Relapsing Multiple Sclerosis (RMS) (DBCOND0044896)

Identifiers

Synonyms
Multiple Sclerosis, Relapsing Forms / Relapsing Multiple Sclerosis / Multiple Sclerosis, Relapsing Forms of Multiple Sclerosis / Relapsing multiple sclerosis (MS) / Relapsing Forms of Multiple Sclerosis / Multiple Sclerosis, Relapsing / Relapsed Multiple sclerosis / Multiple Sclerosis Relapse / Multiple sclerosis flare

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Cladribine
A purine antimetabolite used to treat Multiple Sclerosis (MS) and hairy cell leukemia.
Daclizumab
A monoclonal anti-CD25 antibody that blocks the interleukin-2 receptor which is used to treat relapsing forms of multiple sclerosis.
Diroximel fumarate
A drug used for the treatment of relapsing forms of Multiple Sclerosis (MS).
Fingolimod
A sphingosine 1-phosphate receptor modulator used to treat patients with the relapsing-remitting form of multiple sclerosis (MS) and studied to manage lung complications of COVID-19.
Interferon beta-1a
A form of recombinant human interferon used to slow disease progression and reduce the frequency of clinical symptoms in patients who have relapsing multiple sclerosis.
Interferon beta-1b
A form of recombinant human interferon used to slow the progression of relapsing multiple sclerosis and to reduce the frequency of clinical symptoms.
Ocrelizumab
A CD20 specific monoclonal antibody used to treat relapsing remitting multiple sclerosis.
Ofatumumab
An anti-CD20 antibody used for the treatment of chronic lymphocytic leukemia (CLL) in selected patients with certain treatment histories and responsiveness to anticancer medications.
Ozanimod
A sphingosine 1-phosphate receptor modulator being studied to treat Multiple Sclerosis (MS) and inflammatory bowel disease (IBD).
Peginterferon beta-1a
An interferon beta used to treat relapsing forms of multiple sclerosis.
Ponesimod
A sphingosine 1-phosphate receptor modulator indicated to treat relapsing multiple sclerosis.
Siponimod
A medication used to treat relapsing multiple sclerosis.
Ublituximab
A low-fucose CD20-targeted monoclonal antibody used in the treatment of relapsing forms of multiple sclerosis.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT06486779
Kesimpta (Ofatumumab) in Greek Multiple Sclerosis Patients - an Observational StudyNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT04130997
An Extension Study of Ublituximab in Participants With Relapsing Multiple Sclerosistreatment3active_not_recruiting
NCT03277261
Study to Assess the Efficacy and Safety of Ublituximab in Participants With Relapsing Forms of Multiple Sclerosis (RMS) ( ULTIMATE 1 )treatment3completed
NCT04878211
A Open-label Study to Assess Response to COVID-19 Vaccine in Multiple Sclerosis Participants Treated With Ofatumumabtreatment4terminated
NCT04667949
Study of Efficacy and Safety of Fingolimod (Gilenya) 0.5 mg in Chinese Patients With Relapsing Multiple Sclerosis (RMS) Patientstreatment4active_not_recruiting
NCT03277248
Study to Assess the Efficacy and Safety of Ublituximab in Participants With Relapsing Forms of Multiple Sclerosis (RMS)treatment3completed
NCT03745144
Effects of Cladribine Tablets on the PK of Microgynon®other1completed
NCT02921035
Non-interventional Study to Assess Adherence to Treatment for Patients With RMS (MAIN-MS)Not AvailableNot Availablecompleted
NCT04086225
Effects of Cladribine Tablets on the Pharmacokinetics of Microgynon®other1recruiting
NCT01585766
Safety and Tolerability Study of MEDI-551, a B-cell Depleting Agent, to Treat Relapsing Forms of Multiple Sclerosistreatment1completed
NCT03650114
Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MStreatment3active_not_recruiting
NCT04667117
A Multicenter Study to Assess Response to Influenza Vaccine in Multiple Sclerosis Participants Treated With Ofatumumabtreatment4completed
NCT05232825
A Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Radiological And Clinical Effects Of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab In Patients With Multiple Sclerosistreatment3active_not_recruiting
NCT04586010
A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)treatment3active_not_recruiting
NCT05119569
A Study to Investigate the Efficacy of Fenebrutinib in Relapsing Multiple Sclerosis (RMS)treatment2active_not_recruiting
NCT05147220
Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)treatment3recruiting
NCT05156281
Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)treatment3recruiting
NCT05199571
Study of Efficacy and Safety of Ofatumumab in Relapsing Multiple Sclerosis (RMS) Patients in Chinatreatment4active_not_recruiting
NCT05877963
Study to Evaluate Efficacy of a Modified Regimen of Ublituximabtreatment3recruiting
NCT06143514
A Study Evaluating the Presence and Concentration of BRIUMVI™ (Ublituximab) in Breast MilkNo drug interventionsNot AvailableNot Availablerecruiting
NCT06396039
A Study to Assess the Effectiveness and Safety of Ozanimod in Chinese Adults With Relapsing Multiple Sclerosistreatment4recruiting
NCT06433752
A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)No drug interventionsNot AvailableNot Availablerecruiting
NCT06564311
A Study of Obexelimab in Patients With Relapsing Multiple Sclerosis (MoonStone)treatment2recruiting
NCT06617793
An Open-label Study to Assess the Safety, Efficacy, and Cellular Kinetics of YTB323 in Relapsing Multiple SclerosisNo drug interventionstreatment1 / 2not_yet_recruiting
NCT04626921
A Multi-Center, Open-Label Long-Term Extension Study of CNM-Au8 In Patients With Stable Relapsing Multiple Sclerosistreatment2 / 3completed
NCT01939002
Characterize Flu-like Symptoms in Relapsing Multiple Sclerosis Patients Transitioning From Non-Pegylated Interferon Beta (IFN-β) Therapies to Peginterferon Beta-1a (BIIB017)treatment3completed
NCT01034579
The REbif® vs Glatiramer Acetate in Relapsing Multiple Sclerosis Pharmacogenetics TrialNo drug interventionsNot Available4completed
NCT05090033
Characterizing the Use of Ofatumumab in a Real World SettingNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT00472797
Rebif New Formulation (RNF) Quality of Life (QOL) Studysupportive_care3completed
NCT06104683
A Study of Pirtobrutinib (LY3527727 [LOXO-305]) Versus Placebo in Participants With Relapsing Multiple Sclerosistreatment2withdrawn
NCT04338061
Study of Evobrutinib in Participants With RMS (evolutionRMS 2)treatment3terminated
NCT04047628
Best Available Therapy Versus Autologous Hematopoetic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)treatment3recruiting
NCT04410978
Relapsing Forms of Multiple Sclerosis (RMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (GEMINI 1)treatment3active_not_recruiting
NCT04079088
Study to Evaluate Oral BIIB061 Added to Interferon-beta1 (IFN-β1) or Glatiramer Acetate in Relapsing Multiple Sclerosis (RMS)treatment2withdrawn
NCT00619307
Transition to Rebif New Formulationsupportive_care3completed
NCT06395909
A Study to Assess the Effectiveness and Safety of Mayzent in Chinese Patients With Relapsing Forms of Multiple SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT02241785
Natalizumab as an Efficacy Switch in Participants With Relapsing Multiple Sclerosis After Failure on Other Therapiestreatment4terminated
