Gastrointestinal Stromal Tumor (GIST) (DBCOND0037254)

Identifiers

Synonyms
Gastro-intestinal Stromal Tumors / Gastrointestinal Stromal Tumors / Gastrointestinal Stromal Tumor / Gastrointestinal Stromal Tumour (GIST) / Gastrointestinal Stromal Tumors (GIST) / Gastrointestinal Stromal Tumours / Gastrointestinal Stromal Tumor(GIST) / Gastrointestinal Stromal Tumour / GIST - Gastrointestinal Stromal Tumor / Gastro-intestinal Stromal Tumours / GIST / Gastro-Intestinal Stromal Tumour / Gastro-intestinal Stromal Tumors (GIST) / Gastro Intestinal Stromal Tumor / Gastrointestinal Stromal Tumors (GISTs) / Gastrointenstinal Stromal Tumor (GIST) / Gastrointestinal Stromal Tumor (GIST) of the Gastrointestinal Tract / Gastro Intestinal Stromal Tumour / Gastro-intestinal Stromal Tumor / Stromal Tumor of the Gastrointestinal Tract / Gastrointestinal Stroma Tumors / Gastrointestinal Stroma Tumor / Gastrointestinal stromal tumor (morphologic abnormality) / Gastrointestinal stromal tumor (disorder) / Gastrointestinal Stromal Sarcoma / Gastrointestinal stromal sarcoma (morphologic abnormality)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Imatinib
A tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors.
Sorafenib
A kinase inhibitor used to treat unresectable liver carcinoma, advanced renal carcinoma, and differentiated thyroid carcinoma.
Sunitinib
A receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST).
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05178030
The GALLOP-11 StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT04584008
Targeted Agent Evaluation in Digestive Cancers in China Based on Molecular CharacteristicsNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT05381753
Safety and Efficacy of Avapritinib in Chinese Patients with Gastrointestinal Stromal Tumor (GIST) in the Real WorldNot AvailableNot Availableactive_not_recruiting
NCT00385203
The Biological Activity of Cediranib (AZD2171) in Gastro-Intestinal Stromal Tumours(GIST).treatment2completed
NCT00585221
Study of Imatinib and Peginterferon α-2b in Gastrointestinal Stromal Tumor (GIST) Patientstreatment2terminated
NCT00276302
Safety Study of IPI-504 in Patients With Gastrointestinal Stromal Tumors (GIST) or Soft Tissue Sarcomas (STS)treatment1completed
NCT03556384
Temozolomide (TMZ) In Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST)treatment2active_not_recruiting
NCT01265979
WB-DWI for Early Prediction of Therapy Response in Patients With Advanced Metastatic GIST Treated With RegorafenibNo drug interventionsNot AvailableNot Availablecompleted
NCT01114087
Impact of the Inhibitors of Tyrosine Kinase on the Male FertilitytreatmentNot Availablecompleted
NCT05905887
Rivoceranib Plus Paclitaxel in Patients With Gastrointestinal Stromal Tumortreatment2recruiting
NCT04811833
Gastrointestinal Anastomosis Using MonoPlus® SutureNo drug interventionsNot AvailableNot Availablewithdrawn
NCT03291054
Epacadostat and Pembrolizumab in Patients With GISTtreatment2terminated
NCT03353753
Phase 3 Study of DCC-2618 vs Placebo in Advanced GIST Patients Who Have Been Treated With Prior Anticancer Therapiestreatment3completed
NCT00171977
Post-Marketing Clinical Study of Postoperative Adjuvant Therapy With Imatinib Mesylate in Patients With Gastrointestinal Stromal Tumors (GIST)treatment4completed
NCT02866045
EUS-FNB vs. Single-incision Needle-knife (SINK) Biopsy for Gastrointestinal SELsNo drug interventionsdiagnostic3unknown_status
NCT02260505
Efficiency of Imatinib Treatment Maintenance or Interruption After 3 Years of Adjuvant Treatment in Patients With Gastrointestinal Stromal Tumours (GIST)prevention3completed
NCT05408897
Prediction of Postoperative Treatment Efficacy and Recurrence Risk of High-risk GIST Based on Liquid Biopsy MRDNo drug interventionsNot AvailableNot Availablerecruiting
NCT06507683
Evaluate the Efficacy and Safety of Radiotherapy Combined With Ripretinib in the Treatment of Unresectable Advanced GISTNo drug interventionstreatmentNot Availablerecruiting
NCT01031628
Study of Dose Escalation Versus no Dose Escalation of Imatinib in Metastatic Gastrointestinal Stromal Tumors (GIST) Patientstreatment3terminated
NCT01289028
Efficacy of Nilotinib in Adult Patients With Gastrointestinal Stromal Tumors Resistant to Imatinib and Sunitinib.treatment3completed
NCT03092128
A Retrospective Pharmacokinetics and Pharmacogenomics Research of Imatinib in Gastrointestinal Stromal Tumor TreatmentNo drug interventionsNot AvailableNot Availableunknown_status
NCT01646593
Regorafenib in Subjects With Gastrointestinal Stromal Tumors (GIST) Who Have Progressed After Standard TherapyNot AvailableNot Availableno_longer_available
NCT02662478
Laparoscopic Resection of Large Gastric Stromal TumorsNo drug interventionsNot AvailableNot Availablecompleted
NCT00500188
Preoperative and Postoperative Imatinib Mesylate Study in Patients With c-Kit Positive GISTtreatment2completed
NCT01091207
Sorafenib for Imatinib/Sunitinib-failed GISTtreatment2completed
NCT05697107
Ripretinib in Chinese Patients With Advanced GIST: a Real World StudyNot AvailableNot Availableactive_not_recruiting
NCT04258956
A Study of Avelumab In Combination With Axitinib in Patients With Unresectable/Metastatic Gastrointestinal Stromal Tumor After Failure of Standard Therapytreatment2unknown_status
