Discoid Lupus Erythematosus (DLE) (DBCOND0042421)

Identifiers

Synonyms

Lupus Erythematosus, Discoid / Discoid Lupus Erythematosus / Discoid lupus erythematosis / Chronic cutaneous lupus erythematosus / Chronic discoid lupus erythematosus (disorder) / Lupus erythematosus discoid / Lupus erythematosus discoides / Lupus erythematosis discoid / Discoid lupus erythematosus (disorder) / Lupus erythematosus / Lupus erythematosus (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Betamethasone	A systemic corticosteroid used to relieve inflammation in various conditions, including but not limited to allergic states, dermatologic disorders, gastrointestinal diseases, and hematological disorders.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Aromataseenzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Albumincarrier Corticosteroid-binding globulincarrier
Betamethasone phosphate	A fast acting ester prodrug of a corticosteroid used to treat inflammatory conditions.	Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Glucocorticoid receptortarget Annexin A1target Corticosteroid-binding globulincarrier Albumincarrier Solute carrier organic anion transporter family member 1A2transporter ATP-dependent translocase ABCB1transporter Organic anion transporter 3transporter
Bupivacaine	A local anesthetic used in a wide variety of superficial and invasive procedures.	Sodium channel protein type 10 subunit alphatarget Prostaglandin E2 receptor EP1 subtypetarget Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme
Chloroquine	An antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis.	Tumor necrosis factortarget Toll-like receptor 9target Glutathione S-transferase A2target Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 1A1enzyme Cytochrome P450 2C8enzyme Cytochrome P450 3A5enzyme Glutathione S-transferasetarget ATP-dependent translocase ABCB1transporter Albumincarrier alpha1-acid glycoproteincarrier High mobility group protein B1target Glutathione S-transferase Mu 1target Angiotensin-converting enzyme 2target Atypical chemokine receptor 1target
Dexamethasone	A glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders.	Glucocorticoid receptortarget Annexin A1target Nitric oxide synthase, inducibletarget Nuclear receptor subfamily 0 group B member 1target Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Bile salt export pumptransporter ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Solute carrier organic anion transporter family member 1A2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Steroid 17-alpha-hydroxylase/17,20 lyaseenzyme Cytochrome P450 1A1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A43enzyme Cytochrome P450 4A11enzyme Nuclear receptor subfamily 1 group I member 2target Cytochrome P450 11B1, mitochondrialenzyme Albumincarrier 11-beta-hydroxysteroid dehydrogenase type 2enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme Organic anion transporter 3transporter
Flumethasone	A corticosteroid used to treat contact dermatitis, atopic dermatitis, eczema, psoriasis, diaper rash, and other skin conditions.	Corticosteroid-binding globulincarrier Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Steroid hormone receptor ERR1target Steroid hormone receptor ERR2target Estrogen-related receptor gammatarget
Methylprednisolone	A corticosteroid used to treat inflammation or immune reactions across a variety of organ systems, endocrine conditions, and neoplastic diseases.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 3A Subfamilyenzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Annexin A1target 20-ketosteroid reductase (20-hydroxysteroid dehydrogenase)enzyme 11beta-hydroxysteroid dehydrogenaseenzyme Albumincarrier
Neomycin	An aminoglycoside antibiotic agent used orally and topically to treat a wide variety of infections in the body.	30S ribosomal protein S12target 16S ribosomal RNAtarget Extracellular calcium-sensing receptortarget
Salicylic acid	An acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts.	Albumincarrier Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Aldo-keto reductase family 1 member C1target Solute carrier family 22 member 6transporter Solute carrier family 22 member 10transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Solute carrier organic anion transporter family member 2B1transporter Monocarboxylate transporter 1transporter Solute carrier family 22 member 7transporter Cytochrome P450 2C9enzyme Carbonic anhydrase 6target Carbonic anhydrase 12target Carbonic anhydrase 2target Carbonic anhydrase 4target Carbonic anhydrase 1target
