Chronic Myeloid Leukemia (CML) (DBCOND0036419)

Identifiers

Synonyms
Chronic Myeloid Leukemia / Chronic Myeloid Leukaemia / Chronic Myelocytic Leukemia / Myeloid leukemia, chronic / Chronic Leukemia, Myeloid / Leukemia myelocytic chronic / Leukaemia myelocytic chronic / Chronic granulocytic leukaemia / Chronic myelogenous leukaemia / Chronic myelogenous leukemia / Chronic granulocytic leukemia / Myeloid leukaemia, chronic / CML / Chronic myelocytic leukaemia / Leukaemias chronic myeloid / Chronic myeloid leukemia, BCR/ABL-positive / Chronic myeloid leukemia (disorder) / Chronic myeloid leukemia (morphologic abnormality) / Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Cyclophosphamide
A nitrogen mustard used to treat lymphomas, myelomas, leukemia, mycosis fungoides, neuroblastoma, ovarian adenocarcinoma, retinoblastoma, and breast carcinoma.
Dasatinib
A tyrosine kinase inhibitor used for the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia or chronic myeloid leukemia.
Interferon alfa-2a
A form of recombinant human interferon used to stimulate the innate antiviral response in the treatment of hepatitis B and C viruses.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT06646978
Long-term Risk of Second Primary Malignancies for Chronic Myeloid Leukaemia in the French Imatinib-based SPIRIT TrialNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT00720785
Natural Killer Cells and Bortezomib to Treat Cancertreatment1completed
NCT02790515
Provision of TCRγδ T Cells and Memory T Cells Plus Selected Use of Blinatumomab in Naïve T-cell Depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies Relapsed or Refractory Despite Prior Transplantationtreatment2active_not_recruiting
NCT06130787
Value of Biological Age, in Addition to Individual Frailty, for Personalising the Management of Cancer Treated with Targeted TherapyNo drug interventionsotherNot Availablerecruiting
NCT02889003
Second STOP After Pioglitazone Priming in CML Patientstreatment2unknown_status
NCT00320190
Study of Dasatinib in Patients With Chronic Phase Chronic Myeloid Leukemia and a Suboptimal Response to Imatinibtreatment2terminated
NCT02381379
Malaysia Stop Tyrosine Kinase Inhibitor Trialtreatment3unknown_status
NCT01667133
A Study of Ponatinib in Japanese Participants With Chronic Myeloid Leukemia (CML) and Ph+ Acute Lymphoblastic Leukemia (ALL)treatment1 / 2completed
NCT00481247
A Phase III Study of Dasatinib vs Imatinib in Patients With Newly Diagnosed Chronic Phase Chronic Myeloid Leukemiatreatment3completed
NCT03615105
Donor Stem Cell Transplantation Using α/β+ T-lymphocyte Depleted Grafts From HLA Mismatched Donorstreatment2terminated
NCT00449761
Efficacy and Safety of LBH589B in Adult Patients With Refractory Chronic Myeloid Leukemia in Accelerated or Blast Phasetreatment2terminated
NCT02326311
Optimization of TKIs Treatment and Quality of Life in Ph+ CML Patients ≥60 Years in Deep Molecular Responsetreatment3completed
NCT04126707
The Absorption, Metabolism and Excretion of [14C] HQP1351 in Humanstreatment1completed
NCT00538109
An Open-Label, Multicenter, Expanded Access Study of Oral AMN 107 in Adult Patients With Imatinib (Glivec®/Gleevec®_ - Resistant or Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic PhasetreatmentNot Availablecompleted
NCT00428909
Effect of Imatinib Mesylate and the Pharmacokinetics of Acetaminophen/Paracetamol in Patients With Newly Diagnosed, Previously Untreated Chronic Myeloid Leukemia in Chronic Phase (CML-CP)treatment1completed
NCT00478985
Evaluation of the Persistence of the Complete Molecular Remission After Stopping Imatinib Chronic Myeloid LeukemiaNo drug interventionstreatmentNot Availablecompleted
NCT01015742
Unrelated Double Umbilical Cord Blood Units TransplantationNo drug interventionstreatment2 / 3unknown_status
NCT01592136
Expanded Access Program of PonatinibNot AvailableNot Availableapproved_for_marketing
NCT00210119
Imatinib Mesylate and Zoledronic Acid in Patients With Chronic Myeloid Leukaemia in Cytogenetic Response Without Molecular Responsetreatment2terminated
NCT00763763
Imatinib Mesylate With Vincristine and Dexamethasone in Acute Lymphoblastic Leukemias With BCR-ABL Positivetreatment2completed
NCT02852486
Study of Imatinib Discontinuation in Chronic Myeloid Leukemia With Deep Molecular Responseother2active_not_recruiting
NCT00732186
Study of Ipilimumab and Dasatinib Combination Therapy in Patients With Chronic or Accelerated Chronic Myeloid Leukemiatreatment1withdrawn
NCT04260022
Study of HQP1351 in Subjects With Refractory CML and Ph+ ALLtreatment1recruiting
NCT00445822
Registration of Children With CML and Treatment With ImatinibNo drug interventionsNot AvailableNot Availableunknown_status
NCT00176930
Stem Cell Transplant for Hematological MalignancytreatmentNot Availableterminated
NCT04384848
The EMPATHY Pilot StudyNo drug interventionssupportive_careNot Availablecompleted
NCT05154474
Assessment of Sarcopenia at Diagnosis for Patients With Previously Untreated Metastatic Cancer or Hematologic MalignancyNo drug interventionsNot AvailableNot Availableunknown_status
NCT02389920
Multicenter, PhaseⅣ, Open Label Trial of Nilotinib in Adult Patients Diagnosed Philadelphia Chromosome Positive(Ph+) Chronic Myeloid Leukemia in CP/AP Intolerant to Dasatinibtreatment4unknown_status
NCT00050531
High-Dose Gleevec Alone or in Combination With Peg-Intron and GM-CSF in Early Phase Chronic Myelogenous Leukemia (CML)treatment3completed
NCT00393380
Study of Parathyroid Hormone Following Sequential Cord Blood Transplantation From an Unrelated Donorprevention2terminated
NCT00488592
Peptide Vaccinations to Treat Patients With Low-Risk Myeloid Cancerstreatment2completed
NCT00027144
Study Using Vaccination With Heat Shock Protein 70 (HSP70) for the Treatment of CML in Chronic PhaseNo drug interventionstreatment1completed
NCT00167167
Donor Lymphocyte Infusion (DLI) for Relapsed (Post Transplant) LeukemiaNo drug interventionstreatmentNot Availablecompleted
NCT03578367
Study of Efficacy and Safety of Asciminib in Combination With Imatinib in Patients With Chronic Myeloid Leukemia in Chronic Phase (CML-CP)treatment2active_not_recruiting
NCT02222272
Effect of 2nd Gen TKI in CMLNo drug interventionsNot AvailableNot Availablecompleted
NCT02363868
Healthcare Costs Among Patients With CML Receiving Dasatinib or Nilotinib in a Commercial and Medicare PopulationNo drug interventionsNot AvailableNot Availablecompleted
NCT01066468
Glivec/Gleevec Pediatric (Age 1 to Less Than 4) PK Study in CML, Ph+ ALL Patients and Other Glivec/Gleevec® Indicated Hematological Disorders.Not Available1terminated