NCT00290485
Gleevec Administered Preoperatively to Reduce Gastrointestinal Stromal Tumor (GIST)treatment2unknown_status
NCT05493215
Imatinib TDM in GISTtreatment2recruiting
NCT02342600
SARC029: Trametinib and Pazopanib in Patients With GIST (Gastrointestinal Stromal Tumor)treatment2withdrawn
NCT00455559
Ph II Study of Perifosine Plus Gleevec for Patients With GISTtreatment2completed
NCT04825470
Liver Transplantation for Unresectable GIST Liver MetastasesNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT05385549
5 Years of Adjuvant Imatinib in Patients With Gastrointestinal Stromal Tumor With a High Risktreatment2recruiting
NCT05400018
Clinical Evaluation of Genetron D842V PCR Kit in GIST PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT00782834
Nilotinib in Advanced Gastrointestinal Stromal Tumors (GIST)treatment2terminated
NCT04106024
Efficacy and Safety of Anlotinib in Patients With Advanced Gastrointestinal Stromal Tumor After Failure of Imatinib: a Prospective, Single Arm and Multicenter Trialtreatment2unknown_status
NCT01933958
Regorafenib Post-marketing Surveillance in JapanNot AvailableNot Availablecompleted
NCT01381822
Dose-Escalation Study of TH-302 in Combination With Sunitinib to Treat Patients With Advanced Renal Cell Carcinoma,Gastrointestinal Stromal Tumors and Pancreatic Neuroendocrine Tumorstreatment1unknown_status
NCT01275222
Everolimus in Combination With Imatinib in Patients With Glivec Refractory/Resistant Gastrointestinal Stromal Tumorstreatment1 / 2completed
NCT02800330
The Effects of the Proton Pump Inhibitor Esomeprazole on the Bioavailability of Regorafenibtreatment4completed
NCT01172548
Safety and Efficacy Evaluation of Two Year Imatinib Treatment in Adjuvant Gastrointestinal Stromal Tumor (GIST)prevention2completed
NCT02638766
Single Agent Regorafenib in First-line for Metastatic/Unresectable KIT/PDGFR Wild Type GISTtreatment2completed
NCT06523582
Genetic Bases of Neuroendocrine Neoplasms in Mexican PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT01689376
Regorafenib in Subjects With Gastrointestinal Stromal Tumors (GIST) Who Have Progressed After Standard Therapy (Managed Access Program)Not AvailableNot Availableno_longer_available
NCT00278876
Adjuvant Imatinib in High-risk Gastrointestinal Stromal Tumor (GIST) With C-kit Mutationtreatment2completed
NCT01462994
Detection of CF-DNA in Patients With Gastrointestinal Stromal Tumors (GIST)No drug interventionsdiagnostic3completed
NCT05500391
Assessment of Compliance With Monitoring Conducted by a Physician in Person or by a Nurse in Remote MonitoringNo drug interventionshealth_services_research2recruiting
NCT04282980
A Study of DCC-2618 (Ripretinib) In Patients With With Advanced Gastrointestinal Stromal Tumors (GIST)treatment2completed
NCT04000529
Phase Ib Study of TNO155 in Combination With Spartalizumab or Ribociclib in Selected Malignanciestreatment1terminated
NCT02931929
MITIGATE-NeoBOM: A Study to Evaluate 68Ga- NeoBOMB1 in Patients With Advanced TKI-treated GIST Using PET/CTNo drug interventionsdiagnostic1 / 2completed
NCT03602092
Observational Registry Data on GIST PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT00812240
Masitinib in First Line Treatment of Gastro-Intestinal Stromal Tumor (GIST)treatment3terminated
NCT05867901
Clinical Research of Drug Holiday Based on MRD Detection in GIST Patients at High Risk of RecurrenceNo drug interventionsNot AvailableNot Availablerecruiting
NCT03944304
Paclitaxel in Patients With GIST With Low P-glycoprotein Expression After Failure of at Least Imatinib and Sunitinib, and Regorafenib.treatment2recruiting
NCT05245968
A Study of Pimitespib in Combination With Imatinib in Patients With GIST (CHAPTER-GIST-101)treatment1recruiting
NCT01265810
Caphosol in Oral Mucositis Due to Targeted TherapyNo drug interventionssupportive_care3completed
NCT00444795
Post Marketing Surveillance Study To Observe Safety And Efficacy Of SuteneNot AvailableNot Availablecompleted
NCT04409223
Efficacy and Safety of Famitinib Versus Sunitinib in the Treatment of Advanced Gastrointestinal Stromal Tumour Patients After Failure of Imatinibtreatment3terminated
NCT05132738
Ripretinib Used for Resectable Metastatic GIST After Failure of Imatinib TherapytreatmentNot Availableunknown_status
NCT00457743
A Phase I/II Study of Sunitinib Malate (SU011248) In Patients With Gastrointestinal Stromal Tumor (GIST)treatment1 / 2completed
NCT05461664
Avapritinib in the Treatment of Unresectable or Recurrent Metastatic GIST Non-exon18 Mutations of PDGFRANo drug interventionsNot AvailableNot Availableunknown_status
NCT03165721
A Phase II Trial of the DNA Methyl Transferase Inhibitor, Guadecitabine (SGI-110), in Children and Adults With Wild Type GIST,Pheochromocytoma and Paraganglioma Associated With Succinate Dehydrogenase Deficiency and HLRCC-associated Kidney Cancertreatment2terminated
NCT05080621
Ripretinib in Combination With Binimetinib in Patients With Gastrointestinal Stromal Tumor (GIST)treatment1 / 2withdrawn
NCT01270984
Study to Evaluate the Pharmacokinetic Characteristics of Luckyvec 400mg Tablet, in Healthy Subjectstreatment1completed
NCT05197933
Safety of Laparoscopic Resection for Gastrointestinal Stromal Tumor on Unfavorable Anatomic Site of StomachNo drug interventionstreatmentNot Availablerecruiting