Triamcinolone	A glucocorticoid used to treat a wide variety of inflammatory conditions of organ systems and tissues.	Corticosteroid-binding globulincarrier Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Prostaglandin G/H synthase 2enzyme Cholinesteraseenzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Albumincarrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04857034	A Study to Evaluate Efficacy and Safety of Deucravacitinib in Participants With Active Discoid and/or Subacute Cutaneous Lupus Erythematosus (DLE/SCLE)	Deucravacitinib	treatment	2	active_not_recruiting
NCT00222183	Cutaneous Lupus Erythematosus and Elidel	Pimecrolimus	treatment	Not Available	withdrawn
NCT02428309	Autologous Polyclonal Tregs for Lupus	No drug interventions	treatment	1	terminated
NCT01858792	A Pooled Analysis of the HGS1006-C1056 (BLISS-52) and HGS1006-C1057 (BLISS-76) Studies	Belimumab	Not Available	Not Available	completed
NCT03178188	Efficacy of 595 nm Pulsed-dye Laser in Treatment of Discoid Lupus Erythematosus	No drug interventions	treatment	2 / 3	unknown_status
NCT01923415	A Non-drug Study Profiling Cutaneous Lupus	No drug interventions	Not Available	Not Available	completed
NCT02656082	Targeted Therapy Using Intradermal Injection of Etanercept for Remission Induction in Discoid Lupus Erythematosus	Etanercept	treatment	2	completed
NCT02034344	A Study of Skin and Systemic Biomarkers In Patients With Active Cutaneous Lupus Erythematosus And In Healthy Volunteers	No drug interventions	Not Available	Not Available	completed
NCT01845740	Phase Ib Study of SC Milatuzumab in SLE	Milatuzumab	treatment	1	completed
NCT01597050	Safety and Efficacy of Topical R333 in Patients With Discoid Lupus Erythematosus (DLE) and Systemic Lupus Erythematosus (SLE) Lesions	No drug interventions	treatment	2	completed
NCT00797784	The Safety and Efficacy of Etanercept (Enbrel®) for the Treatment of Discoid Lupus Erythematosus	Etanercept	treatment	2	unknown_status
NCT05591222	Study of Daxdilimab (HZN-7734) in Patients With Moderate-to-Severe Primary Discoid Lupus Erythematosus	Daxdilimab	treatment	2	active_not_recruiting
NCT06261021	Study to Evaluate the Efficacy of Ruxolitinib 1.5% Cream in Adult Subjects with Discoid Lupus Erythematosus	Ruxolitinib	treatment	2	recruiting
NCT00625521	Efficacy and Safety of ASF-1096 Cream 0.5% in the Treatment of Discoid Lupus Erythematosus (DLE) Lesions	Levosalbutamol	treatment	2	completed
NCT05362188	Topical Nicotinamide in Treatment of DLE	Nicotinamide	treatment	0	completed
NCT03159936	Oral Tofacitinib in Adult Subjects With Discoid Lupus Erythematosus (DLE) and Systemic Lupus Erythematosus (SLE)	Tofacitinib	treatment	0	terminated
NCT03866317	A Study to Assess the Safety and Efficacy of Secukinumab in Alleviating Symptoms of Discoid Lupus Erythematosus	Secukinumab	treatment	2	withdrawn
NCT00708916	Safety Study of Clinical and Immune Effects of Phosphodiesterase 4 (PDE-4) Inhibitor in Cutaneous Lupus Patients	Apremilast	treatment	1 / 2	completed
NCT04908280	Study of Ruxolitinib Cream for the Treatment of Discoid Lupus Erythematosus	Ruxolitinib	treatment	2	completed
NCT02125695	Pilot Tape Harvesting Study	No drug interventions	Not Available	Not Available	completed
NCT03958955	Efficacy and Safety of Delgocitinib Cream in Discoid Lupus Erythematosus.	Delgocitinib	treatment	2	terminated
NCT00625157	Efficacy and Safety of ASF-1096 Cream 0.5% in the Treatment of Discoid Lupus Erythematosus (DLE) Lesions (2)	Levosalbutamol	treatment	2	completed
NCT00608673	Comparing the Therapeutic Efficacy of Pimecrolimus Cream With Betamethasone Cream for Discoid Lupus Erythematosus	Betamethasone Pimecrolimus	treatment	Not Available	completed
NCT00001680	A Pilot Trial of Topical Thalidomide for the Management of Chronic Discoid Lupus Erythematosus	Thalidomide	treatment	2	completed
NCT00691769	Expression of Fas Protein in Skin Biopsies of Participants With Scarring Alopecia	No drug interventions	Not Available	Not Available	completed