NCT00988052
A Study To Evaluate the Long-Term Safety, Tolerability and Effect on Disease Coursetreatment3terminated
NCT06526000
Study to Assess Changes in Immunoglobulins in Patients With Relapsing Multiple Sclerosis Treated With Anti-CD20 TherapiesNo drug interventionsNot AvailableNot Availablecompleted
NCT01070836
JC Virus Antibody Study of Participants With Relapsing Forms of MS Receiving Treatment With NatalizumabNot AvailableNot Availablecompleted
NCT04928313
Safety and Effectiveness of Cinnomer® (Glatiramer Acetate) in Multiple Sclerosis (MS) Treatment in IranNot AvailableNot Availablecompleted
NCT02792218
Efficacy and Safety of Ofatumumab Compared to Teriflunomide in Patients With Relapsing Multiple Sclerosistreatment3completed
NCT01601119
Impact of Disease Modifying Therapies (DMTs) and Associated Support Services in Relapsing Multiple Sclerosis (RMS) PatientsNot AvailableNot Availablecompleted
NCT01006941
Trichuris Suis Ova Therapy for Relapsing Multiple Sclerosis - a Safety StudyNo drug interventionstreatment2completed
NCT01404117
A Multinational, Randomized, Double-blind, Parallel-group, Placebo-controlled Study Assessing the Safety and Tolerabilitytreatment2withdrawn
NCT02047734
Efficacy and Safety Study of Ozanimod in Relapsing Multiple Sclerosistreatment3completed
NCT04486716
A Single Arm Study Evaluating the Efficacy, Safety and Tolerability of Ofatumumab in Patients With Relapsing Multiple Sclerosistreatment3active_not_recruiting
NCT04847596
A Multicenter Study to Assess Response to COVID-19 Vaccine in Multiple Sclerosis Participants Treated With OfatumumabNo drug interventionsNot AvailableNot Availablecompleted
NCT03257358
A Study of Immune Phenotype Biomarkers in Patients With Relapsing Multiple Sclerosis (RMS) After Treatment With 0.5mg Fingolimodbasic_science4completed
NCT05809986
Ofatumumab in Portuguese Multiple Sclerosis Patients - an Observational StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT04121065
Role of ADA SNPs in Subjects With Relapsing Multiple Sclerosis (RMS)No drug interventionsNot AvailableNot Availablerecruiting
NCT04510220
9-month Study to Assess the Efficacy of Ofatumumab on Microglia in Patients With Relapsing Forms of Multiple Sclerosistreatment3recruiting
NCT04634994
Novel Assessment of Synaptic Density in Progressive MSNo drug interventionsdiagnostic0unknown_status
NCT03996291
Long Term Safety and Efficacy Study of Tolebrutinib (SAR442168) in Participants With Relapsing Multiple Sclerosistreatment2active_not_recruiting
NCT00853762
Atacicept in Multiple Sclerosis Extension Study, Phase IItreatment2terminated
NCT04353492
An Open-label Study Evaluating Ofatumumab Treatment Effectiveness and PROs in Subjects With RMS Transitioning From Fumarate-based RMS Approved Therapies or Fingolimod to Ofatumumabtreatment3active_not_recruiting
NCT05266469
Exploring the Profiles of RMS Patients on Ofatumumab or Ocrelizumab in a Real-World Setting in the GulfNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT03249714
Efficacy and Safety of Ofatumumab Compared to Placebo in Patients With Relapsing Multiple Sclerosis Followed by Extended Treatment With Open-label Ofatumumabtreatment2completed
NCT03623243
Safety and Tolerability of Conversion From Oral, Injectable, or Infusion Disease Modifying Therapies to Dose-titrated Oral Siponimod (Mayzent) in Advancing RMS Patientstreatment3completed
NCT04121403
Norwegian Study of Oral Cladribine and Rituximab in Multiple Sclerosis (NOR-MS)treatment3recruiting
NCT00642902
A Phase 2 Study of Atacicept in Subjects With Relapsing Multiple Sclerosis (ATAMS)treatment2terminated
