Paroxysmal Supraventricular Tachycardia (PSVT) (DBCOND0075436)

Identifiers

Synonyms

Tachycardia; Paroxysmal, Supraventricular / PVST / Paroxysmal Supraventricular Tachycardia / PSVT / Paroxysmal tachycardia (supraventricular) / Paroxysmal supraventricular tachycardia (disorder) / Supraventricular tachycardia / Tachycardia, Supraventricular / Supraventricular tachycardia (disorder) / Tachycardia supraventricular

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Adenosine	A medication used in myocardial perfusion scintigraphy and to treat supraventricular tachycardia.	Adenosine receptor A3target Adenosine deaminaseenzyme Adenosine kinaseenzyme Adenosine receptor A1target Adenosine receptor A2atarget Adenosine receptor A2btarget Solute carrier family 28 member 3transporter Equilibrative nucleoside transporter 1transporter Equilibrative nucleoside transporter 2transporter Equilibrative nucleoside transporter 3transporter Equilibrative nucleoside transporter 4transporter Sodium/nucleoside cotransporter 1transporter Sodium/nucleoside cotransporter 2transporter Gap junction alpha-1 proteintransporter Adenylate kinase isoenzyme 1enzyme Nucleoside diphosphate kinase Aenzyme Nucleoside diphosphate kinase Benzyme Purine nucleoside phosphorylaseenzyme Xanthine dehydrogenase/oxidaseenzyme Albumincarrier
Diltiazem	A calcium channel blocker used to treat hypertension and to manage chronic stable angina.	Voltage-dependent calcium channel gamma-1 subunittarget Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2C8enzyme Albumincarrier Alpha-1-acid glycoprotein 1carrier Voltage-dependent L-type calcium channel subunit alpha-1Ctarget Voltage-dependent calcium channel subunit alpha-2/delta-1target
Hydroquinidine	A medication indicated in the maintenance of a normal sinus rhythm, as well as the treatment and prevention of abnormal rhythm.	No drug targets
Phenylephrine	An alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics.	Alpha-1A adrenergic receptortarget Alpha-1B adrenergic receptortarget Amine oxidase [flavin-containing] Aenzyme Alpha-1D adrenergic receptortarget Cytochrome P450 1A2enzyme Sulfotransferase 1A3enzyme Amine oxidase [flavin-containing] Benzyme D(2) dopamine receptortarget
Propafenone	A Class 1C antiarrhythmic agent used in the management of paroxysmal atrial fibrillation/flutter and ventricular arrhythmias.	Sodium channel protein type 5 subunit alphatarget Voltage-gated inwardly rectifying potassium channel KCNH2target Cytochrome P450 1A2enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Beta-1 adrenergic receptortarget Beta-2 adrenergic receptortarget
Verapamil	A non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension.	ATP-sensitive inward rectifier potassium channel 11target Voltage-dependent T-type calcium channel subunit alpha-1Gtarget Voltage-gated inwardly rectifying potassium channel KCNH2target Voltage-dependent L-type calcium channel subunit alpha-1Ctarget Cytochrome P450 1A2enzyme Cytochrome P450 3A5enzyme Voltage-dependent N-type calcium channel subunit alpha-1Btarget Voltage-dependent P/Q-type calcium channel subunit alpha-1Atarget Sodium-dependent serotonin transportertarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Solute carrier family 22 member 1transporter ATP-binding cassette sub-family C member 3transporter ATP-binding cassette sub-family C member 4transporter Organic cation/carnitine transporter 2transporter Solute carrier organic anion transporter family member 1A2transporter ATP-binding cassette sub-family C member 10transporter Solute carrier family 22 member 4transporter Solute carrier organic anion transporter family member 1B1transporter Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme Alpha-1A adrenergic receptortarget Alpha-1B adrenergic receptortarget Alpha-1D adrenergic receptortarget Albumincarrier Alpha-1-acid glycoprotein 1carrier Cytochrome P450 2C18enzyme Cytochrome P450 2E1enzyme Multidrug resistance-associated protein 1transporter Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Voltage-dependent T-type calcium channel subunit alpha-1Htarget Voltage-dependent calcium channeltarget ATP-dependent translocase ABCB1target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03353610	The PSVT Place Registry.Paroxysmal Supraventricular Tachycardia (PSVT) Registry.	No drug interventions	Not Available	Not Available	terminated
NCT02296190	Efficacy and Safety of Intranasal MSP-2017 (Etripamil) for the Conversion of PSVT to Sinus Rhythm	Etripamil	treatment	2	completed
NCT04078685	Contact-Force-Sensing-Based Radiofrequency Catheter Ablation in Paroxysmal Supraventricular Tachycardias	No drug interventions	treatment	Not Available	unknown_status
NCT05770921	Pulsed Field Ablation for Paroxysmal Supraventricular Tachycardia（PSVT）	No drug interventions	treatment	Not Available	completed
NCT06573853	Outcomes of PFA Vs. RFA for Patients With PSVT: a Retrospective and Propensity Score Matching Study	No drug interventions	Not Available	Not Available	recruiting
NCT05763953	The NODE-202 Study (Study of Etripamil Nasal Spray in Pediatric Patients)	Etripamil	treatment	2	recruiting
NCT03042078	Zero-fluoroscopy Approach Versus Fluoroscopic Approach for the Ablation of Paroxysmal Supraventricular Tachycardia	No drug interventions	treatment	Not Available	completed
NCT03464019	Efficacy and Safety of Etripamil for the Termination of Spontaneous Paroxysmal Supraventricular Tachycardia (PSVT).	Etripamil	treatment	3	terminated
NCT05820035	A Multicenter Study of Pulsed Field Ablation for Paroxysmal Supraventricular Tachycardia	No drug interventions	treatment	Not Available	active_not_recruiting
NCT04072835	Safety Study of Etripamil Nasal Spray for Patients With Paroxysmal Supraventricular Tachycardia. NODE-303	Etripamil	treatment	3	completed
NCT05410860	Efficacy and Safety Study of Etripamil Nasal Spray Self-Administration for the Termination of Spontaneous Episodes of Paroxysmal Supraventricular Tachycardia	Etripamil	treatment	3	active_not_recruiting
NCT03348436	Study on Left Atrial Function of Paroxysmal Supraventricular Tachycardia After Radiofrequency Ablation	No drug interventions	treatment	Not Available	completed
NCT01655316	Oral Verapamil in Acute Paroxysmal Supra Ventricular Tachycardia(PSVT) Recurrence Control	Verapamil	treatment	4	completed
NCT03635996	Safety Study of Intranasal Etripamil for the Termination of Spontaneous Episodes of Paroxysmal Supraventricular Tachycardia (PSVT). NODE-302	Etripamil	treatment	3	terminated
NCT06327425	MCG for Localization of Tachyarrhythmia's Origin	No drug interventions	diagnostic	Not Available	recruiting
NCT04215640	Radiofrequency Ablation of Paroxysmal Supraventricular Tachycardia Using a Novel Catheter Equipped With Mini Electrodes	No drug interventions	treatment	Not Available	completed
NCT04952610	Etripamil Nasal Spray in Patients With Paroxysmal Supraventricular Tachycardia	Etripamil	treatment	3	enrolling_by_invitation