Gestational Trophoblastic Neoplasia (DBCOND0063077)

Identifiers

Synonyms

Gestational Trophoblastic Tumours / Gestational Trophoblastic Tumor / Gestational trophoblastic tumour / Gestational Trophoblastic Disease / Gestational trophoblastic tumors / Gestational Trophoblastic Neoplasms / Gestational Trophoblastic Neoplasias (GTN) / Gestational trophoblastic neoplasm / Gestational trophoblastic neoplasia / Gestational trophoblastic tumour NOS / Gestational trophoblastic neoplasia (disorder) / Gestational trophoblastic tumor NOS / Gestational trophoblastic neoplasia (morphologic abnormality) / Hydatidiform mole, unspecified / Gestational trophoblastic disease (morphologic abnormality) / Gestational trophoblastic disease (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Dactinomycin	An actinomycin used to treat a wide variety of cancers.	DNAtarget Organic cation/carnitine transporter 2transporter ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 6transporter Multidrug resistance-associated protein 1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter DNA topoisomerase 2target DNA topoisomerase 1target
Dinoprostone	A prostaglandin used to induce labor or abortion as well as to treat nonmetastatic gestational trophoblastic disease.	Prostaglandin E2 receptor EP2 subtypetarget Prostaglandin E2 receptor EP1 subtypetarget Prostaglandin E2 receptor EP4 subtypetarget Prostaglandin E2 receptor EP3 subtypetarget Solute carrier family 22 member 2transporter ATP-binding cassette sub-family C member 5transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Solute carrier family 22 member 7transporter ATP-binding cassette sub-family C member 4transporter Solute carrier organic anion transporter family member 2B1transporter Solute carrier organic anion transporter family member 1A2transporter Organic solute transporter subunit alphatransporter Organic solute transporter subunit betatransporter Solute carrier organic anion transporter family member 2A1transporter Solute carrier organic anion transporter family member 4A1transporter Solute carrier organic anion transporter family member 1C1transporter Solute carrier organic anion transporter family member 3A1transporter Solute carrier organic anion transporter family member 1B1transporter Prostaglandin D2 receptor 2target Prostaglandin F2-alpha receptortarget
Etoposide	A podophyllotoxin derivative used to treat testicular and small cell lung tumors.	DNA topoisomerase 2-alphatarget Cytochrome P450 3A4enzyme ATP-binding cassette sub-family C member 3transporter ATP-binding cassette sub-family C member 6transporter ATP-dependent translocase ABCB1transporter Multidrug resistance-associated protein 1transporter ATP-binding cassette sub-family C member 10transporter ATP-binding cassette sub-family C member 2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 1A2enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A5enzyme UDP-glucuronosyltransferase 1A1enzyme DNA topoisomerase 2-betatarget Glutathione S-transferase theta-1enzyme Glutathione S-transferase Penzyme Prostaglandin G/H synthase 2enzyme Prostaglandin G/H synthase 1enzyme
Methotrexate	An antineoplastic agent used the treatment of a wide variety of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis.	Dihydrofolate reductasetarget Aldehyde oxidaseenzyme Methylenetetrahydrofolate reductase (NADPH)enzyme Albumincarrier ATP-binding cassette sub-family C member 3transporter ATP-binding cassette sub-family C member 4transporter Multidrug resistance-associated protein 1transporter Solute carrier family 22 member 6transporter ATP-binding cassette sub-family C member 10transporter Organic anion transporter 3transporter ATP-binding cassette sub-family C member 2transporter ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Monocarboxylate transporter 1transporter ATP-binding cassette sub-family C member 11transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier family 22 member 11transporter Solute carrier organic anion transporter family member 1C1transporter Solute carrier organic anion transporter family member 3A1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier family 22 member 7transporter Solute carrier organic anion transporter family member 