NCT01412333
A Study of Ocrelizumab in Comparison With Interferon Beta-1a (Rebif) in Participants With Relapsing Multiple Sclerosistreatment3completed
NCT06372145
A Study to Investigate Long-term Safety and Tolerability of Tolebrutinib in Participants With Multiple Sclerosis.treatment3recruiting
NCT01199861
Effect of Treatment With Fingolimod on the Immune Response Following Seasonal Flu Vaccination and Tetanus Booster Injection in Patients With Relapsing Multiple Sclerosis (MS)treatment3completed
NCT01628393
Efficacy and Safety Study of Ozanimod (RPC1063) in Relapsing Multiple Sclerosis Patientstreatment2 / 3completed
NCT05776888
Early Versus Late Ofatumumab (Kesimpta®) Use in Austrian RMS-Patients Over 2 YearsNo drug interventionsNot AvailableNot Availablerecruiting
NCT05077956
Sema 4A as a Marker for Inflammatory Disease in Multiple SclerosisNo drug interventionsNot AvailableNot Availablewithdrawn
NCT02688985
Study to Explore the Mechanism of Action of Ocrelizumab and B-Cell Biology in Participants With Relapsing Multiple Sclerosis (RMS) or Primary Progressive Multiple Sclerosis (PPMS)treatment3completed
NCT00906399
Efficacy and Safety Study of Peginterferon Beta-1a in Participants With Relapsing Multiple Sclerosistreatment3completed
NCT06529406
Prospective Evaluation of Sequencing From antiCD-20 Therapies to Ozanimodtreatment1 / 2not_yet_recruiting
NCT03856619
To Evaluate the Safety and Efficacy of Teriflunomide in Patients With Relapsing Forms of Multiple Sclerosistreatment4completed
NCT01047319
A Study to Evaluate the Long-term Safety, Tolerability and Effect of Daily Oral Laquinimod 0.6 mg on Disease Course in Subjects With Relapsing Multiple Sclerosistreatment3terminated
NCT01332019
Long-Term Safety and Efficacy Study of Peginterferon Beta-1atreatment3completed
NCT04387734
Effects of Ocrevus in Relapsing Multiple Sclerosistreatment4active_not_recruiting
NCT01247324
A Study of Ocrelizumab in Comparison With Interferon Beta-1a (Rebif) in Participants With Relapsing Multiple Sclerosistreatment3completed
NCT03889639
Dose-finding Study for SAR442168 in Relapsing Multiple Sclerosistreatment2completed
NCT04338022
Study of Evobrutinib in Participants With RMS (evolutionRMS 1)treatment3terminated
NCT00726648
CDP323 Biomarker Studybasic_science1 / 2completed
NCT05496894
A Study of Mitoxantrone Hydrochloride Liposome Injection for Relapsing Multiple Sclerosistreatment2withdrawn
NCT04410991
Relapsing Forms of Multiple Sclerosis (RMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (GEMINI 2)treatment3active_not_recruiting
NCT01601080
An Observational, Retrospective, UK & Ireland Audit of Patient Adherence to Rebif® Injections Using the RebiSmart™ Injection DeviceNo drug interventionsNot AvailableNot Availablecompleted
NCT02142192
Natalizumab Subcutaneous Immunogenicity and Safety Studytreatment2terminated
NCT02254304
Effectiveness of Rebif® in Clinically Isolated Syndrome and Relapsing Multiple Sclerosis Using RebiSmart™treatment4completed
NCT05344469
A NIS Evaluating Injectable Treatments in Patients With Relapsing Multiple SclerosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT03183869
Fecal Microbial Transplantation in Relapsing Multiple Sclerosis Patientstreatment2terminated
NCT02234869
Transition to Peginterferon Beta-1a (BIIB017) From Subcutaneous Interferon Therapytreatment4withdrawn
NCT01127750
Tolerability and Safety and Health Outcomes in Relapsing Multiple Sclerosis (MS) Patientstreatment3completed
NCT04466150
Impact of Ocrelizumab on Cerebrospinal Fluid Biomarkers at Multiple Sclerosis Onsetbasic_science4active_not_recruiting
NCT04586023
Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)treatment3active_not_recruiting
NCT04964791
RMS Study of BTK Inhibitor SAR442168Not AvailableNot Availablerecruiting
NCT02307838
Long-term Follow-up of Fingolimod Phase II Study PatientsNo drug interventionsother4completed
NCT05798520
A Study to Learn About the Safety of BIIB091 and Its Effect on Brain Inflammation When Taken Alone or With Diroximel Fumarate (DRF) in Adults With Relapsing Forms of Multiple Sclerosis (MS)No drug interventionstreatment2recruiting
NCT05083923
A Study of Diroximel Fumarate (DRF) in Adult Participants From the Asia-Pacific Region With Relapsing Forms of Multiple Sclerosis (RMS)treatment3completed
NCT02428218
Placebo-Controlled Study of the Efficacy and Safety of BG00012 in Pediatric Subjects With Relapsing-Remitting Multiple Sclerosis (RRMS)treatment3withdrawn
NCT01216072
A 6-month, Randomized, Open-label, Patient OutComes, Safety and Tolerability Study of Fingolimod (FTY720) 0.5 mg/Day vs. Comparator in Patients With Relapsing Forms of Multiple Sclerosistreatment4completed
NCT04909502
Evaluation of Safety, Tolerability and Preliminary Efficacy of EHP-101 in Relapsing Forms of Multiple Sclerosistreatment2suspended
NCT00424788
A Multicenter Study to Assess the Effect of Plasma Exchange in Accelerating the Clearance of Natalizumab in Subjects With Multiple Sclerosis (MS)treatment0completed
NCT01201356
Long-term Safety and Tolerability of 0.5 mg Fingolimod in Patients With Relapsing Forms of Multiple Sclerosistreatment3completed
NCT02097849
Vaccination Response in Tecfidera-Treated Versus Interferon-Treated Participants With Relapsing Forms of Multiple Sclerosis.treatment2completed
NCT01873417
Phase 4 Gastrointestinal Tolerability Study of Dimethyl Fumarate in Patients With Relapsing Forms of Multiple Sclerosis in the United Statestreatment4completed
NCT06251986
A Cross-sectional Study to Assess the Effectiveness and Safety of Ofatumumab (Kesimpta®) in Patients With Relapsing Multiple Sclerosis in the Spanish Clinical PracticeNo drug interventionsNot AvailableNot Availablerecruiting
NCT01903291
Effectiveness of DMF and Its Impact on PROs in Suboptimal GA Responders With RMSNot AvailableNot Availablecompleted
NCT02230969
Plegridy Observational ProgramNot AvailableNot Availablecompleted
NCT04676555
Time and Motion Study for Ocrelizumab and Ofatumumab Administration in Relapsing Multiple SclerosisNot AvailableNot Availablecompleted
NCT04377555
Prospective Study to Assess Disease Activity and Biomarkers in Minority Participants With Relapsing Multiple Sclerosis (RMS) After Initiation and During Treatment With Ocrelizumab.treatment4active_not_recruiting
NCT04902690
The Possible Neuroprotective Effect of Ocrelizumab Via VEGF Protein Expression in Relapsing Multiple Sclerosis PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT02834533
Role of Virtual Reality in MS RehabilitationNo drug interventionstreatmentNot Availablecompleted
NCT05359653
Assessing Changes in Multi-parametric MRI in MS Patients Taking Clemastine Fumarate as a Myelin Repair Therapytreatment1 / 2recruiting
NCT06516458
Development of Camera Based Gait Quality Measure for Persons With Multiple SclerosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT01252355
Efficacy and Safety of Teriflunomide in Patients With Relapsing Multiple Sclerosis and Treated With Interferon-betatreatment3terminated
NCT04237675
Postoperative Relapses in MS PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT05218317
Evaluation of Relapse Presence in Multiple SclerosisNo drug interventionsNot AvailableNot Availablecompleted