Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) (DBCOND0054311)

Identifiers

Synonyms
Allogeneic hematopoietic stem cell transplant / Allogeneic Hematopoietic Cell Transplantation (HCT) / Hematopoietic Steam Cell Transplantation (HCT) / Allogeneic Hematopoietic Cell Transplantation / Allogeneic Hematopoietic Cell Transplant / Allogeneic, Hematopoietic Cell Transplant (HCT) / Allogeneic peripheral haematopoietic stem cell transplant / Allogeneic Hematopoietic Stem Cell Transplantation / Hematopoietic Stem Cell Transplantation, Allogeneic / Allogeneic peripheral hematopoietic stem cell transplant / Allogeneic HSCT / Allogeneic Hematopoietic Stem Cell (HSC) Transplantation / Allogeneic Haematopoietic Stem Cell Transplantation / Allogenic stem cell transplantation / Allogeneic stem cell transplantation

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Letermovir
An antiviral medication used for prophylaxis in adult transplant recipients at risk of cytomegalovirus (CMV) infection and disease.
Methotrexate
An antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis.
Omidubicel
A nicotinamide-modified allogeneic hematopoietic progenitor cell therapy derived from cord blood indicated for use in patients with hematologic malignancies who are planned for umbilical cord blood transplantation following myeloablative conditioning.
No drug targets
Voriconazole
A triazole compound used to treat fungal infections.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05088356
Reduced Intensity Allogeneic HCT in Advanced Hematologic Malignancies w/T-Cell Depleted Grafttreatment1recruiting
NCT03720392
Fecal Microbiota Transplantation (FMT) in Recipients After Allogeneic Hematopoietic Cell Transplantation (HCT)No drug interventionstreatment2terminated
NCT04423939
ACT to Reduce Morbidity and Mortality in Hematopoietic Stem Cell Transplant (HCT) PatientsNo drug interventionssupportive_careNot Availableactive_not_recruiting
NCT04332341
Study of Nicotinamide Riboside Supplementation in Allogeneic Hematopoietic Cell Transplantationtreatment0recruiting
NCT03302754
Precision Dosing of AlemtuzumabotherNot Availablecompleted
NCT05501756
Precision Alemtuzumab Dosing for Allogeneic Hematopoietic Cell Transplantationtreatment2recruiting
NCT02506231
The Effect of Folinic Acid Rescue Following MTX GVHD Prophylaxis on Regimen Related Toxicity and Transplantation Outcomeprevention2 / 3unknown_status
NCT04117477
Xylitol - Healthcare Associated Infection Reduction in Stem Cell Transplant Patientsprevention2terminated
NCT03678493
A Study of FMT in Patients With AML Allo HSCT in Recipientstreatment2completed
NCT00888316
Iron Overload in Patients Undergoing Donor Stem Cell TransplantNo drug interventionsNot AvailableNot Availablecompleted
NCT04088760
TCRαβ+/CD19+ Depleted Allogeneic Hematopoietic Stem Cell Transplantation for Malignant and Non-malignant DisordersNo drug interventionstreatment2terminated
NCT03394365
Tabelecleucel for Solid Organ or Allogeneic Hematopoietic Cell Transplant Participants with Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease (EBV+ PTLD) After Failure of Rituximab or Rituximab and Chemotherapytreatment3recruiting
NCT01903928
A Study to Evaluate Safety and Tolerability of a Therapeutic Vaccine, ASP0113, in Subjects Undergoing Allogeneic Hematopoietic Cell TransplantNo drug interventionstreatment2completed
NCT04926194
Decidual Stromal Cells to Treat Graft-vs-Host Disease After Stem Cell Transplant for Myelodysplastic Syndrome/Myeloproliferative NeoplasmNo drug interventionstreatment2completed
NCT04554914
A Study to Evaluate Tabelecleucel in Participants With Epstein-barr Virus-associated Diseasestreatment2recruiting
NCT01877655
A Study to Evaluate a Therapeutic Vaccine, ASP0113, in Cytomegalovirus (CMV)-Seropositive Recipients Undergoing Allogeneic, Hematopoietic Cell Transplant (HCT)No drug interventionsprevention3completed
NCT06093867
Early Detection of Infectious and Noninfectious Lung Diseases Following Allogeneic Hematopoietic Stem Cell TransplantationNo drug interventionsNot AvailableNot Availablerecruiting
NCT05534620
