Miscellaneous Central Nervous System Agents

Name
Miscellaneous Central Nervous System Agents
Accession Number
DBCAT003658
Description

Not Available

Drugs
DrugDrug Description
AcamprosateA medication used to maintain alcohol abstinence in patients with alcohol dependence.
RiluzoleA glutamate antagonist used to treat amyotrophic lateral sclerosis.
MemantineAn NMDA receptor antagonist used to treat moderate to severe dementia in Alzheimer's.
FlumazenilA benzodiazepine antagonist that is used for the complete or partial reversal of the sedative effects caused by benzodiazepines in various clinical settings, such as induced general anesthesia for diagnostic and therapeutic procedures.
TetrabenazineA vesicular monoamine transporter 2 (VMAT) inhibitor used for the management of chorea associated with Huntington's Disease.
FlibanserinA 5-HT receptor modulator used for the treatment of selected premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD).
BetahistineAn antivertigo agent used for the reduction of episodes of vertigo association with Ménière's disease.
Dimethyl fumarateA medication used to treat patients with the relapsing-remitting form of multiple sclerosis.
Sodium oxybateA central nervous system depressant used to treat cataplexy and excessive daytime sleepiness (EDS) associated with narcolepsy.
AtomoxetineA selective norepinephrine reuptake inhibitor (SNRI) used in the management of Attention Deficit Hyperactivity Disorder (ADHD).
EdaravoneA free radical scavenger used to delay the progression of ALS.
AmifampridineA voltage gated potassium channel blocker used to treat Lambert-Eaton myasthenic syndrome.
Drugs & Drug Targets
DrugTargetType
AcamprosateMetabotropic glutamate receptor 5target
AcamprosateSolute carrier family 22 member 6transporter
AcamprosateGlutamate (NMDA) receptortarget
AcamprosateGamma-aminobutyric acid type B receptor subunit 1target
RiluzoleSodium channel protein type 5 subunit alphatarget
RiluzoleCytochrome P450 1A2enzyme
RiluzoleCystine/glutamate transportertarget
RiluzoleATP-binding cassette sub-family G member 2transporter
RiluzoleCytochrome P450 1A1enzyme
MemantineCytochrome P450 2B6enzyme
MemantineSolute carrier family 22 member 2transporter
Memantine5-hydroxytryptamine receptor 3Atarget
MemantineAlpha-7 nicotinic cholinergic receptor subunittarget
MemantineCytochrome P450 2A6enzyme
MemantineCytochrome P450 2C19enzyme
MemantineDopamine D2 receptortarget
MemantineGlutamate receptor ionotropic, NMDA 1target
MemantineSodium/hydrogen exchanger 1transporter
MemantineSolute carrier family 22 member 4transporter
MemantineMultidrug and toxin extrusion protein 1transporter
MemantineGlutamate (NMDA) receptortarget
MemantineGABA(A) Receptortarget
MemantineGlycine receptorstarget
FlumazenilGamma-aminobutyric acid receptor subunit alpha-1target
FlumazenilGamma-aminobutyric acid receptor subunit gamma-2target
FlumazenilGamma-aminobutyric acid receptor subunit alpha-5target
FlumazenilGABA(A) Receptortarget
TetrabenazineSynaptic vesicular amine transportertarget
TetrabenazineCytochrome P450 2D6enzyme
TetrabenazineDopamine D2 receptortarget
TetrabenazineCarbonyl reductase [NADPH] 1enzyme
Flibanserin5-hydroxytryptamine receptor 1Atarget
Flibanserin5-hydroxytryptamine receptor 2Atarget
FlibanserinDopamine D4 receptortarget
FlibanserinCytochrome P450 3A4enzyme
FlibanserinP-glycoprotein 1transporter
BetahistineHistamine H1 receptortarget
BetahistineHistamine H3 receptortarget
BetahistineMonoamine oxidaseenzyme
Dimethyl fumarateKelch-like ECH-associated protein 1target
Dimethyl fumarateTranscription factor p65target
Sodium oxybateSuccinate-semialdehyde dehydrogenase, mitochondrialenzyme
Sodium oxybateHydroxyacid-oxoacid transhydrogenase, mitochondrialenzyme
AtomoxetineSodium-dependent noradrenaline transportertarget
AtomoxetineCytochrome P450 2D6enzyme
AtomoxetineSodium-dependent serotonin transportertarget
AtomoxetineCytochrome P450 2C19enzyme
AtomoxetineNMDA receptortarget
AtomoxetineSerum albumincarrier
Atomoxetinealpha1-acid glycoproteincarrier
AtomoxetineHigh affinity immunoglobulin gamma Fc receptor Icarrier
AtomoxetineG protein-activated inward rectifier potassium channel 1target
AtomoxetineKappa-type opioid receptortarget
EdaravoneSolute carrier family 22 member 6transporter
EdaravoneSolute carrier family 22 member 8transporter
AmifampridineArylamine N-acetyltransferase 1enzyme
AmifampridineArylamine N-acetyltransferase 2enzyme
AmifampridinePotassium voltage-gated channel subfamily A member 1target