NCT05751733
Apatinib Mesylate Versus Standard Second-line TKI in the Treatment of Advanced GISTtreatmentNot Availablerecruiting
NCT06431451
The Correlation Between Ripretinib Exposure and the Efficacy and Safety in Patients With Advanced GISTsNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT01694277
Masitinib in Patients With Gastrointestinal Stromal Tumour After Progression With Imatinibtreatment3completed
NCT01863745
Nilotinib Roll-over Protocol for Patients in Novartis-sponsored Nilotinib Study and Benefiting From Nilotinib Treatmenttreatment2completed
NCT00877045
Treatment Patterns in Gastrointestinal Stromal Tumors in the Community Oncology SettingNo drug interventionsNot AvailableNot Availablecompleted
NCT00135005
Study of AMN107 With Imatinib in Gastrointestinal Stromal Tumors (GIST)treatment1completed
NCT04714983
DNX-2440 for Resectable Colorectal Liver MetastasisNo drug interventionstreatment1suspended
NCT00471328
Efficacy and Safety of Nilotinib (AMN107) Compared With Current Treatment Options in Patients With GIST Who Have Failed Both Imatinib and Sunitinibtreatment3completed
NCT00718211
A Retrospective Clinical Records Review of Patients Diagnosed With Gastrointestinal Stromal Tumour at Two Tertiary Institutes in SingaporeNo drug interventionsNot AvailableNot Availablecompleted
NCT01178307
Symptom Inventory for Gastrointestinal Stromal TumorsNo drug interventionsNot AvailableNot Availableunknown_status
NCT01541709
Imatinib Dose Escalation to 800 mg/Day in Korean Patients With Metastatic or Unresectable GIST Harboring KIT Exon 9 Mutation: KENEDItreatment2active_not_recruiting
NCT05938309
A Cohort Study on the Safety of Laparoscopic Resection of 5cm or Larger Gastric Gastrointestinal Stromal TumorsNo drug interventionsNot AvailableNot Availablerecruiting
NCT00756509
Treatment of Patients With Metastatic or Unresectable Gastrointestinal Stromal Tumors in First Line With Nilotinibtreatment4active_not_recruiting
NCT04343456
Salvage Surgery for Patients With Metastatic GIST With RegoNo drug interventionsNot AvailableNot Availablecompleted
NCT02401815
CGT9486 (Formerly Known as PLX9486) as a Single Agent and in Combination With PLX3397 (Pexidartinib) or Sunitinib in Participants With Advanced Solid Tumorstreatment1 / 2completed
NCT04276415
DS-6157a in Participants With Advanced Gastrointestinal Stromal Tumor (GIST)No drug interventionstreatment1terminated
NCT02607332
Paclitaxel in Patients With Metastatic or Advanced Gastrointestinal Stromal Tumors (GIST) After Failure to Imatinib and Sunitinibtreatment2completed
NCT01151852
Rechallenge of Imatinib in GIST Having no Effective Treatment: RIGHTtreatment3completed
NCT01440959
Dovitinib for Imatinib/Sumitinib-failed Gastrointestinal Stromal Tumors (GIST): TKI258treatment2completed
NCT05464875
A Multicenter Study of Avapritinib Efficacy and Safety of Metastatic or Unresectable Gastrointestinal Stromal TumorsNo drug interventionsNot AvailableNot Availableunknown_status
NCT04181970
Observational Study, for Quality Assessment, of Sarcoma in European and Latin American Multidisciplinary NETWORKNo drug interventionsNot AvailableNot Availablerecruiting
NCT02012699
Integrated Cancer Repository for Cancer ResearchNo drug interventionsNot AvailableNot Availablerecruiting
NCT05800106
A Bioequivalence Study of Sunitinib Malate Capsules.treatment1completed
NCT00137449
Study Of SU011248 Administered On A Continuous Daily Dosing Schedule In Patients With Gastrointestinal Stromal Tumortreatment2completed
NCT02571036
A Safety, Tolerability and PK Study of DCC-2618 in Patients With Advanced Malignanciestreatment1completed
NCT00751036
Nilotinib 800 Mg And Imatinib 800 Mg For The Treatment Of Patients With Gastrointestinal Stromal Tumors (Gist) Refractory To Imatinib 400 Mgtreatment3terminated
NCT03601234
Laparoscopic Endoscopic Cooperative Surgery in the Treatment of Gastric Stromal TumorsNo drug interventionstreatmentNot Availableunknown_status
NCT00293124
Open-label Trial of GlivecWith Unresectable or Metastatic Malignant Gastrointestinal Stromal Tumorstreatment3completed
NCT03609424
PDR001 Plus Imatinib for Metastatic or Unresectable GISTtreatment1 / 2completed
NCT05366816
ctDNA-Guided Sunitinib And Regorafenib Therapy for GISTtreatment2recruiting
NCT00570635
A Phase 2 Study of XL820 in Adults With Advanced GIST Resistant to Imatinib and/or Sunitinibtreatment2completed
NCT02268435
Dovitinib in Combination With Imatinib in Patients With Gastrointestinal Stromal Tumorstreatment1withdrawn
NCT06087263
Phase 2 Study to Evaluate the Efficacy of Regorafenib in Specific GIST Mutation Subsets (KIT Exon 17, 18, or 14 Mutation and SDHB Deficient GIST) in the Post-imatinib Second-line Setting.treatment2recruiting
NCT02171286
The Oncopanel Pilot (TOP) StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT04254939
A Study of CS3007 in Subjects With Gastrointestinal Stromal Tumortreatment1 / 2completed
NCT01524848
Pazopanib in Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinibtreatment2completed
NCT06208748
SARC044: A Phase II Trial of Bezuclastinib in Combination With Sunitinib in Patients With GISTtreatment2recruiting
NCT01396148
A Study of Sunitinib In Young Patients With Advanced Gastrointestinal Stromal Tumortreatment2completed
NCT05440357