1B1transporter 6-phosphogluconate dehydrogenase, decarboxylatingenzyme Proton-coupled folate transportertransporter Folylpolyglutamate synthase, mitochondrialenzyme Gamma-glutamyl hydrolaseenzyme Dihydrofolate reductaseenzyme Thymidylate synthaseenzyme Bifunctional purine biosynthesis protein ATICenzyme Solute carrier organic anion transporter family member 4C1transporter Reduced folate transportertransporter Folate receptor alphatransporter Cytochrome P450 3A4enzyme Thymidylate synthasetarget Bifunctional purine biosynthesis protein ATICtarget Folate receptor betatransporter Solute carrier family 15 member 1transporter Proton-coupled amino acid transporter 1transporter Carboxypeptidase G2enzyme Proton-coupled folate transportertarget Reduced folate transportertarget
Vincristine	A vinca alkaloid used to treat acute leukemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis.	Tubulin beta chaintarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 3transporter Solute carrier family 22 member 3transporter Multidrug resistance-associated protein 1transporter ATP-binding cassette sub-family C member 10transporter ATP-binding cassette sub-family C member 2transporter Bile salt export pumptransporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Tubulin alpha-4A chaintarget RalA-binding protein 1transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06242522	Fertility and Pregnancy After Avelumab Treatment	No drug interventions	other	Not Available	not_yet_recruiting
NCT00293384	Aprepitant, Granisetron, & Dexamethasone in Preventing Nausea & Vomiting in Pts. Receiving Cyclophosphamide Before a Stem Cell Transplant	Aprepitant Cyclophosphamide Dexamethasone Granisetron	supportive_care	Not Available	completed
NCT00096187	Pemetrexed Disodium in Treating Patients With Recurrent or Persistent Low-Risk Gestational Trophoblastic Tumor After a Molar Pregnancy	Pemetrexed	treatment	2	terminated
NCT00003887	Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation	No drug interventions	treatment	2	completed
NCT00082654	Study of the Emotional Needs of Caregivers of Stem Cell Transplantation Patients	No drug interventions	Not Available	Not Available	completed
NCT00064311	Ravuconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Stem Cell Transplantation	Ravuconazole	supportive_care	1 / 2	completed
NCT00109993	Campath-1H + FK506 and Methylprednisolone for GVHD	Alemtuzumab Methylprednisolone Tacrolimus	supportive_care	2	completed
NCT03885388	Combination of Methotrexate(MTX) and Actinomycin(ACTD) in the Low Risk Gestational Trophoblastic Neoplasma （GTN） Patients With Score of 5-6	Methotrexate	treatment	2 / 3	unknown_status
NCT00003688	Dactinomycin in Treating Patients With Persistent or Recurrent Gestational Trophoblastic Neoplasia	Dactinomycin	treatment	2	completed
NCT00003107	Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors	Edodekin alfa	treatment	1	completed
NCT01823315	Methotrexate Single-dose Treatment and Methotrexate/Actinomycin-D Single-dose Treatment in Low-Risk Gestational Trophoblastic Neoplasia	Methotrexate	treatment	3	unknown_status
NCT00900406	Collecting and Storing Tissue and DNA Samples From Patients Undergoing a Donor Stem Cell Transplant	No drug interventions	Not Available	Not Available	completed
NCT02834013	Nivolumab and Ipilimumab in Treating Patients With Rare Tumors	Ipilimumab Nivolumab	treatment	2	active_not_recruiting
NCT00324324	Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant	Moxifloxacin	supportive_care	3	terminated
NCT00004157	Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors	Filgrastim Oprelvekin	treatment	2	completed
NCT00900068	Blood Samples From Patients on a Clinical Trial to CINV During HSCT	No drug interventions	Not Available	Not Available	terminated
NCT00003408	Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer	Aldesleukin Interferon alfa Sargramostim	treatment	2	completed
NCT04028479	The Registry of Oncology Outcomes Associated With Testing and Treatment	No drug interventions	Not Available	Not Available	recruiting
NCT02096783	Scripted Sexual Health Informational Intervention in Improving Sexual Function in Patients With Gynecologic Cancer	No drug interventions	supportive_care	Not Available	completed
