Myeloproliferative Disorders (MPD) (DBCOND0032773)

Identifiers

Synonyms
Myeloproliferative Disorders / Myeloproliferative Disorder / Myeloproliferative Diseases / Myeloproliferative Disease / Myeloproliferative Syndromes / Myeloproliferative Syndrome / Chronic myeloproliferative disease / Myeloproliferative neoplasm / Myeloproliferative disorder NOS / Myeloid proliferation (morphologic abnormality) / Disorder myeloproliferative / Myeloproliferative disorder (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Anagrelide
A platelet-reducing agent used to treat thrombocythemia, and its related complications, secondary to myeloproliferative neoplasms.
Imatinib
A tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors.
Interferon alfa-2a
A form of recombinant human interferon used to stimulate the innate antiviral response in the treatment of hepatitis B and C viruses.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT06150157
A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative NeoplasmsNo drug interventionstreatment1recruiting
NCT05823571
Itacitinib With High-dose Posttransplantation Cyclophosphamide in Older Patientstreatment1recruiting
NCT06265584
Trial of 2 Step ATG for Prevention of Acute GVHD Post Allogeneic Stem Cell Transplanttreatment2not_yet_recruiting
NCT03977103
Irradiation-based Myeloablative Conditioning Followed by Treg/Tcon Immunotherapy in HSCTNo drug interventionstreatment2unknown_status
NCT05842603
I Can Move With Purpose Now! A Pilot Lifestyle Intervention Study in Myeloproliferative Neoplasm PatientsNo drug interventionssupportive_careNot Availablerecruiting
NCT02580903
Pulmonary Hypertension in Patients With Myeloproliferative NeoplasmsNo drug interventionsNot AvailableNot Availablecompleted
NCT01728402
Pathogenesis of Hematologic MalignanciesNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT03655145
HLA 10/10 Matched Unrelated Donor vs Haploidentical Allogenic Hematopoietic Stem Cell TransplantationNo drug interventionstreatment3unknown_status
NCT02890758
Phase I Trial of Universal Donor NK Cell Therapy in Combination With ALT803treatment1completed
NCT02661035
Allo HSCT Using RIC for Hematological Diseasestreatment2completed
NCT01364363
Unrelated Donor Stem Cell TransplantationNo drug interventionstreatmentNot Availablecompleted
NCT06481345
Characterization of Myeloproliferative Neoplasia With a Mutated IDH, SRSF2 or SF3B1 Allele (CARPEDIEM)No drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT01200498
Study of SB939 in Subjects With Myelofibrosistreatment2completed
NCT04631211
Thrombosomes® in Bleeding Thrombocytopenic Patients Studytreatment2terminated
NCT00943293
Minor Histocompatibility Vaccination After Allogeneic Stem Cell Transplantation for Advanced Hematologic Malignanciestreatment1terminated
NCT06315309
Trial of 2 Step ATG for Acute GVHD Prevention Post Myeloablative Allogeneic Stem Cell Transplanttreatment2not_yet_recruiting
NCT00852709
Phase I Dose-Escalation Trial of Clofarabine Followed by Escalating Doses of Fractionated Cyclophosphamide in Children With Relapsed or Refractory Acute Leukemiastreatment1terminated
NCT05088356
Reduced Intensity Allogeneic HCT in Advanced Hematologic Malignancies w/T-Cell Depleted Grafttreatment1recruiting
NCT02320656
Predictive Clinical and Biological Parameters in Acute Leukemia, Myelodysplastic Syndromes and Myeloproliferative Disorders-HEMATO-BIO-IPC-2013-015No drug interventionsbasic_scienceNot Availableunknown_status
NCT00511537