NCT01605981
Trial Evaluating Nilotinib as Treatment for Newly Diagnosed CML Patients in Accelerated Phase.treatment4withdrawn
NCT00482703
A Study of Dasatinib in Chronic Phase Philadelphia Chromosome Positive Chronic Myeloid Leukemiatreatment1 / 2completed
NCT00455221
Safety Assessment of a Multipeptide-gene Vaccine in CMLNo drug interventionstreatment1completed
NCT00067002
Randomized Double Cord Blood Transplant Studytreatment2completed
NCT00034684
Study of Farnesyl Protein Transferase Inhibitor (FPTI) in Patients With Leukemia (Study P00701)No drug interventionstreatment1 / 2completed
NCT02890784
Dasatinib Holiday for Improved Tolerabilitytreatment3completed
NCT00298987
A Study of Dasatinib in Patients With Chronic Myelogenous Leukemia Who Are Resistant or Intolerant of Imatinib Mesylatetreatment2completed
NCT02086487
Efficacy and Safety Assessment of NIlotinib in CML Patients With Suboptimal Response on Imatinib Therapytreatment4terminated
NCT03746054
Evaluation of a Cardiovascular Active Prevention in Chronic Myeloid Leukemia on the Cardiovascular Morbi-mortalityNo drug interventionsprevention3unknown_status
NCT03849651
TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignanciestreatment2active_not_recruiting
NCT00538447
Prospective Database for Chronic Myelogenous LeukemiaNo drug interventionshealth_services_researchNot Availableunknown_status
NCT00058747
AG-858 in Patients Who Are Cytogenetically Positive After Treatment With Gleevec™treatment2terminated
NCT02733445
Metabolic Outcomes in Patients Receiving Tyrosine Kinase Inhibitor (TKI) Therapy With Dasatinib or NilotinibNot AvailableNot Availablecompleted
NCT00433745
Wilm's Tumor 1 (WT1) Peptide Vaccine for High Risk Hematologic MalignancyNo drug interventionstreatment2completed
NCT00040105
Zarnestra and Gleevec in Chronic Phase Chronic Myelogenous Leukemiatreatment1completed
NCT05963061
Chronic Myeloid Leukemia (CML) Real-Life DatabaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT02973711
A Study of Ruxolitinib in Combination With Nilotinib in Patients With Chronic Phase CMLtreatment1 / 2withdrawn
NCT00406393
Sirolimus/Tacrolimus Versus Tacrolimus/Methotrexate for Preventing Graft-Versus-Host Disease (GVHD) (BMT CTN 0402)treatment3completed
NCT01660607
Phase 1-2 MAHCT w/ TCell Depleted Graft w/ Simultaneous Infusion Conventional and Regulatory T CellNo drug interventionstreatment1 / 2completed
NCT00539656
Transplantation of Umbilical Cord Blood Following Chemotherapy for Blood CancersNo drug interventionstreatment1 / 2terminated
NCT00759837
Study Evaluating The Pharmacokinetics (PK) And Safety Of Bosutinib In Subjects With Liver Disease And In Healthy SubjectsNot Available1completed
NCT00306332
T-cell and B-cell Depletion in Allogeneic Peripheral Blood Stem Cell TransplantationNo drug interventionstreatment3terminated
NCT02061800
CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplanttreatment1 / 2active_not_recruiting
NCT00114959
Homoharringtonine With Oral Gleevec in Chronic, Accelerated and Blast Phase Chronic Myeloid Leukemia (CML)treatment2terminated
NCT00186342
Sibling and Unrelated Donor Hematopoietic Cell Transplant in Hematologic MalignanciesNo drug interventionstreatmentNot Availablecompleted
NCT02543749
DC Vaccination in CMLNo drug interventionstreatment1 / 2terminated
NCT03515018
Evaluation of the Therapeutic Effect of HU Pulse Therapy for CML Patientstreatment3unknown_status
NCT06514534
Open-label Study of Asciminib for CML-CP or CML-AP Patients With T315I Mutation Who Are Resistant, Intolerant or Ineligible to Ponatinib.treatment2not_yet_recruiting
NCT00566696
Mismatched Family Member Donor Transplantation for Children and Young Adults With High Risk Hematological Malignanciestreatment2completed
NCT04709731
Cardiovascular Assessment of Ponatinib as Third Line Treatment in Chronic Phase Chronic Myeloid Leukemiatreatment2not_yet_recruiting
NCT02627573
Trial of GVHD Prophylasxis With PTCy or Thymoglobulin in Unrelated SCTprevention2terminated
NCT00264160
Efficacy and Safety of Oral AMN107 in Adults With Chronic Myelogenous Leukemia Resistant and/or Intolerant to Imatinib Mesylate Therapytreatment2 / 3completed
NCT00246662
Safety Assessment of Two Schedules of Intravenous Infusions of SNS-595 for the Treatment of Hematologic Malignanciestreatment1completed
NCT00167180
Post Transplant Donor Lymphocyte Infusiontreatment2terminated
NCT05143840
Asciminib as Initial Therapy for Patients With Chronic Myeloid Leukemia in Chronic Phasetreatment2recruiting
NCT02269267
The Life After Stopping Tyrosine Kinase Inhibitors Study (The LAST Study)treatment2completed
NCT03481868
EPIgenetics and in Vivo Resistance of Chronic Myeloid Leukemia Stem Cells to Tyrosine Kinase InhibitorsNo drug interventionsotherNot Availablerecruiting
NCT01050946
Hematopoietic Stem Cell Transplantation (HSCT) Using CD34 Selected Mismatched Related Donor and One Umbilical Cord UnitNo drug interventionstreatment2terminated
NCT01761695
Chronic Myelod Leukemia Registry at Asan Medical CenterNo drug interventionsNot AvailableNot Availableterminated
NCT00186823
Haploidentical Stem Cell Transplantation for Patients With Hematologic MalignanciesNo drug interventionstreatment3completed
NCT04943757
Post-transplantation Benadamustine and Cyclophosphamide in Patients With Refractory Myeloid Malignanciestreatment2completed
NCT06236724
Phase II Study Assessing Efficacy and Safety of Asciminib in Patients With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase.treatment2recruiting
NCT03874858
De-escalation and TFR Study in CML Patients Treated With Nilotinib Followed by a Second Attempt After Nilotinib and Asciminib Combinationtreatment2active_not_recruiting
NCT05115630
Off-the-shelf NK Cells + SCT for Myeloid Malignanciestreatment1 / 2recruiting
NCT05362773
A Study of MGD024 in Patients With Relapsed or Refractory Hematologic MalignanciesNo drug interventionstreatment1recruiting
NCT05800210
Alpha/Beta T Cell and CD19+ B Cell Depletion in Allogeneic Stem Cell Transplantation in Patients With Malignant DiseasesNo drug interventionstreatment2recruiting
NCT06398457
Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) Before Standard Desensitization and Allogeneic Peripheral Blood Stem Cell Transplantation in Adult Patients at High-risk for Primary Graft Failure Secondary to Donor Specific Antibodiestreatment0recruiting
NCT01805843
Pulmonary Vasculopathy Under Second-line Therapy of Chronic Myeloid LeukemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT05260203
