Polycythemia Vera (PV)

Also known as: Polycythemia vera / Polycythaemia vera / [M]Polycythemia vera / Primary polycythaemia / Vaquez's disease / Primary polycythemia / Polycythemia rubra vera / Polycythaemia rubra vera

DrugDrug NameDrug Description
DB00945Acetylsalicylic acidA salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events.
DB01008BusulfanAn alkylating agent used to treat chronic myelogenous leukemia.
DB01005HydroxyureaAn antimetabolite used to treat sickle cell anemia crisis.
DB00888MechlorethamineAn antineoplastic agent used to treat Hodgkin's disease, lymphosarcoma, and chronic myelocytic or lymphocytic leukemia.
DB15119Ropeginterferon alfa-2bRopeginterferon alfa-2b is under investigation in clinical trial NCT01949805 (Pegylated Interferon Alpha-2b Versus Hydroxyurea in Polycythemia Vera).
DrugDrug NameTargetType
DB00945Acetylsalicylic acidProstaglandin G/H synthase 1target
DB00945Acetylsalicylic acidProstaglandin G/H synthase 2target
DB00945Acetylsalicylic acidAldo-keto reductase family 1 member C1target
DB00945Acetylsalicylic acidSolute carrier family 22 member 6transporter
DB00945Acetylsalicylic acidP-glycoprotein 1transporter
DB00945Acetylsalicylic acidCytochrome P450 2C19enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acid5'-AMP-activated protein kinasetarget
DB00945Acetylsalicylic acidEndothelin-1 receptortarget
DB00945Acetylsalicylic acidCellular tumor antigen p53target
DB00945Acetylsalicylic acid78 kDa glucose-regulated proteintarget
DB00945Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
DB00945Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
DB00945Acetylsalicylic acidTumor necrosis factor-inducible gene 6 proteintarget
DB00945Acetylsalicylic acidCaspase-1target
DB00945Acetylsalicylic acidCaspase-3target
DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00945Acetylsalicylic acidExtracellular signal-regulated kinase (ERK)target
DB00945Acetylsalicylic acidG1/S-specific cyclin-D1target
DB00945Acetylsalicylic acidMyc proto-oncogene proteintarget
DB00945Acetylsalicylic acidProliferating cell nuclear antigentarget
DB00945Acetylsalicylic acidCyclin Atarget
DB00945Acetylsalicylic acidUDP-glucuronosyltransferase 1-6enzyme
DB00945Acetylsalicylic acidArylamine N-acetyltransferase 2enzyme
DB00945Acetylsalicylic acidSolute carrier family 22 member 8transporter
DB01008BusulfanDNAtarget
DB01008BusulfanCytochrome P450 3A4enzyme
DB01008BusulfanGlutathione S-transferase A2enzyme
DB01008BusulfanGlutathione S-transferase A1enzyme
DB01008BusulfanGlutathione S-transferase Mu 1enzyme
DB01008BusulfanGlutathione S-transferase Penzyme
DB01008BusulfanMicrosomal glutathione S-transferase 2enzyme
DB01005HydroxyureaRibonucleoside-diphosphate reductase large subunittarget
DB01005HydroxyureaCytochrome P450 2D6enzyme
DB00888MechlorethamineDNAtarget
DB00888MechlorethamineCholinesteraseenzyme
DB15119Ropeginterferon alfa-2bCytochrome P450 1A2enzyme
DrugDrug NamePhaseStatusCount
DB09036Siltuximab0Withdrawn1
DB01169Arsenic trioxide1Terminated1
DB04456Arsenous acid1Terminated1
DB00928Azacitidine1Completed1
DB04339Carbocisteine1Active Not Recruiting1
DB00958Carboplatin1Active Not Recruiting1
DB00987Cytarabine1Completed1
DB01262Decitabine1Completed1
DB00773Etoposide1Completed1
DB13040Gandotinib1Completed2
DB12325Idasanutlin1Completed1
DB00619Imatinib1Completed1
DB00008Peginterferon alfa-2a1Completed1
DB08877Ruxolitinib1Active Not Recruiting1
DB09143Sonidegib1Completed1
DB01268Sunitinib1Completed1
DB01030Topotecan1Active Not Recruiting1
