sensory Symptoms of Restless Legs Syndrome (RLS)No drug interventionsNot AvailableNot Availablecompleted
NCT00419692
Restless Legs Patient Study On Absorption, Distribution, Metabolism And Excretion Of Ropinirole And The Effect Of Foodtreatment1completed
NCT01668667
Gabapentin Enacarbil (GSK1838262) Adult Restless Leg Syndrome (RLS) Post Marketing Commitment Studytreatment4completed
NCT00074672
Relationship Between Sensory and Motor Systems in Restless Leg SyndromeNo drug interventionsNot AvailableNot Availablecompleted
NCT01516372
A Study to Evaluate the Effect of Gabapentin on Cardiac Repolarization in Healthy Volunteersbasic_science1completed
NCT05795868
The Effect of Compression Stockings on the Complaints of Pregnant Women With Restless Leg SyndromeNo drug interventionssupportive_careNot Availablecompleted
NCT00263068
An Extension Trial to Investigate Long-Term Treatment With Transdermal Rotigotine in Idiopathic Restless Legs Syndrometreatment3completed
NCT03218969
Treatment of Restless Leg Syndrome (RLS) Augmentation With Ecopipam, a D1 Specific Antagonisttreatment1 / 2unknown_status
NCT00140712
Ropinirole Tablets In Young Patients With Restless Legs Syndrometreatment1completed
NCT01455012
Effects of Neupro on Cardiovascular Observations in Patients With Restless Legs Syndrometreatment4completed
NCT03755310
Treatment of Restless Legs Syndrome With the Hypocretin Antagonist Suvorexanttreatment2unknown_status
NCT04061681
Efficacy of BIPAMS for Restless Legs Syndrome in Adults With Multiple Sclerosis: A Pilot StudyNo drug interventionstreatmentNot Availablecompleted
NCT05529095
Sublingual Apomorphine in Refractory Restless Legs Syndrometreatment4unknown_status
NCT02424695
Effects of Gabapentin Enacarbil on Arousals, Heart Rate, Blood Pressure and PLMs in Restless Legs Syndrometreatment4unknown_status
NCT05908214
The Application of Wide Pulse High Frequency Neuromuscular Electrical Stimulation in Disorders Associated With Motoneuron HyperexcitabilityNo drug interventionstreatmentNot Availablerecruiting
NCT04786314
The Effect of Hot and Cold Water Application on Pregnant Women With Restless Leg SyndromeNo drug interventionssupportive_careNot Availableunknown_status
NCT02419014
Cranial Electrotherapy for Military Beneficiaries With Restless Legs SyndromeNo drug interventionstreatmentNot Availableunknown_status
NCT04874155
Noninvasive Peripheral Nerve Stimulation for Medication-Refractory Primary RLS (The RESTFUL Study)No drug interventionstreatmentNot Availablecompleted
NCT02532608
Infra-slow Oscillations During SleepNo drug interventionsbasic_scienceNot Availablecompleted
NCT03018912
Validating the Use of a Subjectively Reported Sleep Vital SignNo drug interventionsscreeningNot Availableactive_not_recruiting
NCT03063190
Cholecalciferol Supplementation in Restless Leg Syndrome in Patients With Chronic Kidney Diseasetreatment4withdrawn
NCT01672502
Fire Fighter Fatigue Management Program: Operation Fight FatigueNo drug interventionstreatmentNot Availablecompleted
NCT01538147
Restless Leg Syndrome and Severe PreeclampsiaNo drug interventionsNot AvailableNot Availablecompleted
NCT00673088
A Single Dose, 2-Period, 2-Treatment, 2-Way Crossover Bioequivalency Study of Ropinirole 0.25 mg Tablets Und Fasted ConditionstreatmentNot Availablecompleted
NCT00949858
New Data Analysis Methods for Actigraphy in Sleep MedicineNo drug interventionsNot AvailableNot Availablecompleted
NCT02085720
Prevalence of OSAS in Chinese Elderly and Its CPAP ComplianceNo drug interventionsdiagnosticNot Availablecompleted
NCT01988129
Fire Fighter Fatigue Management Program: Operation Healthy SleepNo drug interventionstreatmentNot Availablecompleted
NCT00674310
A Single-Dose, 2-Period, 2-Treatment, 2-Way Crossover Bioequivalency Study of Ropinirole 0.25 mg Tablets Under Fed ConditionstreatmentNot Availablecompleted
NCT02016638
Sleep Quality in Pregnancy and Its Impact on Pregnancy OutcomesNo drug interventionsscreeningNot Availableunknown_status
NCT01245777
Restless Legs Syndrome With Iron Deficiency or Anaemia in the 3rd Trimester of Pregnancytreatment4completed
NCT01931878
Investigation of Efficacy of incobotulinumtoxinA (Xeomin) in Relieving Symptoms of Restless Leg Syndrome.treatment2completed
NCT00872248
Neuraxial Anesthesia and Restless Leg Syndromes in CesareanNo drug interventionstreatmentNot Availablecompleted
NCT06233773
The Effect of Kinesio Taping and Manual Lymph Drainage on Pregnant Women With Restless Legs SyndromeNo drug interventionssupportive_careNot Availablerecruiting
NCT02117076
Blinded, Randomized Study of Gabapentin (Neurontin®) and Gabapentin Enacarbil (Horizant™) in Restless Leg Syndrometreatment4terminated
NCT03337529
Restless Legs Syndrome in Hemodialysis PatientsNo drug interventionsotherNot Availablecompleted
NCT01617044
Probiotics in the Treatment of Iron Deficiency in Children With Restless Leg SyndromeNo drug interventionstreatment2completed
NCT02386423
RESTIFFIC™ Foot Wrap Reduces Moderate to Severe Restless Leg SyndromeNo drug interventionstreatmentNot Availablecompleted
NCT03818243
Circadian Character of Food Compulsions and Impulses Control Disorders in Parkinsonian Patients With and Without Resting Leg SyndromeNo drug interventionspreventionNot Availablecompleted
NCT00685815
Intravenous Iron Metabolism in Restless Legs Syndrometreatment2completed
NCT05249907
Hemodialysis Patients With Restless Legs Syndrome Used VibrationNo drug interventionssupportive_careNot Availablecompleted
NCT02633657
A PK and Safety Evaluation of HORIZANT (Gabapentin Enacarbil) in Adolescents With Moderate-to-Severe Primary RLStreatment1withdrawn
NCT04356794
Heart Rate Variability Assessment in Dialysis Patients by AcupunctureNo drug interventionstreatmentNot Availablecompleted
NCT02633683
An Extension Study to Evaluate the Efficacy and Safety of HORIZANT in Adolescents With Moderate-to-Severe Primary RLStreatment4unknown_status
NCT02560766
An Efficacy and Safety Evaluation of HORIZANT in Adolescents With Moderate-to-Severe Primary RLStreatment4unknown_status