Unrelated Stem Cell Transplantation for Adults With Hematopoietic DisordersNo drug interventionsNot AvailableNot Availablecompleted
NCT01787552
A Phase Ib/II Dose-finding Study to Assess the Safety and Efficacy of LDE225 + INC424 in Patients With MFtreatment1 / 2completed
NCT02806375
PTCy and Ruxolitinib GVHD Prophylaxis in Myelofibrosistreatment1 / 2completed
NCT00075816
Peripheral Blood Stem Cell Transplant vs Bone Marrow Transplant in Individuals With Hematologic Cancers (BMT CTN 0201)No drug interventionstreatment3completed
NCT00185796
TLI & ATG for Non-Myeloablative Allogeneic Transplantation for MDS and MPDNo drug interventionstreatment2completed
NCT04631458
Outcomes in Patients With Myeloproliferative Neoplasm and Splanchnic Vein ThrombosisNo drug interventionsNot AvailableNot Availableunknown_status
NCT05001386
In Vitro Drug Sensitivity Testing of Fresh Human SamplesNo drug interventionsotherNot Availablenot_yet_recruiting
NCT05825326
Epidemiological and Clinical-pathological Factors of Philadelphia-negative Myeloproliferative Neoplasms in EcuadorNo drug interventionsNot AvailableNot Availablecompleted
NCT03452774
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and RegistryNo drug interventionsNot AvailableNot Availablerecruiting
NCT00873574
JAK-STAT Signalling Pathway in Familial Myeloproliferative DisordersNo drug interventionsNot AvailableNot Availablecompleted
NCT00522574
A Safety Study of XL019 in Adults With Myelofibrosistreatment1terminated
NCT01134120
A Study in Myeloproliferative Disorderstreatment1completed
NCT01045382
MSC and HSC Coinfusion in Mismatched MinitransplantsNo drug interventionstreatment2terminated
NCT01787162
Screening for Pulmonary Vascular Changes in Patients With Chronic Myeloproliferative DiseasesNo drug interventionsNot AvailableNot Availablecompleted
NCT00295880
Donor Umbilical Cord Blood Transplant By Injection Into the Bone Marrow in Treating Patients With Hematologic CancerNo drug interventionstreatment1 / 2terminated
NCT01144780
Investigation of Dysregulated Signaling in MPD Via Multiparameter Phospho-specific Flow CytometryNo drug interventionsNot AvailableNot Availableterminated
NCT01392989
Post T-plant Infusion of Allogeneic Cytokine Induced Killer (CIK) Cells as Consolidative Therapy in Myelodysplastic Syndromes/Myeloproliferative Disorderstreatment2completed
NCT00858572
STA-9090 for Treatment of AML, CML, MDS and Myeloproliferative Disorderstreatment1completed
NCT01343368
Preservation of Ovarian Function After Hematopoietic Cell Transplantsupportive_care2terminated
NCT01366612
PRO#1278: Fludarabine and Busulfan vs. Fludarabine, Busulfan and Total Body Irradiationtreatment3terminated
NCT00061581
Experimental Bone Marrow Transplant ProtocolNo drug interventionstreatment2completed
NCT00283114
A Safety Study of Lintuzumab in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndrometreatment1completed
NCT00146055
Low-Intensity Preparation and Allogeneic Transplant in Patients With Cancers of the BloodNo drug interventionstreatment2completed
NCT00745550
A Phase 1/2 Study of Oral SB1518 in Subjects With Chronic Idiopathic Myelofibrosistreatment1 / 2completed
NCT01683123
Study With Intravenous Busulfan And Fludarabine Myeloablative Conditioning Regimen For HLA Identical Sibling Donor HSCTNo drug interventionsNot AvailableNot Availablecompleted
NCT00452023
Pegasys® in Patients With Myeloproliferative Diseasestreatment2completed
NCT00967343
