Treatment Naive (DBCOND0043176)

Identifiers

Synonyms

Treatment naïve / Treatment-Naïve / Therapy naive / Treatment-naive / Drug-naïve patients / Treatment naive / Treatment naive (finding)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Amivantamab	An EGF and MET receptor targeted antibody indicated in the treatment of non-small cell lung cancer with an EGFR 20 exon insertion mutation.	Epidermal growth factor receptortarget Hepatocyte growth factor receptortarget Low affinity immunoglobulin gamma Fc region receptor III-Atarget
Atezolizumab	A monoclonal antibody used to treat advanced or metastatic urothelial carcinoma with disease progression during or up to 12 months after platinum-containing chemotherapy.	Programmed cell death 1 ligand 1target Programmed cell death protein 1target
Avelumab	An anti-PD-L1 monoclonal antibody used to treat metastatic merkel cell carcinoma, metastatic urothelial carcinoma, or renal cell carcinoma.	Programmed cell death 1 ligand 1target
Axitinib	An oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy.	Vascular endothelial growth factor receptor 1target Vascular endothelial growth factor receptor 2target Vascular endothelial growth factor receptor 3target Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C19enzyme UDP-glucuronosyltransferase 1A1enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1B1transporter Tyrosine-protein kinase ABL1target
Cabozantinib	A tyrosine kinase inhibitor used to treat advanced renal cell carcinoma, hepatocellular carcinoma, and medullary thyroid cancer.	Cytochrome P450 3A4enzyme Cytochrome P450 2C9enzyme Hepatocyte growth factor receptortarget Vascular endothelial growth factor receptor 2target Proto-oncogene tyrosine-protein kinase receptor Rettarget Cytochrome P450 2C8enzyme
Dolutegravir	An antiviral agent used for the treatment of HIV-1 infections in combination with other antiretroviral agents.	UDP-glucuronosyltransferase 1A1enzyme Cytochrome P450 3A Subfamilyenzyme Integrasetarget Solute carrier family 22 member 2transporter UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 1A9enzyme Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter ATP-dependent translocase ABCB1transporter Multidrug and toxin extrusion protein 1transporter Albumincarrier alpha1-acid glycoproteincarrier Gag-Pol polyproteintarget
Eltrombopag	A thrombopoietin receptor agonist used to treat thrombocytopenia or aplastic anemia associated with various etiologies.	Thrombopoietin receptortarget Cytochrome P450 2C8enzyme Cytochrome P450 1A2enzyme UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1A3enzyme Solute carrier organic anion transporter family member 1B1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter UDP-glucuronosyltransferase 1A9enzyme
Elvitegravir	An antiretroviral agent used in combination with other antiretrovirals for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults.	Integrasetarget Cytochrome P450 3A4enzyme UDP-glucuronosyltransferase 1A1enzyme Gag-Pol polyproteintarget
Erlotinib	An EGFR tyrosine kinase inhibitor used to treat certain small cell lung cancers or advanced metastatic pancreatic cancers.	Epidermal growth factor receptortarget Cytochrome P450 3A4enzyme Broad substrate specificity ATP-binding cassette transporter ABCG2transporter ATP-dependent translocase ABCB1transporter Nuclear receptor subfamily 1 group I member 2target Cytochrome P450 3A5enzyme Cytochrome P450 1A1enzyme Cytochrome P450 1A2enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2C8enzyme UDP-glucuronosyltransferase 1A1enzyme Albumincarrier Alpha-1-acid glycoprotein 1carrier Solute carrier organic anion transporter family member 2B1transporter Epidermal growth factor receptorenzyme
Gefitinib	A tyrosine kinase inhibitor used as first-line therapy to treat non-small cell lung carcinoma (NSCLC) that meets certain genetic mutation criteria.	Epidermal growth factor receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 3A5enzyme Cytochrome P450 1A1enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Albumincarrier Alpha-1-acid glycoprotein 1carrier
Ibrutinib	An antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia.	Tyrosine-protein kinase BTKtarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Albumincarrier alpha1-acid glycoproteincarrier Cytochrome P450 2D6enzyme
Ipilimumab	A human cytotoxic T-lymphocyte antigen 4 (CTLA-4) blocking antibody used to treat metastatic or unresectable melanoma.	Cytotoxic T-lymphocyte protein 4target
Irbesartan	An angiotensin receptor blocker used to treat hypertension, delay progression of diabetic nephropathy, and treat congestive heart failure.	Type-1 angiotensin II receptortarget Transcription factor Juntarget Cytochrome P450 2C9enzyme Cytochrome P450 2C8enzyme UDP-glucuronosyltransferase 1A3enzyme Prostaglandin G/H synthase 1enzyme Cytochrome P450 3A4enzyme Albumincarrier alpha1-acid glycoproteincarrier
