Complex Partial Seizure Disorder (DBCOND0038432)

Identifiers

Synonyms

Partial complex seizure / Complex partial Seizure / Complex Partial Seizures / Partial complex seizures / Partial seizures, complex / Psychomotor epilepsy / Psychomotor epilepsy (disorder) / Epilepsy, Complex Partial / Focal dyscognitive seizures

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Carbamazepine	An anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia.	Voltage-gated sodium channel alpha subunittarget Cytochrome P450 2C8enzyme Cytochrome P450 2B6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 3A5enzyme UDP-glucuronosyltransferase 2B7enzyme RalA-binding protein 1transporter ATP-binding cassette sub-family C member 2transporter Neuronal acetylcholine receptor subunit alpha-4target Nuclear receptor subfamily 1 group I member 2target UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1-6enzyme UDP-glucuronosyltransferase 1A7enzyme
Ethotoin	A hydantoin antiepileptic used to control tonic-clonic and complex partial seizures.	Sodium channel protein type 5 subunit alphatarget Nuclear receptor subfamily 1 group I member 2target Thyroxine-binding globulincarrier
Phenytoin	An anticonvulsant drug used in the prophylaxis and control of various types of seizures.	Sodium channel protein type 5 subunit alphatarget Sodium channel protein type 1 subunit alphatarget Cytochrome P450 2C8enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2B6enzyme Cytochrome P450 3A5enzyme Albumincarrier Cytochrome P450 3A4enzyme Solute carrier organic anion transporter family member 1C1transporter ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 3A7enzyme Nuclear receptor subfamily 1 group I member 2target Sodium channel regulatory subunit beta-1target Sodium channel protein type 3 subunit alphatarget UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1-6enzyme UDP-glucuronosyltransferase 1A9enzyme Thyroxine-binding globulincarrier Voltage-gated inwardly rectifying potassium channel KCNH2target Voltage-dependent L-type calcium channeltarget Sodium channel protein type 2 subunit alphatarget Sodium channel protein type 8 subunit alphatarget GABA(A) Receptortarget Cytochrome P450 1A2enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2E1enzyme Epoxide hydrolase 1enzyme UDP-glucuronosyltransferase 1A4enzyme Catechol O-methyltransferaseenzyme NAD(P)H dehydrogenase [quinone] 1enzyme Cytochrome P450 2C18enzyme
Valproic acid	An anticonvulsant used to control complex partial seizures and both simple and complex absence seizures.	Histone deacetylase 9target Short/branched chain specific acyl-CoA dehydrogenase, mitochondrialtarget Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme Organic cation/carnitine transporter 2transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Monocarboxylate transporter 1transporter Solute carrier family 22 member 7transporter Cytochrome P450 3A5enzyme UDP-glucuronosyltransferase 1A9enzyme Prostaglandin G/H synthase 1enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme UDP-glucuronosyltransferase 1A4enzyme UDP-glucuronosyltransferase 1A8enzyme UDP-glucuronosyltransferase 1A10enzyme UDP-glucuronosyltransferase 1-6enzyme UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 2B15enzyme 2-oxoglutarate dehydrogenase complex component E1target Succinate-semialdehyde dehydrogenase, mitochondrialtarget Sodium channel proteintarget Histone deacetylase 2target Peroxisome proliferator-activated receptor alphatarget Peroxisome proliferator-activated receptor deltatarget Peroxisome proliferator-activated receptor gammatarget Albumincarrier UDP-glucuronosyltransferase 1A1enzyme Solute carrier organic anion transporter family member 2B1transporter Histone deacetylasetarget Cyclin-dependent kinase inhibitor 1target Hepatocyte growth factortarget Ornithine decarboxylasetarget Programmed cell death 1 ligand 1target 4-aminobutyrate aminotransferase, mitochondrialtarget Glycogen synthase kinase-3 alphatarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03443388	Novel Helmet Design in Patients With Seizures	No drug interventions	prevention	Not Available	completed
NCT00991757	An Open-Label Extension Study to Evaluate the Safety and Tolerability of RWJ 333369 as Adjunctive Therapy in Patients 16 Years and Older With Partial Onset Seizures.	Carisbamate	treatment	3	completed
NCT00425282	A Study of the Efficacy and Safety of RWJ-333369 as add-on Therapy in the Treatment of Partial Onset Seizures.	No drug interventions	treatment	3	completed
NCT00433667	A Study of the Efficacy and Safety of RWJ-333369 as add-on Therapy in the Treatment of Partial Onset Seizures.	No drug interventions	treatment	3	completed
NCT01648959	Intra Cranial EEG Activity During Dexmedetomidine Sedation	No drug interventions	Not Available	Not Available	terminated
NCT01266291	Sabril for Complex Partial Seizures in Adult Tolerability Study (TS) Patients	Vigabatrin	treatment	4	terminated
NCT01749046	Remegal Fixed Dose as Adjunctive Therapy in Patients With Partial Seizures	No drug interventions	treatment	3	completed
NCT00537940	Comparative Study Of Pregabalin And Gabapentin As Adjunctive Therapy In Subjects With Partial Seizures	Gabapentin Pregabalin	treatment	4	completed