Efficacy and Safety of a Donor Lymphocyte Preparation Depleted of Functional Host Alloreactive T-cells (ATIR) in Patients Undergoing a Peripheral Blood Stem Cell Transplant From a Related, Haploidentical DonorNo drug interventionsprevention2 / 3terminated
NCT00074490
Donor Stem Cell Transplant With No or Low-Intensity Chemotherapy Using Sirolimus and Treated Immune Cells to Treat Blood and Lymph Cancerstreatment2terminated
NCT05969821
Clonal Hematopoiesis of Immunological SignificanceNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT06138587
Preemptive CIML NK Cell Therapy After Hematopoietic Stem Cell Transplantationtreatment1recruiting
NCT00038051
Evaluation of the Anti-CD-33 Immunotoxin Hum-195/rGel in Patients With Advanced Myeloid MalignanciesNo drug interventionstreatment1completed
NCT02766153
Exploring the Mechanisms of Resistance of Stem Cells Myeloproliferative Opposite of Tyrosine Kinase Inhibitors in 3d Model Niche EndostealNo drug interventionsNot AvailableNot Availableterminated
NCT00787761
Early Administration of ATG Followed by Cyclophosphamide, Busulfan and Fludarabine Before a Donor Stem Cell Transplant in Patients With Hematological Cancertreatment2completed
NCT00186342
Sibling and Unrelated Donor Hematopoietic Cell Transplant in Hematologic MalignanciesNo drug interventionstreatmentNot Availablecompleted
NCT00569842
Investigation of the Cylex® ImmuKnow® AssayNo drug interventionsNot AvailableNot Availablecompleted
NCT00827099
Umbilical Cord Blood (UCB) Transplant, Fludarabine, Melphalan, and Anti-thymocyte Globulin (ATG) in Treating Patients With Hematologic Cancertreatment2terminated
NCT01135849
B-Receptor Signaling in CardiomyopathyNo drug interventionsNot AvailableNot Availablecompleted
NCT02158858
A Phase 2 Study of CPI-0610 With and Without Ruxolitinib in Patients With Myelofibrosistreatment1 / 2active_not_recruiting
NCT00578539
T-Reg Cell Kinetics, Stem Cell Transplant, REGALEtreatmentNot Availableterminated
NCT02663648
Cell Cycle Regulatory Gene Study in Patients With Myeloproliferative DisordersNo drug interventionsNot AvailableNot Availablewithdrawn
NCT00276926
Study of STI571 in the Treatment of Patients With Idiopathic Hypereosinophilic Syndrome (HES) and Eosinophilic LeukemiasNot Available2unknown_status
NCT00305682
Non-Myeloablative Conditioning for Unrelated Donor Umbilical Cord Blood Transplanttreatment2completed
NCT00186576
Non-Myeloablative Allogeneic Transplant for Myelodysplastic Syndromes and Myeloproliferative DisordersNo drug interventionstreatmentNot Availablecompleted
NCT04464889
HA-1H TCR T Cell for Relapsed/Persistent Hematologic Malignancies After Allogeneic Stem Cell TransplantationNo drug interventionstreatment1withdrawn
NCT00361140
Busulfan Safety/Efficacy as Conditioning Prior to Hematopoietic Cell Transplantation (HCT)treatment4completed
NCT00499668
Aprepitant or Ondansetron in Treating Nausea and Vomiting Caused By Opioids in Patients With Cancersupportive_careNot Availablewithdrawn
NCT01413568
Safety and Efficacy of POL6326 for Mobilization/Transplant of Sibling Donor in Patients With Hematologic MalignanciesNo drug interventionstreatment1 / 2completed
NCT04717414
An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusionstreatment3active_not_recruiting
NCT01684150
A Phase 1, Open-Label, Dose-Escalation & Expanded Cohort, Continuous IV Infusion, Multi-center Study of the Safety, Tolerability,PK & PD of EPZ-5676 in Treatment Relapsed/Refractory Patients With Leukemias Involvingtreatment1completed
NCT00003838
Specialized Blood Cell Transplants for Cancers of the Blood and Bone Marrowtreatment2completed
NCT03808805
