Estrogen Antagonists

Name
Estrogen Antagonists
Accession Number
DBCAT000786
Description

Compounds which inhibit or antagonize the biosynthesis or action of estradiol.

Drugs
DrugDrug Description
AminoglutethimideAn adrenocortical steroid synthesis inhibitor used in the treatment of Cushing's syndrome.
RaloxifeneA selective estrogen receptor modulator that is used to prevent and treat osteoporosis and reduce the risk of invasive breast cancer in high-risk postmenopausal women.
TamoxifenA selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women.
FulvestrantAn estrogen receptor antagonist used to treat HR+ breast cancer that may also be HER2-.
ExemestaneAn aromatase inhibitor used to treat breast cancer in postmenopausal women after treatment with tamoxifen.
LetrozoleAn aromatase inhibitor used to treat breast cancer in postmenopausal women.
AnastrozoleA competitive, selective, non-steroidal aromatase inhibitor used as adjuvant therapy for the treatment of hormone receptor-positive breast cancer in postmenopausal women.
DanazolA synthetic steroid and pituitary gonadotropin inhibitor used in the treatment of endometriosis and symptomatic treatment of severe pain and tenderness associated with benign fibrocystic breasts.
NaringeninNot Available
AfimoxifeneFor the potential treatment of menstrual-cycle related mastalgia, fibrocystic breast disease, breast disease, gynecomastia and Keloid scarring.
EnclomipheneNot Annotated
FormestaneFor the treatment of estrogen-receptor positive breast cancer in post-menopausal women.
MoxestrolNot Annotated
ICI-164384Not Available
ClomifeneA medication used to induce ovulation.
Hydroxyprogesterone caproateA synthetic progestin used for the prevention of spontaneous preterm births in singleton pregnancies in women who have previously had a spontaneous preterm birth.
DroloxifeneDroloxifene, a derivative of the triphenylethylene drug tamoxifen, is a novel selective estrogen receptor modulator (SERM). Droloxifene also exhibits more rapid pharmacokinetics, reaching peak concentrations and being eliminated much more...
VorozoleNot Annotated
FadrozoleNot Annotated
OrmeloxifeneA selective estrogen receptor modulator used as a non-hormonal, non-steroidal oral contraceptive.
Drugs & Drug Targets
DrugTargetType
AminoglutethimideAromatasetarget
AminoglutethimideCytochrome P450 2C19enzyme
AminoglutethimideCytochrome P450 3A4enzyme
AminoglutethimideCholesterol side-chain cleavage enzyme, mitochondrialtarget
RaloxifeneEstrogen receptortarget
RaloxifeneEstrogen receptor betatarget
RaloxifeneAldehyde oxidaseenzyme
RaloxifeneCytochrome P450 2C8enzyme
RaloxifeneCytochrome P450 2B6enzyme
RaloxifeneAromataseenzyme
RaloxifeneCytochrome P450 3A4enzyme
RaloxifeneSerpin B9target
RaloxifeneTrefoil factor 1target
RaloxifeneUDP-glucuronosyltransferase 1A1enzyme
RaloxifeneAlbumincarrier
RaloxifeneAlpha-1-acid glycoprotein 1carrier
RaloxifeneSolute carrier organic anion transporter family member 1B1transporter
RaloxifeneSolute carrier organic anion transporter family member 1B3transporter
RaloxifeneATP-dependent translocase ABCB1transporter
RaloxifeneBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
RaloxifeneATP-binding cassette sub-family C member 2transporter
RaloxifeneATP-binding cassette sub-family C member 3transporter
RaloxifeneATP-binding cassette sub-family C member 4transporter
RaloxifeneUDP-glucuronosyltransferase 1A10enzyme
RaloxifeneUDP-glucuronosyltransferase 1A8enzyme
TamoxifenEstrogen receptortarget
TamoxifenEstrogen receptor betatarget
TamoxifenCytochrome P450 2C9enzyme
TamoxifenCytochrome P450 3A4enzyme
TamoxifenCytochrome P450 2D6enzyme
TamoxifenCytochrome P450 2C8enzyme
TamoxifenCytochrome P450 2B6enzyme
TamoxifenLiver carboxylesterase 1enzyme
TamoxifenCytochrome P450 3A5enzyme
TamoxifenCytochrome P450 1A1enzyme
TamoxifenCytochrome P450 1B1enzyme
TamoxifenCytochrome P450 2C19enzyme
TamoxifenFlavin-containing monooxygenase 1enzyme
TamoxifenFlavin-containing monooxygenase 3enzyme
TamoxifenCytochrome P450 3A7enzyme
TamoxifenATP-dependent translocase ABCB1transporter
TamoxifenBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
TamoxifenAromataseenzyme
TamoxifenCytochrome P450 2A6enzyme
TamoxifenCytochrome P450 2E1enzyme
TamoxifenUDP-glucuronosyltransferase 1A10enzyme
TamoxifenSulfotransferase 1A1enzyme
TamoxifenATP-binding cassette sub-family C member 2transporter
Tamoxifen3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerasetarget
TamoxifenProtein kinase Ctarget
TamoxifenAndrogen receptortarget
TamoxifenVoltage-gated inwardly rectifying potassium channel KCNH2target
TamoxifenNuclear receptor subfamily 1 group I member 2target
TamoxifenEstrogen-related receptor gammatarget
TamoxifenSex hormone-binding globulintarget
TamoxifenBile salt export pumptransporter
TamoxifenThyroxine-binding globulincarrier
TamoxifenSulfotransferase 2A1enzyme
TamoxifenCytochrome P450 1A2enzyme
TamoxifenUDP-glucuronosyltransferase 2B7enzyme
TamoxifenUDP-glucuronosyltransferase 2B17enzyme
TamoxifenSulfotransferase 1E1enzyme
TamoxifenPhospholipid-transporting ATPase ABCA1transporter
TamoxifenMitogen-activated protein kinase 8target
TamoxifenAlbumincarrier
FulvestrantEstrogen receptortarget
FulvestrantCytochrome P450 3A4enzyme
FulvestrantUDP-glucuronosyltransferase 1A1enzyme
ExemestaneAromatasetarget
ExemestaneCytochrome P450 3A4enzyme
ExemestaneAromataseenzyme
LetrozoleAromatasetarget
LetrozoleCytochrome P450 3A4enzyme
LetrozoleCytochrome P450 2A6enzyme
LetrozoleAromataseenzyme
LetrozoleCytochrome P450 2C19enzyme
LetrozoleUDP-glucuronosyltransferase 2B7enzyme
LetrozoleAlbumincarrier
LetrozoleATP-dependent translocase ABCB1transporter
AnastrozoleAromatasetarget
AnastrozoleATP-dependent translocase ABCB1transporter
AnastrozoleCytochrome P450 3A4enzyme
AnastrozoleCytochrome P450 3A5enzyme
AnastrozoleCytochrome P450 2C8enzyme
AnastrozoleUDP-glucuronosyltransferase 1A4enzyme
AnastrozoleUDP-glucuronosyltransferase 1A3enzyme
AnastrozoleUDP-glucuronosyltransferase 2B7enzyme
AnastrozoleCytochrome P450 1A2enzyme
AnastrozoleCytochrome P450 2C9enzyme
DanazolEstrogen receptortarget
DanazolGonadotropin-releasing hormone receptortarget
DanazolPutative gonadotropin-releasing hormone II receptortarget
DanazolSex hormone-binding globulincarrier
DanazolC-C motif chemokine 2target
DanazolAromataseenzyme
DanazolAndrogen receptortarget
DanazolProgesterone receptortarget
DanazolCytochrome P450 3A4enzyme
NaringeninSolute carrier organic anion transporter family member 2B1transporter
NaringeninATP-dependent translocase ABCB1transporter
NaringeninMultidrug resistance-associated protein 1transporter
NaringeninBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
NaringeninHTH-type transcriptional regulator TtgRtarget
NaringeninEstrogen receptortarget
NaringeninAldo-keto reductase family 1 member C1target
NaringeninCytochrome P450 1B1target
NaringeninKAT8 regulatory NSL complex subunit 3target
NaringeninSex hormone-binding globulintarget
NaringeninAromatasetarget
NaringeninEstrogen receptor betatarget
AfimoxifeneEstrogen receptortarget
AfimoxifeneEstrogen receptor betatarget
AfimoxifeneEstrogen-related receptor gammatarget
AfimoxifeneTrefoil factor 1target
AfimoxifeneSteroid hormone receptor ERR1target
AfimoxifeneNuclear receptor subfamily 1 group I member 2target
AfimoxifeneSex hormone-binding globulintarget
EnclomipheneCytochrome P450 2D6enzyme
EnclomipheneEstrogen receptortarget
FormestaneCytochrome P450 3A4enzyme
FormestaneAromatasetarget
ICI-164384Estrogen receptor betatarget
ICI-164384Estrogen receptortarget
ClomifeneEstrogen receptortarget
ClomifeneATP-dependent translocase ABCB1transporter
ClomifeneSex hormone-binding globulintarget
ClomifeneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
Hydroxyprogesterone caproateProgesterone receptortarget
Hydroxyprogesterone caproateCytochrome P450 3A4enzyme
Hydroxyprogesterone caproateCytochrome P450 3A5enzyme
Hydroxyprogesterone caproateCytochrome P450 2C19enzyme
DroloxifeneEstrogen receptortarget
VorozoleAromatasetarget
FadrozoleAromatasetarget
FadrozoleCytochrome P450 11B1, mitochondrialtarget
OrmeloxifeneEstrogen receptortarget
OrmeloxifeneEstrogen receptor betatarget
OrmeloxifeneAlbumincarrier