Second-line Pharmacotherapy Patterns and Outcomes of Advanced Gastrointestinal Stromal Tumor: A Real-world StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT05565066
A Real-world Comparison of FNB and FNA in IHC-required Lesions.No drug interventionsNot AvailableNot Availablecompleted
NCT00688766
Study Evaluating IPI-504 in Patients With Gastrointestinal Stromal Tumors (GIST) Following Failure of at Least Imatinib and Sunitinibtreatment3terminated
NCT00564265
Current Management of Gastrointestinal Stromal Tumors (GIST) in the Region of CoquimboNo drug interventionsNot AvailableNot Availablecompleted
NCT04825574
Study for Patients Previously Treated in Avapritinib Clinical Trialstreatment4active_not_recruiting
NCT02232620
A Study of BBI503 in Adult Patients With Advanced Gastrointestinal Stromal Tumorstreatment2terminated
NCT00716820
Special Investigation For Gist Of Sunitinib Malate (Regulatory Post Marketing Commitment Plan).Not AvailableNot Availablecompleted
NCT00507273
Gastrointestinal Stromal Tumors (GIST) RegistryNo drug interventionsNot AvailableNot Availablecompleted
NCT01478373
Efficacy and Safety of Dovitinib in Patients With Gastrointestinal Stromal Tumors Refractory and/or Intolerant to Imatinibtreatment2completed
NCT04908176
A Drug-drug Interaction Study of Avapritinib and Midazolamother1active_not_recruiting
NCT00718562
Efficacy and Safety of AMN107 in Patients With GastroIntestinal Stromal Tumors (GIST) Who Have Failed Both Imatinib and Sunitinibtreatment2completed
NCT01421680
The Effects of Preoperative and Postoperative Oral Nutritional Supplements in Malnourished Post-gastrectomy PatientsNo drug interventionssupportive_careNot Availablecompleted
NCT03673501
A Study of Ripretinib vs Sunitinib in Advanced GIST Patients After Treatment With Imatinibtreatment3active_not_recruiting
NCT05001204
68Ga-NOTA-RM26 PET/CT for the Detection of Gastrointestinal Stromal TumorNo drug interventionsdiagnostic0unknown_status
NCT00237172
Phase II Clinical Study of Imatinib Mesylate in Patients With Malignant Gastrointestinal Stromal Tumors (Extension Study)treatment2completed
NCT05665868
Study on Integrated Nursing Strategy for Patients With Gastrointestinal Stromal Tumors After Targeted TherapyNo drug interventionssupportive_careNot Availablerecruiting
NCT03862768
Role of Surgery in Patients With Focally Progressive Gastrointestinal Stromal Tumors (GISTs) After Imatinib TreatmenttreatmentNot Availableunknown_status
NCT02488746
Endoscopic Full Thickness Resection of Gastric Subepithelial Tumors (FROST)No drug interventionsNot AvailableNot Availableterminated
NCT06326346
GIST Oral Paclitaxel(Liporaxel)treatment2not_yet_recruiting
NCT00976612
Nilotinib Pharmacokinetics (PK) in Gastrointestinal Stromal Tumor (GIST): Nilotinib PKNot AvailableNot Availablecompleted
NCT01271712
Study of Regorafenib as a 3rd-line or Beyond Treatment for Gastrointestinal Stromal Tumors (GIST)treatment3completed
NCT01483014
Phase ll Study of Imatinib Mesylate for the Neoadjuvant Treatment of Patients With Gastrointestinal Stromal Tumors (GIST)treatment2completed
NCT00441155
Patients Completing Core Protocol (CAMN107A2103), Exhibiting Stable Disease (SD), Partial Response (PR) or Complete Response (CR) to Nilotinib in Combination With Imatinibtreatment1completed
NCT05661643
The Efficacy and Safety of Temozolomide in SDH-deficient GISTtreatment2recruiting
NCT02834013
Nivolumab and Ipilimumab in Treating Patients With Rare Tumorstreatment2active_not_recruiting
NCT02884154
Feasibility and Yield of a New 20 G ProCore Needle With Coiled Sheath in the Gastrointestinal Subepithelial TumorsNo drug interventionsdiagnosticNot Availablecompleted
NCT00265798
Sorafenib in Treating Patients With Malignant Gastrointestinal Stromal Tumor That Progressed During or After Previous Treatment With Imatinib Mesylate and Sunitinib Malatetreatment2active_not_recruiting
NCT00041197
Imatinib Mesylate in Treating Patients With Primary Gastrointestinal Stromal Tumor That Has Been Completely Removed By Surgerytreatment3completed
NCT00005597
S9926 Temozolomide in Patients With Unresectable/Metastatic Gastrointestinal Stromal Tumorstreatment2completed
NCT01389583
A Study of AUY922 for GIST(Gastrointestinal Stromal Tumor) Patientstreatment2unknown_status
NCT00685828
Imatinib Mesylate in Treating Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumortreatment3unknown_status
NCT00004911
Endoscopic Placement of Metal Stent in Patients With Cancer-Related Bowel ObstructionNo drug interventionssupportive_care1 / 2completed
NCT01643278
Dasatinib and Ipilimumab in Treating Patients With Gastrointestinal Stromal Tumors or Other Sarcomas That Cannot Be Removed by Surgery or Are Metastatictreatment1completed
NCT02776878
A Clinical Trial Evaluating the Efficacy and Safety of Dasatinib in Refractory Metastatic GISTtreatmentNot Availableunknown_status
NCT00025415
Imatinib Mesylate in Treating Patients With Advanced Cancer and Liver Dysfunctiontreatment1completed
NCT03493152
Expanded Access to Everolimus, for an Individual Patient With GIST (Gastrointestinal Stromal Tumors)(CTMS#18-0019)Not AvailableNot Availabletemporarily_not_available
NCT00009906
Comparison of Two Different Doses of STI571 in Treating Patients With Metastatic or Unresectable Gastrointestinal Stromal Tumortreatment3terminated
