Anemia, Pernicious (DBCOND0004065)

Identifiers

Synonyms

Pernicious anaemia / Pernicious anemia / Vitamin B12 deficiency anemia due to intrinsic factor deficiency / Addisonian anaemia / Addisonian anemia / Addison's anemia / Pernicious anaemia NOS / Anaemia pernicious / Pernicious anemia (disorder) / Addison-Biermer anemia / Addison-Biermer anaemia / Anemia pernicious type / Anaemia pernicious type / Addisonian pernicious anaemia / Addisonian pernicious anemia / Addison's anaemia

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Ammonium molybdate	Ammonium molybdate is a source of molybdenum that exists in several hydrate forms. It is intravenously administered as an additive to solutions for Total Parenteral Nutrition (TPN). Molybdenum is an...	No drug targets
Cyanocobalamin	A vitamin available in many formulations to correct vitamin B12 deficiency.	Methionine synthase reductasetarget Methylmalonic aciduria type A protein, mitochondrialtarget Methylmalonyl-CoA mutase, mitochondrialtarget Cyanocobalamin reductase / alkylcobalamin dealkylasetarget Methionine synthasetarget Methylenetetrahydrofolate reductase (NADPH)target Protein amnionlesstransporter Transcobalamin-1transporter Transcobalamin-2transporter Corrinoid adenosyltransferase MMABenzyme Cobalamin binding intrinsic factortransporter Cubilintransporter Bifunctional adenosylcobalamin biosynthesis protein CobUenzyme Low-density lipoprotein receptor-related protein 2transporter Multidrug resistance-associated protein 1transporter Pancreatic proteasesenzyme
Ferrous cysteine glycinate	An ingredient found in a variety of supplements and vitamins.	No drug targets
Hydroxocobalamin	A synthetic form of vitamin B12 used to treat vitamin B12 associated disorders and cyanide poisoning.	Methylmalonic aciduria type A protein, mitochondrialtarget Protein amnionlesstarget Transcobalamin-1target Methylmalonyl-CoA mutase, mitochondrialtarget Methionine synthasetarget Cubilintarget Cyanocobalamin reductase / alkylcobalamin dealkylasetarget Transcobalamin-2carrier
Pentagastrin	A gastrin-like molecule used as a diagnostic aid for the evaluation of gastric acid secretory function, gastric hypersecretion, and Zollinger-Ellison tumors.	Gastrin/cholecystokinin type B receptortarget Cholinesteraseenzyme
Pyridoxal phosphate	A vitamin available in many formulations to correct vitamin B6 deficiency.	Cystathionine beta-synthasetarget Alanine--glyoxylate aminotransferase 2, mitochondrialtarget Glutamate decarboxylase 1target Kynureninasetarget Serine hydroxymethyltransferase, cytosolictarget Cysteine desulfurasetarget Aspartate aminotransferase, cytoplasmictarget Ornithine aminotransferase, mitochondrialtarget Ornithine decarboxylasetarget Kynurenine/alpha-aminoadipate aminotransferase, mitochondrialtarget 4-aminobutyrate aminotransferase, mitochondrialtarget Pyridoxine-5'-phosphate oxidasetarget Sphingosine-1-phosphate lyase 1target Tyrosine aminotransferasetarget Kynurenine--oxoglutarate transaminase 1target Glycogen phosphorylase, liver formtarget Serine palmitoyltransferase 2target Cysteine sulfinic acid decarboxylasetarget Histidine decarboxylasetarget Antizyme inhibitor 2target L-serine dehydratase/L-threonine deaminasetarget 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrialtarget Glycine dehydrogenase (decarboxylating), mitochondrialtarget Alanine aminotransferase 1target Phosphoserine aminotransferasetarget 5-aminolevulinate synthase, non-specific, mitochondrialtarget Alanine--glyoxylate aminotransferasetarget Chronophintarget Serine palmitoyltransferase 1target Cystathionine gamma-lyasetarget Branched-chain-amino-acid aminotransferase, cytosolictarget Branched-chain-amino-acid aminotransferase, mitochondrialtarget Pyridoxal phosphate homeostasis proteintarget Aspartate aminotransferase, mitochondrialtarget Glycogen phosphorylase, brain formtarget Glycogen phosphorylase, muscle formtarget Aromatic-L-amino-acid decarboxylasetarget Serine hydroxymethyltransferasetarget Glutamate decarboxylase 2target Kynurenine--oxoglutarate transaminase 3target Acidic amino acid decarboxylase GADL1target Selenocysteine lyasetarget Immunoglobulin superfamily member 10target 5-phosphohydroxy-L-lysine phospho-lyasetarget Serine hydroxymethyltransferase, mitochondrialtarget 5-aminolevulinate synthase, erythroid-specific, mitochondrialtarget Alanine aminotransferase 2target Molybdenum cofactor sulfurasetarget Serine dehydratase-liketarget Serine racemasetarget O-phosphoseryl-tRNA(Sec) selenium transferasetarget Serine palmitoyltransferase 3target Glutamic acid decarboxylasetarget Aspartate aminotransferasetarget Prothrombintarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03941184	Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity	No drug interventions	Not Available	Not Available	completed
NCT04239521	The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata	No drug interventions	Not Available	Not Available	completed
NCT03372447	Megadose of Hydroxocobalamin for the Treatment of Pernicious Anemia	Ascorbic acid Cyanocobalamin Folic acid Hydroxocobalamin Pyridoxine Riboflavin Rutin Thiamine	treatment	4	completed
NCT05098600	The Epidemiology, Management and Comorbidities in Alopecia Areata in Czech Republic	No drug interventions	Not Available	Not Available	completed
NCT05238181	Pyloric or Pseudopyloric Metaplasia of the Corpus Mucosa in Autoimmune Gastritis	No drug interventions	Not Available	Not Available	enrolling_by_invitation