Effect of Moderate Renal Impairment and Race/Ethnicity on Treosulfan Pharmacokineticsother1recruiting
NCT01420562
Pharmacokinetics of Posaconazole in Allogeneic Transplant Patients With MucositisNo drug interventionsNot AvailableNot Availablerecruiting
NCT04995653
A Multiple Dose Study to Evaluate Safety, Tolerability, PK, and Efficacy of SER-155 in Adults Undergoing HSCTtreatment1completed
NCT05667402
Clinical Study of TBF Regimen in Allo-HSCT in Patients With CNS LeukemiaNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT03378102
Antigen Specific Adoptive T Cell Therapy for Adenovirus Infection After Hematopoietic Stem Cell TransplantationNo drug interventionssupportive_care0recruiting
NCT04098653
Decitabine + BUCY vs BUCY Conditioning Regimen for Myeloid Tumors Undergoing Allo-HSCTtreatment2 / 3unknown_status
NCT03530085
Dec+Flu+Bu Conditioning Regimen for Elderly AML in CR Undergoing Allo-HSCTtreatment2 / 3unknown_status
NCT02670252
BuCY vs TBICY Conditioning Regimen for Standard-risk ALL Undergoing Allo-HSCTtreatment3completed
NCT05453552
G-CSF+DAC+BUCY vs G-CSF+DAC+BF Conditioning Regimen for High-risk MDS Undergoing Allo-HSCTtreatment2 / 3recruiting
NCT02250300
MLN9708 for the Prophylaxis of Chronic Graft-versus-host Disease in Patient Undergoing Allogeneic Transplantationtreatment1 / 2completed
NCT05449899
G-CSF+DAC+BUCY vs G-CSF+DAC+BF Conditioning Regimen for Secondary Acute Myeloid Leukemia Undergoing Allo-HSCTtreatment2 / 3recruiting
NCT05692713
Polyomic Biomarker Verification in Adult Chronic Graft-Versus-Host Disease (ABLE3.0/CTTC2201)No drug interventionsNot AvailableNot Availablerecruiting
NCT03902041
The Prospective Randomized Controlled Study of Eltrombopag on Hematopoietic Reconstruction After Allogeneic HSCTNot AvailableNot Availableunknown_status
NCT03294824
Non Randomized Comparative Study With ControlNo drug interventionsNot AvailableNot Availableunknown_status
NCT02653196
A Multi-Institutional Pilot Study of Allogeneic Hematopoietic Stem Cell Transplantation for Patients With Malignant Neuro-Epithelial and Other Solid Tumorstreatment0terminated
NCT05126186
Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation With Post-transplant Cyclophosphamide for Rescuing Patients With Graft FailureNo drug interventionsother2not_yet_recruiting
NCT05327673
Impact of the Use of Allogeneic Hematopoietic Stem Cell Transplantation in Reunion Island Patients: Quality of Life, Determinants of Choices and Financial RepercussionsNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT05084027
Venetoclax Combining With Fludarabine and Melphalan as Conditioning Regimen for Allo-HSCTtreatment2recruiting
NCT03596892
Decitabine+BUCY vs BUCY Conditioning Regimen for MLL+ Acute Leukemia Undergoing Allo-HSCTtreatment2 / 3unknown_status
NCT03357172
Determination of Factors Involved in the Regulation of Immune Responses After Allogeneic Hematopoietic Stem Cell TransplantationNo drug interventionsotherNot Availablerecruiting
NCT01879072
Prospective Cohort for the Evaluation of Biomarkers Following HCT (BMT CTN 1202)No drug interventionsNot AvailableNot Availablecompleted
NCT05596968
The Gut Microbiome and Sorafenib Maintenance Therapy in FLT3-ITD Positive AML After Allo-HSCTNot AvailableNot Availablerecruiting
NCT02270346
Inspiratory Muscle Training in Allogeneic Hematopoietic Stem Cell Transplantation RecipientsNo drug interventionssupportive_careNot Availablecompleted
NCT03384212
CBA Versus FBA Conditioning Followed by Allogeneic HSCT in Treatment of High Risk and Refractory AMLtreatment3unknown_status
NCT02728895
Dose Finding Study of Vedolizumab for GvHD in Participants Undergoing Allogeneic HSCTtreatment1completed
NCT05823714
Venetoclax+Azacytidine+Modified BUCY Conditioning Regimen for Acute Myeloid Leukemia and Myelodysplastic Syndromes Undergoing Allo-HSCTNo drug interventionstreatment2recruiting
NCT05089838
CMV-TCR-T Cells for Refractory CMV Infection After HSCTNo drug interventionstreatment1unknown_status
NCT05104684
Chest Physical Therapy in Patients Waiting for Allogeneic Hematopoietic Stem Cell Transplantation"No drug interventionstreatmentNot Availablecompleted