NCT00005049
Combination Chemotherapy in Treating Patients With Stage III Ovarian Epithelial Cancer or Gastrointestinal Cancertreatment2completed
NCT00003939
Ecteinascidin 743 in Treating Patients With Advanced Soft Tissue Sarcomatreatment2completed
NCT02763748
the Laparoscopic and Endoscopic Cooperative Surgery of Gastrointestinal Stromal TumorNo drug interventionstreatmentNot Availableunknown_status
NCT01769248
Prospective Trial of EUS-FNA Versus EUS-FNB Using a Novel Core Biopsy NeedleNo drug interventionsdiagnosticNot Availablecompleted
NCT04143048
A Study on Non-invasive Early Diagnosis of Gastrointestinal Stromal Tumors and Differentiation of Benign and Malignant NodulesNo drug interventionsNot AvailableNot Availableunknown_status
NCT00006357
STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcomatreatment1 / 2completed
NCT00769782
Surgery in Treating Patients With Liver Metastasis From a Gastrointestinal Stromal TumorNo drug interventionstreatment2completed
NCT00654160
Irinotecan, Fluorouracil, and Leucovorin in Treating Patients With Advanced Gastrointestinal Cancertreatment1completed
NCT01560260
Linsitinib in Treating Patients With Gastrointestinal Stromal Tumorstreatment2completed
NCT02426762
Quick Skin Sealant in Closure of Surgical Wound After Laparoscopic SurgeryNo drug interventionsprevention2unknown_status
NCT02686944
A Study to Evaluate the Safety of Intuvax Administered Intra-tumorally in Patients With Gastrointestinal Stromal Tumorstreatment1completed
NCT02164240
Phase Ib Study of SUnitinib Alternating With REgorafenib in Patients With Metastatic and/or Unresectable GISTtreatment1completed
NCT00573404
Imatinib Mesylate and Sunitinib in Treating Patients With Gastrointestinal Stromal Tumorstreatment1terminated
NCT00103168
Imatinib Mesylate or Observation Only in Treating Patients Who Have Undergone Surgery for Localized Gastrointestinal Stromal Tumortreatment3completed
NCT01110668
Evaluation of Nilotinib In Patients With Advanced Gastrointestinal Stromal Tumor (GIST)treatment2completed
NCT01068769
Regorafenib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumortreatment2completed
NCT04933669
Prospective Multicenter Clinical Study of Neoadjuvant Imatinib Mesylate for Gastrointestinal Stromal Tumorstreatment2recruiting
NCT00004910
Endoscopic Placement of Metal Stents in Treating Patients With Cancer- Related Duodenal ObstructionNo drug interventionssupportive_care1 / 2completed
NCT00031681
7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007)treatment1completed
NCT00764595
Imatinib Mesylate in Treating Patients With Liver Metastasis From a Gastrointestinal Stromal Tumortreatment2completed
NCT00004895
Octreotide as Palliative Therapy for Cancer-Related Bowel Obstruction That Cannot Be Removed by Surgerysupportive_care2completed
NCT01267695
Perioperative Imatinib Mesylate in Treating Patients With Locally Advanced Gastrointestinal Stromal Tumortreatment2completed
NCT02924714
SSG XXV: The Stop-GIST Trial; Discontinuation of Imatinib in Patients With Oligo-metastatic GISTNo drug interventionsotherNot Availablesuspended
NCT00954655
Study of Tumor Samples in Patients Undergoing Treatment for Gastrointestinal Stromal Tumors on Clinical Trial ACOSOG-Z9001No drug interventionsNot AvailableNot Availablecompleted
NCT00028002
Neoadjuvant and Adjuvant Imatinib Mesylate in Treating Patients With Primary or Recurrent Malignant Gastrointestinal Stromal Tumortreatment2completed
NCT00397384
Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancertreatment1completed
NCT00098579
Doxorubicin Hydrochloride and Alvocidib in Treating Patients With Metastatic or Recurrent Sarcoma That Cannot Be Removed By Surgerytreatment1completed
NCT00324987
Imatinib Mesylate With or Without Bevacizumab in Treating Patients With Metastatic or Unresectable Gastrointestinal Stromal Tumortreatment3terminated
NCT01613053
Continuation of Drug Supply in Chinese Patients After CAMN107DBR01study TerminationNot AvailableNot Availableno_longer_available
NCT00091078
Oblimersen and Imatinib Mesylate in Treating Patients With Advanced Gastrointestinal Stromal Tumors That Cannot Be Removed By Surgerytreatment2terminated
NCT02185937
Influence of an Acidic Beverage on the Imatinib Exposure After Major GastrectomyNo drug interventionsother1terminated
NCT00112632
Imatinib Mesylate in Treating Patients With Locally Advanced Gastrointestinal Stromal Tumortreatment2completed
NCT02353052
Prospective Cohort Study of the Clinical Applications for the Pathologic Type, Staging, and Grading of GISTNo drug interventionsNot AvailableNot Availableunknown_status
NCT01154452
Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcomatreatment1 / 2completed
NCT00041249
Brostallicin in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcomatreatment2completed
NCT00075218
A Study To Assess The Safety And Efficacy Of SU11248 In Patients With Gastrointestinal Stromal Tumor(GIST)treatment3completed
NCT01039519
A Study Evaluating STA-9090 in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor (GIST)treatment2completed
NCT01751919
A Clinical Trial to Compare the Pharmacokinetics of Imatinib Mesylate Tablet 400mg (1 Tablet) and Glivec Film-coated Tablet 100mg (4 Tablets)(Phase I)treatment1completed
NCT02336724
A Study of Famitinib in Patients With Gastrointestinal Stromal Tumortreatment2unknown_status
