Pain caused by Rheumatism (DBCOND0148483)

Identifiers

Synonyms

Rheumatic Pain / Musculoskeletal pain (finding) / Musculoskeletal pain

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Acetylsalicylic acid	A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Aldo-keto reductase family 1 member C1target Solute carrier family 22 member 6transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme 5'-AMP-activated protein kinasetarget Endothelin-1 receptortarget Cellular tumor antigen p53target Endoplasmic reticulum chaperone BiPtarget Ribosomal protein S6 kinase alpha-3target NF-kappa-B inhibitor alphatarget Tumor necrosis factor-inducible gene 6 proteintarget Caspase-1target Caspase-3target Inhibitor of nuclear factor kappa-B kinase subunit betatarget Extracellular signal-regulated kinase (ERK)target G1/S-specific cyclin-D1target Myc proto-oncogene proteintarget Proliferating cell nuclear antigentarget Cyclin Atarget UDP-glucuronosyltransferase 1-6enzyme Arylamine N-acetyltransferase 2enzyme Organic anion transporter 3transporter Sialidase-1target 3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
Caffeine	A stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth.	Adenosine receptor A1target 3',5'-cyclic-AMP phosphodiesterase 4Btarget Adenosine receptor A2atarget Cytochrome P450 1A2enzyme Ryanodine receptor 1target Cytochrome P450 3A4enzyme Cytochrome P450 2E1enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2D6enzyme Cyclic nucleotide phosphodiesterasetarget DNA-dependent protein kinase catalytic subunittarget Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformtarget Inositol 1,4,5-trisphosphate receptortarget Serine-protein kinase ATMtarget Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Adenosine receptor A2btarget Adenosine receptor A3target Phosphodiesterase enzymestarget 5'-nucleotidasetarget
Capsaicin	A topical analgesic agent used for the symptomatic relief of neuropathic pain associated with post-herpetic neuralgia, as well as other muscle and joint pain.	Cytochrome P450 3A4enzyme Prostaglandin G/H synthase 2enzyme Myeloperoxidaseenzyme Cytochrome P450 1A2enzyme Cytochrome P450 2E1enzyme Amine oxidase [flavin-containing] Aenzyme Dopamine beta-hydroxylaseenzyme Glutamine synthetaseenzyme Cholinesteraseenzyme Transient receptor potential cation channel subfamily V member 1target Prohibitin-2target
Carbaspirin calcium	An NSAID indicated in the treatment of short term pain and fever.	No drug targets
Cinnamon oil	Not Annotated	No drug targets
Diclofenac	An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Transthyretincarrier Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C8enzyme Albumincarrier ATP-binding cassette sub-family C member 4transporter Multidrug resistance-associated protein 1transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1C1transporter Solute carrier family 22 member 11transporter UDP-glucuronosyltransferase 2B7enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C18enzyme Cytochrome P450 2E1enzyme Solute carrier organic anion transporter family member 1B1transporter Bile salt export pumptransporter UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B4enzyme Polyunsaturated fatty acid 5-lipoxygenaseenzyme Sodium channel protein type 4 subunit alphatransporter Acid-sensing ion channel 1transporter Potassium voltage-gated channel subfamily KQT member 2transporter Potassium voltage-gated channel subfamily KQT member 3transporter Phospholipase A2, membrane associatedenzyme ATP-dependent translocase ABCB1transporter
Felbinac	Not Available	Procathepsin Ltarget Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02260336	The Effect of Panax Notoginseng Powders on Rheumatic Pain	Celecoxib	treatment	Not Available	unknown_status