Showing BioInteractions for Buclizine (DB00354)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

Target Mediated Interactions 3

	Interacting Group	Interacting Drugs
	Buclizine is a Histamine H1 receptor antagonist
1	Histamine H1 receptor antagonists	Aceprometazine, Acrivastine, Alcaftadine, Alimemazine, Amitriptyline, Amoxapine, Antazoline, Aripiprazole, Aripiprazole lauroxil, Asenapine, Astemizole, Azatadine, Azelastine, Benzatropine, Benzquinamide, Bepotastine, Bilastine, Bromodiphenhydramine, Brompheniramine, Butriptyline, Carbinoxamine, Cariprazine, Cetirizine, Chlorcyclizine, Chloropyramine, Chlorpheniramine, Chlorpromazine, Chlorprothixene, Cinnarizine, Clemastine, Clofedanol, Clozapine, Cyclizine, Cyproheptadine, Desipramine, Desloratadine, Dexbrompheniramine, Dexchlorpheniramine maleate, Dimenhydrinate, Dimetindene, Diphenhydramine, Diphenylpyraline, Dosulepin, Doxepin, Doxylamine, Emedastine, Epinastine, Fexofenadine, Flunarizine, Iloperidone, Imipramine, Isothipendyl, Ketotifen, Lamotrigine, Levocabastine, Levocetirizine, Loratadine, Lorpiprazole, Maprotiline, Meclizine, Mepyramine, Mequitazine, Methdilazine, Methotrimeprazine, Mianserin, Mirtazapine, Nortriptyline, Olanzapine, Olopatadine, Orphenadrine, Paliperidone, Phenindamine, Pizotifen, Prochlorperazine, Promazine, Promethazine, Propiomazine, Quetiapine, Risperidone, Rupatadine, Terfenadine, Tesmilifene, Thonzylamine, Trazodone, Trimipramine, Tripelennamine, Triprolidine, Ziprasidone, Zuclopenthixol
2	Histamine H1 receptor inverse agonists	Esmirtazapine, Hydroxyzine, Perospirone, Pheniramine
3	Histamine H1 receptor agonists	Betahistine, Histamine, Tolazoline
4	Histamine H1 receptor inhibitors	Escitalopram, Levocetirizine, Paroxetine
5	Histamine H1 receptor binders	Citalopram, Loxapine

	Interacting Group	Interacting Drugs
	Buclizine is a Muscarinic acetylcholine receptor M1 antagonist
1	Muscarinic acetylcholine receptor M1 agonists	Carbamoylcholine, Cevimeline, Methacholine, Metoclopramide, Minaprine, Pilocarpine, Pyrantel, Succinylcholine
2	Muscarinic acetylcholine receptor M1 antagonists	Aclidinium, Amoxapine, Anisotropine methylbromide, Atropine, Benzatropine, Benzquinamide, Biperiden, Brompheniramine, Chlorpromazine, Chlorprothixene, Clidinium, Clozapine, Cocaine, Cyclopentolate, Cycrimine, Cyproheptadine, Darifenacin, Desipramine, Dicyclomine, Diphenidol, Disopyramide, Dosulepin, Doxepin, Fesoterodine, Flavoxate, Flupentixol, Glycopyrronium, Hexocyclium, Homatropine, Homatropine methylbromide, Hyoscyamine, Imidafenacin, Imipramine, Ipratropium, Maprotiline, Mepenzolate, Methantheline, Methotrimeprazine, Methscopolamine bromide, Nicardipine, Olanzapine, Oxybutynin, Oxyphencyclimine, Oxyphenonium, Pirenzepine, Pizotifen, Procyclidine, Profenamine, Promazine, Promethazine, Propantheline, Propiverine, Pyrantel, Quetiapine, Rociverine, Scopolamine, Solifenacin, Thonzylamine, Tiotropium, Tolterodine, Tramadol, Tridihexethyl, Triflupromazine, Trihexyphenidyl, Trimebutine, Tropicamide, Trospium, Umeclidinium, Ziprasidone
3	Muscarinic acetylcholine receptor M1 inhibitors	Escitalopram
4	Muscarinic acetylcholine receptor M1 binders	Loxapine, Terfenadine
5	Muscarinic acetylcholine receptor M1 ligands	Aripiprazole

	Interacting Group	Interacting Drugs
	Buclizine is a Muscarinic acetylcholine receptor M1 weak inhibitor
1	Muscarinic acetylcholine receptor M1 agonists	Carbamoylcholine, Cevimeline, Methacholine, Metoclopramide, Minaprine, Pilocarpine, Pyrantel, Succinylcholine
2	Muscarinic acetylcholine receptor M1 antagonists	Aclidinium, Amoxapine, Anisotropine methylbromide, Atropine, Benzatropine, Benzquinamide, Biperiden, Brompheniramine, Chlorpromazine, Chlorprothixene, Clidinium, Clozapine, Cocaine, Cyclopentolate, Cycrimine, Cyproheptadine, Darifenacin, Desipramine, Dicyclomine, Diphenidol, Disopyramide, Dosulepin, Doxepin, Fesoterodine, Flavoxate, Flupentixol, Glycopyrronium, Hexocyclium, Homatropine, Homatropine methylbromide, Hyoscyamine, Imidafenacin, Imipramine, Ipratropium, Maprotiline, Mepenzolate, Methantheline, Methotrimeprazine, Methscopolamine bromide, Nicardipine, Olanzapine, Oxybutynin, Oxyphencyclimine, Oxyphenonium, Pirenzepine, Pizotifen, Procyclidine, Profenamine, Promazine, Promethazine, Propantheline, Propiverine, Pyrantel, Quetiapine, Rociverine, Scopolamine, Solifenacin, Thonzylamine, Tiotropium, Tolterodine, Tramadol, Tridihexethyl, Triflupromazine, Trihexyphenidyl, Trimebutine, Tropicamide, Trospium, Umeclidinium, Ziprasidone
3	Muscarinic acetylcholine receptor M1 inhibitors	Escitalopram
4	Muscarinic acetylcholine receptor M1 binders	Loxapine, Terfenadine
5	Muscarinic acetylcholine receptor M1 ligands	Aripiprazole