Fungal skin infection (DBCOND0014379)

Identifiers

Synonyms

Skin Mycoses / Skin fungal infection / Dermatomycoses / Superficial Mycoses / Skin fungal infection NOS / Mycotic skin infection / Fungal Infection of the dermal / Dermatitis fungoid / Cutaneous fungal disease / Dermal mycosis (disorder) / Fungal dermatitis / Dermatitis fungal / Dermatitis fungal NOS / Fungal dermatitis NOS / Dermatomycosis, unspecified

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Amorolfine	A morpholine derivative commonly applied as a lacquer for onychomycosis but is also used for superficial dermatomycosis.	No drug targets
Beclomethasone dipropionate	An inhaled corticosteroid used as maintenance treatment in the prophylaxis of asthma attacks.	Corticosteroid-binding globulincarrier Glucocorticoid receptortarget Cytochrome P450 3A5enzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter
Bifonazole	An azole antifungal drug used to treat fungal skin infections, such as dermatomycosis.	Cytochrome P450 2B6target Lanosterol 14-alpha demethylasetarget Aromataseenzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A4enzyme
Boric acid	No FDA- or EMA-approved therapeutic indications on its own.	No drug targets
Chloroxine	An antibacterial agent used for the treatment of dandruff and mild to moderately severe seborrheic dermatitis of the scalp.	Kappa-type opioid receptortarget
Chlorquinaldol	Chlorquinaldol was used historically as a topical antiseptic agent for skin infections. It maintains use in European countries as a combination vaginal tablet with promestriene for use in the treatment...	No drug targets
Ciclopirox	A broad-spectrum topical antifungal agent used to treat mild to moderate onychomycosis of fingernails and toenails in immunocompetent patients.	Sodium/potassium-transporting ATPase subunit alpha-1target
Clioquinol	An antifungal cream used to treat a variety of fungal infections.	Kappa-type opioid receptortarget
Clotrimazole	A topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis.	Intermediate conductance calcium-activated potassium channel protein 4target Cytochrome P450 2D6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2B6enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2A6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A7enzyme Lanosterol 14-alpha demethylasetarget Nuclear receptor subfamily 1 group I member 2target Hydroxycarboxylic acid receptor 2target Bile salt export pumptransporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Ergosteroltarget C-X-C chemokine receptor type 2target
Econazole	A topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor.	Aromataseenzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A4enzyme Lanosterol 14-alpha demethylasetarget Nuclear receptor subfamily 1 group I member 2target
Fenticonazole	An imidazole antifungal used to treat a variety of topical fungal infections.	No drug targets
Fluprednidene acetate	A corticosteroid indicated in the treatment of corticosteroid-responsive dermatoses.	Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme
Fusidic acid	A topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria.	Chloramphenicol acetyltransferase 3target Chloramphenicol acetyltransferasetarget Bile salt export pumptransporter ATP-binding cassette sub-family C member 2transporter Elongation factor Gtarget Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme UDP-glucuronosyltransferase 1A1enzyme Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter
Hexamidine	An antiseptic drug used for dermatomycoses and superficial bacterial infections alone or in combination with clotrimazole.	HTH-type transcriptional regulator QacRtarget HTH-type transcriptional regulator QacRtarget
Itraconazole	A triazole antifungal agent used to treat various fungal infections, such as blastomycosis and onychomycosis.	Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Cytochrome P450 2B6enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 1A1enzyme Cytochrome P450 2E1enzyme Solute carrier organic anion transporter family member 2B1transporter Cytochrome P450 3A Subfamilyenzyme Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Albumincarrier Lanosterol 14-alpha demethylasetarget Lanosterol 14-alpha demethylasetarget
Miconazole	An azole antifungal with broad-spectrum activity used to treat fungal infections affecting the vagina, mouth and skin, including candidiasis.	Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Lanosterol 14-alpha demethylasetarget Nitric oxide synthase 3target Nitric oxide synthase, inducibletarget Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2E1enzyme Nuclear receptor subfamily 1 group I member 2target Lanosterol 14-alpha demethylaseenzyme Aromataseenzyme Calcium-activated potassium channeltarget Voltage-gated Potassium Channelstarget Inward rectifier potassium channeltarget Voltage gated L-type calcium channeltarget Albumincarrier Cytochrome P450 2C8enzyme
Oxiconazole	A topical antifungal used to treat a variety of dermatophyte infections.	Lanosterol 14-alpha demethylasetarget Lanosterol synthasetarget Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme Nuclear receptor subfamily 1 group I member 2target
Potassium carbonate	Potassium carbonate (K2CO3) is a white salt, soluble in water (insoluble in ethanol) which forms a strongly alkaline solution. It can be made as the product of potassium hydroxide's absorbent...	No drug targets
Salicylic acid	An acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts.	Albumincarrier Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Aldo-keto reductase family 1 member C1target Solute carrier family 22 member 6transporter Solute carrier family 22 member 10transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Solute carrier organic anion transporter family member 2B1transporter Monocarboxylate transporter 1transporter Solute carrier family 22 member 7transporter Cytochrome P450 2C9enzyme Carbonic anhydrase 6target Carbonic anhydrase 12target Carbonic anhydrase 2target Carbonic anhydrase 4target Carbonic anhydrase 1target
Sertaconazole	A topical antifungal agent used in the treatment of interdigital tinea pedis in immunocompetent patients.	Lanosterol 14-alpha demethylasetarget
Tioconazole	An imidazole antifungal used to treat vulvovaginal candidiasis.	Lanosterol 14-alpha demethylasetarget Aromataseenzyme Cytochrome P450 2C19enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A4enzyme Lanosterol 14-alpha demethylasetarget
Triamcinolone	A glucocorticoid used to treat a wide variety of inflammatory conditions of organ systems and tissues.	Corticosteroid-binding globulincarrier Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Prostaglandin G/H synthase 2enzyme Cholinesteraseenzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Albumincarrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00722189	Observational Study of Efficacy and Safety of Travogen Cream and Travocort Cream in the Treatment of Mycoses	No drug interventions	Not Available	Not Available	completed
NCT01646580	Safety Study of Ciclopirox Olamine Cream for Dermatomycoses in Children	Ciclopirox	Not Available	4	terminated
NCT02493738	A Clinical Study to Evaluate the Pharmacokinetics of Lozanoc and Sporanox in Korean Healthy Male Volunteers	Itraconazole	Not Available	1	completed