NCT00112463
Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcomatreatment2completed
NCT02103322
Comparative Bioequivalence Study in Adult Patients Suffering From Chronic Myeloid Leukemia & Gastrointestinal Stromal Tumor Under Fed Conditionstreatment2 / 3completed
NCT04256226
Clinical Outcome of Female Non-gastric Gastrointestinal Stromal TumorNo drug interventionsNot AvailableNot Availablecompleted
NCT01865565
Surgery for Locally Unresectable Advanced GISTs Without Metastasis After Imatinib TherapyNo drug interventionsNot AvailableNot Availablecompleted
NCT00087074
CCI-779 in Treating Patients With Soft Tissue Sarcoma or Gastrointestinal Stromal Tumortreatment2completed
NCT00005874
Nitrocamptothecin in Treating Patients With Soft Tissue Sarcomastreatment2completed
NCT00428220
A Continuation Study Using Sunitinib Malate For Patients Leaving Treatment On A Previous Sunitinib Study.treatmentNot Availablecompleted
NCT02880020
Nivolumab With or Without Ipilimumab in Treating Patients With Gastrointestinal Stromal Tumor That Is Metastatic or Cannot Be Removed by Surgerytreatment2completed
NCT00087191
EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or Non-Small Cell Lung CancerdiagnosticNot Availableterminated
NCT00005862
SU5416 in Treating Patients With Advanced, Metastatic, or Recurrent Soft Tissue Sarcomastreatment2completed
NCT01774162
EUS-guided Fine Needle Biopsy With a New Core Histology Needle Versus Conventional Fine Needle AspirationNo drug interventionsdiagnosticNot Availablecompleted
NCT02576080
Efficacy of Imatinib in Patients With Intermediate-risk Gastrointestinal Stromal Tumor With a High-risk Genomic Grade Indexdiagnostic3unknown_status
NCT00069940
Vaccine Therapy and Sargramostim in Treating Patients With Sarcoma or Brain Tumortreatment1completed
NCT00372567
Safety And Effectiveness Of Daily Dosing With Sunitinib Or Imatinib In Patients With Gastrointestinal Stromal Tumorstreatment3terminated
NCT00030667
Imatinib Mesylate in Treating Patients With Relapsed or Refractory Solid Tumors of Childhoodtreatment2completed
NCT00777504
Study to the Optimal Duration of Therapy With Oral Angiogenesis InhibitorsNo drug interventionstreatment4unknown_status
NCT00956072
Imatinib Mesylate With or Without Surgery in Treating Patients With Metastatic Gastrointestinal Stromal Tumor That is Responding to Imatinib Mesylatetreatment3terminated
NCT00025246
Imatinib Mesylate in Treating Patients With Gastrointestinal Stromal Tumor That Has Been Completely Removed During Surgerytreatment2completed
NCT02931981
Serum Dickkopf-4 as a Biomarker for the Diagnosis and Treatment of Gastrointestinal Stromal TumorNo drug interventionsNot AvailableNot Availableunknown_status
NCT00568750
Dasatinib as First-Line Therapy in Treating Patients With Gastrointestinal Stromal Tumorstreatment2completed
NCT01404650
Study of Hsp90 Inhibitor AUY922 for the Treatment of Patients With Refractory Gastrointestinal Stromal Tumortreatment2completed
NCT02734823
Long Term Effects of Tyrosine Kinase Inhibitor Therapy on Ovarian Reserve and Fertility in Patients With Chronic Myeloid Leukemia or Gastrointestinal Stromal TumorNo drug interventionsNot AvailableNot Availablewithdrawn
NCT02606097
Regorafenib in GIST With Secondary C-KIT Exon 17 Mutationtreatment2completed
NCT00633295
Phase II Study Aiming to Evaluate the Efficacy and Safety of Nilotinib Patients With Gastrointestinal Stromal Tumors (GIST) Resistant or Intolerant to Imatinib and or to 2nd Line Tyrosine Kinas (TK) Inhibitortreatment2completed
NCT02508532
(NAVIGATOR) Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumorstreatment1completed
NCT05160168
A Study of THE-630 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)treatment1 / 2terminated
NCT02877368
Sarcopenia in Patients With Gastrointestinal Stromal TumoursNo drug interventionsNot AvailableNot Availablecompleted
NCT05354388
Ripretinib Combined With Surgery in Advanced GIST That Have Failed Imatinib Therapy: A Multicenter,Observational StudyNo drug interventionsNot AvailableNot Availableunknown_status
NCT03440515
Management of Imatinib-associated Severe Skin Rash in Patients With Gastrointestinal Stromal Tumortreatment2completed
NCT04633122
A Study to Assess the Efficacy and Safety of DCC-2618 and Sunitinib in Patients With Advanced Gastrointestinal Stromal Tumors After Treatment With Imatinibtreatment2completed
NCT02365441
A Randomised Trial of Imatinib Alternating With Regorafenib Compared to Imatinib Alone for the First Line Treatment of Advanced Gastrointestinal Stromal Tumour (GIST)treatment2active_not_recruiting
NCT06619275
Ripretinib (QINLOCK®) According to Current SmPCNot AvailableNot Availablerecruiting
NCT04530981
A Drug-Drug Interaction Study to Evaluate the Effect of Ripretinib on the Pharmacokinetics of a CYP2C8 Probe Substrate in Patients with Advanced GISTtreatment1completed
NCT04148092
Expanded Access Program of Ripretinib (DCC-2618) for the Treatment of Patients With Advanced GISTNot AvailableNot Availableapproved_for_marketing
NCT00998751
Masitinib in Locally Advanced/Metastatic Gastro-intestinal Stromal Tumour (GIST)treatment2completed
NCT06630234
A Master Protocol to Evaluate DCC-3009 in Gastrointestinal Stromal Tumor (GIST)No drug interventionstreatment1 / 2not_yet_recruiting