MargheRITA (Remote Intelligence for Therapeutic Adherence)No drug interventionssupportive_careNot Availablecompleted
NCT01761890
Front-line Treatment of BCR-ABL+ Chronic Myeloid Leukemia (CML) With DasatinibNo drug interventionsNot AvailableNot Availableunknown_status
NCT00522990
Study to Assess the Safety of Escalating Doses of AT9283, in Patients With Leukemiastreatment1 / 2terminated
NCT05236764
Haploidentical Hematopoietic Cell Transplantation Using TCR Alpha/Beta and CD19 DepletionNo drug interventionstreatmentNot Availablerecruiting
NCT00435864
Natural Killer Index From Hematopoietic Stem Cell GraftNo drug interventionshealth_services_researchNot Availablecompleted
NCT04048564
Observational Study on CML Patients in Any Phase of the Disease Treated With Ponatinib (Iclusig®)No drug interventionsNot AvailableNot Availablecompleted
NCT00845221
Glivec in Pediatric Chronic Myeloid Leukemia (CML)Not Available4completed
NCT00511121
Study of the Combination of a Tyrosine Kinase Inhibitor (STI571) and a Pegylated Human Recombinant Interferon alfa2b (PEGINTRON)treatment2terminated
NCT00815321
Autologous Cytokine Induced Killer Cells (CIK) for Chronic Myeloid Leukemia (CML) Patients on Standard Drug TherapyNo drug interventionstreatment2completed
NCT03326921
HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplanttreatment1suspended
NCT04835584
KRT-232 and TKI Study in Chronic Myeloid Leukemiatreatment1 / 2recruiting
NCT03795779
CLL1-CD33 cCAR in Patients With Relapsed and/or Refractory, High Risk Hematologic Malignanciestreatment0unknown_status
NCT05605379
CML Pediatric ITK Response According to Molecular Identification at DiagnosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT06092879
Asciminib Prospective Non Interventional Study as 3rd Line Therapy or More to Treat Adult Patients With CML- CP in Real World Setting in FranceNo drug interventionsNot AvailableNot Availablerecruiting
NCT01606579
Safety and Efficacy Study of PRI-724 in Subjects With Advanced Myeloid Malignanciestreatment1 / 2completed
NCT01114087
Impact of the Inhibitors of Tyrosine Kinase on the Male FertilitytreatmentNot Availablecompleted
NCT01903733
Bosutinib Treatment Extension Study Only For Subjects With Chronic Myeloid Leukemia (CML) Who Have Previously Participated In Bosutinib Studies B1871006 Or B1871008Not AvailableNot Availablecompleted
NCT02016833
Development of Immunological Assays for the Evaluation of Tumor Antigen Specific ImmunityNo drug interventionsNot AvailableNot Availablecompleted
NCT00593554
Phase 2 Haplotype Mismatched HSCT in Patients With Hematological Malignanciestreatment2terminated
NCT03678454
Iclusig® (Ponatinib) in Clinical Practice for the Treatment of Chronic Myeloid Leukemia or Ph+ Acute Lymphoblastic Leukemia in BelgiumNo drug interventionsNot AvailableNot Availablecompleted
NCT04595851
Pharmacists Coordinated Care Oncology Model (PCOM) for Patients Taking Oral Anti-cancer MedicationsNo drug interventionshealth_services_researchNot Availableterminated
NCT01490853
Follow-up of Ph+ Chronic Myleoid Leukemia Patients in Complete Cytogenetic Response With Interferon Based TherapyNot AvailableNot Availablecompleted
NCT01866553
Nilotinib Plus Pegylated Interferon-α2b in CMLtreatment2terminated
NCT00352677
Safety and Tolerability Study of INNO-406 to Treat Chronic Myeloid Leukemia or Acute Lymphocytic Leukemiatreatment1completed
NCT00257647
Use of SV40 Vectors to Treat Chronic Myeloid Leukemia (CML)No drug interventionsNot AvailableNot Availablecompleted
NCT02011945
A Phase 1B Study to Investigate the Safety and Preliminary Efficacy for the Combination of Dasatinib Plus Nivolumab in Patients With Chronic Myeloid Leukemiatreatment1completed
NCT01223898
To Evaluate the Effects of Multiple Doses of Nilotinib on the Pharmacokinetics and Metabolism of Midazolam in CML Patients With Additional Extension Phase to Evaluate the Safety of Nilotinibother1completed
NCT01650805
Ponatinib in Newly Diagnosed Chronic Myeloid Leukemia (CML) (EPIC)treatment3terminated
NCT00895297
Efficacy and Safety Study of Dasatinib in Patients With Chronic Myeloid Leukemiatreatment2terminated
NCT02709083
Dasatinib or Nilotinib Followed by Imatinib in Patients With Newly Diagnosed, Chronic Phase Chronic Myeloid Leukemiatreatment2terminated
NCT04167683
Muscle Dysfunction in Patients With Hematological Diseases Referred to Stem Cell TransplantNo drug interventionsNot AvailableNot Availablerecruiting
NCT03625583
The Hong Kong CML RegistryNo drug interventionsNot AvailableNot Availableunknown_status
NCT06355583
Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) TrialNo drug interventionsprevention2not_yet_recruiting
NCT00067028
Clofarabine Combinations in Relapsed/Refractory Acute Myeloid Leukemia (AML), Myelodysplastic Syndromes (MDS) and Myeloid Blast Phase Chronic Myeloid Leukemia (CML)treatment2completed
NCT01749111
Comparison Between Cyclophosphamide and Combination of Methotrexate + Calcineurin Inhibitor for GVHD Prophylaxisprevention3terminated
NCT04605211
A Distress Reduction Intervention for Patients With BCR-ABL-Negative MPNs or CML on Tyrosine Kinase InhibitorsNo drug interventionssupportive_careNot Availablecompleted
NCT02007811
Open-label Clinical Trial to Investigate the Safety and Tolerability of Allogeneic B-cell Concentrates for Immune Reconstitution After Allogeneic Stem Cell Transplantation Measured as Response to a Antedated Single VaccinationNo drug interventionstreatment1 / 2unknown_status
NCT06148493
Real-World Usage of Asciminib Among Patients With Chronic Myeloid Leukemia in Chronic Phase in the United States Using a Large Claims DatabaseNo drug interventionsNot AvailableNot Availablecompleted
NCT00905593
Nilotinib in Adult Patients With Imatinib-resistant or Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic PhaseNot AvailableNot Availableapproved_for_marketing
NCT05619978
French Study to Highlight the Unmet Treatment Needs of 3L+ CP-CML and With T315I-mutated CML PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT02767388
Electrophysiological Biomarkers of Chemotherapy-related Cognitive Impairment and RecoveryNo drug interventionsNot AvailableNot Availablecompleted
NCT04156256
CD123-CD33 cCAR in Patients With Relapsed and/or Refractory, High Risk Hematologic MalignanciesNo drug interventionstreatment0unknown_status
NCT02057185
Occupational Status and Hematological DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT05701215
Venetoclax After TKI to Target Persisting Stem Cells in CMLtreatment2recruiting
