Insect Bites (DBCOND0042295)

Identifiers

Synonyms

Insect bite - wound (disorder) / Insect bite NOS

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Bamipine	An H1 antihistamine used topically to relieve mild to moderate symptoms associated with insect bites.	No drug targets
Bendazac	A non-steroidal anti-inflammatory drug (NSAID) available as an eye drop for the treatment of cataracts and as a topical cream for the treatment of dermatitis, eczema, hives, skin ulcers and other inflammatory skin conditions.	Free radicalstarget Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target
Benzyl alcohol	An antiparasitic agent used for the topical treatment of head lice infestation in patients 6 months of age and older.	Cytochrome P450 2C8enzyme Cytochrome P450 1A1enzyme Aldehyde dehydrogenase, mitochondrialenzyme Cytochrome P450 1A2enzyme Cytochrome P450 2E1enzyme Cytochrome P450 2D6enzyme
Cetrimonium	A compound that can be used as a topical antiseptic.	Cyclopropane mycolic acid synthase MmaA2target Cyclopropane mycolic acid synthase 1target
Dexchlorpheniramine	A chlorpheniramine enantiomer antihistamine indicated in the treatment of sunburns, insect bites, and allergic reactions of the skin.	Cytochrome P450 2D6enzyme
Dexpanthenol	An alcoholic analogue of D-pantothenic acid that is used as a supplement or application to support a healthy epithelium and is also used to prevent vitamin deficiency in patients receiving total parenteral nutrition (TPN).	No drug targets
Diethyltoluamide	An insect repellant, also known as DEET.	No drug targets
Diphenhydramine	A H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.	Histamine H1 receptortarget Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Solute carrier family 22 member 2transporter Organic cation/carnitine transporter 2transporter Prostaglandin G/H synthase 1enzyme Muscarinic acetylcholine receptor M2target Histamine N-methyltransferasetarget
Eucalyptus oil	An ingredient used in a variety of natural health products.	No drug targets
Euflavine	A topical disinfectant indicated in the treatment of wounds, blisters, insect bites, and infected wounds.	No drug targets
Eugenol	A phenol used for the temporary relief of toothaches.	Estrogen receptortarget Estrogen receptor betatarget Androgen receptortarget Transient receptor potential cation channel subfamily V member 3target Amine oxidase [flavin-containing] Btarget
Glycerin	It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.	Group IIE secretory phospholipase A2target Inositol-3-phosphate synthase 1target All-trans-retinol dehydrogenase [NAD(+)] ADH1Btarget Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1target Glycodelintarget Alpha-N-acetylgalactosaminidasetarget ADP-ribosylation factor 1target Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1target DNA mismatch repair protein MutLtarget Ribonucleoside-diphosphate reductase 1 subunit betatarget Adenine DNA glycosylasetarget tRNA (cytosine(38)-C(5))-methyltransferasetarget Cytochrome P450 2E1enzyme Aldehyde dehydrogenase 1A1enzyme Peroxisome proliferator-activated receptor deltatarget Maleylacetoacetate isomerasetarget Aquaporin-7transporter Aquaporin-9transporter Glycerol uptake facilitator proteintransporter
Icaridin	Icaridin is indicated for use to repel insects, such as mosquitoes, biting flies, ticks, chiggers, and fleas, via topical use or over clothing .	Odorant binding proteintarget
Lidocaine	A local anesthetic used in a wide variety of superficial and invasive procedures.	Sodium channel protein type 5 subunit alphatarget Sodium channel protein type 10 subunit alphatarget Epidermal growth factor receptortarget Sodium channel protein type 9 subunit alphatarget Cytochrome P450 1A2enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Organic cation/carnitine transporter 2transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Sodium channel protein type 4 subunit alphatarget Alpha-1-acid glycoprotein 1target Alpha-1-acid glycoprotein 2target Sodium channel protein type 11 subunit alphatarget
Mepyramine	An antihistamine agent used for the symptomatic treatment of allergy, hypersensitivity reactions, and pruritic skin disorders.	Cytochrome P450 2D6enzyme Histamine H1 receptortarget Solute carrier family 22 member 4transporter Organic cation/carnitine transporter 2transporter
Pheniramine	An antihistamine used to treat allergic rhinitis and pruritus.	Histamine H1 receptortarget Nuclear receptor subfamily 1 group I member 3target Histamine H4 receptortarget
Tetracaine	A local anaesthetic agent used to induce local analgesia in the eyes and skin during medical procedures.	Ryanodine receptor 1target Ryanodine receptor 2target Voltage-gated sodium channel alpha subunittarget Sodium channel protein type 10 subunit alphatarget
Urea	A keratolytic emollient used to treat hyperkeratotic lesions and moisturize the skin.	Arginase-1target Carbonic anhydrase 2target Catenin beta-1target Sulfoxide reductase catalytic subunit YedYtarget Urea transporter 2transporter Urea transporter 1transporter Dihydrofolate reductasetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04512742	A Clinical Study to Develop a Controlled Human Infection Model Using Leishmania Major-infected Sand Flies	No drug interventions	other	Not Available	completed
NCT03619746	Point-of-Care Ultrasound Educational Initiative for Insect Bites	No drug interventions	supportive_care	Not Available	terminated
NCT00825214	Evaluation of Zapperclick Device for Relief From Mosquito Bites	No drug interventions	treatment	3	unknown_status
NCT00995397	Non-inferiority Clinical Trial of Dexchlorpheniramine (Cream Versus Lotion) in the Relief of Insect Bite Related Symptoms	Dexchlorpheniramine	treatment	3	unknown_status
NCT03999970	A Clinical Study to Develop an Uninfected Sand Fly Biting Protocol	No drug interventions	other	Not Available	completed
NCT01233934	Comparative Study of Two Forms of Topical Dexchlorpheniramine Maleate (Cream Versus Gel) for Insect Bites	Dexchlorpheniramine	treatment	3	unknown_status