NCT04557969
Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic AnalysisNo drug interventionsNot AvailableNot Availablerecruiting
NCT04821895
Oncogenetic Panel and Integrated Clinical Data Registry Study for Wild Type Gastrointestinal Stromal Tumor PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT01391611
Pazopanib in Imatinib Refractory or Intolerant Gastrointestinal Stromal Tumors (GIST)treatment2terminated
NCT00785785
A Study of Nilotinib Versus Imatinib in GIST Patientstreatment3completed
NCT05489237
A First-in-human (FIH) Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (GIST) [Study ID: StrateGIST 1]treatment1recruiting
NCT01034670
Advanced Gastrointestinal Endoscopic ImagingdiagnosticNot Availableterminated
NCT00867113
Five Year Adjuvant Imatinib Mesylate (Gleevec®) in Gastrointestinal Stromal Tumor (GIST)treatment2completed
NCT00767234
Permission to Collect Blood Over Time for ResearchNo drug interventionsNot AvailableNot Availableterminated
NCT02452424
A Combination Clinical Study of PLX3397 and Pembrolizumab To Treat Advanced Melanoma and Other Solid Tumorstreatment1 / 2terminated
NCT01316263
A Study of Olaratumab (IMC-3G3) in Previously Treated Participants With Unresectable and/or Metastatic Gastrointestinal Stromal Tumorstreatment2terminated
NCT02574663
TGR-1202 Alone and in Combination With Either Nab-paclitaxel + Gemcitabine or With FOLFOX in Patients With Select Relapsed or Refractory Solid Tumorstreatment1completed
NCT03594422
A Study of HQP1351 in Patients With GIST or Other Solid Tumorstreatment1recruiting
NCT02443948
Circulating Cell-free Tumor DNA in the Plasma of Patients With Gastrointestinal Stromal Tumors (GIST)No drug interventionsNot AvailableNot Availableunknown_status
NCT00464620
Trial of Dasatinib in Advanced Sarcomastreatment2completed
NCT00623831
A Phase 1 Study of Mixed Bacteria Vaccine (MBV) in Patients With Tumors Expressing NY-ESO-1 AntigenNo drug interventionstreatment1completed
NCT03404076
Unifying Advanced Treatment With Advanced ImagingNo drug interventionsNot AvailableNot Availablecompleted
NCT00780494
Ph II of Capecitabine, Carboplatin & Bevacizumab for Gastroesophageal Junction & Gastric Carcinomatreatment2completed
NCT01048281
Clinical & Pathological Studies of Upper Gastrointestinal CarcinomaNo drug interventionsNot AvailableNot Availablerecruiting
NCT03158103
A Study of MEK162 (Binimetinib) in Combination With Pexidartinib in Patients With Advanced Gastrointestinal Stromal Tumor (GIST)treatment1completed
NCT01294202
A Study to Investigate the Safety and Efficacy of AT13387, Alone or in Combination With Imatinib, in Patients With GISTtreatment2completed
NCT01991379
MEK162 in Combination With Imatinib Mesylate in Patients With Untreated Advanced Gastrointestinal Stromal Tumor (GIST)treatment1 / 2active_not_recruiting
NCT01135849
B-Receptor Signaling in CardiomyopathyNo drug interventionsNot AvailableNot Availablecompleted
NCT05453292
Endoscopic Ultrasound Radiofrequency Ablation for GISTsNo drug interventionstreatmentNot Availablerecruiting
NCT06640361
A Study of Olverembatinib in SDH-deficient GIST.No drug interventionstreatment3not_yet_recruiting
NCT05734105
A Study of Ripretinib Vs Sunitinib in Patients with Advanced GIST with Specific KIT Exon Mutations Who Were Previously Treated with Imatinibtreatment3recruiting
NCT03082079
Long Outcome of Endoscopic Submucosal Dissection for Small Gastrointestinal Stromal Tumors (<2cm)No drug interventionstreatmentNot Availableunknown_status
NCT05443087
TARGETed Therapy Drug MONITOring in DIGestive OncologyNo drug interventionstreatmentNot Availablerecruiting
NCT05641233
Preoperative Radiotherapy in Patients at High Risk of Postoperative Pancreatic Fistula After PancreatoduodenectomyNo drug interventionsprevention1 / 2recruiting
NCT04097093
Long-term Surival of GIST Patients ≥ 10 Years on ImatinibNo drug interventionsNot AvailableNot Availablewithdrawn
NCT00687778
11C-Acetate PET/CT Non-FDG-Avid TumorsNo drug interventionsNot AvailableNot Availableunknown_status
NCT03862885
Early Access Program (EAP) for Avapritinib in Patients With Locally Advanced Unresectable or Metastatic GISTNot AvailableNot Availableapproved_for_marketing
NCT01323400
Efficacy of Pazopanib in Gastrointestinal Stromal Tumors (GIST)treatment2completed
NCT05895942
Exploring the Molecular Mechanism Based on KIT MutationNot AvailableNot Availablerecruiting
NCT00618319
An Open-Label, 18FDG-PET Pharmacodynamic Assessment of the Effect of BIIB021 in Subjects With Gastrointestinal Stromal Tumors (GIST)treatment2completed
NCT03880617
Distress, Medication Adherence and Care Needs in Patients With CML and GIST Receiving Oral Targeted TherapyNo drug interventionsNot AvailableNot Availablecompleted
NCT01459757
Non-Interventional Retrospective Correlation Of Tumor Mutational Status To Clinical Benefit Of GIST Patients Treated With SunitinibNo drug interventionsNot AvailableNot Availablecompleted
NCT01874665
A Phase 2 Trial of Ponatinib in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumortreatment2completed
NCT03424876
To Compare the Efficacy of Surgery Followed by Sunitinib With Surgery Followed by Imatinib in GIST Patients With Progression on Imatinib.Not AvailableNot Availableunknown_status
NCT04599660