NCT03696537
IMRT-TMI With Fludarabine as Myeloablative Conditioning for Allogeneic HSCTtreatment1terminated
NCT04991532
Dasatinib Down-regulates the Expression of PD-1 and Enhances Killing pH + Leukemia Stem CellsNo drug interventionsNot AvailableNot Availableunknown_status
NCT00001432
The Collection of Peripheral Blood Lymphocytes and Marrow Progenitor Cells From Normal Volunteers and Volunteers With Lymphoid or Hematologic MalignanciesNo drug interventionsNot AvailableNot Availablecompleted
NCT00219752
Safety and Efficacy of Imatinib in Chronic Myelogenous Patients Older Than 70 Yearstreatment2completed
NCT02317159
Efficacy and Safety of Imatinib Mesylate as First-line Treatment for the Patients With Chronic Phase of Chronic Myeloid Leukemiatreatment4unknown_status
NCT00513175
Non-Myeloablative Allogeneic Stem Cell Transplantation With Matched Unrelated Donors for Treatment of Hematologic Malignancies, Renal Cell Carcinoma, and Aplastic AnemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT00570999
Palifermin After Haploidentical PBSCTtreatment2withdrawn
NCT00858806
Intermittent Imatinib Treatment in Chronic Myeloid Leukemia and Philadelphia Chromosome (Ph+CML) Patients Who Achieved a Complete Cytogenetic Response (CCgR) on Standard Imatinib Therapytreatment2completed
NCT06390306
The Efficacy and Safety of Third-generation TKIs Combined With Azacitidine and Bcl-2 Inhibitor in Patients With CML-MBPNot AvailableNot Availablenot_yet_recruiting
NCT01564836
Discontinuation Study of Imatinib in Adult CP CML Patients Who Have a Complete Molecular Response to ImatinibNo drug interventionstreatmentNot Availableunknown_status
NCT06409936
PEARL Study: PotEntial of Asciminib in the eaRly Treatment of CMLtreatment2not_yet_recruiting
NCT01578213
Validation of Digital-PCR Analysis Through Programmed Imatinib Interruption in PCR Negative CML Patientsother4completed
NCT00145613
Haploidentical Stem Cell Transplant for Treatment Refractory Hematological MalignanciesNo drug interventionstreatment2completed
NCT00988013
Intensity Modulated Total Marrow Irradiation (IM-TMI) for Advanced Hematologic MalignanciesNo drug interventionstreatmentNot Availablecompleted
NCT00146913
AFR10 - Combination Therapy of Imatinib Mesylate (IM) + Alpha-2A Interferon for Chronic Phase CML Patients Resistant or Refractory to IM Used as Single Therapy for at Least One YearNot Available2unknown_status
NCT00349518
Study of Dasatinib in Imatinib Resistant or Intolerant Subjects With Chronic or Advanced Phase CML or Philadelphia Chromosome Positive ALLtreatment2 / 3withdrawn
NCT01200017
Expanded Access Protocol (EAP) Using the CliniMACS® Device for Pediatric Haplocompatible Donor Stem Cell TransplantNo drug interventionsNot AvailableNot Availableno_longer_available
NCT00598624
Clinical Trial to Evaluate the Safety and Efficacy of Treosulfan Based Conditioning Prior to Allogeneic Haematopoietic Stem Cell Transplantation (HSCT)treatment2unknown_status
NCT04626024
Safety And Efficacy Of TKI Cessation For CML Patients With Stable Molecular Response In A Real World Populationtreatment2recruiting
NCT00965224
Efficacy of Dendritic Cell Therapy for Myeloid Leukemia and MyelomaNo drug interventionstreatment2unknown_status
NCT00302016
Expanded Access Program of AMN107 in Imatinib-resistant or Intolerant Adult Patients With Chronic Myeloid LeukemiaNot AvailableNot Availableno_longer_available
NCT05611216
Clinical Outcomes of 3L+ Therapies Among Patients With Chronic Myeloid Leukemia and Those With T315I MutationNo drug interventionsNot AvailableNot Availablecompleted
NCT03509896
Study of Chinese Newly Diagnosed Participants With Philadelphia Chromosome-Positive (Ph+) Chronic Myeloid Leukemia in Chronic Phase (CML-CP)No drug interventionsNot AvailableNot Availablecompleted
NCT01275196
Safety and Efficacy of Nilotinib vs. Imatinib in the Treatment of Newly Diagnosed Chinese Ph+ CML-CP Patientstreatment3completed
NCT02890758
Phase I Trial of Universal Donor NK Cell Therapy in Combination With ALT803treatment1completed
NCT03353558
Sleep Assessment in CMLNo drug interventionsNot AvailableNot Availableunknown_status
NCT01819558
Phase I/II Study of Immune Therapy After Allograft in Patients With Myeloid HemopathyNo drug interventionstreatment1 / 2completed
NCT04104035
Leukemic Stem Cell Detection for Chronic Myeloid Leukemia Patients With Major Molecular ResponseNo drug interventionsNot AvailableNot Availableunknown_status
NCT05400122
Natural Killer (NK) Cells in Combination With Interleukin-2 (IL-2) and Transforming Growth Factor Beta (TGFbeta) Receptor I Inhibitor Vactosertib in Cancertreatment1recruiting
NCT02398825
Activity and Risk Profile of Ponatinib in Chronic Phase Patients With Chronic Myeloid Leukemia Resistant to Imatinibtreatment2unknown_status
NCT00947830
Investigating Intracellular and Plasma Imatinib Levels in Chronic Myeloid LeukemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT03885830
Precision Dosing of Tyrosine Kinase Inhibitors in CML PatientsNot AvailableNot Availablecompleted
NCT01220648
Determining the Maximum Tolerated Dose of Low Dose Interferon-alpha in Conjunction With Nilotinib in Pretreated Philadelphia Chromosome Positive (Ph+) Chronic Myeloid Leukemia Patients in Chronic Phase (CML-CP)treatment1completed
NCT01549548
Compassionate Use PonatinibNot AvailableNot Availableno_longer_available
NCT00145626
HLA-Nonidentical Stem Cell and Natural Killer Cell Transplantation for Children Less the Two Years of Age With Hematologic Malignanciestreatment2completed
NCT00219726
Safety and Efficacy of Imatinib in Chronic Myelogenous Patients in Relapse After Stem Cell Transplantationtreatment2completed
NCT00852566
Randomized Study Comparing the Effect of Dasatinib and Imatinib on Malignant Stem Cells in Chronic Myeloid Leukemiatreatment2completed
NCT02885766
Study to Evaluate Tolerability, Safety, Pharmacokinetics and Preliminary Efficacy of PF-114 for Oral Administration in Adults With Ph+ Chronic Myeloid Leukemia, Which is Resistant to the 2-nd Generation Bcr-Abl Inhibitors or Has T315I Mutation in the BCR-ABL Genetreatment1 / 2unknown_status
NCT01167166
Safety and Efficacy of 72-hour and 120-hour Infusion of Rigosertib in Acute Myeloid Leukemia (AML) and Acute Lymphoid Leukemia (ALL)treatment1 / 2completed
NCT00219765
Safety and Efficacy of Imatinib in Combination With High Dose Chemotherapy for Acute Phase Chronic Myelogenous Patientstreatment1 / 2terminated
NCT02546674
