Refractory Acute Lymphoblastic Leukemia (ALL)

Also known as: Acute Lymphoblastic Leukemia, Refractory / Acute lymphocytic leukaemia refractory / Refractory Acute Lymphoblastic Leukemia / Acute lymphocytic leukemia refractory / Acute, refractory Lymphoblastic Leukemia / Acute, refractory Lymphocytic Leukemia / Acute, refractory Lymphoblastic Leukaemia / Acute, refractory Lymphocytic leukaemia / Refractory Acute lymphoblastic leukaemia

DrugDrug NameDrug Description
DB00631ClofarabineA purine nucleoside used to treat relapsed or refractory acute lymphoblastic leukemia in patients 1 to 21 years old.
DB00619ImatinibA tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors.
DB01280NelarabineA purine nucleoside analog and antineoplastic agent used for the treatment of with acute T-cell lymphoblastic leukemia and T-cell lymphoblastic lymphoma with inadequate clinical response to prior chemotherapeutic treatments.
DrugDrug NameTargetType
DB00631ClofarabineDNA polymerase alpha catalytic subunittarget
DB00631ClofarabineRibonucleoside-diphosphate reductase large subunittarget
DB00631ClofarabineDeoxycytidine kinaseenzyme
DB00631ClofarabineDNAtarget
DB00631ClofarabineATP-binding cassette sub-family G member 2transporter
DB00619ImatinibPlatelet-derived growth factor receptor betatarget
DB00619ImatinibTyrosine-protein kinase ABL1target
DB00619ImatinibMast/stem cell growth factor receptor Kittarget
DB00619ImatinibRET proto-oncogenetarget
DB00619ImatinibHigh affinity nerve growth factor receptortarget
DB00619ImatinibMacrophage colony-stimulating factor 1 receptortarget
DB00619ImatinibPlatelet-derived growth factor receptor alphatarget
DB00619ImatinibEpithelial discoidin domain-containing receptor 1target
DB00619ImatinibCytochrome P450 3A4enzyme
DB00619ImatinibBreakpoint cluster region proteintarget
DB00619ImatinibCytochrome P450 1A2enzyme
DB00619ImatinibCytochrome P450 2D6enzyme
DB00619ImatinibCytochrome P450 2C9enzyme
DB00619ImatinibCytochrome P450 2C19enzyme
DB00619ImatinibCytochrome P450 3A5enzyme
DB00619ImatinibCytochrome P450 3A7enzyme
DB00619ImatinibSolute carrier family 22 member 1transporter
DB00619ImatinibP-glycoprotein 1transporter
DB00619ImatinibSolute carrier family 22 member 2transporter
DB00619ImatinibATP-binding cassette sub-family G member 2transporter
DB00619ImatinibATP-binding cassette sub-family A member 3transporter
DB00619ImatinibProstaglandin G/H synthase 1enzyme
DB00619ImatinibSerum albumincarrier
DB00619ImatinibAlpha-1-acid glycoprotein 1carrier
DB00619ImatinibBile salt export pumptransporter
DB00619ImatinibCytochrome P450 2C8enzyme
DB01280NelarabineDNAtarget
DB01280NelarabineAdenosine deaminaseenzyme
DB01280NelarabineDeoxycytidine kinaseenzyme
DB01280NelarabineDeoxyguanosine kinase, mitochondrialenzyme
DB01280NelarabineDNA polymerase alpha catalytic subunittarget
DrugDrug NamePhaseStatusCount
DB01254Dasatinib0Recruiting1
DB00877Sirolimus0Terminated1
DB12001Abemaciclib1Recruiting1
DB05812Abiraterone1Recruiting1
DB08916Afatinib1Recruiting1