Aprepitant Versus Hydroxyzine in Persistent Aquagenic Pruritus for Patients With Myeloproliferative Neoplasmstreatment3unknown_status
NCT04473911
Haplo Peripheral Blood Sct In GVHD Preventiontreatment1active_not_recruiting
NCT03852407
Allogeneic Hematopoietic Cell Transplantation From HLA-matched Donor After Flu-Mel-PTCy Versus Flu-Mel-ATG Reduced-intensity Conditioningtreatment2recruiting
NCT03907436
The NUTRIENT Trial (NUTRitional Intervention Among myEloproliferative Neoplasms): Feasibility PhaseNo drug interventionstreatmentNot Availablecompleted
NCT03434730
Tocilizumab for the Prevention of Graft Versus Host Disease After Cord Blood Transplantationtreatment2active_not_recruiting
NCT03869476
Pilot Study for the Development of a Diagnostic Score to Differentiate Myeloproliferative Neoplasms.No drug interventionsdiagnosticNot Availablerecruiting
NCT03734601
Total Body Irradiation +/- Total Lymphoid Irradiation & Anti-Thymocyte Globulin in Non-myeloablative Hematopoietic Cell Transplantationtreatment2completed
NCT00687414
Evaluation of Formin Gene Status and Expression in Myeloproliferative and Myelodysplastic DisordersNo drug interventionsNot AvailableNot Availablecompleted
NCT03149055
Fungal Prophylaxis With Isavuconazole for Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant (HCT)treatment2completed
NCT00175838
Primary Thrombocythaemia 1 TrialtreatmentNot Availablecompleted
NCT03688490
Clinical Characteristics of Aquagenic Pruritus in Patients With Myeloproliferative NeoplasmsNo drug interventionsNot AvailableNot Availablecompleted
NCT05884333
Cord Blood Transplant in Adults With Blood CancersNo drug interventionstreatment2recruiting
NCT01499147
Fludarabine Based Conditioning for Allogeneic Transplantation for Advanced Hematologic MalignanciestreatmentNot Availablecompleted
NCT06246006
Functional Characterization of Thrombopoietin/cMPL Receptor Mutations in Myeloproliferative NeoplasiaNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT01866839
Preventing Stem Cell Transplant Complications With a Blood Separator MachineNo drug interventionstreatment1 / 2completed
NCT00588666
Phase II Trial of Gemcitabine, Carboplatin, and Bevacizumab in Chemotherapy Naive Patients With Advanced/Metastatic Urothelial Carcinomatreatment2completed
NCT03480360
Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expressiontreatment3active_not_recruiting
NCT00909467
Early Recognition of Pulmonary Arterial Hypertension in Myelodysplastic and Myeloproliferative DiseasesNo drug interventionsNot AvailableNot Availablecompleted
NCT00683046
T-Cell Depleted Allogeneic Stem Cell Transplantation for Patients With Hematologic Malignanciestreatment2completed
NCT00539695
Low Dose IL-2, Hematopoietic Stem Cell Transplantation, IL2 for GVHDtreatment2completed
NCT00533923
Nonmyeloablative Allogeneic Stem Cell Transplantation From HLA-Matched Unrelated Donor for the Treatment of Hematologic Disorderstreatment2completed
NCT02720679
Investigation of the Genetics of Hematologic DiseasesNo drug interventionsNot AvailableNot Availablerecruiting
NCT01518153
Planned Donor Lymphocyte Infusion (DLI) After Allogeneic Stem Cell Transplantation (SCT)treatment2terminated
NCT00606307
Phase IIA Study of the HDAC Inhibitor ITF2357 in Patients With JAK-2 V617F Positive Chronic Myeloproliferative Diseasestreatment2completed
NCT00513175
Non-Myeloablative Allogeneic Stem Cell Transplantation With Matched Unrelated Donors for Treatment of Hematologic Malignancies, Renal Cell Carcinoma, and Aplastic AnemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT01444742