Study in Low Risk Gastrointestinal Stromal Tumor (GISTs)No drug interventionsNot AvailableNot Availablecompleted
NCT04927260
French Long Term Registry With Longitudinal Follow up of PDGFRA D842V-GIST PatientsNot AvailableNot Availableactive_not_recruiting
NCT05957367
A Study of DCC-3116 in Combination With Anticancer Therapies in Participants With Advanced Malignanciestreatment1 / 2recruiting
NCT03715933
Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomastreatment1recruiting
NCT03475953
A Phase I/II Study of Regorafenib Plus Avelumab in Solid Tumorstreatment1 / 2recruiting
NCT01376505
Vaccine Therapy in Treating Patients With Metastatic Solid Tumorstreatment1completed
NCT01770405
Clinical Registry of nCLE in Masses and Cystic Tumors of the Pancreas, Lymph Nodes, Submucosal Lesions of the GI TractNo drug interventionsNot AvailableNot Availablecompleted
NCT00399152
Perifosine + Sunitinib Malate for Patients With Advanced Cancerstreatment1completed
NCT03896958
The PIONEER Initiative: Precision Insights On N-of-1 Ex Vivo Effectiveness Research Based on Individual Tumor Ownership (Precision Oncology)No drug interventionsNot AvailableNot Availableunknown_status
NCT02246322
A Clinical Trial With a New Needle Device Comparing Two Needles for EUS_FNA of Solid Lesions.No drug interventionsdiagnosticNot Availableunknown_status
NCT03465722
(VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GISTtreatment3completed
NCT01768325
Evaluation of a New EUS-guided Needle (ProCore) Comparing to EUS-TCB Needle (Quick-Core)No drug interventionsdiagnosticNot Availablecompleted
NCT02015065
Phase II Trial of Vandetanib in Children and Adults With Wild-Type Gastrointestinal Stromal Tumorstreatment2completed
NCT05804331
The Australia and New Zealand Multicentre Upper Gastrointestinal Endoscopic Tissue Resection StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT05474794
Detective Flow Imaging Endoscopic Ultrasonography in Subepithelial LesionsNo drug interventionsdiagnosticNot Availablerecruiting
NCT00979329
Study on the Influence of Sunitinib and Sorafenib on Fatigue, QoL, Depression in Patients With Metastatic RCC or GISTNo drug interventionsNot AvailableNot Availablecompleted
NCT04761172
NIR Fluorescence Imaging With ICG for the Intraoperative Identification of Gastrointestinal Stromal Cell TumoursNo drug interventionstreatment2 / 3unknown_status
NCT03050268
Familial Investigations of Childhood Cancer PredispositionNo drug interventionsNot AvailableNot Availablerecruiting
NCT00979381
Study of the Immunoresponse in Patients Treated With a Tyrosine Kinase InhibitorNo drug interventionsNot AvailableNot Availablecompleted
NCT04138381
Selinexor as Single Agent and With Imatinib in Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (SeliGIST)treatment1 / 2active_not_recruiting
NCT01089595
Trial of Tasigna (Nilotinib) 400 mg Twice Daily Alone or With Gleevec (Imatinib Mesylate) 400 mg Daily for Patients With Advanced Gastrointestinal Stromal Tumor (GIST)treatment2terminated
NCT01246843
Evaluation of Cognitive Function of Patients With Sunitinib or SorafenibNo drug interventionsNot AvailableNot Availablecompleted
NCT02009423
Masitinib in Patients With Localized, Primary GIST After Complete Surgery and With High Risk of Recurrencetreatment3terminated
NCT00367861
Prospective Multicentric Randomized Study of Glivec® in Advanced GIST Expressing C-kit: Interruption After 5 Years vs Maintenancetreatment3completed
NCT01506336
Masitinib in Patients With Gastro-Intestinal Stromal Tumour Resistant to Imatinibtreatment2completed
NCT03963544
Patterns of Care and Outcomes of Patients With METAstatic Gastrointestinal Stromal Tumors (METAGIST)Not AvailableNot Availablerecruiting
NCT03426722
L-carnitine vs Placebo for the Treatment of Muscle Cramps After Imatinib in Gastrointestinal Stromal Tumorstreatment3completed
NCT01768104
ESTD vs. VATS for Upper Gastrointestinal Submucosal TumorsNo drug interventionstreatmentNot Availableunknown_status
NCT02889328
Phase II Study of Regorafenib Continuous Dosing of Regorafenib in Patients With GISTstreatment2completed
NCT02712112
A Study of Intermittent Dosing Schedule of Imatinib in Patients With Tyrosine Kinase Inhibitor Refractory GISTstreatment2completed
NCT01031056
Collection of Biospecimen & Clinical Information in Patients w/ Gastrointestinal CancersNo drug interventionsNot AvailableNot Availablewithdrawn
NCT04193553
Multicentre Placebo-controlled Double-blinded Phase II Study of Lenvatinib Efficacy in Patients With Locally Advanced or Metastatic GIST (Gastrointestinal Stromal Tumor) After Imatinib/Sunitinib Failuretreatment2completed
NCT04566614
Preventing Viral Pandemic Associated Risk of Cancer Death Using Less Invasive Diagnostic Tests- Liquid BiopsiesNo drug interventionsNot AvailableNot Availablerecruiting
NCT02331914
GIST: Assessment of Tumor Mutations and TKI Plasma ExposureNo drug interventionsNot AvailableNot Availablerecruiting
NCT00700258
Registry For Temsirolimus, Sunitinib, And Axitinib Treated Patients With Metastatic Renal Cell Carcinoma (mRCC), Mantle Cell Lymphoma (MCL), And Gastro-Intestinal Stroma Tumor (GIST) [STAR-TOR]Not AvailableNot Availablecompleted
NCT01402089
Cytochrom p450 3A4 and 1A2 Phenotyping for the Individualization of Treatment With Sunitinib or Erlotinib in Cancer Patientstreatment4completed