DB00062Albumin human1Recruiting1
DB00023Asparaginase Escherichia coli1Active Not Recruiting1
DB09495Avobenzone1Recruiting1
DB00112Bevacizumab1Recruiting1
DB01128Bicalutamide1Recruiting1
DB00188Bortezomib1Recruiting2
DB16741Bortezomib D-mannitol1Recruiting1
DB06772Cabazitaxel1Recruiting1
DB08875Cabozantinib1Recruiting1
DB01101Capecitabine1Recruiting1
DB00958Carboplatin1Recruiting1
DB00482Celecoxib1Recruiting1
DB05239Cobimetinib1Recruiting1
DB09110Coenzyme M1Recruiting1
DB12483Copanlisib1Recruiting1
DB00531Cyclophosphamide1Active Not Recruiting1
DB00531Cyclophosphamide1Recruiting2
DB00987Cytarabine1Active Not Recruiting1
DB00987Cytarabine1Recruiting1
DB00987Cytarabine1Terminated1
DB08912Dabrafenib1Recruiting1
DB11963Dacomitinib1Recruiting1
DB12941Darolutamide1Recruiting1
DB01254Dasatinib1Recruiting1
DB00694Daunorubicin1Recruiting1
DB01262Decitabine1Recruiting1
DB01234Dexamethasone1Active Not Recruiting1
DB01234Dexamethasone1Recruiting2
DB00997Doxorubicin1Active Not Recruiting1
DB00997Doxorubicin1Recruiting2
DB11714Durvalumab1Recruiting1
DB13874Enasidenib1Recruiting1
DB11986Entrectinib1Recruiting1
DB08899Enzalutamide1Recruiting1
DB00530Erlotinib1Recruiting1
DB01590Everolimus1Recruiting1
DB01073Fludarabine1Active Not Recruiting1
DB01073Fludarabine1Recruiting4
DB00544Fluorouracil1Recruiting1
DB00741Hydrocortisone1Active Not Recruiting1
DB09054Idelalisib1Recruiting1
DB00619Imatinib1Recruiting1
DB06186Ipilimumab1Recruiting1
DB00480Lenalidomide1Active Not Recruiting1
DB09078Lenvatinib1Recruiting1
DB00650Leucovorin1Recruiting1
DB12130Lorlatinib1Recruiting1
DB00678Losartan1Recruiting1
DB00888Mechlorethamine1Active Not Recruiting1
DB00563Methotrexate1Active Not Recruiting1
DB00688Mycophenolate mofetil1Active Not Recruiting1
DB15721Natural Killer Cell1Active Not Recruiting1
DB11828Neratinib1Recruiting1
DB09035Nivolumab1Recruiting1
DB09496Octinoxate1Recruiting1
DB09074Olaparib1Recruiting1
DB00526Oxaliplatin1Recruiting1
DB01229Paclitaxel1Recruiting1
DB09073Palbociclib1Recruiting3
DB06603Panobinostat1Recruiting1
DB00059Pegaspargase1Active Not Recruiting1
DB16281Pegcrisantaspase1Recruiting1
DB09037Pembrolizumab1Recruiting1
DB06366Pertuzumab1Recruiting1
DB11759Pevonedistat1Active Not Recruiting1
DB08901Ponatinib1Recruiting1
DB08896Regorafenib1Recruiting1
DB00073Rituximab1Active Not Recruiting1
DB08877Ruxolitinib1Recruiting1
DB14797SEphB4-HSA1Terminated1
DB11942Selinexor1Active Not Recruiting1
DB00877Sirolimus1Recruiting1
DB00398Sorafenib1Recruiting2
DB01268Sunitinib1Recruiting1
DB00864Tacrolimus1Active Not Recruiting1
DB08911Trametinib1Recruiting1
DB05773Trastuzumab emtansine1Recruiting1
DB00755Tretinoin1Recruiting1
DB08881Vemurafenib1Recruiting1
DB11581Venetoclax1Recruiting1
DB00541Vincristine1Active Not Recruiting1
DB00541Vincristine1Terminated1
DB08828Vismodegib1Recruiting1
DB02546Vorinostat1Recruiting1
DB00928Azacitidine1 / 2Recruiting1
DB09052Blinatumomab1 / 2Recruiting1
DB09110Coenzyme M1 / 2Recruiting2
DB14681Cortisone1 / 2Recruiting1
DB00531Cyclophosphamide1 / 2Recruiting3
