BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
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| Picrotoxin is a Gamma-aminobutyric acid receptor subunit alpha-1 antagonist |
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| 1 | Gamma-aminobutyric acid receptor subunit alpha-1 potentiators | Amobarbital, Aprobarbital, Barbital, Butalbital, Butobarbital, Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione, Dihydroquinidine barbiturate, Eszopiclone, Fludiazepam, Heptabarbital, Hexobarbital, Metharbital, Methylphenobarbital, Pentobarbital, Phenobarbital, Primidone, Quinidine barbiturate, Secobarbital, Talbutal, Thiopental, Zaleplon, Zopiclone |
| 2 | Gamma-aminobutyric acid receptor subunit alpha-1 agonists | Ethanol, Etomidate, Glutethimide, Isoflurane, Meprobamate, Methoxyflurane, Methyprylon, Progabide, Sevoflurane, Thiamylal, Topiramate, Zolpidem |
| 3 | Gamma-aminobutyric acid receptor subunit alpha-1 antagonists | Amoxapine, Flumazenil, Methohexital |
| 4 | Gamma-aminobutyric acid receptor subunit alpha-1 negative modulators | Ginkgo biloba |
| 5 | Gamma-aminobutyric acid receptor subunit alpha-1 activators | Carisoprodol |
| 6 | Gamma-aminobutyric acid receptor subunit alpha-1 modulators | Carisoprodol |
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| Picrotoxin is a Glycine receptor subunit alpha-1 antagonist |
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| 1 | Glycine receptor subunit alpha-1 ligands | Glycine |
| 2 | Glycine receptor subunit alpha-1 agonists | Desflurane, Ethanol, Isoflurane, Methoxyflurane, Sevoflurane, Taurine |
| 3 | Glycine receptor subunit alpha-1 antagonists | Atropine, Ginkgo biloba, Lindane, Thiocolchicoside |
| 4 | Glycine receptor subunit alpha-1 inhibitors | Zinc chloride, Zinc sulfate, unspecified form |
| 5 | Glycine receptor subunit alpha-1 potentiators | Enflurane |
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| Picrotoxin is a Cytochrome P450 1A1 inducer |
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| 1 | Cytochrome P450 1A1 substrates | (R)-warfarin, Amiodarone, Amodiaquine, Azelastine, Azimilide, Banoxantrone, Carvedilol, Chloroquine, Chlorzoxazone, Cinnarizine, Clenbuterol, Clonidine, Copanlisib, Dacarbazine, Dapagliflozin, Dasatinib, Daunorubicin, Debrisoquine, Difloxacin, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Flunarizine, Flutamide, Fluvastatin, Gefitinib, Granisetron, Haloperidol, Indirubin, Istradefylline, Loratadine, Lorcaserin, Melatonin, Nicotine, Omeprazole, Pentamidine, Perospirone, Phenacetin, Pioglitazone, Progesterone, Resveratrol, Riluzole, Riociguat, Risdiplam, Romidepsin, Solifenacin, Tamoxifen, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Theophylline, Toremifene, Tretinoin, Triclabendazole |
| 2 | Cytochrome P450 1A1 inhibitors | Amlodipine, Azelastine, Benzyl alcohol, Caffeine, Cannabidiol, Cholecalciferol, Dexamethasone, Dexamethasone acetate, Dexmedetomidine, Ellagic acid, Ethanol, Fluvoxamine, Gefitinib, Isoprenaline, Ketoconazole, Manidipine, Medical Cannabis, Melatonin, Menadione, Methoxsalen, Nabiximols, Nifedipine, Nitroprusside, Norfloxacin, Propofol, Propranolol, Pyridoxine, Quinidine, Quinine, Resveratrol, Safinamide, Sulindac, Theophylline, Topiroxostat |
| 3 | Cytochrome P450 1A1 inducers | Albendazole, Bezafibrate, Clofibrate, Clozapine, Dexamethasone, Dexamethasone acetate, Dovitinib, Ellagic acid, Fluvastatin, Itraconazole, Ketoconazole, Lansoprazole, Mebendazole, Menadione, Nicotine, Omeprazole, Phenobarbital, Primaquine, Propylthiouracil, Quinine, Rabeprazole, Streptozocin, Thiabendazole, Triclocarban, Troglitazone |