Study Assessing Deep Molecular Response in Adult Patients With CML in Chronic Phase Treated With Nilotinib Firstline.treatment4completed
NCT01400074
Efficacy of Nilotinib Versus Imatinib in Ph+ CML in Early CP Who Have a Suboptimal Molecular Response to Imatinibtreatment3unknown_status
NCT00354120
Thymoglobuline Versus Alemtuzumab in Patients Undergoing Allogeneic TransplantNo drug interventionstreatment2 / 3completed
NCT02556931
Shorter Course Tacro After NMA, Related Donor PBSCT With High-dose Posttransplant Cy for Hard-to-Engraft Malignanciestreatment2completed
NCT00574873
Compare Bosutinib To Imatinib In Subjects With Newly Diagnosed Chronic Phase Philadelphia Chromosome Positive CMLtreatment3completed
NCT04043676
Consolidation Treatment With Ponatinib 15 mg on Treatment Free-Remission Rate in Patients With Chronic Myeloid Leukemiatreatment2unknown_status
NCT01344876
Phase I Study of OPB-51602 in Patients With Hematologic MalignanciesNo drug interventionstreatment1completed
NCT06229860
Impact of Personality on Adherence to Tyrosine Kinase Inhibitor Therapy in Pts w/Chronic Myeloid LeukemiaNo drug interventionsNot AvailableNot Availablerecruiting
NCT02078960
A Study to Evaluate the Pharmacokinetics, Safety,and Efficacy of Omacetaxine Given Subcutaneously as a Fixed Dose in Patients With Chronic Phase (CP) or Accelerated Phase (AP) Chronic Myeloid Leukemia (CML) (Referred to as the SYNSINCT Study)other1 / 2terminated
NCT06042660
Comorbidity Burden and Use of Concomitant Medications at CML DiagnosisNo drug interventionsNot AvailableNot Availablecompleted
NCT00460694
Allogeneic Cytokine-induced Killer Immunotherapy for Relapse After Allogeneic Marrow Transplant for Haematological MalignanciesNo drug interventionstreatment1 / 2completed
NCT05421091
Special Drug Use-results Surveillance of Scemblix TabletsNo drug interventionsNot AvailableNot Availablecompleted
NCT00327262
Comparing Imatinib Standard Dose With Imatinib High Dose Induction in Pretreated Chronic Myeloid Leukemia (CML) Patients in Chronic Phasetreatment3unknown_status
NCT01752062
Observational Study of Conception/Pregnancy in Adult Patients With CML Treated With Tyrosine Kinase InhibitorsNo drug interventionsNot AvailableNot Availableunknown_status
NCT01572662
Allogeneic Transplantation Using Timed Sequential Busulfan and Fludarabine Conditioningtreatment2completed
NCT00469729
Efficacy and Safety Study of StemEx®, to Treat Subjects With High Risk Hematologic Malignancies, Following Myeloablative Therapytreatment2 / 3completed
NCT01252589
Patient Reported Outcomes in Chronic Myeloid LeukemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT03906292
Frontline Asciminib Combination in Chronic Phase CMLtreatment2active_not_recruiting
NCT00001144
Modified Bone Marrow Stem Cell Transplantation for Chronic Myelogenous LeukemiaNo drug interventionstreatment2completed
NCT01207440
Ponatinib for Chronic Myeloid Leukemia (CML) Evaluation and Ph+ Acute Lymphoblastic Leukemia (ALL)treatment2completed
NCT01657604
TKI and Interferon Alpha Evaluation Initiated by the German Chronic Myeloid Leukemia Study Group - the TIGER Studydiagnostic3completed
NCT02115672
Imatinib and BL-8040 (Novel Anti CXCR4 Antagonist) for Improving Molecular Response in Chronic Myelogenous Leukemiatreatment1 / 2withdrawn
NCT00514969
Protein-Tyrosine Kinase Inhibitor (STI571) for Treatment of Patients With Ph+ Chronic Myeloid Leukemia in Accelerated and Blastic Phasetreatment2completed
NCT03075969
Phase IV EORTC Quality of Life Module for Patients With Chronic Myeloid LeukemiaNo drug interventionsNot AvailableNot Availableunknown_status
NCT03326310
Selumetinib and Azacitidine in High Risk Chronic Blood Cancerstreatment1recruiting
NCT00061581
Experimental Bone Marrow Transplant ProtocolNo drug interventionstreatment2completed
NCT00493181
Interleukin 11, Thrombocytopenia, Imatinib in Chronic Myelogenous Leukemia (CML) Patientstreatment2completed
NCT00101595
Dasatinib (BMS-354825) in Subjects With Lymphoid Blast Phase Chronic Myeloid Leukemia or Philadelphia Chromosome Positive Acute Lymphoblastic Leukemiatreatment2completed
NCT03802695
A Phase 1 Study of Orca-Q in Recipients Undergoing Allogeneic Transplantation for Hematologic MalignanciesNo drug interventionstreatment1recruiting
NCT04595955
Effects of a Digital Patient Platform (CMyLife) for Patients With Chronic Myeloid Leukemia (CML) on Information Provision, Patient Empowerment, Medication Compliance, Guideline Adherence and Quality of LifeNo drug interventionshealth_services_researchNot Availablecompleted
NCT00632255
Long Term Therapy With Imatinib: Development of Late Side Effects and Compliance to TreatmentNot AvailableNot Availablecompleted
NCT01244750
Studying First Line Treatment of Chronic Myeloid Leukemia (CML) in a Real-world SettingNo drug interventionsNot AvailableNot Availablecompleted
NCT01683123
Study With Intravenous Busulfan And Fludarabine Myeloablative Conditioning Regimen For HLA Identical Sibling Donor HSCTNo drug interventionsNot AvailableNot Availablecompleted
NCT03018223
Calcineurin Inhibitor-Free GVHD Prevention Regimen After Related Haplo PBSCTprevention1completed
NCT05282108
Efficacy and Safety of Generic Imatinib (Carcemia®) Compared to Glivec® in Real-Life Management of Chronic Phase of Chronic Myeloid LeukemiaNot AvailableNot Availablerecruiting
NCT00827138
Study Safety and Preliminary Efficacy of DCC-2036 in Patients With Leukemias (Ph+ CML With T315I Mutation)treatment1completed
NCT01297543
Safety Study of Human Myeloid Progenitor Cells (CLT-008) After Chemotherapy for Leukemiasupportive_care1 / 2completed
NCT02164903
LEONIDAS: Quality of Life Study in Chronic Myeloid Leukemia PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT03228303
Nilotinib Versus Imatinib in Treatment of Patients With Newly Diagnosed Chronic Myeloid Leukemiatreatment0unknown_status
NCT00511303
Protein-Tyrosine Kinase Inhibitor (STI571) for Treatment of Patients With Ph+ Chronic Myeloid Leukemiatreatment2completed
NCT02258490
Expanded Use of G-CSF Mobilized Donor CD34+ Selected Cells for Allogeneic TransplantationNot AvailableNot Availableno_longer_available
NCT06233890
The Analysis of Fatigue on Tyrosine Kinase Inhibitor Therapy in Chronic Myeloid LeukaemiaNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT00303290
PEG Interferon Alpha 2B and Low-Dose Ara-C in Early Chronic Phase CMLtreatment1completed
NCT02810990
Bosutinib in Elderly Chronic Myeloid Leukemiatreatment2completed
NCT00968864
T-cell Depleted Alternative Donor TransplantationNo drug interventionstreatment2terminated
NCT01290302