Clofarabine Plus Low-Dose Cytarabine for Patients With Higher-Risk Myelodysplastic Syndrome (MDS)treatment2completed
NCT01572662
Allogeneic Transplantation Using Timed Sequential Busulfan and Fludarabine Conditioningtreatment2completed
NCT01375140
Ruxolitinib and Lenalidomide for Patients With Myelofibrosistreatment2completed
NCT02410551
Pacritinib Before Transplant for Myeloproliferative Neoplasms (MPN)treatment2terminated
NCT02267278
Ruxolitinib and Pracinostat Combination Therapy for Patients With Myelofibrosis (MF)treatment2completed
NCT01875237
Donor Lymphocyte Infusion (DLI) of T-cells Genetically Modified With iCasp9 Suicide Genetreatment1 / 2terminated
NCT01800643
Evaluation of Plasmatic Levels of Busulfan in Patients Undergoing Hematopoietic Stem Cell TransplantationNo drug interventionstreatment2 / 3unknown_status
NCT01749111
Comparison Between Cyclophosphamide and Combination of Methotrexate + Calcineurin Inhibitor for GVHD Prophylaxisprevention3terminated
NCT01758042
Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood DisordersNo drug interventionstreatmentNot Availablerecruiting
NCT01167166
Safety and Efficacy of 72-hour and 120-hour Infusion of Rigosertib in Acute Myeloid Leukemia (AML) and Acute Lymphoid Leukemia (ALL)treatment1 / 2completed
NCT02308787
Retrospective Data Collection of Routine Use With Spectra Optia® for Platelet DepletionsNo drug interventionsNot AvailableNot Availablecompleted
NCT01884974
A Case Control Study of the Prevalence of Pulmonary Hypertension in Patients With Myeloproliferative Diseases.No drug interventionsNot AvailableNot Availableunknown_status
NCT05553873
Evaluation of Inflammatory Markers in ph Negative Myeloproliferative Neoplasms: Impact on Outcome and Response to Therapy. Multicenter Retro-prospective Observational Study. The INFLA-ME (INFLAmmation in Myeloproliferative Disease) Study.No drug interventionsNot AvailableNot Availablerecruiting
NCT01394640
Immunologic Response After Pandemic Influenza A (H1N1) Vaccine in Onco- Hematologic PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT00665067
Correlative Biomarker Study in Patients With Myeloproliferative DisordersNo drug interventionsNot AvailableNot Availablecompleted
NCT04935684
Faecal Microbiota Transplantation After Allogeneic Stem Cell Transplantationtreatment2recruiting
NCT04992949
Evaluation of CPX-351 Monotherapy in Acute Myeloid Leukemia Secondary to Myeloproliferative NeoplasmNo drug interventionstreatment2recruiting
NCT04968834
Protocol For Genomically Profiling, Collecting, Archiving And Distributing Blood And Bone Marrow Specimens From Children And Young Adults With Hematologic MalignancyNo drug interventionsNot AvailableNot Availablerecruiting
NCT05400122
Natural Killer (NK) Cells in Combination With Interleukin-2 (IL-2) and Transforming Growth Factor Beta (TGFbeta) Receptor I Inhibitor Vactosertib in Cancertreatment1recruiting
NCT02508038
Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumorstreatment1recruiting
NCT01660607
Phase 1-2 MAHCT w/ TCell Depleted Graft w/ Simultaneous Infusion Conventional and Regulatory T CellNo drug interventionstreatment1 / 2completed
NCT02873832
Efficacy of Heat-shock Protein (HSP) Inhibitors in Myeloproliferative Syndromes (MPS)No drug interventionsNot AvailableNot Availablecompleted
NCT02129582
Targeted Marrow Irradiation, Fludarabine Phosphate, and Busulfan Before Donor Progenitor Cell Transplant in Treating Patients With Hematologic Malignanciestreatment1completed