NCT00010283	Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon	Beclomethasone dipropionate	supportive_care	1 / 2	completed
NCT00058071	Amifostine in Treating Peripheral Neuropathy in Patients Who Have Received Chemotherapy for Cancer	Amifostine	supportive_care	3	completed
NCT00897442	Collecting Tumor Samples From Patients With Gynecological Tumors	No drug interventions	Not Available	Not Available	completed
NCT00651716	T Cells in Predicting Acute Graft-Versus-Host Disease in Patients Undergoing Donor Stem Cell Transplant	No drug interventions	Not Available	Not Available	terminated
NCT04562558	Biweekly Actinomycin-D Treatment or Multi-day Methotrexate Protocol in Low-risk Gestational Trophoblastic Neoplasia	Dactinomycin Leucovorin Methotrexate	treatment	Not Available	recruiting
NCT00410657	Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant	Alemtuzumab Methylprednisolone Prednisone	supportive_care	2	completed
NCT04047017	Camrelizumab Combined With Apatinib for Recurrent Resistant GTN	Camrelizumab Rivoceranib	treatment	2	completed
NCT06339827	ASk Questions in GYnecologic Oncology (ASQ-GYO)	No drug interventions	health_services_research	Not Available	recruiting
NCT03280979	Rescue Regimen and High Dose Methotrexate in Management of Presistent Gestational Trophoplastic Neoplasia	No drug interventions	treatment	2 / 3	unknown_status
NCT02892877	The French National Reference Centre of GTD	No drug interventions	Not Available	Not Available	recruiting
NCT00706875	A Global Assessment of Medical, Emotional and Reproductive Concerns in Gestational Trophoblastic Disease Survivors	No drug interventions	Not Available	Not Available	completed
NCT05203562	Letrozole as a Prophylaxis From GTN for Complete Mole Patients	Letrozole	prevention	2 / 3	unknown_status
NCT05635344	A Feasibility Window Study of Pembrolizumab Prior to Second Evacuation for Post-molar Gestational Trophoblastic Neoplasia	Pembrolizumab	other	2	recruiting
NCT02606539	Surgery Plus Single Agent Chemotherapy Versus Primary Chemotherapy for Gestational Trophoblastic Neoplasms	Leucovorin Methotrexate	treatment	2 / 3	unknown_status
NCT02639650	Study of Paclitaxel Plus Cisplatin as the First-line Chemotherapy in High Risk Gestational Trophoblastic Tumor	Carboplatin Cisplatin Cyclophosphamide Dactinomycin Etoposide Methotrexate Paclitaxel Vincristine	treatment	3	recruiting
NCT04812002	Study of PD-1 Antibody and Bevacizumab in the Treatment of High-risk GTN After Combined Chemotherapy	Bevacizumab Camrelizumab	treatment	2	recruiting
NCT02664961	Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN)	Bevacizumab Carotuximab	treatment	2	terminated
NCT03703271	Study of Hysteroscopic Repeat Curettage as the First-line Treatment in Low-risk Postmolar Gestational Trophoblastic Neoplasia	Methotrexate	treatment	3	unknown_status
NCT04756713	Second Uterine Evacuation for Low-risk Gestational Trophoblastic Neoplasia	No drug interventions	treatment	3	recruiting
NCT03785574	Study of Different Therapeutic Strategies in Hydatidiform Mole With Lung Nodule	No drug interventions	treatment	Not Available	recruiting
NCT06028672	Toripalimab Plus Actinomycin-D as Fist-Line Treatment for GTN With FIGO Score 5-6	Dactinomycin Toripalimab	treatment	Not Available	recruiting
NCT05139095	Camrelizumab Plus Apatinib in Patients With High-risk Gestational Trophoblastic Neoplasia	Camrelizumab Rivoceranib	treatment	2	unknown_status
NCT04303884	Phase 2 Trial for Chemo-Resistant Gestational Trophoblastic Neoplasias With Pembrolizumab (CR-GTP)	Pembrolizumab	treatment	2	unknown_status
NCT05405192	Dostarlimab in Chemoresistant Gestational Trophoblastic Neoplasia	Dostarlimab	treatment	2	withdrawn
NCT06169644	The Psychological Impact of GTN on Women Who Have Completed Chemotherapy Treatment	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT06020755	Toripalimab Plus Actinomycin-D as Fist-Line Treatment for GTN With FIGO Score 7	Dactinomycin Toripalimab	treatment	2	not_yet_recruiting
NCT03135769	Avelumab in Chemo-resistant Gestational Trophoblastic Neoplasias	Avelumab	treatment	2	completed
NCT04396223	Avelumab and Methotrexate in in Low-risk Gestational Trophoblastic Neoplasias as First Line Treatment	Avelumab Methotrexate	treatment	1 / 2	recruiting