Bioequivalence Trial of Luitpold Azacitidine Versus Vidaza® in Patients With Myelodysplastic Syndrome, Myelofibrosis, Chronic Myeloid Leukemia or Chronic Lymphocytic Leukemiatreatment1completed
NCT06453902
TGRX-678 Chinese Phase II in Chronic Myelogenous Leukemia (CML) PatientsNo drug interventionstreatment2not_yet_recruiting
NCT01270984
Study to Evaluate the Pharmacokinetic Characteristics of Luckyvec 400mg Tablet, in Healthy Subjectstreatment1completed
NCT06532084
Sorafenib Relapase Prophylaxis After HCT With PTBCy Regimentreatment2recruiting
NCT05753384
Discontinuation of TyrosIne Kinase Inhibitors (TKI) in Chronic Myeloid Leukemia (CML) and Impact on the Immune SystemNo drug interventionstreatment3recruiting
NCT01342679
A Study of Complete Molecular Response for Chronic Myeloid Leukemia in Chronic Phase Patients, Treated With Dasatinibtreatment2completed
NCT04028479
The Registry of Oncology Outcomes Associated With Testing and TreatmentNo drug interventionsNot AvailableNot Availablerecruiting
NCT01215487
A Study Investigating the Predictive Value of Philadelphia Positive Stem Cell Properties in Newly Diagnosed Patients With Chronic Myeloid Leukemia in Chronic Phase Receiving Treatment With ImatinibNo drug interventionsNot AvailableNot Availablecompleted
NCT03348033
Safety and Feasibility of the Use of Natural Killer Cells in Patients With Chronic Myeloid LeukemiaNo drug interventionstreatment1 / 2unknown_status
NCT03540654
Budget Impact Analysis of Discontinuing Tyrosin Kinase Inhibitors in Patients With Chronic Myeloid Leukemia Achieving a Complete Molecular Response by Using Probabilistic Markov ApproachNo drug interventionsNot AvailableNot Availablecompleted
NCT04621851
Retro-prospective Observational Study on Risk of Progression in CP-CML Patients Eligible for TKI DiscontinuationNo drug interventionsNot AvailableNot Availableunknown_status
NCT01169753
Nuvigil in Treatment of Cancer-Related Fatigue in Chronic Myeloid Leukemia PatientstreatmentNot Availableterminated
NCT05734053
Nilotinib for Patients With Chronic Myeloid Leukemia in First Line and Any Subsequent LineNo drug interventionsNot AvailableNot Availablecompleted
NCT05304377
A Phase 1a/1b Study of ELVN-001 for the Treatment Chronic Myeloid LeukemiaNo drug interventionstreatment1recruiting
NCT02253277
Safety and Tolerability of Combined Treatment With Nilotinib and Ruxolitinib in CML and Ph+ ALL Patientstreatment1completed
NCT05440747
Treatment Free Remission (TFR) in CML Patients (CML-CP)StudyNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT01562847
Prospective Investigation of Dynamics of ABL Mutations in Imatinib Failed CML Patients Treated With NilotinibNot AvailableNot Availableunknown_status
NCT04769947
Italian Treatment Free Remission RegistryNo drug interventionsNot AvailableNot Availablerecruiting
NCT04578847
A Study of REduction And DIscontinuation Treatment of TKI (Imatinib, Nilotinib, Dasatinib and Bosutinib)treatment2active_not_recruiting
NCT01350245
Bone Marrow Transplantation of Patients in Remission Using Partially Matched Relative Donortreatment2completed
NCT02174445
An Open-label, Randomised Multicenter Phase 3b Study to Determine the Confirmed Rate of Molecular Response ≥ 4 Log (MR4) at Two Yearstreatment3terminated
NCT01698905
Treatment-free Remission After Achieving Sustained MR4.5 on Nilotinib (ENESTop)treatment2active_not_recruiting
NCT01490983
Telemonitoring Study - for Chronic Myeloid Leukemia (CML)No drug interventionssupportive_careNot Availableterminated
NCT05201183
A Dose Escalation Study of Intensity Modulated Total Marrow Irradiation (IMRT-TMI) Followed by Fludarabine as a Myeloablative Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation for Patients With Relapsed and Refractory Hematologic Malignanciestreatment1 / 2withdrawn
NCT02353728
Stem Cell Monitoring for CML Patients Undergoing Nilotinib Therapybasic_science2completed
NCT06423911
Study of Olverembatinib (HQP1351) in Patients With CP-CMLtreatment3recruiting
NCT05768711
Azacitidine Combined With Venetoclax in Patients With Higher-risk Chronic Myelomonocytic Leukemia (AVENHIR)treatment2recruiting
NCT04155411
Dose Reduced Dasatinib (70 mg Daily) as First-line Treatment for Newly Diagnosed CML-CPtreatment4unknown_status
NCT02707393
Allogeneic Stem Cell Transplantation for Children With CMLtreatment2 / 3completed
NCT00573378
Imatinib or Nilotinib With Pegylated Interferon-α2b in Chronic Myeloid Leukemiatreatment2terminated
NCT01254188
Safety and Efficacy of Nilotinib in Newly Diagnosed Chronic Myeloid Leukemia Patientstreatment3completed
NCT00514488
Imatinib Standard Dose (400 mg/Day) Versus Imatinib High Dose (800 mg/Day)Not Available3completed
NCT01860456
TyrosIne Kinase Inhibitors in Chronic Myeloid Leukemia: Efficacy and Tolerability. The TIKlet StudyNot AvailableNot Availablerecruiting
NCT02869256
Regional Central Database Recording of Chronic Myeloid LeukemiaNo drug interventionsNot AvailableNot Availableunknown_status
NCT00267085
Synthetic Vaccine in Patients With Chronic Myeloid Leukemia and Minimal Residual Diseasetreatment2completed
NCT04013685
Precision-T: A Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic MalignanciesNo drug interventionstreatment1active_not_recruiting
NCT06001385
HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxistreatment2recruiting
NCT05413915
Asciminib Used in Consolidation With Imatinib vs. Imatinib to Achieve TFR in CP-CMLtreatment3recruiting
NCT00328237
Treatment of Hematologic Malignancies With Single-Unit or Double-Unit Cord Blood TransplantationNo drug interventionstreatment2unknown_status
NCT01627132
Discontinuation of Dasatinib in Patients With Chronic Myeloid Leukemia-CP Who Have Maintained Complete Molecular Remission for Two Years; Dasatinib Stop Trialtreatment2unknown_status
NCT05433532
Study of Azacitidine,Venetoclax,and Flumatinib in Newly Diagnosed Ph-positive Acute Leukemia and CML-AP/BP Patientstreatment2completed
NCT00516152
Phase II Study Evaluating Busulfan and Fludarabine as Preparative Therapy in Adults With Hematopoietic Disorders Undergoing MUD SCTtreatment2completed
NCT00481052
Nilotinib as First-line Treatment of Ph+ CML in Early Chronic Phasetreatment2completed
NCT04663100
Oral Adherence in Hematological Oncology Agents and Impact on Comorbid Therapy AdherenceNo drug interventionshealth_services_researchNot Availablerecruiting
NCT00750659
Nilotinib Pre and Post Allogeneic Stem Cell Transplantationtreatment2completed
NCT00143559
Stem Cell Transplantation as Immunotherapy for Hematologic MalignanciesNo drug interventionstreatment2completed
