Mixed manic depressive episode (DBCOND0024284)

Identifiers

Synonyms

Mixed episode / Mixed episodes / Acute mixed episode / Bipolar affective disorder, mixed / Mixed manic episode / Mixed/manic episode / Mixed bipolar affective disorder (disorder) / Bipolar affective disorder, mixed, unspecified degree / Mixed bipolar affective disorder, NOS (disorder) / Bipolar disorder / Bipolar I disorder / Bipolar I disorder (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Aripiprazole	An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome.	D(2) dopamine receptortarget 5-hydroxytryptamine receptor 1Atarget 5-hydroxytryptamine receptor 2Atarget Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme 5-hydroxytryptamine receptor 1Btarget 5-hydroxytryptamine receptor 1Dtarget 5-hydroxytryptamine receptor 1Etarget D(1A) dopamine receptortarget D(1B) dopamine receptortarget D(3) dopamine receptortarget D(4) dopamine receptortarget 5-hydroxytryptamine receptor 2Ctarget 5-hydroxytryptamine receptor 3Atarget 5-hydroxytryptamine receptor 6target 5-hydroxytryptamine receptor 7target Histamine H1 receptortarget Alpha-1A adrenergic receptortarget Alpha-1B adrenergic receptortarget Alpha-2A adrenergic receptortarget Alpha-2B adrenergic receptortarget Alpha-2C adrenergic receptortarget Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Albumincarrier 5-hydroxytryptamine receptor 2Btarget 5-hydroxytryptamine receptor 5Atarget Beta-1 adrenergic receptortarget Beta-2 adrenergic receptortarget Histamine H2 receptortarget Histamine H3 receptortarget Histamine H4 receptortarget Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M3target Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M5target Kappa-type opioid receptortarget Mu-type opioid receptortarget Delta-type opioid receptortarget Glutamate (NMDA) receptortarget Sodium-dependent dopamine transportertarget Sodium-dependent serotonin transportertarget ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter
Asenapine	An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia.	5-hydroxytryptamine receptor 1Atarget 5-hydroxytryptamine receptor 1Btarget 5-hydroxytryptamine receptor 2Atarget 5-hydroxytryptamine receptor 2Btarget 5-hydroxytryptamine receptor 2Ctarget 5-hydroxytryptamine receptor 6target 5-hydroxytryptamine receptor 7target Alpha-2A adrenergic receptortarget Alpha-2B adrenergic receptortarget Alpha-2C adrenergic receptortarget Alpha-1A adrenergic receptortarget D(1A) dopamine receptortarget D(2) dopamine receptortarget D(3) dopamine receptortarget D(4) dopamine receptortarget Histamine H1 receptortarget Histamine H2 receptortarget Cytochrome P450 1A2enzyme Cytochrome P450 2D6enzyme 5-hydroxytryptamine receptor 5Atarget UDP-glucuronosyltransferase 1A4enzyme Cytochrome P450 3A4enzyme Beta-1 adrenergic receptortarget Beta-2 adrenergic receptortarget Albumincarrier alpha1-acid glycoproteincarrier
Carbamazepine	An anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia.	Voltage-gated sodium channel alpha subunittarget Cytochrome P450 2C8enzyme Cytochrome P450 2B6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 3A5enzyme UDP-glucuronosyltransferase 2B7enzyme RalA-binding protein 1transporter ATP-binding cassette sub-family C member 2transporter Neuronal acetylcholine receptor subunit alpha-4target Nuclear receptor subfamily 1 group I member 2target UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1-6enzyme UDP-glucuronosyltransferase 1A7enzyme
Clonazepam	A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, and seizures.	Cytochrome P450 3A4enzyme Albumincarrier Cytochrome P450 2E1enzyme Arylamine N-acetyltransferase 2enzyme GABA(A) Receptortarget Nuclear receptor subfamily 1 group I member 2target GABA(A) Receptor Benzodiazepine Binding Sitetarget
Lithium carbonate	A medication used to treat manic episodes of bipolar disorder.	Inositol monophosphatase 2target Inositol monophosphatase 1target Glycogen synthase kinase-3 betatarget Glutamate receptor 3target Amiloride-sensitive sodium channel subunit alphatransporter Amiloride-sensitive sodium channel subunit betatransporter Amiloride-sensitive sodium channel subunit gammatransporter
Olanzapine	An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders.	D(1A) dopamine receptortarget Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M3target 5-hydroxytryptamine receptor 2Atarget D(4) dopamine receptortarget Histamine H1 receptortarget Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M2target D(2) dopamine receptortarget 5-hydroxytryptamine receptor 2Ctarget D(3) dopamine receptortarget Alpha-1B adrenergic receptortarget Cytochrome P450 1A2enzyme 5-hydroxytryptamine receptor 3Atarget 5-hydroxytryptamine receptor 6target Alpha-1A adrenergic receptortarget D(1B) dopamine receptortarget Albumincarrier Alpha-1-acid glycoprotein 1carrier Flavin-containing monooxygenase 3enzyme Cytochrome P450 2D6enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2C19enzyme D(1) dopamine receptortarget Beta adrenergic receptortarget 5-hydroxytryptamine receptor 1target GABA(A) Receptor Benzodiazepine Binding Sitetarget Cytochrome P450 2C9enzyme UDP-glucuronosyltransferase 1A4enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A Subfamilyenzyme
Quetiapine	An atypical antipsychotic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder.	5-hydroxytryptamine receptor 2Atarget 5-hydroxytryptamine receptor 2Ctarget D(2) dopamine receptortarget 5-hydroxytryptamine receptor 1Atarget Histamine H1 receptortarget Cytochrome P450 3A4enzyme Alpha-1 adrenergic receptorstarget Alpha-2A adrenergic receptortarget Alpha-2B adrenergic receptortarget Alpha-2C adrenergic receptortarget 5-hydroxytryptamine receptor 1Dtarget Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M3target Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M5target 5-hydroxytryptamine receptor 1Btarget 5-hydroxytryptamine receptor 1Etarget 5-hydroxytryptamine receptor 3Atarget 5-hydroxytryptamine receptor 6target 5-hydroxytryptamine receptor 7target D(1B) dopamine receptortarget D(1A) dopamine receptortarget D(3) dopamine receptortarget D(4) dopamine receptortarget Cytochrome P450 3A5enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A7enzyme
Risperidone	A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression.	Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Albumincarrier Alpha-1-acid glycoprotein 1carrier 5-hydroxytryptamine receptor 2Atarget D(2) dopamine receptortarget Alpha-1B adrenergic receptortarget Alpha-2B adrenergic receptortarget Alpha-1A adrenergic receptortarget Alpha-2C adrenergic receptortarget Histamine H1 receptortarget 5-hydroxytryptamine receptor 2Ctarget 5-hydroxytryptamine receptor 1Dtarget 5-hydroxytryptamine receptor 1Atarget 5-hydroxytryptamine receptor 7target D(1A) dopamine receptortarget

Clinical Trials

Not Available