DB14989Umbralisib1Active Not Recruiting1
DB07232Veliparib1Active Not Recruiting1
DB02546Vorinostat1Completed1
DB05243XL0191Terminated2
DB00041Aldesleukin1 / 2Completed1
DB00928Azacitidine1 / 2Recruiting1
DB00987Cytarabine1 / 2Recruiting1
DB00694Daunorubicin1 / 2Recruiting1
DB12645Givinostat1 / 2Completed1
DB06469Lestaurtinib1 / 2Unknown Status1
DB11697Pacritinib1 / 2Completed1
DB11759Pevonedistat1 / 2Recruiting1
DB08877Ruxolitinib1 / 2Completed2
DB08877Ruxolitinib1 / 2Recruiting1
DB09143Sonidegib1 / 2Completed1
DB11581Venetoclax1 / 2Recruiting1
DB00945Acetylsalicylic acid2Active Not Recruiting2
DB00945Acetylsalicylic acid2Not Yet Recruiting1
DB00945Acetylsalicylic acid2Withdrawn1
DB06605Apixaban2Not Yet Recruiting1
DB01008Busulfan2Active Not Recruiting1
DB04339Carbocisteine2Recruiting1
DB00958Carboplatin2Recruiting1
DB00758Clopidogrel2Withdrawn1
DB00531Cyclophosphamide2Active Not Recruiting2
DB00531Cyclophosphamide2Recruiting2
DB00091Cyclosporine2Completed1
DB01254Dasatinib2Completed1
DB01254Dasatinib2Terminated1
DB01262Decitabine2Recruiting1
DB00530Erlotinib2Terminated1
DB12500Fedratinib2Recruiting1
DB01073Fludarabine2Active Not Recruiting2
DB01073Fludarabine2Completed4
DB01073Fludarabine2Recruiting2
DB12645Givinostat2Completed1
DB01005Hydroxyurea2Completed1
DB15126IMG-72892Recruiting1
DB12325Idasanutlin2Terminated1
DB00619Imatinib2Completed3
DB14909Imetelstat2Completed1
DB05258Interferon alfa2Completed1
DB12154Itacitinib2Not Yet Recruiting1
DB00480Lenalidomide2Completed1
DB06469Lestaurtinib2Completed1
DB01042Melphalan2Completed1
DB00563Methotrexate2Completed1
DB08893Mirabegron2Completed1
DB11763Momelotinib2Completed1
DB11763Momelotinib2Terminated1
DB00688Mycophenolate mofetil2Active Not Recruiting2
DB00688Mycophenolate mofetil2Completed3
DB00688Mycophenolate mofetil2Recruiting1
DB01024Mycophenolic acid2Recruiting1
DB14852PRM-1512Completed1
DB09037Pembrolizumab2Completed1
DB08910Pomalidomide2Completed1
DB00635Prednisone2Completed2
DB00172Proline2Active Not Recruiting1
DB15119Ropeginterferon alfa-2b2Active Not Recruiting2
DB15119Ropeginterferon alfa-2b2Enrolling by Invitation1
DB08877Ruxolitinib2Active Not Recruiting2
DB08877Ruxolitinib2Completed1
DB08877Ruxolitinib2Not Yet Recruiting1
DB08877Ruxolitinib2Recruiting1
DB00864Tacrolimus2Active Not Recruiting2
DB00864Tacrolimus2Completed2
DB00864Tacrolimus2Recruiting1
DB04572Thiotepa2Recruiting1
DB04960Tipifarnib2Completed1
DB01030Topotecan2Recruiting1
DB11940Triapine2Completed1
DB07232Veliparib2Recruiting1
DB02546Vorinostat2Unknown Status1
DB01005Hydroxyurea3Completed2
DB01005Hydroxyurea3Recruiting1
DB01005Hydroxyurea3Terminated1
DB01005Hydroxyurea3Unknown Status1
DB00008Peginterferon alfa-2a3Unknown Status1
DB00022Peginterferon alfa-2b3Unknown Status1
DB00172Proline3Active Not Recruiting1
DB00172Proline3Completed1
DB15119Ropeginterferon alfa-2b3Active Not Recruiting1
DB15119Ropeginterferon alfa-2b3Completed2
DB08877Ruxolitinib3Completed4
DB08877Ruxolitinib3Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)Not AvailableCompleted1
DB01008BusulfanNot AvailableCompleted2
DB00531CyclophosphamideNot AvailableCompleted1
DB00091CyclosporineNot AvailableCompleted1
DB01073FludarabineNot AvailableCompleted2
DB00529FoscarnetNot AvailableCompleted1
DB01004GanciclovirNot AvailableCompleted1
DB00619ImatinibNot AvailableCompleted1
DB01042MelphalanNot AvailableCompleted1
DB00563MethotrexateNot AvailableCompleted1
DB00688Mycophenolate mofetilNot AvailableCompleted1
DB00864TacrolimusNot AvailableCompleted1
DB01610ValganciclovirNot AvailableCompleted1