DB00091Cyclosporine1 / 2Recruiting1
DB00987Cytarabine1 / 2Recruiting1
DB01234Dexamethasone1 / 2Recruiting2
DB00099Filgrastim1 / 2Recruiting2
DB01073Fludarabine1 / 2Recruiting3
DB00650Leucovorin1 / 2Recruiting1
DB16620Methopterin1 / 2Recruiting1
DB00563Methotrexate1 / 2Recruiting1
DB00723Methoxamine1 / 2Recruiting1
DB00959Methylprednisolone1 / 2Recruiting1
DB00075Muromonab1 / 2Recruiting1
DB00688Mycophenolate mofetil1 / 2Recruiting2
DB09037Pembrolizumab1 / 2Recruiting1
DB08901Ponatinib1 / 2Recruiting1
DB01263Posaconazole1 / 2Recruiting1
DB00635Prednisone1 / 2Recruiting1
DB00073Rituximab1 / 2Recruiting2
DB00877Sirolimus1 / 2Recruiting1
DB00864Tacrolimus1 / 2Recruiting1
DB11581Venetoclax1 / 2Recruiting3
DB00541Vincristine1 / 2Recruiting2
DB00582Voriconazole1 / 2Recruiting1
DB09312Antilymphocyte immunoglobulin (horse)2Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)2Recruiting1
DB02379Beta-D-Glucose2Recruiting2
DB09052Blinatumomab2Active Not Recruiting1
DB09052Blinatumomab2Recruiting2
DB00188Bortezomib2Recruiting1
DB16741Bortezomib D-mannitol2Recruiting1
DB01008Busulfan2Recruiting2
DB00631Clofarabine2Recruiting3
DB06189Clofarabine2Recruiting2
DB14681Cortisone2Active Not Recruiting1
DB14681Cortisone2Recruiting1
DB00531Cyclophosphamide2Active Not Recruiting1
DB00531Cyclophosphamide2Recruiting5
DB00987Cytarabine2Active Not Recruiting1
DB00987Cytarabine2Recruiting2
DB01254Dasatinib2Active Not Recruiting1
DB01254Dasatinib2Terminated1
DB00694Daunorubicin2Active Not Recruiting1
DB00694Daunorubicin2Recruiting1
DB01234Dexamethasone2Recruiting1
DB00997Doxorubicin2Recruiting1
DB00773Etoposide2Recruiting2
DB00099Filgrastim2Recruiting3
DB15223Flotetuzumab2Withdrawn1
DB01073Fludarabine2Active Not Recruiting1
DB01073Fludarabine2Recruiting2
DB09054Idelalisib2Terminated1
DB05889Inotuzumab ozogamicin2Terminated1
DB00888Mechlorethamine2Recruiting2
DB01033Mercaptopurine2Active Not Recruiting1
DB16620Methopterin2Active Not Recruiting2
DB16620Methopterin2Recruiting2
DB00563Methotrexate2Active Not Recruiting2
DB00563Methotrexate2Recruiting2
DB00959Methylprednisolone2Active Not Recruiting1
DB00959Methylprednisolone2Recruiting1
DB00075Muromonab2Active Not Recruiting1
DB00075Muromonab2Recruiting2
DB00688Mycophenolate mofetil2Active Not Recruiting1
DB00688Mycophenolate mofetil2Recruiting1
DB15721Natural Killer Cell2Recruiting1
DB06650Ofatumumab2Recruiting2
DB11697Pacritinib2Terminated1
DB00019Pegfilgrastim2Recruiting2
DB08901Ponatinib2Recruiting2
DB08901Ponatinib2Terminated1
DB00635Prednisone2Active Not Recruiting1
DB00635Prednisone2Recruiting1
DB00073Rituximab2Recruiting5
DB08877Ruxolitinib2Terminated1
DB00398Sorafenib2Terminated1
DB14546Sulfate ion2Active Not Recruiting1
DB14546Sulfate ion2Recruiting1
DB01268Sunitinib2Terminated1
DB00864Tacrolimus2Active Not Recruiting1
DB00864Tacrolimus2Recruiting1
DB04572Thiotepa2Active Not Recruiting1
DB03754Tromethamine2Active Not Recruiting1
DB00541Vincristine2Active Not Recruiting1
DB00541Vincristine2Recruiting3