NCT02201459
Nilotinib ± Peg-IFN for First Line Chronic Phase CML Patientstreatment3unknown_status
NCT00038675
Therapy of HES, PV, Atypical Chronic Myelocytic Leukemia (CML) or Chronic Myelomonocytic Leukemia (CMML), and Mastocytosis With Imatinib MesylatetreatmentNot Availablecompleted
NCT02268370
Treatment-free Remission Accomplished With Dasatinib in Patients With CMLother2unknown_status
NCT02895542
Preparatory Work to Assess Adherence to Oral ChemotherapyNo drug interventionsNot AvailableNot Availablecompleted
NCT03241199
The Efficacy and Safety of Induction-Maintenance Protocol for Patients With Chronic Myelogenous Leukaemiatreatment2unknown_status
NCT06508099
Vitamin A and D Supplementation in Allogeneic HCTtreatment2recruiting
NCT04645706
Innate T Cells and TKI DiscontinuationNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04151706
CD34 Selected Allogeneic HCT w/ Myeloablative Conditioning Plus CD8+ Memory TCell Infusion in MDS, AL and CMLtreatment2completed
NCT01073436
Discontinuation of Imatinib Mesylate in Patients With Chronic-Phase Chronic Myeloid Leukemia Previously Treated With Interferon-AlphaNo drug interventionsNot AvailableNot Availableterminated
NCT00866736
A Study of Dasatinib in Patients With Imatinib Resistant or Intolerant Chronic Myeloid Leukemiatreatment2completed
NCT02883036
Vitro Study of Tigecycline to Treat Chronic Myeloid LeukemiaNo drug interventionsNot AvailableNot Availableunknown_status
NCT03062436
To Study the Impact of Stopping Therapy in Patients of CML With Molecular RemissionNo drug interventionstreatmentNot Availableunknown_status
NCT00464113
Study of XL228 in Subjects With Chronic Myeloid Leukemia or Philadelphia-Chromosome-Positive Acute Lymphocytic Leukemiatreatment1terminated
NCT00162513
Allogeneic Tumor Cell Vaccination in Patients With Chronic Myeloid LeukemiaNo drug interventionstreatment1 / 2withdrawn
NCT02422719
Radotinib as 3rd or Later Line Therapy in CP-CMLtreatment2unknown_status
NCT04818619
TIGIT in Patients With Chronic Myeloid LeukemiaNo drug interventionsNot AvailableNot Availableunknown_status
NCT00375219
Homoharringtonine (Omacetaxine Mepesuccinate) in Treating Patients With Chronic Myeloid Leukemia (CML) With the T315I BCR-ABL Gene Mutationtreatment2completed
NCT01751919
A Clinical Trial to Compare the Pharmacokinetics of Imatinib Mesylate Tablet 400mg (1 Tablet) and Glivec Film-coated Tablet 100mg (4 Tablets)(Phase I)treatment1completed
NCT00854841
The Randomized Study of Dasatinib and High-Dose Imatinib (600mg) in Suboptimal ResponderNot AvailableNot Availableavailable
NCT03709017
Iclusig PMS in CML or Ph+ALL PatientsNot AvailableNot Availableactive_not_recruiting
NCT03455517
Activity and Safety of Front-line Venetoclax and Rituximab in Young and Fit Patients With Chronic Lymphocytic Leukemiatreatment2completed
NCT00101816
Dasatinib (BMS-354825) in Subjects With Myeloid Blast Phase Chronic Myeloid Leukemia Resistant to or Intolerant of Imatinib Mesylatetreatment2completed
NCT01795716
Bioequivalence Study of Mesylate Imatinib Capsule in Chronic Myeloid Leukemia Bodytreatment1completed
NCT03533816
Expanded/Activated Gamma Delta T-cell Infusion Following Hematopoietic Stem Cell Transplantation and Post-transplant Cyclophosphamidetreatment1recruiting
NCT03996096
Tyrosine Kinase Inhibitor Withdrawal Syndrome in CML Patients: Observatory Trial Studying the Biological Factors.No drug interventionsNot AvailableNot Availablecompleted
NCT01281735
International Chronic Myeloid Leukemia Pediatric StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT00152139
Stem Cell Transplantation for Patients With Hematologic MalignanciesNo drug interventionstreatment3completed
NCT00219739
STI571 ProspectIve RandomIzed Trial: SPIRITtreatment3completed
NCT04089839
A Study of Dasatinib Management Among CP-CML (Chronic Phase, Chronic Myeloid Leukemia) Participants Initiating Dasatinib in a Real Life SettingNo drug interventionsNot AvailableNot Availablecompleted
NCT05943522
Asciminib RMP StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT02204722
A Study to Evaluate Efficacy and Safety of Glinib in Newly Diagnosed CML Patientstreatment4terminated
NCT02103322
Comparative Bioequivalence Study in Adult Patients Suffering From Chronic Myeloid Leukemia & Gastrointestinal Stromal Tumor Under Fed Conditionstreatment2 / 3completed
NCT05387330
Dynamic Changes in the Levels of sCD62L and SPARC in Chronic Myeloid Leukemia Patients During Imatinib TreatmentNo drug interventionsNot AvailableNot Availablecompleted
NCT06163430
CARDINAL- A Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of TERN-701 in Participants With Chronic Myeloid LeukemiaNo drug interventionstreatment1not_yet_recruiting
NCT02663648
Cell Cycle Regulatory Gene Study in Patients With Myeloproliferative DisordersNo drug interventionsNot AvailableNot Availablewithdrawn
NCT01394666
Non-interventional Treatment Patterns Study in Chronic Phase Chronic Myelogenous Leukemia (CP-CML)No drug interventionsNot AvailableNot Availablecompleted
NCT02172365
Allogeneic SCT for CML, TKI Failure After TKI FailureNo drug interventionsNot AvailableNot Availableunknown_status
NCT03262974
Effect of Pharmacogenetics on Imatinib Plasma Level and ResponseNo drug interventionsNot AvailableNot Availablecompleted
NCT02842320
Targeting Leukemic Stem Cell Expressing the IL-1RAP Protein in Chronic Myelogenous Leukemia (CML)No drug interventionsotherNot Availablecompleted
NCT02917720
2nd or 3rd TKI-stop After 2 Years Nilotinib Pre-treatment in CML-patientstreatment2active_not_recruiting
NCT02129582
Targeted Marrow Irradiation, Fludarabine Phosphate, and Busulfan Before Donor Progenitor Cell Transplant in Treating Patients With Hematologic Malignanciestreatment1completed
NCT03831776
Long-acting Low Dose Ropeginterferon for Chronic Myeloid Leukemia Treated With Bosutinib From Diagnosistreatment2recruiting
NCT00101660
Study of BMS-354825 (Dasatinib) in Patients With Chronic Myeloid Leukemia Who Are Either Resistant or Intolerant to Imatinibtreatment2completed
NCT03480360
Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expressiontreatment3active_not_recruiting
NCT01535391
Nilotinib in PH+, BCR-, ABL+ CML Patientstreatment3completed
NCT05476562
Study Conducted Among Patients With CMLNo drug interventionsNot AvailableNot Availablecompleted
NCT00896129
Mid-to Long-Term Outcomes in Chronic Myeloid Leukemia (CML) Patients With Complete Cytogenetic Response After Imatinib as First Line TherapyNo drug interventionsNot AvailableNot Availablecompleted
