Sickle Cell Disease (SCD)
Also known as: Sickle Cell SC Disease / Sickle Cell Disorders / Sickle Cells Disease / Sickle-cell Disease (SCD) / Sickle-Cell Disease / Sickle Cell Disorder / Sickle Cell Disease / SC Disease / Sickle-cell anemia, unspecified / Sickle-cell anaemia, unspecified / Sickle-cell disorders / Sickle cell anemia of unspecified type (disorder) / Sickle cell syndrome / Sickle cell anaemia / Anaemia sickle cell / Sickle cell anemia NOS (disorder) / Sickle-cell anaemia / Sickle cell disease NOS / Sickling disorder due to hemoglobin S (disorder) / Sickle-cell anemia / Sickle cell anemia / Hemoglobin S disease / Sickle cell-hemoglobin SS disease (disorder) / Anemia sickle cell / Anemia, Sickle Cell / Double heterozygous sickling disorders / Double heterozygous sickling disorder (disorder)
| Drug | Drug Name | Drug Description |
|---|---|---|
| DB15271 | Crizanlizumab | A monoclonal antibody that targets selectin to reduce the frequency of vasooclusive crises in patients with sickle cell disease. |
| DB09210 | Piracetam | A nootropic cyclic GABA derivative used in myoclonus, sickle cell disease, alcohol dependence, and as a general cognitive enhancer. |
| DB14975 | Voxelotor | A drug used to inhibit the polymerization of hemoglobin S, preventing the painful and sometimes lethal vaso-occlusive crises associated with sickle cell disease. |
| Drug | Drug Name | Target | Type |
|---|---|---|---|
| DB15271 | Crizanlizumab | P-selectin | target |
| DB14975 | Voxelotor | Cytochrome P450 3A4 | enzyme |
| DB14975 | Voxelotor | Cytochrome P450 2C9 | enzyme |
| DB14975 | Voxelotor | Cytochrome P450 2B6 | enzyme |
| DB14975 | Voxelotor | Cytochrome P450 2C19 | enzyme |
| DB14975 | Voxelotor | Hemoglobin subunit alpha | target |