Lamivudine	A reverse transcriptase inhibitor used to treat HIV and hepatitis B infections.	DNAtarget Protein Ptarget Multidrug resistance-associated protein 1transporter Solute carrier family 22 member 6transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Reverse transcriptase/RNaseHtarget Solute carrier family 22 member 1transporter Solute carrier family 22 member 2transporter Solute carrier family 22 member 3transporter Deoxycytidine kinaseenzyme UMP-CMP kinaseenzyme Phosphoglycerate kinase 1enzyme Nucleoside diphosphate kinase Aenzyme Nucleoside diphosphate kinase Benzyme Choline-phosphate cytidylyltransferase Aenzyme Ethanolamine-phosphate cytidylyltransferaseenzyme ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 4transporter ATP-binding cassette sub-family C member 3transporter ATP-binding cassette sub-family C member 2transporter 5'(3')-deoxyribonucleotidase, cytosolic typeenzyme Albumincarrier Gag-Pol polyproteintarget
Ofatumumab	An anti-CD20 antibody used for the treatment of chronic lymphocytic leukemia (CLL) in selected patients with certain treatment histories and responsiveness to anticancer medications.	B-lymphocyte antigen CD20target
Pegaspargase	A modified form of L-asparagine amidohydrolase used to treat acute lymphoblastic leukemia, which is dependent on an external source of asparagine.	L-asparaginetarget Thyroxine-binding globulincarrier
Rilpivirine	A non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other antiretrovirals to specifically treat human immunodeficiency virus type 1 (HIV-1).	Cytochrome P450 3A4enzyme Reverse transcriptase/RNaseHtarget Nuclear receptor subfamily 1 group I member 2target Cytochrome P450 2C19enzyme Cytochrome P450 2B6enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Albumincarrier Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2E1enzyme Gag-Pol polyproteintarget Sodium channel protein type 10 subunit alphatarget
Telaprevir	An NS3/4A viral protease inhibitor used in combination with other antivirals for the curative treatment of chronic Hepatitis C Virus infections.	Cytochrome P450 3A4enzyme Genome polyproteintarget ATP-dependent translocase ABCB1transporter Albumincarrier Alpha-1-acid glycoprotein 1carrier Solute carrier organic anion transporter family member 1B1target Solute carrier organic anion transporter family member 2B1target Genome polyproteintarget
Tenofovir alafenamide	A nucleoside analog reverse transcriptase inhibitor used for the treatment of chronic hepatitis B virus infection in adults with compensated liver disease.	Reverse transcriptase/RNaseHtarget ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 4transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Lysosomal protective proteinenzyme Liver carboxylesterase 1enzyme Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Reverse transcriptasetarget DNA polymerasetarget Albumincarrier Cytochrome P450 3A4enzyme Adenylate kinase isoenzyme 1enzyme Adenylate kinase 2, mitochondrialenzyme Nucleoside diphosphate kinase Aenzyme Nucleoside diphosphate kinase Benzyme Gag-Pol polyproteintarget
Trametinib	A kinase inhibitor used alone or in combination with dabrafenib to treat patients with cancers with specific BRAF mutations, such as melanoma and non-small cell lung cancer.	Cytochrome P450 2C8enzyme Cytochrome P450 3A4enzyme Dual specificity mitogen-activated protein kinase kinase 1target Dual specificity mitogen-activated protein kinase kinase 2target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04155515	A Phase III Study to Evaluate Efficacy and Safety of TG-2349 in Combination With DAG181 and RBV for HCV Type I Patients	Furaprevir Ribavirin Yimitasvir	treatment	3	completed
NCT03593447	To Evaluate Efficacy and Safety in TG-2349 Combination With DAG181 (± Ribavirin) in HCV Genotype I Infected Patients	Furaprevir Ribavirin Yimitasvir	treatment	2	completed
NCT04548700	Liposomal Mitoxantrone Hydrochloride Injection,Cyclophosphamide, Vincristine and Prednisone in the Treatment of PTCL	Cyclophosphamide Mitoxantrone Prednisone Vincristine	treatment	1	terminated
NCT03708289	Body Composition, Bone Health and Hormonal Status in HIV-1-infected Individuals	No drug interventions	Not Available	Not Available	terminated
NCT01241760	VX-950-C211 - A Dosing Regimen Study (Twice Daily Versus Every 8 Hours) of Telaprevir in Treatment-naïve Participants With Genotype 1 Chronic Hepatitis C Virus Infection	Peginterferon alfa-2a Ribavirin Telaprevir	treatment	3	completed
NCT00852618	Intensive Viral Dynamics Substudy of A5248	No drug interventions	Not Available	Not Available	completed