NCT02896829
Follow-up of the Persistence of the Complete Molecular Remission After Stopping Imatinib Chronic Myeloid LeukemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT00460629
Prophylactic Transfer of Leukemia-reactive T Cells After Allogeneic TransplantationNo drug interventionstreatment1 / 2completed
NCT00461929
Chromosome Abnormalities in Chronic Myeloid Leukemia (CML) on Imatinib. GIST Patients on ImatinibNo drug interventionsdiagnostic4terminated
NCT04464889
HA-1H TCR T Cell for Relapsed/Persistent Hematologic Malignancies After Allogeneic Stem Cell TransplantationNo drug interventionstreatment1withdrawn
NCT01188889
RAD001 in Patients With Chronic Phase Chronic Myeloid Leukemia w/ Molecular Disease.treatment1 / 2withdrawn
NCT00710892
CASPALLO: Allodepleted T Cells Transduced With Inducible Caspase 9 Suicide GeneNo drug interventionstreatment1active_not_recruiting
NCT01126892
A Study of Nilotinib in Adult Patients With Imatinib Resistant or - Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phasetreatment3completed
NCT01077544
A Pharmacokinetic (PK) Study of Nilotinib in Pediatric Patients With Philadelphia Chromosome-positive (Ph+) Chronic Myelogenous Leukemia (CML) or Acute Lymphoblastic Leukemia (ALL)treatment1completed
NCT00103844
Dasatinib (BMS-354835) Versus Imatinib Mesylate in Subjects With Chronic Myeloid Leukemiatreatment2completed
NCT01068301
A Pediatric Study of a Plerixafor Containing Regimen In Second Allogeneic Stem Cell Transplantationtreatment1completed
NCT05334069
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer DetectionNo drug interventionsNot AvailableNot Availablerecruiting
NCT02487069
Allo-HSCT With Alternative Donor in Treatment of Hematologic MalignancytreatmentNot Availablecompleted
NCT00261846
Study Evaluating SKI-606 (Bosutinib) In Philadelphia Chromosome Positive Leukemiastreatment2completed
NCT04233346
The Study for CML Who Failed Prior TKIs or With T315I Mutation or Ph+ ALL Who Failed Prior TKIs or With T315I Mutationtreatment2active_not_recruiting
NCT00786812
Study of Treatment With Nilotinib in Adult Patients With Imatinib - Resistant or - Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phasetreatment4completed
NCT00531310
Reduced Intensity AlloSCT in(CML) With Persistent Diseasetreatment2terminated
NCT03193281
KISS Study: Kinase Inhibition With Sprycel Start uptreatment2active_not_recruiting
NCT02448095
Retrospective Evaluation of CML Patients in the National Compassionate ProgramNot AvailableNot Availableterminated
NCT01596114
European Stop Tyrosine Kinase Inhibitor StudyNo drug interventionstreatment3completed
NCT00469014
Busulfan, Fludarabine, Clofarabine With Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemiatreatment2completed
NCT00790855
Bendamustine in Acute Leukemia and MDStreatment1 / 2terminated
NCT01802450
Dasatinib in Patients With Chronic Myeloid Leukemia in Chronic Phasetreatment2unknown_status
NCT05130138
Interest of PHARMaceutical Conciliation to Understand Drug Interactions, Phytotherapy, and Targeted Therapies in Chronic Myeloid LeukemiaNo drug interventionsotherNot Availablerecruiting
NCT00462943
Open Label Study of Subcutaneous Homoharringtonine (Omacetaxine Mepesuccinate) in Patients With Advanced CMLtreatment2completed
NCT05286528
Study to Evaluate Chronic Myeloid Leukemia Treatment Landscape and Real-life Treatment Outcomes in Hungary: Analysis of National Health Insurance Fund DatabaseNot AvailableNot Availablecompleted
NCT01804985
De- Escalation and Stopping Treatment of Imatinib, Nilotinib or sprYcel in Chronic Myeloid Leukaemiatreatment2unknown_status
NCT02001818
Pegylated Interferon Alfa-2b and Nilotinib for Augmentation of Complete Molecular Response in Chronic Myeloid Leukaemiatreatment2completed
NCT05682924
Condition Vasoregulation Function Endothelium in Patients With CML Getting TKI II Generation BosutinibNo drug interventionsNot AvailableNot Availablerecruiting
NCT01343173
Multicenter Trial Estimating the Persistence of Molecular Remission in Chronic Myeloid Leukaemia in Long Term After Stopping ImatinibtreatmentNot Availablecompleted
NCT01475110
Observational Study in Adults With Imatinib-resistant/Intolerant Chronic Myeloid Leukemia Treated With NilotinibNot AvailableNot Availablecompleted
NCT00390897
Glivec® (Imatinib Mesylate, STI571) in Monotherapy Versus Glivec®-Interferon Alpha in the Treatment of Chronic-Phase Chronic Myeloid Leukaemiatreatment4completed
NCT02546375
A Study To Describe The Real World Use Of Bosutinib In The UK And NetherlandsNot AvailableNot Availablecompleted
NCT05893836
Real-World Disease Management and Outcomes in Chronic Myeloid LeukaemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT01597219
Trial of Haploidentical Stem Cell Transplantation for Haematological CancersNo drug interventionstreatment2completed
NCT01699217
Front-line Nilotinib Treatment of BCR-ABL+ Chronic Myeloid Leukaemia in Chronic PhaseNo drug interventionsNot AvailableNot Availableunknown_status
NCT01621724
WT1 TCR Gene Therapy for Leukaemia: A Phase I/II Safety and Toxicity StudyNo drug interventionstreatment1 / 2completed
NCT04256317
A Study of ASTX030 (Cedazuridine in Combination With Azacitidine) in MDS, CMML, or AMLtreatment2 / 3recruiting
NCT01621477
T-Cell Replete Haploidentical Donor Hematopoietic Stem Cell Plus Natural Killer (NK) Cell Transplantation in Patients With Hematologic Malignancies Relapsed or Refractory Despite Previous Allogeneic Transplanttreatment2terminated
NCT01188798
Methotrexate or Pentostatin for Graft-versus-host Disease Prophylaxis in Risk-adapted Allogeneic Bone Marrow Transplantation for Hematologic Malignanciestreatment3completed
NCT01300611
TXA127 in Enhancement of Engraftment in Adult Double Cord Blood Transplantationsupportive_care1terminated
NCT04150471
Assess Long-term Feasibility of Reduced Dose Dasatinib in Chronic Phase Chronic Myeloid Leukemia PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT01045382
MSC and HSC Coinfusion in Mismatched MinitransplantsNo drug interventionstreatment2terminated
NCT02975115
Evaluating True PCR-negative Rate of Frontline Dasatinib in Early Chronic Phase CML for Therapeutic HarmonizationNo drug interventionsNot AvailableNot Availableunknown_status
NCT00859586
Mismatched Donor Lymphocyte Infusions for Relapsed Disease Following Allogeneic Stem Cell TransplantationNo drug interventionstreatmentNot Availablecompleted
NCT00854646
Phase I Study of ON 01910.Na in Refractory Leukemia or Myelodysplastic Syndrome (MDS)treatment1completed