NCT04247945
Co-transplantation of MSC in the Setting of Allo-HSCTNo drug interventionsprevention2 / 3recruiting
NCT03148197
Changes in the Gut Microbiota of Patients Undergoing Allogeneic Stem Cell Transplantation (COLLECT)No drug interventionsNot AvailableNot Availableunknown_status
NCT02993783
A Dose-Finding Study of Vedolizumab for Treatment of Steroid-Refractory Acute Intestinal Graft-Versus-Host Disease (GvHD) in Participants Who Have Undergone Allogeneic Hematopoietic Stem Cell Transplantation (Allo-HSCT)treatment2terminated
NCT03593161
Humor Therapy and Distress After Allogeneic Stem Cell TransplantationNo drug interventionssupportive_careNot Availableunknown_status
NCT06028828
Risk-ADAPTed Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantationtreatment2recruiting
NCT03297528
Chemotherapy and DLI for Prevention of Second Relapse in Patients With Relapsed Acute Leukemia After AllotransplantNo drug interventionsprevention2unknown_status
NCT03256071
Low Dose Decitabine + Modified BUCY Conditioning Regimen for High Risk Acute Myeloid Leukemia Undergoing Allo-HSCTtreatment2 / 3unknown_status
NCT04713956
G-CSF+DAC+BUCY vs G-CSF+DAC+BF Conditioning Regimen for RAEB-1,REAB-2 and AML Secondary to MDS Undergoing Allo-HSCTtreatment2 / 3unknown_status
NCT04822532
Precision Dosing of Busulfan in Children Undergoing HSCTNo drug interventionstreatmentNot Availablerecruiting
NCT02744742
G-CSF+Decitabine+BUCY vs BUCY Conditioning Regimen for RAEB-1, REAB-2 and AML Secondary to MDS Undergoing Allo-HSCTtreatment2 / 3completed
NCT05727917
Hetrombopag for the Enhancement of Platelet Engraftment After Allogeneic Hematopoietic Stem Cell TransplantationtreatmentNot Availablerecruiting
NCT04372524
Biomarker Verification in Pediatric Chronic GvHD: ABLE 2.0 / PTCTC GVH 1901 StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT05674539
Reduced Intensity Conditioning Regimens for Acute Myeloid Leukemia and Myelodysplastic Syndrometreatment3recruiting
NCT00429039
A Study to Accelerate Immune System Recovery Following Stem Cell TransplantationNo drug interventionstreatment2terminated
NCT03384225
CBA Versus FBA Conditioning Followed by Haploidentical Allogeneic HSCT in Treatment of High Risk and Refractory AMLtreatment3unknown_status
NCT03624530
Effect of Prophylactic TKI Therapy Post-transplants on Ph+ ALL Undergoing Allo-HSCT With MRD Positive Pre-transplantstreatment2 / 3unknown_status
NCT05149365
Sitagliptin for Prevention of aGVHD After Alternative Donor Transplantationprevention3recruiting
NCT01379391
Efficacy and Safety of rHuTPO on Platelet Engraftment After Allo-HSCTtreatment4unknown_status
NCT04123392
Decitabine + BUCY vs BUCY Conditioning Regimen for TP53+ Myeloid Tumors Undergoing Allo-HSCTtreatment2 / 3unknown_status
NCT05809167
Venetoclax+Azacytidine+Modified BUCY Conditioning Regimen for Acute Lymphoblastic Leukemia Undergoing Allo-HSCTNo drug interventionstreatment2recruiting
NCT05379569
Comparative Study of BFC and BuCy Conditioning Regimen for Allo-PBSCT in Acute B-cell ALLtreatment4recruiting
NCT05596981
The Gut Microbiome in FLT3-ITD+ AML Undergoing Allo-HSCT With Or Without Sorafenib Maintenance After Allo-HSCTNot AvailableNot Availablerecruiting
NCT05601895
The Gut Microbiome in FLT3- AL Undergoing Allo-HSCT With Or Without Sorafenib MaintenanceNot AvailableNot Availablerecruiting
NCT02312830
Belgian Cross-sectional Allogeneic Transplant Survivor StudyNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT03605953
Expansion of Invariant NKT Cells for a Cell Immunotherapeutic Approach Allowing the Control of Graft Versus Host-disease and Preserving the Graft Versus Leukemia Effect After Allogeneic Hematopoietic Stem Cell TransplantationNo drug interventionsNot AvailableNot Availableunknown_status
NCT02048800
Treosulfan Pharmacokinetics in Children Undergoing Allogeneic HSCTNot AvailableNot Availablecompleted
NCT00169728
Vaccination of Children Following Allogeneic Stem Cell Transplantationprevention3completed
NCT00990249
Busulfan Plus Clofarabine Followed by Allogeneic Hematopoietic Stem Cell Transplantationtreatment2completed